http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jia, Lina,Lee, Hun Seok,Wu, Chun Fu,Kundu, Juthika,Park, Sang Gyu,Kim, Ryong Nam,Wang, Li-Hui,Erkin, Ö,zgü,r Cem,Choi, Jong-Sun,Chae, Seoung Wan,Yang, Ho Bin,Choi, Yoon-La,Shin, Young Kee American Association for Cancer Research 2014 Molecular Cancer Research Vol.12 No.12
<P>SMAD4 has been suggested to inhibit the activity of the WNT/β-catenin signaling pathway in cancer. However, the mechanism by which SMAD4 antagonizes WNT/β-catenin signaling in cancer remains largely unknown. Aurora A kinase (AURKA), which is frequently overexpressed in cancer, increases the transcriptional activity of β-catenin/T-cell factor (TCF) complex by stabilizing β-catenin through the inhibition of GSK-3β. Here, SMAD4 modulated AURKA in a TGFβ-independent manner. Overexpression of SMAD4 significantly suppressed AURKA function, including colony formation, migration, and invasion of cell lines. In addition, SMAD4 bound to AURKA induced degradation of AURKA by the proteasome. A luciferase activity assay revealed that the transcriptional activity of the β-catenin/TCF complex was elevated by AURKA, but decreased by SMAD4 overexpression. Moreover, target gene analysis showed that SMAD4 abrogated the AURKA-mediated increase of β-catenin target genes. However, this inhibitory effect of SMAD4 was abolished by overexpression of AURKA or silencing of AURKA in SMAD4-overexpressed cells. Meanwhile, the SMAD4-mediated repression of AURKA and β-catenin was independent of TGFβ signaling because blockage of TGFβR1 or restoration of TGFβ signaling did not prevent suppression of AURKA and β-catenin signaling by SMAD4. These results indicate that the tumor-suppressive function of SMAD4 is mediated by downregulation of β-catenin transcriptional activity via AURKA degradation in a TGFβ-independent manner.</P><P><B>Implications:</B> SMAD4 interacts with AURKA and antagonizes its tumor-promoting potential, thus demonstrating a novel mechanism of tumor suppression. <I>Mol Cancer Res; 12(12); 1779–95. ©2014 AACR</I>.</P>
Jia Kim,Hyo-jeong Hong,Ji-hye Hwang,Na-Ri Shin,Kyungwon Hwang 질병관리본부 2023 Osong Public Health and Research Persptectives Vol.14 No.3
Objectives: Severe fever with thrombocytopenia syndrome (SFTS) has no vaccine or treatment and an extremely high fatality rate. We aimed to analyze and evaluate the risk factors for death associated with SFTS.Methods: Among reports from 2018 to 2022, we compared and analyzed 1,034 inpatients aged 18 years or older with laboratory-confirmed SFTS who underwent complete epidemiological investigations.Results: Most of the inpatients with SFTS were aged 50 years or older (average age, 67.6 years). The median time from symptom onset to death was 9 days, and the average case fatality rate was 18.5%. Risk factors for death included age of 70 years or older (odds ratio [OR], 4.82); agriculture-related occupation (OR, 2.01); underlying disease (OR, 7.20); delayed diagnosis (OR, 1.28 per day); decreased level of consciousness (OR, 5.53); fever/chills (OR, 20.52); prolonged activated partial thromboplastin time (OR, 4.19); and elevated levels of aspartate aminotransferase (OR, 2.91), blood urea nitrogen (OR, 2.62), and creatine (OR, 3.21).Conclusion: The risk factors for death in patients with SFTS were old age; agriculture-related occupation; underlying disease; delayed clinical suspicion; fever/chills; decreased level of consciousness; and elevated activated partial thromboplastin time, aspartate aminotransferase, blood urea nitrogen, and creatine levels.
SNS 이용 동기와 사회적 지지가 문화적응에 미치는 영향 - 국내 거주 중국인 유학생의 문화적응을 중심으로
문신일(Shin-Il Moon),료가(Liao Jia),이현주(Hyunjoo Lee),김기태(Kitae Kim) 한국콘텐츠학회 2021 한국콘텐츠학회논문지 Vol.21 No.1
최근 국내 중국 유학생 수가 가파르게 증가함에 따라 국내 중국 유학생들의 문화적응에 영향을 주는 요인에 대한 관심 역시 증가하고 있다. 본 연구는 개인적 특성(성별, 연령, 국내 체류 기간, 한국어 교육 기간, 한국어 구사 능력), SNS 이용행태(네트워크 크기, 이용량, 이용목적), 중국인이나 한국인으로부터의 사회적 지지 세가지 차원을 고려하여 관련 요인들이 국내 중국인 유학생들의 한국 문화적응에 미치는 영향 정도를 위계적 회귀분석을 통해 실증적으로 분석하였다. 총 322명의 국내 거주 중국인 유학생을 대상으로 온라인 설문조사를 실시한 결과, 중국 유학생들이 한국 SNS를 이용해서 한국 친구들로부터 사회적 지지를 얻는 행위는 문화적응에 긍정적 영향을 주지만, SNS상의 중국 친구들과 시간을 보내고 타국살이의 외로움을 달래면서 사회적 지지를 얻는 방식은 한국 문화적응에 도움이 되지 않고 오히려 한국 문화적응에 부적인 효과를 불러일으킬 수 있다는 점을 발견했다. 따라서 본 연구는 교육 및 실무적인 차원에서 SNS 중독과 같은 병리적인 현상에만 관심을 쏟기보다 유학생들이 국내 문화적응에 도움이 되는 방향으로 SNS 이용을 유도하는 것이 유학생들의 문화적응에 더 도움이 되는 방안 및 정책이 될 것이라 제안한다. A recent rapid growth in the number of Chinese international students in Korea has generated interest in the key factors to affect their acculturation in domestic culture. In accordance with the growing interest, the present study aims to empirically test and analyze the effects of demographics (gender, age, the length of stay, the length of Korean language education and the level of Korean language skills), SNS use patterns (personal network sizes and hours of use for Korean and Chinese SNS, and motivations of Korean or Chinese SNS uses), and social support through Korean and Chinese SNS on acculturation for Chinese international students in Korea. A total of 322 Chinese international students in Korea participated in the online survey. Results showed that use of Chinese SNS for entertainment had an negative impact on the acculturation, while the use of Korean SNS had an overall positive impact. Finally, this study suggests that the practitioners regarding the issue of acculturation for international students in Korea should focus more on specific guidelines to help their appropriate SNS uses rather than on to prevent their SNS addiction problems.
Seonghyu Shin,Marcial Pastor-Corrales,Qijiang Song,Gaofeng Jia,Miok Woo,Perry Cregan 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07
Recently whole genome SNP genotyping has been used to do association analysis and to map a gene of interest. Here we report application of bulked segregant analysis(BSA) using Infinium HD assay with ‘BARC Bean6K_3’, a SNP genotyping beadchip containing 5,399 SNPs for common bean to locate a target gene. We used BSA using Infinium HD assay was performed to find the candidate region of a single dominant rust resistant gene in PI310762, a common bean cultivar. And SSR markers were identified and mapped on the candidate region using F2 population derived from the cross of susceptible Pinto114 x resistant PI310762. BSA revealed the candidate region of the resistant gene is on chromosome 4 where we developed nine SSR markers. Three SSR markers (beanssr1170, beanssr1168, and beanssr1167) of them appeared closely linked to the resistant gene which is located between beanssr1167 at 0.1cM and beanssr1170 at 0.5cM on chromosome 4. This study showed BSA using high-throughput whole genome SNP genotyping is a very fast and efficient method to locate a gene of interest on chromosome.