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권지웅 ( Ji Wung Kwon ),이희권 ( Hee Kwon Lee ),박희전 ( Hee Jeon Park ),송지영 ( Ji Young Song ) 한국식품조리과학회(구.한국조리과학회) 2012 한국식품조리과학회지 Vol.28 No.1
This study was carried out to evaluate biological activities concerning extracts according to extraction methods from unripened fruit of Rubus coreanus Miq. The extraction methods were HWE (hot water extraction for 4 hr at 100℃), SFE (extraction for 3 hr at 40℃ under 300 bar, 100% of CO2 fluid), USE (ultrasonification extraction for 4 hr at 50℃ with water), USE+HWE (hot water extraction for 2 hr at 100℃ after ultrasonification process for 2 hr), VE (vacuum extraction for 4 hr at 90℃ under 0.9 bar with water). VE extract showed the highest contents of total polyphenol (178.78±3.79 mg/g) and total flavonoid (40.93±0.68 mg/g). IC50 values of DPPH radical scavenging activity, linoleic acid peroxidation inhibition activity and LDL (low density lipoprotein) oxidation inhibition activity of HWE extract showed the lowest 35.39±0.25 μg/mL, 12.61±0.31 μg/mL and 1.31±0.02 μg/mL among other all extracts, respectively. IC50 values of α-glucosidase inhibitory activities of VE and HWE extracts showed lower 14.34±0.20 μg/mL and 15.83±0.20 μg/mL than those of other extracts, respectively. Specifically, HWE and VE extracts have relatively better biological activities than other extracts; these could be potentially used as a bioactive source for health functional foods.
Han, Ji-Wung,La, Tae-Min,Kim, Ji-Hoon,Choi, In-Soo,Song, Chang-Seon,Park, Seung-Yong,Lee, Joong-Bok,Lee, Sang-Won Elsevier 2018 INFECTION GENETICS AND EVOLUTION Vol.65 No.-
<P><B>Abstract</B></P> <P>We determined a complete genome sequence of the Korean field strain, KUMC-62, of human adenovirus type 3 (HAdV-3) and performed comparative genome analyses. Interestingly HAdV-3 has a distinct genomic sequence for the fiber CDS region on average 62.46% of nucleotide sequence identity to other types of HAdV-B1, while remaining genomic region of HAdV-3 is very similar (on average 95.71% of nucleotide sequence identity) to other types of HAdV-B1. The blast results showed that the fiber CDS region of HAdV-3 exhibited the highest nucleotide sequence identity with that of simian adenovirus type 32 (SAdV-32), except other strains of HAdV-3. In the Simplot analysis, a potential recombination event was detected between HAdV-7 and SAdV-32, which might have created HAdV-3 in the past. These findings suggest that HAdV-3 highly likely was created by a natural inter-species recombination event between human and non-human primate AdVs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> First complete genome sequencing of the Korean strain of human adenovirus type 3 using high-throughput sequencing technology. </LI> <LI> Shows distinct nucleotide sequences of the fiber CDS region of human adenovirus type 3 in comparative genome analysis. </LI> <LI> Evidence of multiple recombination events between adenoviruses from human and non-human primates. </LI> </UL> </P>
Ni-Mn 전착층의 기계적 성질에 미치는 공정조건의 영향
신지웅 ( Ji Wung Shin ),양승기 ( Seung Gi Yang ),황운석 ( Woon Suk Hwang ) 한국부식방식학회(구 한국부식학회) 2014 Corrosion Science and Technology Vol.13 No.3
Nickel electrodeposition from sulfamate bath has several benefits such as low internal stress, high current density and good ductility. In nickel deposited layers, sulfur induces high temperature embrittlement, as Ni-S compound has a low melting temperature. To overcome high temperature embrittlement problem, adding manganese is one of the good methods. Manganese makes Mn-S compound having a high melting temperature above 1500℃. In this work, the mechanical properties of Ni-Mn deposited layers were investigated by using various process variables such as concentration of Mn(NH2SO3)2, current density, and bath temperature. As the Mn content of electrodeposited layers was increased, internal stress and hardness were increased. By increasing current density, internal stress increased, but hardness decreased. With increasing the bath temperature from 55 to 70℃, internal stress of Ni deposit layers decreased, but hardness didn``t change by bath temperature. It was likely that eutectoid manganese led to lattice deformation, and the lattice deformation increased hardness and internal stress in Ni-Mn layers. Increasing current density and decreasing bath temperature would increase a mount of H2 absorption, which was a cause for the rise of internal stress.
Ha, Young Mi,Kim, Jin-Ah,Park, Yun Jung,Park, Daeui,Choi, Yeon Ja,Kim, Ji Min,Chung, Ki Wung,Han, Yu Kyeong,Park, Ji Young,Lee, Ji Yeon,Moon, Hyung Ryong,Chung, Hae Young Royal Society of Chemistry 2011 MedChemComm Vol.2 No.6
<P>In this study, we describe the synthesis and tyrosinase inhibitory activity of a new family of hydroxybenzylidenyl pyrrolidine-2,5-dione compounds. Among them, compound 3f (HMP) exhibited the highest inhibition, 83.87%, at a concentration of 20 μM, on the <SMALL>L</SMALL>-DOPA oxidase activity of mushroom tyrosinase. We also predicted the tertiary structure of tyrosinase, simulated its docking with HMP and confirmed that HMP strongly interacts with tyrosinase residues. This result suggested that the binding activity of HMP with tyrosinase could be high. Based on these results, we determined the IC<SUB>50</SUB> value for HMP inhibition of mushroom tyrosinase activity. HMP inhibited mushroom tyrosinase with an IC<SUB>50</SUB> value of 2.23 ± 0.44 μM, which is more potent than the anti-tyrosinase activity of kojic acid (IC<SUB>50</SUB> = 20.99 ± 1.80 μM), a well-known tyrosinase inhibitor. Kinetic analysis of tyrosinase inhibition revealed that HMP is a competitive inhibitor (<I>K</I><SUB>i</SUB> = 4.24 × 10<SUP>−7</SUP> M at 1.25 μM and <I>K</I><SUB>i</SUB> = 1.82 × 10<SUP>−6</SUP> M at 20 μM). HMP also inhibited melanin production and tyrosinase activity in B16F10 melanoma cells (B16 cells). These data strongly suggest that HMP can suppress the production of melanin <I>via</I> the modulation of tyrosinase activity.</P> <P>Graphic Abstract</P><P>Computational structure prediction for mushroom tyrosinase and docking simulation with compound HMP. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0md00234h'> </P>
경골 분절 골절 치료 시 다양한 정복술을 이용한 금속정 고정술의 결과
신지훈 ( Ji Hoon Shin ),손욱진 ( Oog Jin Shon ),하철웅 ( Chul Wung Ha ) 대한골절학회 2013 대한골절학회지 Vol.26 No.1
목적: 골수강 내 금속정을 이용한 경골 분절 골절 치료에서 다양한 술식을 이용한 임상적 결과에 대해 알아보았다. 대상 및 방법: 2003년 1월부터 2009년 6월까지 경골 분절 골절 환자 중 골수강 내 금속정을 이용하여 수술 후 1년 이상 추시 가능한 18예를 대상으로 하였다. 평균 추시 기간은 38개월(15-72개월)이었다. 골절 분류는 AO 분류 42C2.1 4예, 42C2.2 10예, 42C2.34예였다. 폐쇄성 골절이 10예, 개방성 골절은 8예였다. 수술 시 정복을 위한 다양한 술식을 이용하였고, 골유합 시기와 불유합 또는 부정유합 등의 합병증을 조사하였다. 결과: 지연유합으로 뼈이식이 필요한 경우가 3예였으나, 추후 전 예에서 골유합을 얻었다. 평균 골유합 기간은 16.3주(범위 12-21주)였다. 5도 이상의 각형성은 2예에서만 나타났고 평균 각변형 정도는 2.2°였다. 슬관절 운동범위는 129°, 족관절의 운동범위는 68°였으며 관절의 구축이나 25° 이상의 운동 범위의 감소는 관찰되지 않았다. 다른 합병증은 국소감염증 2예가 있었다. 결론: 금속정 삽입 시 부가적인 술식의 사용이 동반되면 경골 분절 골절에서 교합성 골수강 내 금속정을 이용한 치료는 높은 골유합률과 낮은 합병증, 만족할 정렬을 얻을 수 있을 것으로 생각된다. Purpose: We evaluated the clinical outcomes of tibia segmental fractures treated by intramedullary nailing using various reduction techniques. Materials and Methods: From January 2003 to June 2009, 18 segmental tibial fracture patients treated by intramedullary nail were enrolled with a minimum 12-month follow-up. The mean follow-up was 38 months (range 15-72). According to the AO classification, the fractures were types 42C2.1, 42C2.2, and 42C2.3 in four, ten, and four patients, respectively. Ten fractures were closed and eight were open. We used various techniques for reduction during operation and investigated bone union time and complication (non-union, malunion etc.). Results: Bone grafting was performed in three patients. Complete union was achieved in all patients. The mean time for union was 16.3 weeks (range 12-21), except in three delayed union patients. All radiological evaluations showed good alignment (less than 5 degree) except in two patients; and the mean deformity angle was 2.2 degree. Knee range of motion (ROM) was 129 degree, and ankle ROM was 68 degree. Local wound infection occurred in two patients. Conclusion: Intramedullary nailing is a successful method in the acute management of segmental tibial fractures, if accompanied by appropriate reduction technique.
Lee, Ji-Eun,Bark, Chung Wung,Quy, Hoang Van,Seo, Seung-Jun,Lim, Jae-Hong,Kang, Sung-A,Lee, Youngkyun,Lee, Jae-Mok,Suh, Jo-Young,Kim, Yong-Gun MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.11
<P>The regeneration of bone defects caused by periodontal disease or trauma is an important goal. Porous hydroxyapatite (HA) is an osteoconductive graft material. However, the hydrophobic properties of HA can be a disadvantage in the initial healing process. HA can be coated with TiO<SUB>2</SUB> to improve its hydrophilicity, and ultraviolet irradiation (UV) can further increase the hydrophilicity by photofunctionalization. This study was designed to evaluate the effect of 5% TiO<SUB>2</SUB>-coated HA on rabbit calvarial defects and compare it with that of photofunctionalization on new bone in the early stage. The following four study groups were established, negative control, HA, TiO<SUB>2</SUB>-coated HA, and TiO<SUB>2</SUB>-coated HA with UV. The animals were sacrificed and the defects were assessed by radiography as well as histologic and histomorphometric analyses. At 2 and 8 weeks postoperatively, the TiO<SUB>2</SUB>-coated HA with UV group and TiO<SUB>2</SUB>-coated HA group showed significantly higher percentages of new bone than the control group (<I>p</I> < 0.05). UV irradiation increased the extent of new bone formation, and there was a significant difference between the TiO<SUB>2</SUB>-coated HA group and TiO<SUB>2</SUB>-coated HA with UV group. The combination of TiO<SUB>2</SUB>/HA and UV irradiation in bone regeneration appears to induce a favorable response.</P>