http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Wei?Jian Yi,Fan Yi,Yun Zhou 한국콘크리트학회 2021 International Journal of Concrete Structures and M Vol.15 No.4
In the recent two decades, the progressive collapse of reinforced concrete (RC) frame structures attracted unprecedented research interests in the structural engineering community. Experiments are regarded as an essential method in this field since actual cases can barely provide sufficient and effective data to support rigorous research. In this paper, prevailing experimental assumptions and configurations among over 100 series of experiments are quantitatively revealed by a bibliometric collection based on systematic search in an academic database. Since numerous experiments have been reported on the progressive collapse of RC frame structures, this paper subsequently presents a state-of-the-art review summarizing both experimental consensuses and controversies constituted by three main aspects: (a) static mechanisms, (b) dynamic behavior, and (c) threat-dependent research. The significance of secondary mechanisms, existing problems of dynamic effects, and potential flaws of the threat-independent assumption are discussed in detail with experimental findings. Future needs are emphasized on research targets, correlations between experiments and design, dynamic effects, threat-dependent issues, and retrofitting. These recommendations might help researchers or designers realize a more reliable and realistic progressive collapse design of RC frame structures in the future.
DNA methylation and mRNA expression of COL6A3 in antler mesenchyme of female and male reindeer
Jian‑Cheng Zhai,Ruo‑Bing Han,Sheng‑Nan Wang,Qiang‑Hui Wang,Yan‑Ling Xia,Wei‑Shi Liu,Ya‑Jie Yin,He‑Ping Li 한국유전학회 2019 Genes & Genomics Vol.41 No.9
Backgroud Reindeer is the only deer species that both male and female produce antlers, which provides a particularly interesting case in studying the differences between antlers of the two sexes. Alpha 3(VI) Collagen Gene (COL6A3), forms a microfibrillar network associated with the structural integrity and biomechanical properties, has been found to be one of the differentially expressed genes in antler mesenchyme of female and male reindeer. Objective and Methods The promoter sequence of reindeer COL6A3 gene was obtained using the cloning technology and analyzed by the bioinformatics methods. Bisulfite sequencing PCR (BSP) was used to detect the methylation status of the COL6A3 promoter in reindeer antler mesenchyme. Real-time quantitative PCR was used to detect COL6A3 expression in the antler mesenchyme of female and male reindeer. Results Sequence analysis revealed that the reindeer COL6A3 partial promoter sequence was 983 bp including the possible promoter region at + 105 bp to + 155 bp. Homology and phylogenetic analysis indicated that the COL6A3 promoter of reindeer had the closest genetic distance with Bos taurus, Capra hircus and Ovis aries. BSP results indicated that the methylation level of COL6A3 promoter in the female reindeer antler mesenchyme was significantly higher than in the male. Correlating with increased methylation status, we also found that COL6A3 mRNA expression in female reindeer antler mesenchyme was significantly lower than in the male. Conclusion The higher methylation level of the COL6A3 gene in female reindeer antler mesenchyme coincides with decreased COL6A3 mRNA expression, thereby affecting the transposon silencing mechanism and possibly contributing to apparent differences of antlers in female and male reindeer.
Jian-Wei Pan,Ren-Ya Zhan,Liang Wen,Ying Tong,Shu Wan,Yong-Ying Zhou 연세대학교의과대학 2009 Yonsei medical journal Vol.50 No.4
Purpose: To describe the therapeutic effect and possibility of the ultra-early surgery for poor-grade aneurysmal subarachnoid hemorrhage (Hunt-Hess grades Ⅳ-Ⅴ). Materials and Methods: Nine cases with intracranial aneurysms, demonstrated by computed tomographic angiography (CTA), were treated by ultra-early surgery under general anesthesia within 24 hours from subarachnoid hemorrhage (SAH), 5 cases were treated within 6 hours and 4 cases in 6 - 24 hours. Preoperative Hunt-Hess grade: 6 cases were Ⅳ and 3 cases were Ⅴ. The clinical outcome was evaluated by Glasgow Outcome Scores (GOS). Results: In operation, difficult dissection occurred in 5 cases (55.6%), and rupture of aneurysm occurred and temporary obstructions were performed in 4 cases (44.4%). After clipping of aneurysm, 2 cases underwent V-P shunt because of hydrocephalus, pulmonary infection occurred in 3 cases, hypothalamus reaction accompanied with upper gastrointestinal hemorrhage in 2 cases. The clinical outcome were favorable (GOS 4 - 5) in 4 cases (44.4%), dissatisfied (GOS 2 - 3) in 3 cases (33.3%), and dead (GOS 1) in 2 cases (22.2%) when patients departed from our hospital. Conclusion: The ultra-early surgery can avoid early rebleeding of intracranial aneurysm, therefore, should be considered in the treatment of Hunt-Hess grade Ⅳ-Ⅴ intracranial aneurysms. The appliance of CTA can make it possible to use of ultra-early surgery and improve the therapeutic effect. Purpose: To describe the therapeutic effect and possibility of the ultra-early surgery for poor-grade aneurysmal subarachnoid hemorrhage (Hunt-Hess grades Ⅳ-Ⅴ). Materials and Methods: Nine cases with intracranial aneurysms, demonstrated by computed tomographic angiography (CTA), were treated by ultra-early surgery under general anesthesia within 24 hours from subarachnoid hemorrhage (SAH), 5 cases were treated within 6 hours and 4 cases in 6 - 24 hours. Preoperative Hunt-Hess grade: 6 cases were Ⅳ and 3 cases were Ⅴ. The clinical outcome was evaluated by Glasgow Outcome Scores (GOS). Results: In operation, difficult dissection occurred in 5 cases (55.6%), and rupture of aneurysm occurred and temporary obstructions were performed in 4 cases (44.4%). After clipping of aneurysm, 2 cases underwent V-P shunt because of hydrocephalus, pulmonary infection occurred in 3 cases, hypothalamus reaction accompanied with upper gastrointestinal hemorrhage in 2 cases. The clinical outcome were favorable (GOS 4 - 5) in 4 cases (44.4%), dissatisfied (GOS 2 - 3) in 3 cases (33.3%), and dead (GOS 1) in 2 cases (22.2%) when patients departed from our hospital. Conclusion: The ultra-early surgery can avoid early rebleeding of intracranial aneurysm, therefore, should be considered in the treatment of Hunt-Hess grade Ⅳ-Ⅴ intracranial aneurysms. The appliance of CTA can make it possible to use of ultra-early surgery and improve the therapeutic effect.
Influences of stochastic perturbation of parameters on dynamic behavior of gear system
Jian-Wei Lu,Fan-Ling Zeng,Jia-Yun Xin,En-Min Miao,Meng-Jun Liu 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.7
Gear systems are commonly used in vehicles, and the vibration of the gear system was paid more attention in recent years. In this paper,the dynamic behavior of gear system with stochastic perturbation of system parameters was analyzed. A stochastic nonlinear dynamic model of gear system, with consideration of the stochastic perturbation of system parameters, was established. The influences of stochastic perturbation of system parameters, such as excitation frequency, damping ratio, and backlash, on the dynamic behavior of the system were discussed. It was found that when the perturbation intensity is weak, the topological structure of the system solutions will not change, and there is no transition of the attractors. But if the perturbation intensity increases further, there will be transition between the attractors. In general, for single-DOF gear system, the multi-periodic attractor will jump to the quasi-period-1 attractor. But the quasiperiod-1 attractor will not jump to other attractors. If the perturbation intensity is considerable great, bi-directional transition will occur. Yet, the probability of transition from multi-periodic attractor to quasi-period-1 attractor is greater than the probability of transition from multi-periodic attractor to other attractors. Which provide theoretical basis for effective vibration control of gear system.
집파리유충 hemolymph 중신형의 anti-fungal peptides의 분리정제
Jian-Wei Wu,Li-juan Gu,Xiao-Qing Su,성창근 한국생명과학회 2006 생명과학회지 Vol.16 No.3
To isolate and purify anti-fungal active substances from immunized housefly (Musca domestica), low dose of Candida albicans was injected into the larvae of the housefly to induce the appearance of potent anti-fungal active substances in the hemolymph. This purification work was performed by the routine isolation and purification processes of protein, namely, solid phase extraction (SPE), SDS-PAGE electrophoresis, HPLC purification. Three 4~16 kDa peptides which exhibited antifungal activity against Candida albican and other fungi were isolated from induced hemolymph. Consequently, further anti-fungal activity study showed that these three peptides were different either in molecular weight or in anti-fungal activity. All isolated substances were proved to be active and resistant to high-temperature. It was deduced that these peptides isolated from induced housefly were novel members of the insect defensin family and they were inducible. 유도된 집파리유통 hemolymph중에서 Candida albicans의 3가지 anti-fungal peptides를 분리하였다. 3개 anti-fungal peptides는 분자량이 4-16 kDa 사이의 분명한 구별이 있을 뿐만 아니라, 각 peptide는 anti-fungal peptides 작용이 있었다. 이들 peptide의 공통 특징은 모두 열을 받은 뒤 활성이 변하지 않는 비교적 강한 내열성을 보여주었다.
Jian-Wei Zheng,Yinshen Yang,Shujuan Yang,Wei Zhou,Hongtian Qiu,Xiaoping Li,Qiuyun Cai,Ting Li,Gang Luo 한국통합생물학회 2018 Animal cells and systems Vol.22 No.2
Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide, which appears as a consequence of multiple molecular genetic events in various chromosomes and genes. In order to unveil the possible mechanisms underlying OSCC tumorigenesis, the OSCC-related gene expression variance and the gene interaction network should be further investigated. Herein, we conducted the NimbleGen Human Gene Expression Microarray to analyze expression heterogeneity between OSCC primary tumor tissue and its adjacent normal tissue from two patients. A total number of 7872 out of 32,448 detected genes are differentially expressed in OSCC. Gene ontology (GO) analysis demonstrated that these differentially expressed transcripts were critical in a series of metabolic processes, cancer-related signal pathways, and biological regulations. KEGG signaling pathway enrichment suggested a number of pathways (metabolic process and immune response) which are frequently enrolled during cancer progression. 15 most differential regulated genes between OSCC tumor and non-tumor were confirmed by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Furthermore, the interaction network analysis of these confirmed genes by STRING database showed the two subunits of RACK1 had direct interaction with 14 differential proteins. This bioinformatics research lends support about the critical role of RACK1 which functions as a key node protein driving OSCC development.
A New Ambiguity Elimination Method for BSS Block Signals in Time Domain
Wei Zhao,Fengshan Wang,Yuehong Shen,Yuanyuan Wu,Zhigang Yuan,Pengcheng Xu,Pengcheng Xu,Yimin Wei,Wei Jian 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.11
This paper deals with the ambiguity problem of blind source separation (BSS) in the case where continuously received mixture signals are split in time and processed block by block. Due to the inherent permutation and scaling ambiguities of BSS, tying the separated components at each adjacent time blocks doesn’t recover the original source signals correctly in general. Inspired by the Permutation Method of reconstructing source signal blocks in time domain, a new ambiguity elimination approach is proposed in this paper. This method aims to concatenate the separated components in adjacent blocks by artificially setting contrast blocks for each adjacent time blocks. The core idea of this method is to utilize the associativity between components recovered from contrast blocks and corresponding adjacent blocks. Compared with Permutation Method, the main advantage of this new method consists in the fact that it is much more efficient in terms of separation quality and computational speed. Besides, a tradeoff can be adjusted between separation quality and computational speed by choosing different length of contrast blocks. Real-life experiments are performed to validate the performance of this method on the wireless communication system with two transmitting and receiving antennas.
A Novel and Efficient Wireless Communication System
Wei Zhao,Yuehong Shen,Zhigang Yuan,Yimin Wei,Wei Jian 보안공학연구지원센터 2015 International Journal of Future Generation Communi Vol.8 No.5
This paper aims to construct a novel wireless communication system, in which source signals are transmitted simultaneously in the same frequency band. The transmitted signals are only required to be statistically independent or statistically distinguished. Therefore, the source signals can be recovered at the receiver by utilizing the classical algorithms of blind source separation (BSS) and independent component analysis (ICA) such as the fast fixed-point algorithm (FastICA). On the one hand, because the source signals are transmitted simultaneously in the same frequency band, the spectrum efficiency of this novel system is much higher than those of time division multiplexing (TDM), frequency division multiplexing (FDM), and code division multiplexing (CDM) systems, in which TDM, FDM and CDM signals are limited in time interval, frequency band and code. On the other hand, inspired by recently proposed reference-based schemes, the reference signals are introduced to the classical separation algorithms of BSS and ICA, which makes this novel system much more efficient than classical ones in terms of computational speed. The performance of this new system is validated through realistic experiments. Additionally, it is theoretically shown that the information content of all the source signal inputs can be recovered by this novel wireless communication system.
Wei, Jin-Jian,Jin, Lei,Wan, Kun,Zhou, Cheng-He Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.1
A series of novel glucose derived benzyl and alkyl 1,2,3-triazoles and their hydrochlorides have been synthesized via Cu(I)-catalyzed 1,3-dipolar cycloaddition. All the new compounds were characterized by MS, IR and NMR spectra. The DEPT, APT, $^1H$-$^1H$ and $^1H-^{13}C$ 2D NMR spectra for some compounds were also recorded. These compounds were evaluated for their in vitro antibacterial activities against Staphylococcus aureus ATCC 29213, Bacillus subtilis, Bacillus proteus, Pseudomonas aeruginosa, Escherichia coli ATCC 25922, and antifungal activities against Candida albicans and Aspergillus fumigatus. The bioactive data revealed that (3R,4S,5S,6S)-2-(hydroxymethyl)-6-methoxy-4,5-bis((1-octyl-1H-1,2,3-triazol-4-yl)methoxy)-tetrahydro-2H-pyran-3-ol 8a exhibited excellent antifungal activity against A. fumigatus with an MIC value of 0.055 mM compared to Fluconazole. It also showed broad inhibitory efficacy against tested bacterial strains with MIC values ranging from 0.049 mM to 0.39 mM.