http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Jian Jin ),( Sun Woo Lim ),( Long Jin ),( Ji Hyun Yu ),( Hyun Seon Kim ),( Byung Ha Chung ),( Chul Woo Yang ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.2
Background/Aims: Metformin (MET) is a first-line drug for type 2 diabetes mellitus (DM); its effect on new-onset diabetes after transplantation caused by immunosuppressant therapy is unclear. We compared the effects of MET on DM caused by tacrolimus (TAC) or sirolimus (SRL). Methods: DM was induced by injection of TAC (1.5 mg/kg) or SRL (0.3 mg/kg) for 2 weeks in rats, and MET (200 mg/kg) was injected for 2 more weeks. The effects of MET on DM caused by TAC or SRL were evaluated using an intraperitoneal glucose tolerance test (IPGTT) and by measuring plasma insulin concentration, islet size, and glucose-stimulated insulin secretion (GSIS). The effects of MET on the expression of adenosine monophosphate-activated protein kinase (AMPK), a pharmacological target of MET, were compared between TAC- and SRL-treated islets. Results: IPGTT showed that both TAC and SRL induced hyperglycemia and reduced plasma insulin concentration compared with vehicle. These changes were reversed by addition of MET to SRL but not to TAC. Pancreatic islet cell size was decreased by TAC but not by SRL, but addition of MET did not affect pancreatic islet cell size in either group. MET significantly increased GSIS in SRL- but not in TAC-treated rats. AMPK expression was not affected by TAC but was significantly decreased in SRL-treated islets. Addition of MET restored AMPK expression in SRL-treated islets but not in TAC-treated islets. Conclusions: MET has different effects on hyperglycemia caused by TAC and SRL. The discrepancy between these drugs is related to their different mechanisms causing DM.
Jian Jin,Wei-jie Zhou,Ying Chen,Yi-long Liu,Xiao-qiang Sun,Hai-tao Xi 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.2
Two classes of morpholino-substitued thioacetate have been successfully synthesized and their electrochemical properties of self-assembled monolayers (SAMs) on Au electrode are measured by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The barrier property of the SAMs-modified surfaces is evaluated by using potassium ferro/ferri cyanide. The results suggest that the arenethioacetate forms higher- quality close-packed blocking monolayers in comparison with alkanethioacetate. Furthermore, it has shown that the barrier properties of these monolayers can be significantly improved by mixed SAMs formation with decanethiol. From our experimental results we find that the electron transfer reaction of [Fe(CN) 6 ] 3-/4- redox couple occurs predominantly through the pinholes and defects present in the SAM and both SAMs show a good and fast capacity in recognition for Ag + . The morphological and elementary composition have also been examined by scanning electron microscope (SEM) and energy dispersive spectrometer (EDS).
Yunqin Lin,Jianjin Liang,Shubin Wu,Baohan Wang 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.1
The study focused on the mesophilic anaerobic hydrogen production from PPS (pulp and paper sludge)and FW (food waste) pretreated by NaOH or H2SO4, and the subsequent thermophilic anaerobic methane production with the effluent in a two-stage process. The maximum hydrogen yield (78.35 mL gˉ1 VSfed)which was 50.21% higher than that of CK, was achieved when 10 g NaOH/100 g TSsubstrate was used. However, the maximum methane yield (383.8 mL gˉ1 VSfed) was obtained in CK as well as 64% SCOD removal efficiency was achieved. In short, NaOH/H2SO4 pretreatment was suitable to enhance the hydrogen production.
A novel ceramic GEM used for neutron detection
Zhou, Jianrong,Zhou, Xiaojuan,Zhou, Jianjin,Jiang, Xingfen,Yang, Jianqing,Zhu, Lin,Yang, Wenqin,Yang, Tao,Xu, Hong,Xia, Yuanguang,Yang, Gui-an,Xie, Yuguang,Huang, Chaoqiang,Hu, Bitao,Sun, Zhijia,Chen, Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.6
A novel ceramic Gas Electron Multiplier (GEM) has been developed to meet the demand of high counting rate for the neutron detection which is an alternative to <sup>3</sup>He-based detector at China Spallation Neutron Source (CSNS). An experiment was performed to measure the neutron transmittance of ceramic-GEM and FR4-GEM at the small angle neutron scattering (SANS) instrument. The result showed the ceramic-GEM has higher transmittance and less self-scattering especially for cold neutrons. One single ceramic GEM could give a gain of 10<sup>2</sup>-10<sup>4</sup> in the mixture gas of Ar and CO<sub>2</sub> (90%:10%) and its energy resolution was about 27.7% by using <sup>55</sup>Fe X ray of 5.9 keV. A prototype has been developed in order to investigate the performances of the ceramic GEM-based neutron detector. Several neutron beam tests, including detection efficiency, spatial resolution, two-dimensional imaging, and wavelength spectrum, were carried out at CSNS and China Mianyang Research Reactor (CMRR). The results show that the ceramic GEM-based neutron detector is a good candidate to measure the high intensity neutrons.
Yang, Jianqing,Zhou, Jianrong,Zhang, Lianjun,Tan, Jinhao,Jiang, Xingfen,Zhou, Jianjin,Zhou, Xiaojuan,Hou, Linjun,Song, Yushou,Sun, XinLi,Zhang, Quanhu,Sun, Zhijia,Chen, Yuanbo Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.7
The <sup>n</sup>MCP (Neutron sensitive microchannel plate) combined with advanced readout electronics is widely used in energy selective neutron imaging because of its good spatial and timing resolution. Neutron detection efficiency is a crucial parameter for the <sup>n</sup>MCP. In this paper, a mathematical model based on the oblique cylindrical channel and elliptical pore was established to calculate the neutron absorption probability, the escape probability of charged particles and overall detection efficiency of <sup>n</sup>MCP and analyze the effects of neutron incident position, pore diameter, wall thickness and bias angle. It was shown that when the doping concentration of the <sup>n</sup>MCP was 10 mol%, the thickness of <sup>n</sup>MCP was 0.6 mm, the detection efficiency could reach maximum value, about 24% for thermal neutrons if the pore diameter was 6 ㎛, the wall thickness was 2 ㎛ and the bias angle was 3 or 6°. The calculated results are of great significance for evaluating the detection efficiency of the <sup>n</sup>MCP. In a subsequent companion paper, the mathematical model would be extended to the case of the spatial resolution and detection efficiency optimization of the coating <sup>n</sup>MCP.
Jiang, Xingfen,Xiu, Qinglei,Zhou, Jianrong,Yang, Jianqing,Tan, Jinhao,Yang, Wenqin,Zhang, Lianjun,Xia, Yuanguang,Zhou, Xiaojuan,Zhou, Jianjin,Zhu, Lin,Teng, Haiyun,Yang, Gui-an,Song, Yushou,Sun, Zhiji Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.6
Gadolinium oxysulfide (GOS) is regarded as a novel scintillator for the realization of ultra-high spatial resolution in neutron imaging. Monte Carlo simulations of GOS scintillator show that the capability of its spatial resolution is towards the micron level. Through the time-of-flight method, the light output of a GOS scintillator was measured to be 217 photons per captured neutron, ~100 times lower than that of a ZnS/LiF:Ag scintillator. A detector prototype has been developed to evaluate the imaging solution with the GOS scintillator by neutron beam tests. The measured spatial resolution is ~36 ㎛ (28 line pairs/mm) at the modulation transfer function (MTF) of 10%, mainly limited by the low experimental collimation ratio of the beamline. The weak light output of the GOS scintillator requires an enormous increase in the neutron flux to reduce the exposure time for practical applications.