가감청영탕(加減淸營湯)에 효과를 보인 열성 아토피 피부염 환자 6례 증례 보고

서지혜,정창환,박선정,임소영,한수련,Seo, Ji-Hye,Jung, Chang?Hwan,Park, Seon-Jeong,Lim, So-Young,Han, Su-Ryun 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.3

Objective : The purpose of this study is to investigate the effect of Gagamchengyoung-tang($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) for atopic dermatitis patients diagnosed as the febrile tendency. Method : This case study was done on 6 atopic patients with febrile tendency who have visited Korean Medicine Clinic from 2013.08.01. to 2014.04.30.. Gagamchengyoung-tang($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) was prescribed to all 6 patients and evaluated the symptom change through photographs and questionnaire. Objective SCORAD Index(OSI) was used to evaluate the objective symptom and VAS was used to evaluate the subjective change. Results & Conclusion : The Objective SCORAD index and VAS were decreased in all patients. The average OSI reduction score was 26.3. Most symptoms of 6 patients were improved. Gagamchengyoung-tang ($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) can be effective in patients who were diagnosed as febrile tendency.

전립선 기질세포의 증식과 COX-2 발현에 대한 프로게스테론의 영향

정수련,김성한,최이화,박지은,전은미,강영진,이광윤,최형철 영남대학교 의과대학 2006 Yeungnam University Journal of Medicine Vol.23 No.1

전립선비대증은 노인 남성에서 흔히 유발되는 질환이며, 노화가 진행될 수록 빈도가 높아지는 특징을 가진다. 이 질환의 원인은 전립선기질세표의 과도한 증식으로 유발된다고 알려져 있지만 그 자세한 기전에 대해서는 잘 알려져 있지 않다. 전립선비대증에서 progesterone 수용체 양성 세포가 다른 전립선 종양에 비해서 많고, progesterone은 testosterone에서 DHT로 전환되는 것을 감소시키는 역할을 가진다고 알려졋다. 또한 남성 전립선 평활근의 과증식에 의한 질환이므로 평활근 세포의 증식과 관련성이 있다고 보고된 COX-2의 전립선비대증에 대한 영향에 대한 연구가 필요하다. 전립선 기질세포에 progesterone을 3일간 투여하여 배양한 경우 기질세포 증식은 차이가 없었다. Progesterone을 단독 또는 DHT와 같이 투여한 기질세포에서 남성호르몬 수용체 mRNA 발현은 비처리군과 비교하여 유의한 차이가 없었다. 또한 progesterone과 DHT 동시 투여에 의한 COX-2 mRNA 발현에도 차이가 없었다. 그러나 progesterone에 의한 남성 호르몬 수용체와 COX-2 단백 발현에서는 대조군과 비교하여 유의하게 감소시켰다. 이상의 결과는 progesterone은 남성호르몬 수용체에 대해 전사 후 반응 (post-transcriptional response)에 효과를 나타내어 남성호르몬 수용체 발현을 감소시키는 작용은 가지며, COX-2 발현 억제효과를 나타내므로 전립선비대증의 치료에 이용될 수 있을 것으로 사료된다. Background: Benign prostatic hyperplasia (BPH) is the most common benign tumor in older men; the etiology of this disease remains poorly understood. Testosterone and dihydrotestosterone (DHT) both act as androgen via a single androgen receptor. Testosterone is converted to DHT by 5α-reductase in prostatic stromal cells. Progesterone has been reported to inhibit DHT conversion; howevwe, its effect on prostatic stromal cells remains to be elucidated. Materials and Methods: In this experiment, we investigated the effect of progesterone on androgen receptor expression induced by DHT. We also tested the effect of progesterone on cyclooxygenase-2 (COX-2) expression, as well as prostate stromal cell proliferation using the cell count kit-8. Results: Progesterone did not cause an increase of prostate stromal cell proliferation. The mRNA expression of the androgen receptor and COX-2 were not changed by progesterone; the expressions of androgen receptor and COX-2 proteins were decreased by progesterone in prostate stromal cells. Conclusion: These results suggest that in prostate stromal cells, progesterone decreases androgen receptor protein expression, which results in decrement of COX-2 protein expression. This effect might be mediated by post-transcriptional regulation.

서울 시내 4년제 남자 대학생의 우울과 흡연량, 흡연기간, 니코틴 의존도와의 관계

박지영,박소영,이미숙,백수진,신의경,예혜련,오승진,장윤정,조혜진,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

Background: With reports on the relation between smoking and depression appearing since 1980, it has become clear that depression is one of the psychodynamics of smoking, though there has been little or no progress made in the study of whether or not there is indeed a relation between depression and nicotine dependence. Purpose: The purpose of the study was to investigate the effects of depression on the amount and period of smoking and nicotine dependence among university man student smokers. Method: In periodical examination between 14 and 21, May, 2003, using 170 university male. The CES-D(Center for Epidemiologic Studies Depression) Scale and the FTQ(Fagerstrom Tolerance Qustionnaire) were utilized to measure the level of depression and nicotine dependency. The amount of smoking was calculated based on the number of cigarette used. Result: Results indicated that depression had something to do with amount of smoking. Nicotine dependence also was related to depression but total value was relatively low. finally the period of smoking had nothing to do with depression. Conclusion: The results of this study revealed that the amount of smoking of university man student smokers was very high. Both the amount of smoking and nicotine dependence were affected by levels of depression. Accordingly psychiatric nursing access such as emotional support is needed to manage depression and decrease smoking.

공터키안(Empty sella)을 동반한 급성췌장염으로 발현된 부갑상선 선종 1예

전언주,오지혜,배경륜,장샛별,전승운,정의달,손호상,원규장 영남대학교 의과대학 2009 Yeungnam University Journal of Medicine Vol.26 No.1

The incidence of coexisting hyperparathyroidism and empty sella syndrome is rare and the etiology and incidence of their coexistence is not known. The association of hyperparathyroidism and the empty sella syndrome may be related to multiple endocrine neoplasia (MEN) syndrome due to a genetic disorder. We experienced a rare case of hyperparathyroidism presenting as acute pancreatitis combined with empty sella. We report here a 37-year old female who manifested epigastric pain because of acute pancreatitis. She had hypercalcemia due to parathyroid adenoma. A pituitary gland was not visible in the sella turcica on MRI scans. On genetic analysis, she did not show a mutation of the MENIN gene. Empty sella is thought to be a coincidental finding with hyperparathyroidism.

축구선수의 Detraining과 Retraining이 혈청지질 및 호르몬농도에 미치는 영향

정정화,박재현,채종훈,성혜련,황지인,윤미숙,노금선,윤종관,윤영학,노순덕,정경숙,박일규,김은희,박현태,박상갑 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

The purpose of this study was to investigate the effects of detraining and retraining on serum lipid and hormones in soccer players. Subjects were seven male high-school soccer players. V˙O_2max was determined for each subjects by administering a treadmill test(initial speed: 90m/min, grade: 5%, increasing speed per 3 min: 30m/min). Serum lipid(T-C, TG, HDL-C LDL-C) and hormones(epinephrine, norepinephrine, growth hormones, cortisol) were assayed pre and post detraining in 10, 20, 30 days after retraining. The repeated ANOVA was used to determine significant differences. The 0.05 level of significance was as critical level for the study. The results of the study were as follows: 1. V˙O_2max(ml/min) were 3576.3±204.2ml/min pre detraining, 3234.1±198.9 ml/min post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/min) were 3601.4±170.9 ml/min. There were significantly(p<.05) increased in retraining periods. 2. V˙O_2max(ml/kg/min) were significantly(p<.05) decreased from 62.3±2.9 ml/kg/min to 55.9±4.7 ml/kg/min in detraining. In 10, 20, 30 days after retraining, V˙O_2max(ml/kg/min) were 62.4±3.4ml/kg/min, 62.7±2.3ml.kg/min, 67.3±7.2ml/kg/min respectively. There were significantly(p<.05) increased in retraining periods. 3. T-C were significantly (p<.05) increased from 166.6±8.5mg/dl to 175.3±10.3 mg/dl in detraining. In 10, 20, 30 days after retraining, T-C were 160.1± 3.2mg/dl, 156.7±3.7mg/dl, 140.3±9.0mg/dl. There were significantly(p<.05) decreased in retraining periods. 4. HDL-C were 61.4±6.6mg/di pre detraining, 5.3±6.6mg/dl post detraining. There are significant(p<.05) difference between pre and post detraining. In 10, 20, 30 days after retraining, HDL-C were 56.9±7.1mg/dl, 56.4±9.2mg/dl, 57.7±9.1mg/dl respectively. There were no significant difference in retraining periods. 5. The hormones(epinephrine. norepinephrine, growth hormone, cortisol) were changed as same patterns. Epinephrine were 26.0±7.0[g/ml pre detraining, 24.6±3.2pg/ml post detraining. In 10, 20, 30 days after retraining, epinephrine were 26.9±5.6pg/ml, 30.6±6.2pg/ml, 29.4±5.6pg/ml respectively. There were no significant difference in retraining periods. In conclusion, HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were decreased, T-C, LDL-C and TG were increased in detraining. But HDL-C, epinephrine, norepinephrine, growth hormone and cortisol were increased, T-C, LDL-C and TG were decreased in retraining.

한국 진도개와 삽사리 혈액 단백질의 비교연구 : Ⅱ. 혈청 Lactate Dehydrogenase와 혈청 Alkaline Phosphatase의 동위효소와 활성도 Ⅱ. Isozymes and Activities of Serum Lactate Dehydrogenase and Serum Alkaline Phosphatase

김종봉,윤인숙,옥현숙,탁영빈,하지홍 대구효성가톨릭대학교 자연과학연구소 1992 基礎科學硏究論集 Vol.1992 No.1

진도개와 삽사리 혈청 lactate dehydrogenase와 혈청 alkaline phosphatase의 동위효소 및 효소활성도를 분석하였다. 전기영동결과 진도개와 삽사리의 혈청에서는 5가지 종류의 LDH의 동위효소가 모두 확인되었다. LDH의 활성도는 진돗개의 경우 522.53 ± 279.96(U/L)이었고 삽사리는 534.10 ± 280.35(U/L)이었다. 진도개와 삽사리의 혈청 alkaline phosphatase전기영동상에서는 한 종류의 동위효소만 관찰되었고 활성도는 진도개의 경우 7.61 ± 4.52(K-A unit)였고 삽사리는 10.46 ± 7.10(K-A unit)였다. 삽사리의 ALP 활성도는 연령에 따라 커다란 차이를 나타내었다. Isozymes and activities of serum lactate dehydrogenase and serum alkaline phosphatase were examined in Korean Jindo dog and Sapsaree. The electrophoretic pattern of serum lactate dehydrogenase showed five isozymes. The activities of serum lactate dehydrogenase were 522.53 ± 279.96 and 534.10 ± 280.35(U/L) in Jindo dog and Sapsaree. One kind of isozymes was observed in electrophoretic phenotypes of serum alkaline phosphatase. The activities of serum alkaline phosphatase were 7.61 ± 4.52 and 10.46 ± 7.10 (K-A unit) in Jindo dog and Sapsaree. A significant difference of alkaline phosphatase was observed according to the age in Sapsaree.

Long-Term Survival and Tumor Recurrence of Patients with Superficial Esophageal Cancer after Complete, Non-Curative Endoscopic Resection: a Single Center Case Series

Ji Wan Lee,Charles J. Cho,Do Hoon Kim,Ji Yong Ahn,Jeong Hoon Lee,Kee Don Choi,Ho June Song,Sook Ryun Park,Hyun Joo Lee,Hyun Joo Lee,Gin Hyug Lee,Hwoon-Yong Jung,Sung-Bae Kim,Jong Hoon Kim,Seung-Il Par 대한소화기내시경학회 2018 Clinical Endoscopy Vol.51 No.5

Background/Aims: To report the long-term survival and tumor recurrence outcomes in patients with superficial esophageal cancer(SEC) after complete non-curative endoscopic resection (ER). Methods: We retrieved ER data for 24 patients with non-curatively resected SEC. Non-curative resection was defined as the presence ofsubmucosal and/or lymphovascular invasion on ER pathology. Relevant clinical and tumor-specific parameters were reviewed. Results: The mean age of the 24 study patients was 66.3±8.3 years. Ten patients were closely followed up without treatment, while14 received additional treatment. During a mean follow-up of 59.0±33.2 months, the 3- and 5-year survival rates of all cases were90.7% and 77.6%, respectively. The 5-year overall survival rates were 72.9% in the close observation group and 82.1% in the additionaltreatment group (p=0.958). The 5-year cumulative incidences of all cases of recurrence (25.0% vs. 43.3%, p=0.388), primary ECrecurrence (10.0% vs. 16.4%, p=0.558), and metachronous EC recurrence (16.7% vs. 26.7%, p=0.667) were similar between the twogroups. Conclusions: Patients with non-curatively resected SEC showed good long-term survival outcomes. Given the similar oncologicoutcomes, close observation may be an option with appropriate caution taken for patients who are medically unfit to receive additionaltherapy

Evaluation of in vitro potential of Bacillus subtilis KCTC1326 for antibacterial activity

Ji-Yoon Park,Ji-Su Kim,Eun-sup Lee,Sung-Jun Lee,In-Joo Shin,Hyunwoo Kim,Joon Yeong Kwon,Se Ryun Kwon 한국수산과학회 양식분과 2022 한국수산과학회 양식분과 학술대회 Vol.2022 No.10

농산 및 임산폐자원의 xylan 을 이용한 기능성 물질 생산 ( 1 ) - xylan 의 단리 및 정제 -

변지혜(Ji Hye Ryun),임부국(Bu Kug Lim),양재경(Jae Kyung Yang),장준복(Jun Pok Chang),이종윤(Jong Yoon Lee) 한국목재공학회 2000 목재공학 Vol.28 No.3

N/A N/A

한국에서 다문화가족의 혼인, 출생, 자녀의 추이에 대한 통계적 고찰 및 주산기 정책 전망

이지현 ( Ji Hyun Lee ),한명희 ( Myung Hee Hahn ),정성훈 ( Sung Hoon Chung ),최용성 ( Yong Sung Choi ),장지영 ( Ji Young Chang ),배종우 ( Chong Woo Bae ),김유경 ( Yu Kyung Kim ),김혜련 ( Hye Ryun Kim ) 대한주산의학회 2012 Perinatology Vol.23 No.2

목적: 최근 결혼이민자(marriage-based immigrants)의 증가로 인해서 한국에서 다문화가족(multi-cultural family)이 증가 추세이다. 한국에서 최근 20년간 다문화가족의 혼인, 출생, 자녀에 관한 통계적 변화추이를 조사하였다. 방법: 국가통계포털의 통계청 자료, 통계청의 2010년 인구동태통계연보, 행정안전부의 지방자치단체 외국인주민현황 조사결과, 한국보건사회연구원에서 발표된 다문화가족에 대한 보고서와 보건복지포럼의 해설들, 한국보건사회연구원, 보건복지부 등의 다문화가족에 관련된 보고서 자료들을 이용하여 분석하였다. 결과: 2010년 한국에서 전체 혼인건수는 326,104 중에서 다문화 가족 혼인건수는 35,098건으로, 10.8%이었다. 이는 최근 20년 간 현저히 증가되는 추세이었다. 2010년 다문화가족 혼인건수의 행정 지역별 분포는 경기도가 18.5%로 가장 높았고, 그 다음이 서울 15.4%이었고, 제주가 1.1%로 가장 낮았다. 서울(15.4%), 인천(4.5%), 경기도(18.3%)의 수도권에서 전부 38.2%로 약 1/3이 수도권이었다. 2010년에서 다문화가족 혼인건수 중 한국인 남편과 외국인 아내의 경우에서는 외국인 아내의 출신국적이 베트남, 중국이 가장 많았고, 그 다음이 필리핀, 캄보디아, 일본태국, 미국, 통골, 네팔, 대만 순이었다. 다문화가족에서 출생한 출생 수는 2008, 2009, 2010년에서 출생 수는 13,443, 19,024, 20,312명으로 증가 추세이며, 한국의 전체 출생 수에 차지하는 비율은 각각 2.9%, 4.3%, 4.3% 이었다. 자녀 수는 2007, 2008, 2009, 2010년에 각각 44,258, 58,007, 99,684,105,502명으로 중가추세이었다. 2009년 다문화가족 자녀의 연령별 수와 분포는 6세 미만, 7-12, 13-15, 16-18, 19-22, 23세 이상이 각각 66,825 (67.0%), 20,888 (21.0%), 3,174 (3.2%), 1,934 (1.9%), 2,160 (2.2%), 4,703(4.7%)명 이었다. 18세 이하 소아청소년은 전체에서 93.1%이었다. 향후 10년간 한국에서 다문화가족 수, 자녀 수의 전망에서 2011년에 비해서 약 1.5배 증가할 것으로 예상된다. 주산기 건강관리 면에서 산모의 영양 문제, 건강관리인식 부족, 빈혈, 저체중출생아의 출생 등 여러 문제가 있어서 향후 개선을 위한 방법이 제시되고 있다. 결론: 이상의 결과에서 다문화가족의 혼인건수(특히 외국인 아내가 주된 결혼형태), 출생 수, 자녀 수의 증가 추세와 이들의 발생을 파악함으로서 이들에 대한 주산기, 산과, 신생아, 소아청소년과 관리에서 다문화가족에 대한 특별한 관리 제도의 필요성을 보이고 있어, 의료 측면에서 이들을 잘 관리할 수 있는 제도적 뒷받침이 필요할 것이다. 다문화가족에 대한 혼인, 출생, 자녀 수, 자녀 연령 등에 관한 통계자료 들이 기본 자료로 활용되기를 기대한다. Purpose: Recently, the trend of multi-cultural families is rising in number due to increasing marriage-based immigrants in Korea. We evaluated statistic changes of characteristics in international marriage, births, and offsprings for the past 20 years in Korea. Methods: The annual report of national population from Statistics Korea, the survey results about the present status of resident foreigners from Korea Ministry of Health and Welfare, Korea Ministry of Public Administration and Security, and editorials from Health and Welfare Forum and other related reports of Korea Institute for Health and Social Affairs and Korea Ministry of Health and Welfare were used. Results: There were 35,098 (10.8%) international marriages among total 326,104 marriages in 2010 in Korea. The regional distribution of the international marriage was the highest in Gyeonggi (18.5%), and the lowest in Jeju (1.1%). The metropolitan area Seoul (15.4%), Incheon (4.5%) and Gyeonggi (18.3%) comprised one third of the entire international marriage. The number of childbirths was 13,443 (2.9%) in 2008, 19,024 (4.3%) in 2009, and 20,312 (4.3%) in 2010 with increasing trend. The number of off-springs was 44,258 in 2007, 58,007 in 2008, 99,684 in 2009 and 105,502 in 2010. Children less than 18 years old was 93.1%, We expected 1.5 times of increase over the next coming 10 years in the number of multi-cultural international marriage and offsprings compared with 2011. Conclusion: When we evaluated the characteristics of multi-cultural marriages, childbirths, and off-springs, systemic nationwide care seemed to be necessary in the aspect of health problems such as perinatology, obstetrics, neonatology, and pediatrics. We expect our results to be utilized for the basic health data.