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Yong Luo,Ling Lan,Yong-Guang Jiang,Jia-Hui Zhao,Ming-Chuan Li,Neng-Bao Wei,Yun-Hua Lin 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.2
Although cancer stem cells (CSCs) play a crucial role in seeding the initiation of tumor progression, they do not always possess the same potent ability as tumor metastasis. Thus, precisely how migrating CSCs occur, still remains unclear. In the present study, we first comparatively analyzed a series of prostate CSCs, which exhibited a dynamically increasing and disseminating ability in nude mice. We observed that the transcriptional activity of HIF-1 and -catenin became gradually elevated in these stem cells and their epithelial-mesenchymal transition (EMT) characteristic altered from an epithelial type to a mesenchymal type. Next, we further used cancer-associated fibroblasts (CAFs), which were cultured from surgically re-sected tissues of prostate cancer (PCa) to stimulate prostate CSCs. Similar results were reconfirmed and showed that the protein levels of both HIF-1 and -catenin were markedly improved. In addition, the EMT phenotype displayed a homogenous mesenchymal type, accompanied with increased aggressive potency in vitro. Most importantly, the aforementioned promoting effect of CAFs on prostate CSCs was completely repressed after “silencing” the activity of -catenin by transfection of stem cells with ShRNA. Taken together, our observations suggest that prostate migrating CSCs, with a mesenchymal phenotype, could be triggered by CAFs in a HIF-1alpha/beta-catenin-depen-dent signaling pathway.
Jia Li,Yan An,Jia-Ning Wang,Xiao-Ping Yin,Huan Zhou,Yong-Sheng Wang 대한생리학회-대한약리학회 2020 The Korean Journal of Physiology & Pharmacology Vol.24 No.5
This study aimed to evaluate the effect of curcumin on brain hypoxicischemic (HI) damage in neonatal rats and whether the phosphoinositide 3-kinase (PI3K)/Akt/vascular endothelial growth factor (VEGF) signaling pathway is involved. Brain HI damage models were established in neonatal rats, which received the following treatments: curcumin by intraperitoneal injection before injury, insulin-like growth factor 1 (IGF-1) by subcutaneous injection after injury, and VEGF by intracerebroventricular injection after injury. This was followed by neurological evaluation, hemodynamic measurements, histopathological assessment, TUNEL assay, flow cytometry, and western blotting to assess the expression of p-PI3K, PI3K, p-Akt, Akt, and VEGF. Compared with rats that underwent sham operation, rats with brain HI damage showed remarkably increased neurological deficits, reduced right blood flow volume, elevated blood viscosity and haematocrit, and aggravated cell damage and apoptosis; these injuries were significantly improved by curcumin pretreatment. Meanwhile, brain HI damage induced the overexpression of p-PI3K, p-Akt, and VEGF, while curcumin pretreatment inhibited the expression of these proteins. In addition, IGF-1 treatment rescued the curcumin-induced down-regulated expression of p- PI3K, p-Akt, and VEGF, and VEGF overexpression counteracted the inhibitory effect of curcumin on brain HI damage. Overall, pretreatment with curcumin protected against brain HI damage by targeting VEGF via the PI3K/Akt signaling pathway in neonatal rats.
Yong Jia,Yezhuang Tian,Yang Yang,Hongyi Sun,Shahab Alam Malik 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.5
Though servitization is hot in theory and practice, empirical research on the relationship between servitization and business performance is limited. Furthermore, existing empirical studies yield mixed results which constrains the development of servitization. Different from most servitization researches focusing on the service business, this empirical research, based on an international large-scale survey database-International Manufacturing Strategy Survey (IMSS), investigates the servitization improvements from the strategic fit perspective. “Service extension, service skill improvement and product design modification”, three improvement actions directly related to service business, are investigated. The results show that the strategic fit of “service extension” and “service skill improvement” significantly influence the business performance. The findings highlight the importance of the strategic fit of servitization improvements, reveal the conditions when servitization will enhance the business performance, and offer guidelines on the implementation of servitization.
Yong-Gui Chen,Yong He,Wei-min Ye,Ling-Yan Jia 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.26 No.-
The competitive adsorption of Na(I)/Cr(III) and Cr(III)/Cu(II) on GMZ bentonite was studied by batch experiments. The results show that the bentonite has larger total adsorption amount of Cu(II) and Cr(III) in binary ions solution compared to that of single ion solution. Increasing of Na(I) concentration reduces the adsorption capacity of Cr(III) in their binary solution. The phenomenon Cr(III) has a lager adsorption than Cu(II) indicate that the adsorption capacity of Cu(II) is inhibited in their binary solution. The sequence of distribution coefficients (Kd) in the solution as follow: Kd binary (Cr) > Kd single (Cu) > Kd single (Cr) > Kd binary (Cu).
Jia-Jia Lin,Young-Hyun Han,Jung-Woo Kwon,Yong-Nan Xu,Yi-Bo Luo,Yu-Jin Jo,Chang-Eun Park,Jung-Kyu Baang,Suk Namgoong,Nam-Hyung Kim 한국동물생명공학회(구 한국동물번식학회) 2014 Reproductive & Developmental Biology(Supplement) Vol.38 No.2s
In meiosis, Emi2 plays important role as CSF (Cytostatic Factor) to make the oocyte arrested in mII stage by the inhibition of APC/C (anaphase promoting complex/cyclosome). Once the oocyte fertilized, Emi2 was destabilized and degraded. For the degradation of Emi2, calcium signaling activate calmodulin-dependent protein kinase (CaMK) and phosphorylate emi2. Phosphorylated emi2 is recognized by polo-box domain of polo-like kinase 1 (Plk1) and further degradated by ubiquitin-dependent proteolysis. But recognition of Plk1 and emi2 is unknown. In this works, we determined the high-resolution crystal structure of polo-box domain of Plk1 and phosphorylated emi2 peptide at 1.90Å. Determined structure revealed that several unique features, including binding of Phe169 in the tyrosin-rich hydrophobic pocket. This is the first report of crystallization that Plk1-emi2 complex. Based on the complex structure, we designed the peptide analogs which pontentially inhibits recognition of Emi2 by Plk1 and assessed its biological activity in oocyte maturation and pathernogenetic activation. Injection of AB103-8, the inhibitor of Plk1 Polo-box domain, in mouse oocytes, induced the maturation arrest in GV stage and the delay in mII parthenogenetic activation. Further investigations of the mechanism that Plk1 involved into the Emi2 mII arrest are underway.
Jia-Yong Wu 대한수학회 2018 대한수학회지 Vol.55 No.2
In this paper, we introduce a general Ricci flow system, which is closely linked with the Ricci flow and the renormalization group flow, etc. We prove the short-time existence, the entropy functionals, the higher derivatives estimates and the compactness theorem for this general Ricci flow system on closed Riemannian manifolds. These basic results are useful tools to understand the singularities of this system.
Yong Feng,Haoxiang Wang,Min Zhang,Zihao Zhu,Xiaoyu Wang,Binhui Jia,Xiaolin Jia 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.5
Titanium Matrix Composites (TMCs) are widely used in aerospace because of their excellent mechanical properties, but itis accompanied by the diffi culty of machining. Ultrasonic Vibration Assisted Drilling (UVAD) can eff ectively reduce theaxial force in the drilling process and improve the integrity of machined surface. In this paper, the discontinuous titaniummatrix composite TiBw/TC4 was developed by preparation method of in situ. In order to obtain the machining parameters ofTiBw/TC4 and guide the application of UVAD in TiBw/TC4, the contrast experiments between conventional drilling (CD)and UVAD were carried out to analyze the variation law of axial force. In this experiment, the frequency and amplitude ofultrasonic vibration were set as 35 kHz and 2.5 μm respectively, and the drilling conditions were that the spindle speed was(1500/1600/1700/1800/1900) r/min and the feed speed was (6/7/8/9/10) mm/min. The surface integrity of hole wall suchas roughness, residual stress and white layer was discussed. The experimental results show that the yield strength of TiBw/TC4 developed by in situ is 51% higher than that of pure TC4. Compared with CD, the axial force of TiBw/TC4 in UVADis signifi cantly reduced, and the formation of continuous chips and winding cutters is eff ectively reduced. Besides, the wearrate of the cutters is reduced. The number and size of hole wall defects, such as scratches, delamination and tearing, areobviously reduced. As well as the residual stress, white layer thickness and hole wall roughness are reduced by 4.67–16.31%,42.48% and 5.98–29.27% respectively. Within the limits of the experiment, when the spindle speed is 1700 r/min and thefeed speed is 8 mm/min, UVAD can obtain better hole wall surface integrity parameters.
Simultaneous removal of SO2 and NOX with ammonia absorbent in a packed column
Yong Jia,Daqian Du,Xinxi Zhang,Xilou Ding,Oin Zhong 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.9
Catalytic oxidation of NO followed by simultaneous removal of SO2 and NOX with ammonia is a promising method for control of coal-fired flue gas pollutants. We investigated simultaneous absorption of SO2 and NOX in a packed column with ammonia, and found that SO2 and NOX could promote absorption with each other in the process of simultaneous removal SO2 and NOX. The removal efficiency of SO2 and NOX was, respectively, about 98% and 70.9% at pH 5.5, temperature 323.15 K, SO2 concentration 1,800×10−6, NOX concentration 400×10−6 and mNO2/mNO 1 in our experimental system. The experimental results also show that the formation of sulfite oxidized by reacting with dissolved NO2and the molar ratio of sulfite to total sulfur is more than 0.8 in the solution. Accordingly, the energy consumption for sulfite oxidation would be greatly reduced in the process of simultaneous desulfurization and denitrification with ammonia.
Jia-Chen Yang,Jia-Yu Chen,Yin Ding,Yong-Jie Yin,Zhi-Ping Huang,Xiu-Hua Wu,Zu-Cheng Huang,Yi-Kai Li,Qing-An Zhu 대한척추신경외과학회 2024 Neurospine Vol.21 No.1
Objective: The effect on fat infiltration (FI) of paraspinal muscles in degenerative lumbar spinal diseases has been demonstrated except for spinopelvic parameters. The present study is to identify the effect of spinopelvic parameters on FI of paraspinal muscle (PSM) and psoas major muscle (PMM) in patients with degenerative lumbar spondylolisthesis. Methods: A single-center, retrospective cross-sectional study of 160 patients with degenerative lumbar spondylolisthesis (DLS) and lumbar stenosis (LSS) who had lateral full-spine x-ray and lumbar spine magnetic resonance imaging was conducted. PSM and PMM FIs were defined as the ratio of fat to its muscle cross-sectional area. The FIs were compared among patients with different pelvic tilt (PT) and pelvic incidence (PI), respectively. Results: The PSM FI correlated significantly with pelvic parameters in DLS patients, but not in LSS patients. The PSM FI in pelvic retroversion (PT > 25°) was 0.54 ± 0.13, which was significantly higher in DLS patients than in normal pelvis (0.41 ± 0.14) and pelvic anteversion (PT < 5°) (0.34 ± 0.12). The PSM FI of DLS patients with large PI ( > 60°) was 0.50 ± 0.13, which was higher than those with small ( < 45°) and normal PI (0.37 ± 0.11 and 0.36 ± 0.13). However, the PSM FI of LSS patients didn’t change significantly with PT or PI. Moreover, the PMM FI was about 0.10–0.15, which was significantly lower than the PSM FI, and changed with PT and PI in a similar way of PSM FI with much less in magnitude. Conclusion: FI of the PSMs increased with greater pelvic retroversion or larger pelvic incidence in DLS patients, but not in LSS patients.