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Wang, Shuhao,Zhang, Lin,Li, Jiaolong,Cong, Jiahui,Gao, Feng,Zhou, Guanghong Asian Australasian Association of Animal Productio 2017 Animal Bioscience Vol.30 No.1
Objective: This experiment was conducted to investigate the effects of dietary supplementation with marigold extract on growth performance, pigmentation, antioxidant capacity and meat quality in broiler chickens. Methods: A total of 320 one-day-old Arbor Acres chickens were randomly divided into 5 groups with 8 replicates of 8 chickens each. The chickens of control group were fed with basal diet and other experimental groups were fed with basal diet supplemented with 0.075%, 0.15%, 0.30%, and 0.60% marigold extract respectively (the corresponding concentrations of lutein were 15, 30, 60, and 120 mg/kg). Results: The results showed that marigold extract supplementation increased the yellowness values of shank, beak, skin and muscle and the redness ($a^*$) value of thigh muscle (linear, p<0.01). Marigold extract supplementation significantly increased the total antioxidant capacity, and the activities of superoxide dismutase in liver and thigh muscle (linear, p<0.01) and significantly decreased the malondialdehyde contents of liver and thigh muscle (linear, p<0.01). Marigold extract supplementation significantly decreased the drip loss and shear force of thigh muscles (linear, p<0.01). There was no significant effect on growth performance with marigold extract supplementation. Conclusion: In conclusion, dietary supplementation of marigold extract significantly increased the yellowness values of carcass, antioxidant capacity and meat quality in broiler chickens.
Research Progress of the Structure Vibration-Attitude Coordinated Control of Spacecraft
Yang, Jingyu,Qu, Shiying,Lin, Jiahui,Liu, Zhiqi,Cui, Xuanming,Wang, Chu,Zhang, Dujiang,gu, Mingcheng,Sun, Zhongrui,Yang, Kang,Zhou, Lanwei,Chen, Guoping The Korean Society for Aeronautical and Space Scie 2015 International Journal of Aeronautical and Space Sc Vol.16 No.4
This paper gives an overview of research on the field of structure vibration-attitude coordinated control of spacecraft. First of all, the importance of the technology has been given an introduction, and then later the research progress of space structure dynamics modeling, research progress of structure vibration-attitude coordinated control of flexible spacecraft have been discussed respectively. Finally, future research on application of structure vibration-attitude coordinated control of spacecraft has been recommended.
Research Progress of the Structure Vibration-Attitude Coordinated Control of Spacecraft
Jingyu Yang,Shiying Qu,Jiahui Lin,Zhiqi Liu,Xuanming Cui,Chu Wang,Dujiang Zhang,Mingcheng gu,Zhongrui Sun,Kang Yang,Lanwei Zhou,Guoping Chen 한국항공우주학회 2015 International Journal of Aeronautical and Space Sc Vol.16 No.4
This paper gives an overview of research on the field of structure vibration-attitude coordinated control of spacecraft. First of all, the importance of the technology has been given an introduction, and then later the research progress of space structure dynamics modeling, research progress of structure vibration-attitude coordinated control of flexible spacecraft have been discussed respectively. Finally, future research on application of structure vibration-attitude coordinated control of spacecraft has been recommended.
Identification of DNA methylation and genetic alteration simultaneously from a single blood biopsy
Chen Xiaomin,Liu Jiahui,Li Jun,Xie Yinpeng,Yu Zichen,Shen Lu,Liu Qingfeng,Wu Wei,Zhao Qiang,Lin Haoxiang,Liu Gaotong,Luo Qiuping,Yang Ling,Huang Yi,Zhao Meiru,Yi Xin,Xia Xuefeng 한국유전학회 2023 Genes & Genomics Vol.45 No.5
Background High-throughput sequencing of blood cell-free DNA (cfDNA) techniques offer an opportunity to characterize and monitor cancer rapidly in a non-invasive and real-time manner. Nonetheless, there lacks a tool within therapeutic arsenal to identify multi-omics alterations simultaneously from a single biopsy. In current times, bisulfite-based sequencing detects 5mC and 5hmC at single-base resolution is the golden standard of DNA methylation, while the degradation of DNA and biased sequencing data are the problems of this method. Objective To identify the consistency analysis of methylation and genetic variation with single library, we presented a platform detecting multi-omics data simultaneously from a single blood biopsy using bisulfite-free method of genomic methylation sequencing (GM-seq) mediated by TET enzyme. Methods We detected methylomic and genetic changes simultaneously from a single blood biopsy in NA12878 and randomly chose ten blood biopsies from colorectal cancer or lung cancer patients to validate the ability of GM-seq. Results Similar cytosine methylation level between whole genome bisulfite sequencing (WGBS) and GM-seq were identified in NA12878. Moreover, longer insert size, CpGs coverage and GC distribution were outperformed than WGBS. In addition, the comparison of the single nucleotide polymorphism (SNP), insertion-deletion (Indel) and copy number variation (CNV) in NA12878 or ctDNA from liver cancer between GM-seq and whole genome sequencing (WGS) show a good consistency, indicating that this method is feasible for detecting genetic variation in blood. Conclusion In conclusion, our work demonstrated a method for identification of the methylated modification and genetic variations simultaneously from a single blood biopsy.
Yuan Jing,Chunwei Zhang,Su Zhang,Guangyi Lin,Huidong Cao,Jiahui Wen,Zonglong Wang,Yuanyuan Niu,Zetao Lin 한국고분자학회 2023 폴리머 Vol.47 No.6
The application of vegetable oil-based softeners canola oil and cottonseed oil in Solution polymerized styrene-butadiene rubber (SSBR) system composites was investigated. The results showed that when the aromatic oil was replaced by 5 parts of vegetable oil-based softeners in equal amounts in the base formulation of SSBR system, the work-ing performance of the rubber was better, the tear strength and elongation at break were improved and the tensile strength was reduced; the vulcanization time of the rubber prepared with vegetable oil-based softeners was significantly reduced compared with that of aromatic oil; the glass transition temperature of the rubber was significantly reduced and the cold resistance and snow performance of the rubber were improved.
Jiayi Wu,Shuning Ding,Linling Yin,Xiaochun Fei,Caijin Lin,Lisa Andriani,Chihwan Goh,Jiahui Huang,Jin Hong,Weiqi Gao,Siji Zhu,Hui Wang,Ou Huang,Xiaosong Chen,Jianrong He,Yafen Li,Kunwei Shen,Weiguo Che 대한암학회 2020 Cancer Research and Treatment Vol.52 No.3
Purpose This retrospective study aimed to evaluate the distribution pattern and prognostic value of 21-gene recurrence score (RS) in Chinese patients with mucinous breast cancer (MC) and compared with infiltrating ductal carcinoma (IDC). Materials and Methods Patients diagnosed with MC or IDC from January 2010 to January 2017 were retrospectively recruited. Reverse transcriptase–polymerase chain reaction assay of 21 genes was conducted to calculate the RS. Univariate and multivariate analyses were performed to assess the association between RS and clinicopathological factors. Survival outcomes including disease-free survival (DFS) and overall survival (OS) were estimated by Kaplan-Meier method and compared by log-rank test. Results The MC cohort included 128 patients and the IDC cohort included 707 patients. The proportions of patients with a low (RS < 18), intermediate (18-30), or high risk (RS > 30) were 32.0%, 48.4%, and 19.5% in MC cohort, and 26.9%, 46.8% and 26.3% in IDC cohort. The distribution of RS varied significantly according to different Ki-67 index and molecular subtype in both cohorts. Moreover, the receipt of chemotherapy was associated with RS in both cohorts. Among patients with MC, tumor stage was related to the DFS (p=0.040). No significant differences in DFS and OS were found among MC patients in different RS risk groups (OS, p=0.695; DFS, p=0.926). Conclusion RS was significantly related to Ki-67 index and molecular subtypes in MC patients, which is similar in IDC patients. However, RS was not able to predict DFS and OS in patients with MC.
Zhou Nan,Zhang Ye,Lei Gongyun,Chen Yifan,Lin Ting,Liu Qin,Zhao Yinshuang,Mao Jiahui,Jiang Yongying,Mao Renfang 한국유전학회 2022 Genes & Genomics Vol.44 No.10
Background: Heat shock response is a protected mechanism against environmental changes for the organism, which must be tightly regulated. Bromodomain and extra terminal-containing protein family (BETs) regulate numerous gene expression in many physiological and pathological conditions, including viral infection. SV40 is considered as a highly human disease-associated virus. Objective: We aimed to explore whether BETs play a role in heat shock in SV40 large T antigen transfected cells. Methods: SV40LTA was transfected in HeLa cells using the Lipofectamine 8000. BETs inhibitor JQ1 and I-BET-762 was employed to treat transfected cells and HEK-293 T cells. Heat shock treatment was performed to determine the effect of JQ1 and I-BET-762 on these cells. Western blot and quantitative RT-PCR were carried out to assess the expression of HSP70 and other HSPs. Results: We found that inhibition of BETs by JQ1 and I-BET-762 protects cells from heat shock-induced death in HEK293T cells. Both JQ1 and I-BET-762 induce the expression of HSPs and HSF1 in HEK-293 T cells. However, neither JQ1 nor I-BET-762 fail to induce the expression of HSPs in either HeLa or HBL-1 cells. When SV40 large T antigen was transfected into HeLa cells, the induction of HSP70 expressing and the protection of heat shock-induced cell death are reproduced by JQ1 and IBET treatment in these transfected cells. Conclusions: Inhibition of BETs by JQ1 and I-BET-762 prevents heat shock-induced cell death via upregulating HSPs in SV40 large T antigen transfected cells. Our data indicate a novel function of BETs in SV40 large T antigen transformed cells, affecting HSPs and HSF1 as well as its function on heat shock response.
Jinrong Jiang,Xuze Hu,Meiying Huang,Guoxin Lan,Lian Ma,Jiahui Lin,Junsheng Qi,Changjun Zou 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.127 No.-
A facile and efficient strategy was introduced to prepare p-tolylsulfonyl-b-cyclodextrin (TsO-b-CD). Subsequently, the smart and recyclable Fe3O4@APTES-b-CD nanoparticles were prepared via betweenFe3O4@APTES and TsO-b-CD. And then, the structures of TsO-b-CD and Fe3O4@APTES-b-CD were characterizedand analyzed. Finally, the Fe3O4@APTES-b-CD nanoparticles was utilized as a heterogeneousFenton-like catalyst. The catalytic performance of Fe3O4@APTES-b-CD for 2-chloro-4-nitrophenol (4-C-2-NP) were assessed and studied. Accordingly, the degradation process of 4-C-2-NP fitted the pseudofirst-order kinetics model. In the meantime, the catalytic activity of Fe3O4@APTES-b-CD was higher thanthat of Fe3O4@APTES-a-CD or Fe3O4@APTES-c-CD. More importantly, the Fe3O4@APTES-b-CD possessedgood regeneration and reuse ability. In addition, the possible reaction route and degradation mechanismwere proposed with synergistic effects. Consequently, the Fe3O4@APTES-b-CD can potentially serve as asmart and recyclable heterogeneous Fenton-like catalyst.