일부 도시농촌 영유아의 빈혈에 관한 연구

강지용,위자형,구연철 梨花女子大學校 醫科大學 醫科學硏究所 1982 EMJ (Ewha medical journal) Vol.5 No.4

From August to September of 1982, the study was conducted a survey of 152 urban infants and children (who visited the well baby and out patient clinic of th Department of Pediatrics of the Han Kang Sung Shim Hospital located at Young Deung Po Koo, Seoul) and of 62 rural infants and children (who are the children and infants living at Soo Dong Myun, Yang Choo Country, which is a comprehensive rural medical care demonstration area of Ewha Womans Universi-ty). The purpose of this survey has been to know the relationship between ane-mia and social demographic background, maternal child health status, and the intake of nutrition. The results were as follows : 1) The frequency of anemia in urban area was shown as 25.7% and that of rural area as 11.7%, which means that the frequency of anemia is higher in ur-ban area than in rural area. 2) In terms of the frequency of anemia according to age, the infants and chil-dren aged 12-18 months in ruban area showed a highest rate of 31.6%, and those aged 0-12 months in rural area a highest rate of 20.0%. In terms of sex, female infants and children were contracted with a little more anemia than male counterparts in urban area. And male infants and children were contracted with a little more anemia than female counterparts in rural area. 3) In terms of mothers, 29 year old mother were set as standard age and those under 29 years in urban area showed an frequency rate of 28.7%, and those un-der 29 years in rural area showed an frequency rate of 13.2%. This means that there was more frequency rate in the mothers under 29 years than in those above 29 years. 4) In terms of economic situation, 290,000 won per month was set as standard amound made per month. And those earning less than 290,000 won in urban areas showed an frequency rate of 35.7%, and those earning less than 290,000 won in rural area 33.3%, which means that there was more frequency of anemia among those making less than 290,000 won than those making more than 290,000 won. And this was significant in terms of statistics. 5) The more the number of siblings was, the higher the frequency of anemia was. The frequency in case of two brothers was shown as 27.6% in ruban area, and as 15.2% in rural area respectively. 6) Such things as number of parity and birth interval were not so much signi-ficant in ruban area. However, the higher the number of parity was in rural area, the higher the frequency of anemia was. And in case birth interval was long, the frequency of anemia was rather high. 7) In terms of the relationship between pregnancy and anemia symptom during pregnancy of index child those pregnant women with anemia symptom in urban area showed an frequency rate of 27.8%, and those in rural area 19.2% respecit-vely. This reveals that the frequency rate of anemia symptom of pregnant women was higher in ruban area than in rural area. 8) In case infant and children took an initial(first) step within the age under one year, those in urban area showed an frequency rate of anemia of 31.7%, which is higher than in those who took an initial step when they were above one year old. And none of the rural infant and children under the age less than one year showed any frequency rate of anemia. 9) In terms of nurition, the infant and children raised by breast feeding showed an frequency rate of anemia of 36.9% and 12.8% in urban area and rural area and rural area respectively. This means that the infant and children who were weaned after six months showed more frequency rate of anemia than those who were weaned within six months. 10) In case food intake was irregular, the frequency rate of anemia were disc-losed as 30.0% and 18.0% un ruban area and rural area respecitvely, which me-ans that irregular food intake has brought about more frequency rate of anemia than regular food intake. And in case iron contained food was rarely taken, the frequency rates of anemia were 25.0% and 3.6% in urban area and rural area respectively. This shows that rarely taking of iron conained food has led to more frequency rate of anemia than frequently taking of iron contained food.

기능성 위장관장애 환자의 자율신경계기능과 음-양(陰陽)체질 특성에 관한 연구

이정호,송지영,황의완,정두훈,김영미 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

연구목적 : 기질적 원인이 없이 장기간 소화장애 및 복통이 지속되는 기능성 위장관 장애 환자를 대상으로 하여, 음양체질의 특성이 위장관을 조절하는 자율신경계 기능 이상과 관련되는지를 알아보기 위하여, 사상체질 특성에 따른 자율신경계 기능의 차이유무를 측정해 보고자 하였다. 이로써 이들 환자에서 보이는 자율신경계 기능의 불균형 상태가 한의학에서 말하는 음양(陰陽)이론으로 설명할 수 있을지 알아 보고자 하였다. 그리고 만일 이러한 설명이 가능하게 되면 향후 기능성 위장관 장애 환자에 대한 음양이론에 입각한 치료의 이론적 배경이 될 것으로 기대하였다. 방 법 : 기능성 위장관 장애 환자 27명과 대조군으로서 위장관 증상 이외의 증상을 가진 신체형 장애 환자(이하 기타 신체형 장애) 28명과 건강 대조군 26명을 조사 대상으로 하였다. 이들에게 사상체질(四象體質)분류검사를 이용하여 소음 체질과 기타 체질군으로 나누고, 자율신경 기능검사를 실시하여 체질에 따른 자율신경계 기능을 비교해 보았다. 결 과 : 기능성 위장관 환자군에서 소음체질이 의미있게 많은 빈도를 차지하지는 않았으며, 기능성 위장관 장애군과 기타 신체형 장애군과의 비교에서 자율신경 기능의 차이는 없었다. 이로서 비기질성 기능 장애의 하나인 기능성 위장 장애에서 체질 특성과 부교감신경계 기능 저하와는 관련성은 거의 없다고 추정된다. 단지 기능성 위장 장애군과 기타 신체형 장애군을 합한 신체형 장애 환자군에서는 건강 대조군에 비하여 소음체질의 빈도가 높았으며 부교감신경 기능이 의미있게 낮은 소견을 보였다. 결 론 : 비기질성 기능 장애인 기능성 위장관 장애에서는 한의학에서의 음양가설이라는 일원론에 입각한 이분법적인 개념이 자율신경계의 교감, 부교감 신경계 기능과 일치하는 부분은 적은 것으로 추정된다. 기능성 위장관 장애를 대상으로 해서 앞으로는 음양의 체질이라는 포괄적인 개념보다는 확실한 증상 몇 개 중심으로 하는 좀 더 세분화된 부분으로부터 접근해 볼 필요가 있으리라 사료된다. Objectives : It was revealed that autonomic dysfunction especially decreased parasympathetic functions, seems to be one of the major etiological factors in functional gastrointestinal disorders(FGID). The physiological characteristics of sympathetic and parasympathetic functions are externally similar to the features of Yin and Yang based on oriental medicine theory. And it was also revealed that gastrointestinal symptoms are prevalent in Lesser Yin con-stitutional type(少陰) originated from four types of constitution shown in Sasang constitutional theory(四象醫學). If we obtain the findings on the similarities or compatibilities between autonomic nervous functions and physical constitutional features in functional gastrointestinal disorders, we could apply various oriental treatment modalities to the patients with functional disorders, especially according to Yin-Yang constitutional concept. Methods : We investigated the correlations between characteristics of physical constitution (Yin and Yang) and imbalance of the autonomic functions in patients with FGID. Subjects consisted with three groups : 27 patients with FGID (including irritable bowel syndrome, functional dyspepsia, functional abdominal pain syndrome according to the Rome criteria), 28 patients with somatoform disorders who had symptoms other than abdominal symptoms(other somatoform disorders), and 26 normal healthy controls. Characteristics of constitutions were evaluated and divided into two major groups, i.e., Lesser Yin constitution and other constitutions(Greater Yin & Yang and Lesser Yang included) according to the Je-Ma Lee's Classification Questionnaire for Four Constitutional Types(Song et al. 1993). For evaluating the autonomic functions, three parasympathetic functions and two sympathetic functions were measured. Levels of anxiety and depression were also evaluated to be used as a covariant controlling the autonomic functions. Results : 1) FGID group showed significantly lower parasympathetic functions compared to healthy controls, however, there was no differences between FGID and other somatoform disorder groups. 2) Lesser Yin constitutional type was not so prevalent in FGID group. 3) When FGID and other somatoform disorder groups were combined and compared with normal healthy controls, the former group showed significantly lower parasympathetic functions than the latter group. Conclusions : According to these results, Lesser Yin constitutional type do not seem to be closely related with FGID. However, it was suggested that decreased parasympathetic functions were partly associated with this group. We could not find any correlations or compatibilities between two constitutional characteristics and autonomic dysfunction in FGID. This means that functional symptoms of FGID when those were deducted as Yin and Yang characteristics based on oriental medicine could not be understood as two oppositional and co-operative functions such as autonomic functions. Further research with more restricted symptoms selected in the functional disorders and with other physiological cues applied would be needed.

Abnormal Seedlings Emerged during Embryo Rescue and Its Remedy for Seedless Grape Breeding

Ji, Wei,Li, Zhiqian,Yao, Wenkong,Gong, Peijie,Wang, Yuejin Korean Society of Horticultural Science 2013 원예과학기술지 Vol.31 No.4

The abnormal seedlings, a common physiological anomalies, emerged during embryo rescue severely restricted grape breeding. To enhance the efficiency of the seedless grape breeding by reducing the production of abnormal seedlings in the course of embryo rescue, we investigated the effects of genotype, media type, embryo style, pre-chilling on the deformity rate of the abnormal seedlings during embryo rescue. The abnormal seedlings were firstly classified into seven categories based on their morphology. Our results indicated that the emergence of abnormal seedlings was highly dependent on the female parent genotype. Polyembryony was advantageous to diminish the number of abnormal plantlets and the germination rate of embryo was 100%. We also found that pre-chilling treatment could reduce the number of abnormal plantlets and promote the embryo germination. The abnormal plantlets were reduced significantly by the addition of $ZnSO_4$ $10{\mu}mol{\cdot}L^{-1}$ or mashed-banana $500mg{\cdot}L^{-1}$ to either embryo development or germination media. Transferring the abnormal seedlings onto the suitable fresh media in 4 weeks after embryo germination provided an effective way to transform them into normal seedlings.

Analysis of the Shear Buckling Strength of Variable-Section Corrugated Steel Webs

Wei Ji,Xucong Liu 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.8

Though composite box girder bridges with variable-section corrugated steel webs (CSWs) have been constructed worldwide, their shear behavior has seldom been investigated. This study accordingly analyzed the parameters affecting the elastic shear buckling strength of variable-section CSWs using a finite element analysis (FEA) of the Nanzhao Huaihe Bridge as a case study. The existing formulas for calculating the shear buckling strength of prismatic CSWs were first shown to be inapplicable when the web height exceeded 4,000 mm; alternative formulas were therefore derived and verified to provide suitable accuracy. New formulas were then proposed to calculate the shear buckling strength of variable-section CSWs, and their results exhibited good agreement with those from the FEA. The findings of this study indicate that the boundary conditions have insignificant effect on the calculated buckling strength of different types of variable-section CSWs, as their shear strengths differed by less than 5% under simple and fixed boundary conditions. The results of this study provide an important reference for the design of variable-section CSW bridges.

Tetrandrine Exerts a Radiosensitization Effect on Human Glioma through Inhibiting Proliferation by Attenuating ERK Phosphorylation

( Ji-wei Ma ),( Yong Zhang ),( Ji-cheng Ye ),( Ru Li ),( Yu-lin Wen ),( Jian-xian Huang ),( Xue-yun Zhong ) 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.2

Tetrandrine (Tet), a bisbenzylisoquinoline alkaloid, has been reported to have a radiosensitization effect on tumors. However, its effects on human glioma and the specific molecular mechanisms of these effects remain unknown. In this study, we demonstrated that Tet has a radiosensitization effect on human glioma cells. It has been hypothesized that Tet has a radiosensitization effect on glioma cells by affecting the glioma cell cycle and DNA repair mechanism and that ERK mediates these activities. Therefore, we conducted detailed analyses of the effects of Tet on the cell cycle by performing flow cytometric analysis and on DNA repair by detecting the expression of phosphorylated H2AX by immunofluorescence. We used western blot analysis to investigate the role of ERK in the effect of Tet on the cell cycle and DNA repair. The results revealed that Tet exerts its radiosensitization effect on glioma cells by inhibiting proliferation and decreasing the expression of phosphorylated ERK and its downstream proteins. In summary, our data indicate that ERK is involved in Tet-induced radiosensitization of glioma cells via inhibition of glioma cell proliferation or of the cell cycle at G0/G1 phase.

The Optimum Dietary Essential Amino Acid Pattern for Male Taiwan Country Chicks

Wei, Hen-Wei,Kuo, Hsin-Mei,Chiu, Wen-Zan,Chen, Bao-Ji Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.8

The objective of this study was to estimate the optimum dietary essential amino acid pattern for male Taiwan country chicks. A series of experiments was conducted with chicks, 14 d of age, for 2 wks. A basal synthetic diet was established using a dose response test for all essential amino acids referring to the broiler requirements recommended by NRC (1994). Twelve chicks were sacrificed at the beginning to provide initial body nitrogen data, and every group of six birds received the basal diet or a diet with a deficiency in a single essential amino acid in twenty one treatments by intubation according to their daily metabolic body weight (MBW). Deposited body nitrogen was determined using comparative slaughtering. According to the daily intake from the limiting amino acid per unit of MBW and the body nitrogen accretion rates for every two deficient groups with the same limiting amino acid but at different levels, a corresponding straight line was computed for each essential amino acid to intersect with a horizontal line made by the body nitrogen accretion rate of the control group. The x coordinate of the intersection represented the daily requirement for growth plus maintenance based on MBW corresponding to the essential amino acid. The amino acid ratios can be considered as the optimum pattern of dietary essential amino acids. The results, expressed with respect to lysine = 100, were arginine 105, methionine 81, histidine 34, tryptophan 18, leucine 103, phenylalanine 135, isoleucine 69, threonine 65 and valine 79. This pattern could be utilized to compute the dietary requirements (g/kg feed) for all essential amino acids by multiplying by the requirement of a single essential amino acid cited from the literature.

Analysis of TRRAP as a Potential Molecular Marker and Therapeutic Target for Breast Cancer

Ji Wang,Ming Shan,Tong Liu,Qingyu Shi,Zhenbin Zhong,Wei Wei,Da Pang 한국유방암학회 2016 Journal of breast cancer Vol.19 No.1

Purpose: This study was designed to assess the protein levels of transformation/transcription domain-associated protein (TRRAP) in invasive ductal breast carcinomas, and investigated the association between TRRAP and the clinicopathological features of breast cancer. Methods: We examined TRRAP protein expression in 470 breast cancer tissues and normal breast tissues by tissue microarray to study the correlation between TRRAP expression and clinicopathological features. This was analyzed using the chi-square test. Kaplan-Meier survival curves and log-rank tests were applied to analyze the survival status. Cox regression was applied for multivariate analysis of prognosis. Results: The data demonstrated that expression of TRRAP was significantly lower in breast carcinomas (36.6%) than in corresponding normal breast tissues (50.8%). In addition, TRRAP protein levels negatively correlated with tumor size, and indicated poor differentiation, increased nodal involvement, and low p53-positive rates. Analysis of survival revealed that lower TRRAP expression correlated with shorter survival time. Univariate analyses identified TRRAP and progesterone receptor as independent protective factors for breast cancer prognosis. However, Ki-67, tumor size, and nodal involvement appeared to be independent risk factors. Conclusion: The findings indicate a significant correlation between TRRAP protein levels and adverse prognosis in breast cancer. Therefore, TRRAP could be a prognostic biomarker for breast cancer. In addition, TRRAP is also a predictive biomarker of breast cancer treatment.

A MapReduce Implementation of C4.5 Decision Tree Algorithm

Wei Dai,Wei Ji 보안공학연구지원센터 2014 International Journal of Database Theory and Appli Vol.7 No.1

De novo assembly and transcriptome analysis of differentially expressed genes relevant to variegation in hawthorn flowers

Wei Ji,Wei Zhao,Rong‑Chen Liu,Xiao‑Bo Jiao,Kai Han,Zhong‑Yi Yang,Mei‑Ying Gao,Rui Ren,Xiu‑Juan Fan,Ming‑Xia Yang 한국식물생명공학회 2019 Plant biotechnology reports Vol.13 No.6

Flower color variegation has been observed in many plant species. However, pink flowers on the white-blooming hawthorn trees found by our group earlier have never been reported. To better understand the differentially expressed genes (DEGs) in variegated hawthorn flowers, white and pink flowers at different developmental stages (S1 and S2) underwent transcriptome sequencing separately. Approximately 34.28 Gb of high-quality data were obtained and assembled into 100,013 unigenes with an average length of 706.93 bp. These unigenes were further subjected to functional annotation and biochemical pathway analysis, and DEGs of two types of hawthorn flowers at different developmental stages were studied. Based on the enrichment analysis of DEGs, eight anthocyanin-modified enzyme genes or other enzyme genes that indirectly affect anthocyanin synthesis (5AT, 3GGT , and AI, β-Glu, two Aux/IAAs, two PODs), eight structural genes (UFGT, DFR, CHI, two F3Hs, and three PALs), and three transcription factors (one MYB and two bHLHs) were also identified. We randomly selected 15 genes, and the trends in the expression levels of these genes in the organs of white and pink flowers at different developmental stages were verified by quantitative real-time PCR. Mass sequence data obtained by RNA-seq of variegated hawthorn flowers provided basic sequence information and a unique opportunity to uncover the genetic mechanisms under-lying flower color variegation.

Abnormal Seedlings Emerged during Embryo Rescue and Its Remedy for Seedless Grape Breeding

Wei Ji,Zhiqian Li,Wenkong Yao,Peijie Gong,Yuejin Wang 한국원예학회 2013 원예과학기술지 Vol.31 No.4

The abnormal seedlings, a common physiological anomalies, emerged during embryo rescue severely restricted grape breeding. To enhance the efficiency of the seedless grape breeding by reducing the production of abnormal seedlings in the course of embryo rescue, we investigated the effects of genotype, media type, embryo style, pre-chilling on the deformity rate of the abnormal seedlings during embryo rescue. The abnormal seedlings were firstly classified into seven categories based on their morphology. Our results indicated that the emergence of abnormal seedlings was highly dependent on the female parent genotype. Polyembryony was advantageous to diminish the number of abnormal plantlets and the germination rate of embryo was 100%. We also found that pre-chilling treatment could reduce the number of abnormal plantlets and promote the embryo germination. The abnormal plantlets were reduced significantly by the addition of ZnSO₄ 10 μmol・L<SUP>-1</SUP> or mashed-banana 500 mg・L<SUP>-1</SUP> to either embryo development or germination media. Transferring the abnormal seedlings onto the suitable fresh media in 4 weeks after embryo germination provided an effective way to transform them into normal seedlings.