Computational load reduction by avoiding the recalculation of angular redundancy in computer‐generated holograms

Jia Jia,Jhensi Chen,Daping Chu 한국전자통신연구원 2019 ETRI Journal Vol.41 No.1

A fast hologram calculation approach is proposed to reduce computational load by avoiding the recalculation of redundancy information. In the proposed method, the hologram is divided into several sub‐holograms that record and reconstruct different views of 3D objects. The sub‐hologram is generated from its adjacent calculated sub‐holograms by only adding the holograms of difference images between an adjacent pair of views. The repetitive information of two adjacent views is called angular redundancy. Therefore, avoiding the recalculation of this angular redundancy can considerably reduce the computational load. Experimental results confirm that the proposed method can reduce the computational time for the statue head, rabbits, and car to 4.73%, 6.67%, and 10.4%, respectively, for uniform intensity, and to 56.34%, 57.9%, and 66.24%, respectively, for 256 levels intensity, when compared to conventional methods.

Inhibition of human liver cancer cell growth by evodiamine involves apoptosis and deactivation of PI3K/AKT pathway

Jia Jia,Kang Xigang,Liu Yanfang,Zhang Jianwei 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.5

Evodiamine is an active alkaloid member found in Traditional Chinese Herb (TCH) Evodia rutaecarpa. It has been reported to exhibit remarkable biological and medicinal activities including anticancer and anti-inflammatory. This study was designed to investigate the anticancer effects of evodiamine against human liver cancer and evaluate its effects on cell migration, cell invasion, cellular apoptosis and PI3K/AKT pathway. The results showed that evodiamine exhibits potent antiproliferative effects against two human liver cancer cell lines (HepG2 and PLHC-1) with an IC50 of 20 μM. Nonetheless, the cytotoxic effects of evodiamine were comparatively low against the normal cells as evident from the IC50 of 100 μM. The growth inhibitory effects of evodiamine were found to be due to the induction of apoptosis as revealed by the DAPI, AO/EB and annexin V/PI staining assays. The induction of apoptosis was also associated with upregulation of Bax and downregulation of Bcl-2 expression in a concentration dependent manner. The wound healing and transwell assay revealed that evodiamine caused a significant decline in the migration and invasion of the HepG2 and PLHC-1 cells. Investigation of the effects of evodiamine on the PI3K/AKT signalling revealed that evodiamine inhibited the phosphorylation of PI3K and AKT proteins. Taken together, the results showed that evodiamine inhibits the growth of human liver cancer via induction of apoptosis and deactivation of PI3K/AKT pathway. The results point towards the therapeutic potential of evodiamine in the treatment of liver cancer.

Identification of novel Est-ssr markers by transcriptome sequencing in ridgetail white prawn Exopalaemon carinicauda

Jiajia Wang,Qianqian Ge,Jitao Li,Haiyu Gao,Jian Li,Fazhen Zhao 한국유전학회 2018 Genes & Genomics Vol.40 No.2

The ridgetail white prawn Exopalaemon carinicauda is one of the major commercial mariculture species in eastern China. However, only limited molecular markers are currently available due to the lack of genome information, which hinders its genetic and breeding studies. In this study, we identified new simple sequence repeats from transcriptome sequences by Illumina Hiseq 2500 platform. A total of 14273 SSR loci were identified from 130,082 assembled transcripts, with 6590 pairs of PCR primers designed. A total of 12,155 sequences containing SSR were predicted; and 2764 (22.74%) transcripts had significant matches to the NCBI non redundant protein (Nr) database. 11,563 transcripts were assigned into gene ontology (GO) categories. A set of 200 primers selected randomly were synthesized, of which 152 (76.0%) were successfully amplified. Further test with 60 pairs of polymorphic SSR primers to evaluate the genetic diversity of 30 wild populations and 43 loci were polymorphic, which had a polymorphic information content between 0.204 and 0.911. The results enriched genomic resources of E. carinicauda and provided powerful information for future conservation and breeding researches.

Three-dimensional trajectory tracking for underactuated AUVs with bio-inspired velocity regulation

Jiajia Zhou,Dingqi Ye,Junpeng Zhao,Dongxu He 대한조선학회 2018 International Journal of Naval Architecture and Oc Vol.10 No.3

This paper attempts to address the motion parameter skip problem associated with three-dimensional trajectory tracking of an underactuated Autonomous Underwater Vehicle (AUV) using backstepping-based control, due to the unsmoothness of tracking trajectory. Through kinematics concepts, a three-dimensional dynamic velocity regulation controller is derived. This controller makes use of the surge and angular velocity errors with bio-inspired models and backstepping techniques. It overcomes the frequently occurring problem of parameter skip at inflection point existing in backstepping tracking control method and increases system robustness. Moreover, the proposed method can effectively avoid the singularity problem in backstepping control of virtual velocity error. The control system is proved to be uniformly ultimately bounded using Lyapunov stability theory. Simulation results illustrate the effectiveness and efficiency of the developed controller, which can realize accurate three-dimensional trajectory tracking for an underactuated AUV with constant external disturbances.

Semiparametric estimation methods for the accelerated failure time mixture cure model

Jiajia Zhang,Yingwei Peng 한국통계학회 2012 Journal of the Korean Statistical Society Vol.41 No.3

This paper provides an overview of two semiparametric estimation methods recently proposed in the literature for the accelerated failure time mixture cure model. We prove that the two estimation methods are asymptotically equivalent. A simulation is conducted to investigate the rate of convergence of the two methods. We apply these methods to fit the accelerated failure time mixture cure model to the survival times of leukemia patients receiving bone marrow transplantation.

Alpha radionuclide-chelated radioimmunotherapy promoters enable local radiotherapy/chemodynamic therapy to discourage cancer progression

Jiajia Zhang,Feize Li,Yuzhen Yin,Ning Liu,Mengqin Zhu,Han Zhang,Weihao Liu,Mengdie Yang,Shanshan Qin,Xin Fan,Yuanyou Yang,Kun Zhang,Fei Yu 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4

Background: Astatine-211 is an α-emitter with high-energy α-ray and high cytotoxicity for cancer cells. However, the targeted alpha therapy (TAT) also suffers from insufficient systematic immune activation, resulting in tumor metastasis and relapse. Combined immune checkpoint blockade (ICB) with chemodynamic therapy (CDT) could boost antitumor immunity, which may magnify the immune responses of TAT. This study aims to discourage tumor metastasis and relapse by tri-model TAT-CDT-ICB strategy. Methods: We successfully designed Mn-based radioimmunotherapy promoters (211At-ATE-MnO2-BSA), which are consisting of 211At, MnO2 and bovine serum albumin (BSA). The efficacy of 211At-ATE-MnO2-BSA was studied as monotherapy or in combination with anti-PD-L1 in both metastatic and relapse models. The immune effects of radioimmunotherapy promoters on cytotoxic T lymphocytes and dendritic cells (DCs) were analyzed by flow cytometry. Enzymelinked immunosorbent assay and immunofluorescence were used to explore the underlying mechanism. Results: Such radioimmunotherapy promoters could not only enhance the therapeutic outcomes of TAT and CDT, but also induce robust anti-cancer immune activity by activating dendritic cells. More intriguingly, 211At-ATE-MnO2-BSA could effectively suppress the growths of primary tumors and distant tumors when combined with immune checkpoint inhibitors. Conclusions: The tri-model TAT-CDT-ICB strategy provides a long-term immunological memory, which can protect against tumor rechallenge after eliminating original tumors. Therefore, this work presents a novel approach for TATCDT-ICB tri-modal cancer therapy with repressed metastasis and relapse in clinics.

Using Modified UCT Algorithm Basing on Risk Estimation Methods in Imperfect Information Games

Jiajia Zhang,Xuan Wang 보안공학연구지원센터 2014 International Journal of Multimedia and Ubiquitous Vol.9 No.10

Durable Moisture-wicking and Fast-dry Polyester Fabric Prepared by UV-induced Click Reaction

Jiajia Liu,Wei Wang,Dan Yu,Kai Zhao 한국섬유공학회 2020 Fibers and polymers Vol.21 No.1

Polyester (PET) fabric is an important fabric to make sportswear due to its good mechanical strength, wearresistance and low cost, but poor hygroscopicity will accumulate moisture and excessive heat of human body which therebycausing thermo-physiological dicomfort. To obtain satisfying moisture-wicking, hydroscopic and fast-dry properties, facileand efficient single-sided click chemistry was used to substitute traditional methods. Firstly, PET fabric was alkali treated andmodified with 3-mercaptopropyltrimethoxysilane to obtain thiol groups. Then it was gradiently grafted with potassium 3-sulfopropyl acrylate by thiol-ene click chemistry under single-sided ultraviolet (UV) irradiation to enlarge effects. Thereaction was proved by FTIR and Ellman method, the surface morphology was observed by SEM, and the mass loss atdifferent temperatures in thermalgravimetry (TG) test illustrated the quantity change of grafting. The results demonstratedthat the resultant fabric has good performance of moisture absorbing and sweat releasing, fast drying as well as outstandingantistatic and soil release properties.

Structure and magnetic properties of Ni0.5Zn0.5Mn0.5-xMoxFe1.5O4 ferrites prepared by sol-gel auto-combustion method

Jiajia Pei,Zhi Wang,Yu Gao,Haoming Zhang 한국물리학회 2019 Current Applied Physics Vol.19 No.4

A series of Mo doped Ni-Mn-Zn ferrites compounds with the formula Ni0.5Zn0.5Mn0.5-xMoxFe1.5O4 (x=0, 0.025, 0.05, 0.075 and 0.1) were first synthesized by sol-gel auto-combustion method. The X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), and vibrating sample magnetometer (VSM) analysis were carried out to characterize the microstructural and magnetic properties of ferrites. Rietveld refinement of X-ray diffraction data confirmed the formation of cubic spinel structure and the emergence of FeMoO4 phase with the substitution of Mo6+ contents. The grain size increased remarkably due to the formation of the liquid phase. The saturation magnetization (Ms) increased while the coercivity (Hc) decreased from 67.3 to 12.1 Oe due to the decrease of magneto-crystalline anisotropy constant. The initial permeability (μi) increased significantly from 34 (x=0) to 114 (x=0.075) and later decreased for x=0.1. In our experiment, Ni0.5Zn0.5Mn0.425Mo0.075Fe1.5O4 ferrite presented the best microstructure and soft magnetic properties.

Transcriptome comparative analysis between the cytoplasmic male sterile line and fertile line in soybean (Glycine max (L.) Merr.)

Jiajia Li,Shouping Yang,Junyi Gai 한국유전학회 2017 Genes & Genomics Vol.39 No.10

To further elucidate the molecular mechanism and fertility restoration of cytoplasmic male sterility (CMS) in soybean, a comparative transcriptome analysis was conducted between the CMS line NJCMS1A, restorer line NJCMS1C and their hybrid F1 progeny (NJCMS1A × NJCMS1C) using RNA-Seq strategy. After pairwise comparative analysis of these soybean lines, 294, 222, and 288 differentially expressed genes (DEGs) were identified, respectively. Further bioinformatic analysis indicated that these DEGs were involved in diverse molecular functions and metabolic pathways. qRT-PCR analysis validated that the gene expression pattern in RNA-Seq was reliable. These results significantly showed that the male sterility and fertility restoration in NJCMS1A might be related to a series of the abnormal of growth development and metabolic processes, such as pollen development, DNA methylation process, pollen viability, cell wall development, programmed cell death, as well as carbohydrate and energy metabolism. This study could facilitate our understanding of the molecular mechanisms and fertility restoration behind CMS in soybean.