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Jian-Jun He,Fu-Liang Han,Qing-Quan Yu,Qiu-Hong Pan,Chang-Qing Duan,Guo-Li Cheng 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.3
The effects of the maceration enzymes on the evolution of 4-vinylphenols pyranoanthocyanins and cinnamic acids were investigated during the Cabernet Gernischet red wine making. The results showed that the contents of p-coumaric acid and caffeic acid in the maceration enzyme-treated wine (the treated wine) were higher than those in the maceration enzyme-untreated wine (the control wine) at the alcoholic fermentation (AF),maceration (M), and malolactic fermention (MLF) stages. Malvidin-3-O-glucoside-4-vinylphenol (Mv-glu-vp) and malvidin-3-O-(6-O-acetyl)-glucoside-4-vinylphenol (Mvacet-glu-vp) were formed at the AF and M stages in the treated wine, while they were formed at the end of MLF stage in the control wine. However, the contents of these 2kinds of 4-vinylphenol pyranoanthocyanins in the control wine were higher than those in the treated wine during aging. These results showed that the use of maceration enzymes in winemaking can promote p-coumaric acid and p-caffeic acid transformed to vinylphenols and accelerate the formation of pyranoanthocyanins.
Duan-Jian Tao,Yan Dong,Zhi-Jun Cao,Feng-Feng Chen,Xiang-Shu Chen,Kuan Huang 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.41 No.-
A series of sulfonic functionalized ionic liquids (SFILs) with different acidity were designed and preparedfor the synthesis of terpene esters (e.g. geranyl acetate). The effect of acidity of SFILs on their performancewas investigated systematically. It is found that tuning the acidity of SFILs to an appropriate value resultsin not only high conversion of geraniol but also superior selectivity of geranyl acetate. The SFILs can beeasily separated from products byfiltration under room temperature, thus showing good reusability. Furthermore, the kinetics for SFILs in the esterification of geraniol were determined as the basis for futureprocess design.
The history source of heated kang in jing ji district’s traditional houses
Zhi Jun Duan,Jian Dai,Zhao Na Dong 국제온돌학회 2016 International Journal of Ondol Vol.9 No.1
From the northern and southern dynasties, undergo tang、song、jin and yuan dynasty, to the Ming and qing dynasties, heated kang is widely used in residential house lay and heating facilities in Beijing and Hebei areas folk house. In this paper, by collating relevant historical facts to follow Beijing and Hebei area is the historical origins of the necessary historical explanation.
The history source of heated kang in jing ji district’s traditional houses /2015
Zhi Jun Duan,Jian Dai,Zhao Na Dong 국제온돌학회 2015 International Journal of Ondol Vol.2015 No.-
From the northern and southern dynasties, undergo tang、song、jin and yuan dynasty, to the Ming and qing dynasties, heated kang is widely used in residential house lay and heating facilities in Beijing and Hebei areas folk house. In this paper, by collating relevant historical facts to follow Beijing and Hebei area is the historical origins of the necessary historical explanation.
Shi, Yong Gang,Duan, Yu Lian,Chen, Jian Hua,Wu, Xiang Hua,Zhou, Ying,Zhang, Jun Feng Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.1
A bottom-modified (4-position) naphthalimide derivative 1 with 1,8-naphthyridine as binding site has been designed and synthesized. Compound 1 is the first 1,8-naphthyridine-modified naphthalimide-based sensor that can detect $Hg^{2+}$ selectively with respect to ratiometric fluorescent change and blue shift in organic aqueous solution. The Job's plot and FAB mass indicate that 1 formed a 1:1 complex with $Hg^{2+}$. A top-modified naphthalimide derivative 2 with 1,8-naphthyridin as binding site has also been synthesized for comparison.
Fu-Liang Han,Shou-Mei Jiang,Jian-Jun He,Qiu-Hong Pan,Chang-Qing Duan,Ming-Xia Zhang 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.3
Anthocyanins are considered one of the main color determinants in aged red wine. The anthocyanins in aged red wine made from ‘Cabernet Gernischet’ (Vitis vinifera L. cv.) grape were investigated by high performance liquid chromatography- electronic spray ionization- mass spectrometry (HPLC-ESI-MS) and their color presented in aqueous solution were evaluated using partial least square regression (PLS). The results showed that there were 37 anthocyanins identified in this wine, including 22 pyranoanthocyanins. The analysis of PLS indicated that different anthocyanins showed distinct color values: malvidin 3-O-(6-O-acetyl)-glucoside-4-vinylguaiacol (Mv3-acet-glu-vg) presented the highest color values, while malvidin 3-O-glucoside (Mv3-glu) showed least. Among the free non-acylated anthocyanins, peonidin 3-Oglucoside (Pn3-glu) showed the highest color values; the coumarylated anthocyanins presented higher color values than their corresponding acetylated anthocyanins and parent anthocyanins; pyranoanthocyanins presented also higher color values than their original anthocyanins; the color of anthocyanins depended on their structure. This work will be helpful to reveal evolution in aged red wine.
Peptidoglycans Promotes Human Leukemic THP-1 Cell Apoptosis and Differentiation
Wang, Di,Xiao, Pei-Ling,Duan, Hua-Xin,Zhou, Ming,Liu, Jin,Li, Wei,Luo, Ke-Lin,Chen, Jian-Jun,Hu, Jin-Yue Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12
The innate immune system coordinates the inflammatory response to pathogens. To do so, its cells must discriminate self from non-self utilizing receptors that identify molecules synthesized exclusively by microbes. Toll-like receptors have a crucial role in the detection of microbial infection in mammals and insects. In mammals, they have evolved to recognize conserved products unique to microbial metabolism. These include lipopolysaccharide (LPS), lipotechoic acids, and peptidoglycans (PGN). We show here that TLRs, including TLR2, are expressed on the THP-1 human leukemia cell line. Activation of TLR2 signaling in THP-1 by PGN induces the synthesis of various soluble factors and proteins including interleukin-$1{\beta}$, interleukin-8 and TNF-${\alpha}$ and apoptosis of THP-1 with PGN dose and time dependence. Moreover, in this study we show that PGN induces apoptosis of THP-1 cells in a TNF-${\alpha}$-dependent manner. These findings indicate that TLR2 signaling results in a cascade leading to tumor apoptosis and differentiation, which may suggest new clinical prospects using TLR2 agonists as cytotoxic agents in certain cancers.
Cho, Soo-Jeong,Yoon, Changhwan,Lee, Jun Ho,Chang, Kevin K.,Lin, Jian-xian,Kim, Young-Ho,Kook, Myeong-Cherl,Aksoy, Bu¨lent Arman,Park, Do Joong,Ashktorab, Hassan,Smoot, Duane T.,Schultz, Nikolaus,Yoon, American Association for Cancer Research 2018 Clinical Cancer Research Vol.24 No.24
<P><B>Purpose:</B></P><P>Lauren diffuse-type gastric adenocarcinomas (DGAs) are generally genomically stable. We identified lysine (K)-specific methyltransferase 2C (<I>KMT2C</I>) as a frequently mutated gene and examined its role in DGA progression.</P><P><B>Experimental Design:</B></P><P>We performed whole exome sequencing on tumor samples of 27 patients with DGA who underwent gastrectomy. Lysine (K)-specific methyltransferase 2C (<I>KMT2C</I>) was analyzed in DGA cell lines and in patient tumors.</P><P><B>Results:</B></P><P><I>KMT2C</I> was the most frequently mutated gene (11 of 27 tumors [41%]). KMT2C expression by immunohistochemistry in tumors from 135 patients with DGA undergoing gastrectomy inversely correlated with more advanced tumor stage (<I>P</I> = 0.023) and worse overall survival (<I>P</I> = 0.017). KMT2C shRNA knockdown in non-transformed HFE-145 gastric epithelial cells promoted epithelial-to-mesenchymal transition (EMT) as demonstrated by increased expression of EMT-related proteins N-cadherin and Slug. Migration and invasion in gastric epithelial cells following KMT2C knockdown increased by 47- to 88-fold. In the DGA cell lines MKN-45 and SNU-668, which have lost KMT2C expression, KMT2C re-expression decreased expression of EMT-related proteins, reduced cell migration by 52% to 60%, and reduced cell invasion by 50% to 74%. Flank xenografts derived from KMT2C-expressing DGA organoids, compared with wild-type organoids, grew more slowly and lost their infiltrative leading edge. EMT can lead to the acquisition of cancer stem cell (CSC) phenotypes. KMT2C re-expression in DGA cell lines reduced spheroid formation by 77% to 78% and reversed CSC resistance to chemotherapy via promotion of DNA damage and apoptosis.</P><P><B>Conclusions:</B></P><P><I>KMT2C</I> is frequently mutated in certain populations with DGA. KMT2C loss in DGA promotes EMT and is associated with worse overall survival.</P>
Kai Zang,Xiaoyi Wang,Zhongqi Yang,Ke Wei,Jian Jun Duan 한국응용곤충학회 2017 Journal of Asia-Pacific Entomology Vol.20 No.1
Agrilus fleischeri Obenberger (Coleoptera: Buprestidae) is anemerging pest of poplar trees in northeast China, and is responsible for poplarmortality throughout its range. Its biology and natural enemieswere studied at two field locations from 2013 to 2015 as well as via laboratory experiments. Life history of A. fleischeri was univoltine on exotic Populus nigra var. italica and overwintered asmature larvae in pupal chambers; however,was semivoltine on native Populus davidiana and overwintered as 2nd or 3rd instar larvae in Liaoning Province, China. Adults emerged fromlateMay to mid-Augustwith a peak in early June. Eggswere first discovered in early June and continued to late August. Larvae fed frommid-June to late September of univoltine or frommid-June to the next early September of semivoltine. The sex ratio of adult beetleswas approximately 1:1 (M:F).Mean longevities of female and male adults were 34.87 ± 18.70 and 34.33 ± 18.10 days, respectively. Mean duration of egg stage was 12.83±1.10 days and pupal duration 26.40±1.32 days.Mortality in the fieldwas mainly caused by parasitoids; however, pathogens, predators, and host tree resistance were also noted. The egg parasitoids, Oobius spp. attacked 48.0% and 6.48% of A. fleischeri eggs in P. nigra var. italica and P. davidiana, respectively. Polystenus rugosus and Paramblynotus sp. parasitized 0.71% and 52.17% of larvae in P. nigra var. italica respectively. Euderus fleischeri, Polystenus rugosus, andSpathius sp.were found in P. davidianawith parasitismrates of 7.63%, 4.83%, and 0.25% respectively.
Zhang, Lu-Ping,Liao, Xing-Yun,Xu, Yan-Mei,Yan, Lv-Jun,Yan, Gui-Fang,Wang, Xin-Xin,Duan, Yu-Zhong,Sun, Jian-Guo Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7
Background: Soft tissue sarcomas (STS) are a heterogeneous group of tumors, and approximately 40-50% of patients with STS develop metastatic disease. The median overall survival of those patients was 12 months and their 5-year survival rate was 8%. Therefore, study on more effective treatment, especially the targeting therapies, is urgently needed. Objective: To evaluate the efficacy and safety of Endostar$^{(R)}$ combined with chemotherapy in patients with advanced STS. Methods: A retrospective case-series study was conducted in Cancer Institute of PLA, Xinqiao Hospital. A total of 71 patients suffering from advanced STS (IIB - IV) were included, of whom 49 cases treated with chemotherapy alone were defined as the control group and the rest 22 cases treated with the traditional chemotherapy combined with Endostar$^{(R)}$ were defined as the test group. The short-term therapeutic effects including objective response rate (ORR), disease control rate (DCR) and safety were evaluated in the two groups. In the follow-up, progression-free survival (PFS) and overall survival (OS) were also observed. Results: In the test and control groups, the ORR was 18.2% and 12.2%, respectively (P=0.767), and the DCR was 86.4% and 61.2%, respectively (P=0.034). The median time to progression in the test and control groups was 120 days and 70 days with significant difference (P = 0.017), while the median overall survival was 452 days and 286 days without significant difference (P=0.503). The one-year survival rate in the test group and control group was 56.2% and 35.4%, respectively, while the two-year survival rate was 30.2% and 26.5%, respectively. No significant difference in the side effects was found between the two groups. Conclusions: Endostar$^{(R)}$ combined with chemotherapy resulted in a higher DCR and longer PFS in the patients with advanced STS, and the toxicity was tolerable.