알부민이 첨가된 시험관내 약역학 감염모델을 이용한 폐렴알균 치료에서 Ceftriaxone 일일 1회 요법

허지안,전혜선,박선희,최수미,김시현,이동건,최정현,유진홍,신완식 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

배경 : Penicillin 내성 폐렴알균이 증가하는 지역에서 대안 중의 하나로 사용되는 ceftriaxone (CTR)의 적절한 용법, 용량을 파악하는 것이 중요하다. 본 연구는 임상에서 분리된 폐렴알균을 대상으로 시험관내 약역학 감염모델을 이용하여 알부민이 첨가된 경우와 첨가되지 않은 경우 CTR의 일일 1회 요법의 효과를 비교해 보고자 하였다. 재료 및 방법 : Penicillin 감수성(SM24), 중간내성(SM47), 내성(SM60)주를 대상으로 2-구획 시험관내 약역학 감염모델을 적용하였다. CTR 주입은 2 g씩 24시간마다로 사람의 약동학을 모의하였다. 알부민은 모델에서 4g/ dL가 유지되도록 하였다. 살균효과는 0, 2, 4, 6, 24, 30, 48시간째 집락수 변화로 측정하였다. 결과 : 모든 균주에서 알부민이 첨가되지 않은 경우 6시간 이내에 살균력이 관찰되었다. 최저억제농도 및 알부민 첨가유무에 관계없이 3주 모두 24시간째 살균력이 관찰되었고, 48시간째는 모두 측정한계 이하의 집락수로 감소하였다. 전 실험과정에서 CTR에 대한 내성주는 출현하지 않았다. 결론 : CTR의 일일 1회 요법은 알부민이 첨가되었을 때, 감수성, 중간내성, 내성주 모두에서 살균력 발현이 지연되었으나 최종효과는 알부민이 없을 때와 다르지 않았다. 앞으로 알부민 결합효과와 관련된 기초적인 추가 연구가 필요할 것으로 생각된다. Background : During the era of increasing penicillin resistant Streptococcus pneumoniae, it is important to have knowledge about adequate dosage and dosing interval of ceftriaxone (CTR). We examined efficacies of once-daily CTR and compared results in an in vitro pharmacodynamic infection model (IVPDIM) supplemented with albumin and those without albumin. Methods : Using three clinically isolated S. pneumoniae that were susceptible (SM24), intermediate (SM47) and resistant (SM60) against CTR, we utilized a two-compartment IVPDIM. CTR 2 g was administered intravenously every 24 h. Human albumin was added with concentration of 4 g/dL. Samples were removed at multiple time points over a 48-h period to determine the colony counts. Results : In SM24 and SM60, bactericidal effects were observed within 6 hours in groups without albumin. The number of colonies during 1st 6 hours were more decreased in albumin-free groups than in albumin-supplemented groups (P<0.05). In SM47, similar results were found during 1st 6 hours (P=0.03). But, regrowth was observed in albumin supplemented group at 30 h. Irrespective of results of minimal inhibitory concentrations and albumin supplementation, bactericidal effects were shown at 24 h in all 3 strains. All groups were decreased below the detection limit at 48 h. Development of resistance was not detected throughout the entire study period in either strain. Conclusions : Although extents of killing in albumin supplemented broth of once-daily CTR dosing were delayed in all 3 strains compared with those of albumin free broth, final efficacies were not different between the two groups.

문학 장르별 한국 문화교육 연구 -고향과 관련한 작품들을 중심으로-

김지안 ( Kim Ji An ),이정희 ( Lee Jung Hee ) 한국사회복지경영학회 2021 사회복지경영연구 Vol.8 No.2

고향에 대한 한국인의 정서는 문학작품에 녹아들어 대를 이어 향유되고 있다. 한국어학습자들 또한 고향을 떠나 한국사회라는 타향에서의 삶을 살기에 고향에 대한 남다른 의미를 가질 것이다. 따라서 한국어학습자 자신을 비추어 볼 수 있기도 하며, 한국인들이 갖는 남다른 ‘고향’에 대한 정서를 여러 문학 장르의 문학작품을 통해 함께 공유하고 소통하고자 한다. 본 고에서는 한국어교육에 있어서 한국어 학습자에게 읽기 텍스트로서의 접근성과 언어 수준을 고려한 문장의 길이 그리고 내용 파악의 용이성을 염두에 두고 고향이라는 주제와 소재가 포함된 문화요소를 고려하여 단편소설, 수필, 현대시, 시조의 장르를 선정하였다. 소설에서는 고향 상실과 고향 회귀에 대해 심도 있게 다룬 황석영의 ‘삼포로 가는 길’과 문순태의 ‘징 소리’를 선택하였다. 외지를 떠도는 주인공들에게 고향은 마음속에 담겨 있고, 돌아가고 싶은 곳으로 정착하고픈 곳이다. 수필에서는 수필가로 인지도가 있고, 내 고향에서 고향에 대한 애착을 잘 표현한 치옹 윤오영의 ‘내 고향’과 우리나라의 대표적인 국어학자로서 국어사연구 및 국어정책 발전에 힘썼으며, 월남 학자로서 고향에 대한 의식이 남달랐고, 고향과 어머니를 그리워하는 마음도 강하게 나타난 해암 김형규의 ‘고향’을 중심으로 논의하였다. ‘내 고향’에서는 고향에 대한 애착과 자부심이 ‘고향’에서는 두고 온 고향과 홀로 계신 어머니를 생각하며 회한에 빠진 모습이 잘 나타난다. 시에서는 정지용의 ‘향수’와 이시영의 ‘마음의 고향6 초설’을 선택하였다. ‘향수’에서는 고향의 정경을 잘 묘사하고 있고, 감각적 이미지를 사용하여 고향에 대한 그리움을 나타내고 있고, ‘내 마음의 고향’에서는 고향을 잃은 상실감과 그리움의 정서를 반어적으로 강조하고 있다. 시조에서는 고향에 대한 작품을 많이 남긴 백수 정완영의 ‘고향생각’과 초정 김상옥의 ‘사향’을 선택하였다. ‘고향생각’에서는 단지 태어나 자란 곳이 아닌 조상 곁으로 돌아가는 공간으로의 고향으로 그려지고 있다. ‘사향’에서는 고향을 떠나 일경의 추적을 피하면서도 고향에 대한 애틋한 생각을 담고 있다. 작품들에서 고향은 한국인들에게 고향은 자기가 태어난 곳을 넘어 자신의 뿌리가 되고 힘들 때 생각나고, 언젠가는 돌아가야 할 곳으로 생각하고 있다. 문학 장르별 문화 교육 방안으로 소설과 수필은 고향을 주제로 써보는 것을, 시와 시조에서는 모방시 짓기와 시조 창작 활용을 제시하였다. 고향이란 테마에 한국인의 효와 가족 사랑을 묶는다면 한국어 문화교육 현장에서 좋은 소재가 될 것이고, 한국의 문화를 교육하는데 일조할 것이다. Koreans' emotions about their hometown have been melted into literary works and enjoyed for generations. Korean language learners will also have a special meaning for their hometowns because they leave their hometowns and live in other regions of Korean society. Therefore, Korean learners themselves can be seen in light of themselves, and they intend to share and communicate with Koreans through literary works of various literary genres. In this paper, short stories, essays, modern poems, and sijo genres were selected in consideration of cultural elements including the theme and subject of hometown, with Korean learners in mind of accessibility as reading texts, language level, and ease of identification. In the novel, Hwang Seok-young's "The Way to Sampo" and Moon Soon-tae's "Jingsori," which dealt with in-depth loss of hometown and return to hometown, were selected. For the protagonists wandering around the country, their hometown is contained in their hearts and they want to settle down as a place they want to return to. In his essay, he was recognized as an essayist, and he worked hard to study Korean history and develop Korean language policies as a representative Korean scholar in Korea, and discussed Haeam Kim Hyung-gyu's hometown, which showed a strong sense of longing for his hometown and mother. In My Hometown, attachment and pride to my hometown are well seen in regret, thinking about my hometown and my mother who is alone. The poem chose Jeong Ji-yong's "Nostalgia" and Lee Si-young's "Hometown of Heart 6." In "Nostalgia," the scenery of the hometown is well described, the longing for the hometown is expressed using a sensuous image, and in "Hometown of My Heart," the emotion of loss and longing for the loss of hometown is ironically emphasized. In the progenitor's book, Baeksu Jeong Wan-young's "Hometown Thoughts" and Chojeong Kim Sang-ok's "Sahyang" were chosen. In "Hometown Thinking," it is depicted as a hometown that goes back to the ancestor's side, not just a place where he was born and raised. ‘Sahyang’ contains affectionate thoughts about the hometown while avoiding the pursuit of Ilgyeong, leaving his hometown. In the works, I think of my hometown as a place for Koreans to go beyond where I was born, become my roots, think of when I have a hard time, and go back someday. As a cultural education plan for each literary genre, novels and essays were written on the theme of hometown, and poems and sijos suggested writing imitations and the use of sijo creation. If Koreans' filial piety and family love are tied to the theme of hometown, it will be a good material in the Korean language culture education field and help educate Korean culture.

주폐자충 폐렴으로 발현된 Felty 증후군 1예

김성호,남대근,문재현,김지홍,김보석,안진광,문태건,안병재,김성일 全南大醫大 2001 전남의대학술지 Vol.37 No.3

대량의 각혈로 사망한 장티푸스 1예

한상우,유진홍,권순석,김성훈,박지찬,홍은정,최경성,박용완,장준희,안지원,박유경,강지영,박상미,신완식 대한감염학회 2004 감염과 화학요법 Vol.36 No.5

We experienced a 25 year-old male patient with typhoid fever complicated with massive hemoptysis. Pulmonary complication in typhoid fever is very rare and to our knowledge, there has been no report of hemoptysis as a main cause of death with this disease. We herein report a rare case of typhoid fever.

실물과 사진제시에 의한 화색과 식물형태의 비교 : focusing on the students of mental ratardation 정신지체학생을 대상으로

안기완,백지성,김은일,조희두,서성철,오찬교 韓國植物ㆍ人間ㆍ環境學會 1999 인간식물환경학회지 Vol.2 No.4

This study was carried out to verify the differences in preference of flower colors by displaying flowered plants and their photos to mentally retarded students. As a result, normal students showed consistent preference against both the objects. But mentally retarded students had a different preference for flowered plants and their photos.

고삼투압성 비케톤성 상태의 예후인자

안성훈,김양원,김미란,진헌철,안지영,이상래,류석용,김홍용,김성준,이병권,김경환 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2

Background: A hyperosmolar nonketotic state has been known to have a high mortality, and even now, despite this high mortality, only a few studies of this disease have been performed. We studied the prognostic factors for the hyperosmolar nonketotic state. Methods: We retrospectively studied the cases of 40 patients who were in a hypersomolar nonketotic state when admitted to Sanggye Paik Hospital during the 6-year Period from 1995 through 2000. We divided the hyperosmolar nonketotic patients into two groups, the complete recovery group and the incomplete recovery group, and compared the clinical features, the laboratory findings, and the precipitating factors between two groups. Results: 1) A total of 40 patients were studied: 24 in the complete recovery group and 16 patients in the incomplete recovery group. The mortality rate was 32.5%. 2) No significant statistical difference existed among the clinical features of the two groups, except for the sex(p<0.01). 3) Among the laboratory findings of both groups, analysis revealed that the effective osmolarity was significantly higher among those in the incomplete recovery group(p<0.01). Serum sodium concentration was also significantly higher among those in the incomplete recovery group(p<0.01). Serum creatinine was also significantly higher among those in the incomplete recovery group(p<0.05). Serum bicarbonate concentration, on the other hand, was significantly lower among those in that group(p<0.05).4) Infection was identified as the most common precipitating factor(62.5%). Among the precipitating factors of the two groups, there were significant statistical difference in pneumonia, UTI, and inappropriate glucose control. 5) A significant statistical difference existed among the initial level of consciousness of both groups(p<0.05). 6) The only significant independent factor responsible for prognosis of nonketotic hyperosmolar state patients was the sex. Conclusion: The sex was only significant independent prognostic factor of nonketotic hyperosmolar state patients.

한국인 영어학습자들의 발음오류 분석

안지인,정현성 대구대학교 사범대학 부설 교육연구소 2005 敎育硏究 Vol.1 No.1

This paper examines the patterns of Korean EFL learners' English pronunciation difficulties in terms of segmental and suprasegmental features. It also aims to present effective English pronunciation teaching techniques to improve communicative competence of Korean EFL learners. The paper presents the importance and theoretical justification for English pronunciation teaching. General properties and theoretical backgrounds of English pronunciation teaching are presented. It overviews the history of English pronunciation teaching from the audio-lingual method to community language learning. The paper examines how these methods were applied to Korean English education curriculum, specifically to English pronunciation teaching. This paper concludes that it is necessary to provide teachers with English pronunciation teaching training program to improve their teaching skills in Communicative Language Learning. A wide variety of teaching materials also need to be developed for more effective pronunciation teaching. 본 논문에서는 발음교육의 측면에서 한국인 영어학습자들이 가지는 영어발음의 문제점들을 고찰하고, 의사소통기능을 원활하게 하기 위하여 한국인 영어학습자들이 학습해야 할 언어자질들에 대하여 제시하였다. 언어자질의 내용적 측면을 제시하기 위해, 영어의 분절자질과 초분절자질에 대해 분석하고, 이러한 자질들이 의사소통중심 영어발음교육에 어떻게 적용될 수 있을지 모색해 보았다. 또한 청화식 교수법에서 의사소통중심 영어발음교육에 이르기까지의 영어발음교육의 이론을 고찰하여, 이러한 영어발음교육의 이론들이 한국의 영어교육 과정에는 어떻게 적용되어 왔는지 분석하고, 이러한 분석을 바탕으로 효과적인 영어발음 지도방안을 모색하고, 영어발음교육이 지향해야 할 방향을 제시하였다.

Reading Performance Improvement in PDF-417 2-dimensional Bar code

안라연,박지후,우홍체 대구대학교 2006 대구대학교 학술논문집 Vol.1 No.2

As life style becomes to be complicated, lots of supportive technologies were developed. The bar code technology is one of them. It was renovating approach to merchandise industry. However, data storage ability of one dimensional bar code is limited because of growing the number of merchandise.. Two-dimensional bar code was proposed to overcome one-dimension bar code. PDF-417 bar code most commonly used in standard two-dimension bar codes has good performance at data decoding and error correction area. An algorithm to improve reading performance with PDF-417 is suggested. The threshold value is computed, and bar and space are extracted according to threshold value. PDF-417 is used everyday and is printed in many different materials. The printed PDF-417 is especially influenced by various light sources. It is hard to recognize the bar and space separation under the circumstance of changing illumination. The fixed threshold value to distinguish the bar and space can not be applied. The proposed algorithm is developed to investigate the variable threshold. The variable threshold can be obtained by simple calculation.

어린이의 치과치료시 약물에 의한 진정요법 사용에 대한 실태조사

안소연,최병재,곽지윤,강정완,이제호 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.3

진정요법은 소아치과에서 사용하는 보상, 속박, 체계적 탈감작법(말-시범-시행), 친밀감 같은 통상의 방법으로는 환자의 반응이 개선되지 않아 일반적인 치과치료가 불가능할 때 사용하는 행동조절법이다. 최근 국내에서도 진정요법을 이용하는 사례가 증가하는 추세이나 그 기준이나 방법들에 대한 연구는 매우 부족한 상태이다. 미국소아치과학회의 진정요법에 관한 기준이 있기는 하지만 국내의 상황이 미국과 다르므로 한국에서의 연구가 필요하다. 이에 저자는 국내에 거주하고 있는 소아치과의사들을 대상으로 국내 소아치과에서의 진정요법 현황에 대한 실태를 조사, 그 결과를 정리하여 향후 소아치과 임상에서의 진정요법에 대한 임상 기준을 정하는데 기여하고자 국내에 거주하고 있는 대한소아치과학회 회원 573명을 대상으로 진정요법 사용 실태에 관한 설문지를 발송하여 이 중 회신을 한 220명의 설문을 분석하여 다음의 결과를 얻었다. 1. 응답자의 약 66%가 진정요법을 사용하고 있다고 답했다. 진정요법에 관한 이전 연구 결과와 비교해 볼 때, 국내 소아치과에서 진정요법의 사용빈도가 증가하였다. 2. 진정요법으로 치료를 결정 하게 된 요인은 행동조절, 치료내용과 양, 보호자의 요구, 내원횟수, 전신질환의 순서이었다. 3. 진정요법으로 치료받는 환자의 연령은 만 3세가 가장 많았고, 만 4-5세, 만 2세 미만, 만 6-10세, 만 10세 이상의 순서로 조사되었다. 4. 진정요법 시 chloral hydrate는 60-70mg/kg, hydroxyzine은 10-40mg/kg(25mg/kg)을 사용하고 있었고, 경구 투여가 가장 선호하는 약물투여 경로였다. 5. 진정요법 시 사용하는 환자감시 방법은 피부나 손톱색 둥의 관찰을 포함한 환자 평가와 맥박 산소측정기(pulse oximeter)를 통한 환자감시를 선호하는 것으로 조사되었다. 6. 진정요법을 사용하고 있다고 응답한 사람의 약 56%에서 심폐소생술 교육을 받은 것으로 조사되었다. Sometimes the dentists encounter a child who can not be treated with traditional behavior management techniques (for example, reward, restraint, Tell-Show-Do, familialization). In such a case, the dentists use sedation technique. Recently, in Korea, the use of sedation by pediatric dentists is increased. But, the guideline and survey of sedation is very insufficient. Now, we need a survey of sedation practice in Korea. We carried out research on the actual condition about sedation with a questionaire to pediatric dentists in Korea. Followings are the conclusions 1. Sixty six percent of pediatric dentists use sedative agents in their practice. In this study, using sedation shows an increase as compared with the past. 2. Determinative factors of using sedation were orderly behavior management, number of visiting, guidian's opinion, amount of treatment, general condition. 3. Distribution of ages in patients sedated with agents was orderly 3 years, 4-5 years, under 2 years, 6-10 years, more than 10 years. 4. Particular sedative drugs were chloral hydrate 60-70mg/kg, hydroxyzine 10-40mg/kg(25mg/kg), and oral route was the most favorable route. 5. Observation of skin and nail color, pulse oximeter were the most frequently utillized monitoring method during sedation. 6. Only fifty six percent of pediatric dentists complete the cardiopulmonary resuscitation course.

지구력 운동이 급성기 뇌졸중 쥐의 뒷다리근 질량에 미치는 영향

안경주,이윤경,임지회,최스미,최명애 대한기초간호자연과학회 2000 Journal of korean biological nursing science Vol.2 No.2

The purpose of this study was to identify hindlimb muscle atrophy in stroke induced rat and determine the effect of endurance exercise on body weight, weight of hindlimb muscle during 7 days after stroke induction. Thirty four male Sprague-Dawley rats with 200-270g body weight were divided into four groups : control, control+exercise(Con+Ex), stroke, and exercise after stroke(St+Ex) group. The control group and Con+Ex group received sham operation and the stroke group and St+Ex group received right MCA occlusion operation by using silicon-coated probe. The Con+Ex and St+Ex groups ran on a treadmill for 20min/day at 10m/min and 10 "grade. Daily body weight and diet intake were measured every morning for 7 days. Cerebral infarction of stroke and St+Ex groups were identified by staining with TCC for 30minutes. The data were analyzed by Kruskd-Wallis test and Mann-Whitney U test using the SPSSWIN 9.0 program. Body weight of the control group at the 7th day increased by 18.3% significantly from the first day of experiment, that of the stroke group at the 7th day decreased by 6.7% significantly compared to the day of receiving right MCA occlusion operation. Body weight of the Con+Ex group at the 7th day increased by 10.3% significantly from the first day of experiment, that of St+Ex group at the 7th day also increased by 13.4% significantly compared to the day of receiving right MCA occlusion operarion. The total amount of diet in stroke group decreased significantly compared to that of St+Ex and that of control group. In stroke group the wet weight of both sides of soleus, plantaris, and gastrocnemius muscles decreased significantly compared to that of control group. The relative weight of affected(left) plantaris and gastrocnemius muscles decreased significantly compared to that of the control group. The difference between the weight of affected and unaffected soleus, plantaris, and gastrocnemius muscles were not significant in stroke group. The wet weight of right gastrocnemius muscles in Con+Ex group increased compared to that of control group. The relative weight of right gastrocnemius muscle increased significantly compared to that of the control group. The wet weight of St+Ex group increased significantly compared to that of the stroke group in both sides of soleus, plantaris, and gastrocnemius muscles. The relative weight of affected plantaris muscle increased significantly compared to that of the stroke group. The difference between the weight of affected and unaffected soleus, plantaris, and gastrocnemius muscles were not significant in St+Ex group. Body weight and wet weight of soleus, plantaris, and gastrocnemius muscles in the St+Ex group did not recover to the values of control group. Based on these results, it can be suggested that endurance exercise during acute stage of stroke can reduce muscle atrophv related to denervation. inactivity and undernutrition.