전기충격요법 사용에 관한 정신과의사의 견해 및 실시현황

정환증,변원탄 大韓神經精神醫學會 1983 신경정신의학 Vol.22 No.4

한국 정신과 의사 211명의 전기충격요법에 관한 의견을 다음과 같이 요약할 수 있었다. 1. 735가 치료방법으로서의 전기충격요법을 찬성하는 태도였고, 찬성하는 가장 큰 이유로서는 적응증만 잘 고려된다면 일반적으로 우수한 효과를 볼 수 있다는 것이었다. 그러나, 그 실제적인 사용에 있어서는 다수에서 조심스러운 태도를 보이고 있었고, 어떤 견해에 있어서는 미국의 정신과 의사들보다 훨씬 더 소극적인 태도를 가지고 있었다. 2. 전기충격요법의 적응증에 관한 한 역시 예상한 바와 같이 주요 우울장애, 조증 흥분, 정신분열증의 순으로 찬성하는 경향이 많았고, 이 방법을 선택한 이유로는 '응급처치로 시행하거나' 다른 치료방법에 실패했거나' '보다나은 결과를 얻기 위한 병용 치료로서 선택' 등이 가장 많았다. 3. 정신분열증에서의 전기충격요법은 사용의 한계를 나타내고 있었다. 4. 시행 이전의 동의나 시행 전 감사에 대해서는 비교적 엄격한 태도를 유지하고 있으나, 연성 전기충격요법, 편측 전기충격요법의 활용은 적었으며, 강력 또는 유지 전기충격요법 역시 시행율이 낮은 편이였다. 시행빈도는 79%가 주2-3회를 실시하는 것으로 나타났고, 향정신약물을 사용하던 환자에서 전기충격요법을 시행한 경우, 대체로 약간의 약물 감량을 실시하는 것으로 나타났다(59%) 5. 전기충격요법 시행 이후의 합병증으로는 골절이나 탈구, 직업 수행 능력에 영구적인 장애, 자발적인 경련 발작 등이 예상외로 많아 합병증은 역시 소홀히 할 수 없는 문제임을 나타내 보였으며, 전기충격요법 이후 24시간이내 사망을 경험한 예가 6경우가 있었다. The authors of this suveyed the opinions of 211 Korean psychiatrists about the use of Electoconvulsive Theraoy(ECT). The results of the survey are summarized as follows; 1. ECT was accepted with a favorable attitude by 73% of the psychiatrists surveyed. The most common reason for agreement was that if indication is followed the ECT generally produces excellent results. But in actual clinical practice most Korean psychiatrists are hesitant in preforming the ECT and have a somewhat less active attitude towards ECT than psychia trists in America. 2. The major indications for theuse of ECT were major depression, manic excithment and schizophrenia in the order of their frequency. The main reasons for the selection of ECT as a therapeutic tool were emergency therapy, when all other treatment methods have failed and as a combined treatment that can. 3. The use of the ECT for the treatment of schizophrenia was very limited for a few selected cases. 4. Korean psychiatrists showed relatively rigid adherence to obtaining the consent before ECT and the preoperational work-up. The softening and unilateral ECT had received little use in Korea and a similar tendency was shown towards intensive and maintenance ECT. Most psychiatrists(79%) tended to use the ECT 2 or 3 times a ewek with a majority of their patients. In cases where the ECT was used in concomitant with antipsychotic drug therapy, there showed a tendency for a slight reduction in drug dosages during the ECT. 5. Post-ECT complications and/or adverse effects were fracture, dislocation, premanent disability in occupational performane and spontaneous seizures etc. Occurrences of above complications seem to be mlre than expected in this study and this was not negligible. A total of six patients were known to habe expired within twenty-four hours after ECT.

객체지향 개념을 이용한 시스템의 프로세스 모델링 방법

이은정,임근,이경환 한국정보과학회 1994 韓國情報科學會誌 Vol.21 No.1

數種動物의 膵組織內 Protein Methylases의 活性度 分布에 관한 硏究

李香雨,韓正煥 成均館大學校 科學技術硏究所 1984 論文集 Vol.35 No.1

Post- translational modification of amino acid residue side-chains in protein has come to be a well known biochemical phenomenon. These reactions include methylation, carboxylation, acetylation, phosphorylation, and hydroxylation. One such side-chain modification of protein, protein methylation is being investigated actively with regard to bacterial chemotaxis, cytochrome c, gene regulation, and carnitine biosynthesis. The methylated amino acids occur in nature in highly specialized proteins. These methylated amino acids are formed by reactions catalyzed by protein methylase Ⅰ, Ⅱ and Ⅲ. In recent studies it was reported that protein carboxymethylation is involved in amylase secretion of parotid gland by isoproterenol. It was also suggested that a small part of the total cellular protein carboxymethylation is directly involved in pancreatic enzyme secretion. On the contrary, other authors reported that there is no relationship between protein carboxymethylation and secretion in pancreas and parotid. In this study we first examined the activities of protein methylase I, II, and III in pancreatic tissues of various animals, such as rat, mouse, guinea pig, rabbit, pig, cow, cat, chicken, and frog. The following results were obtained; 1. The activities of protein methylases were generally high in pancreatic tissues of cat, pig, and rabbit. Specifically, the activity of protein methylase I was very high in pancreatic tissue of cat, but low in the tissue of rat. Bovine pancreas had been shown to be the richest source for protein methylase Ⅱ, while the activity of protein methylase Ⅲ was relatively high in pancreatic tissue of cat. 2. The activities of protein methylase Ⅰ, Ⅱ, and Ⅲ in pancreatic tissue of chicken were generally high. 3. Interestingly, the activities of protein methylase Ⅰ, Ⅱ, and Ⅲ were not detected in pancreatic tissue of frog which is amphibian.

항암화학요법을 받는 암 환자에 대한 Nucare^R의 영양지지효과

조덕연,김현수,곽상혁,강정현,김철희,배광봉,김종숙,박상준,윤환중,김삼용 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

Purpose : The purpose of this study was to evaluate the effect of nutritional support with enteral liquid supplement in cancer patients receving chemotherapy for possible benefit in nutritional, immunologic and golbal function of patients. Patients and Methods : From October 1995 to February 1997, 30 advanced cancer patients receving chemotherapy were divided two roups. The Nycare group, in addition to normal diet, Nucare^R enteral supplement was given for 1week right after chemotherapy for the duration of 2 chemotherapy cycles. Control group received only normal diet without parenteral fluid supplement for 2 chemotherapy cycles. Results : Median ages were 53 end 56 years for Nucare group and Contrl group respectively. Performance scores was less than 2 by ECOG scale. All patients were stage Ⅲ or Ⅳ. The physical parameters, such as weight, arm muscle circumference(AMC) and triceps skin fold(TSF) were decreased in both groups after 2 cycles of anticancer therapy. but it was less severe in Nucare group(p<0.05). Serum transferrin was maintained in mild deficit state in Nucare group, whereas it aggravated form mild to moderate deficit in Control group(p<0.05). Serum albumin level increased in Nucare group without statistical significance. but it decreased from normal to mild deficit in Control group. Serum total protein did not change significantly in Nucare group. but in Control group, serum total protein was decreased from 7.24±0.9 to 6.52±0.5(P<0.05). Total lymphocyte count did not change significantly in both groups. Conclusion : This study shows that the nutritional support with Nucare^R was effective in the prevention of nutritional deficit status in patients receving a nticancer chemotherapy.

요배부 수술 실패 증후군에서 자기공명영상의 이용

이준규,안재성,권순태,김환정,정제택 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

This study was compared pre-operative MRI finding with operative finding on 36 cases with the failed back surgery syndrome (FBSS) retrospectively. The purpose of this study was to determine the accuracy of the MRI on the FBSS including early complications such as hematoma of infection. Of the 51 patients with FBSS, we analyzed pre-operative MRI finding compared with operative finding on 36 cases excluding nonunion, instability, metal failure and pseudoarthrosis who underwent an operation for the FBSS from December 1994 to June 1997. There were 25 men (69.4%) and 11 women (30.6%), aged from 16 to 68 years (average 43.6 years). These were divided into 5 sub-groups and calculated sensitivity, specificity and positive predictability. MRI accuracy in recurred disc was 84%, scar adhesion, recurred or developed stenosis, infection and hematoma 100% each and all, overall accuracy of the MRI 93%, respectively. Average interval of re-operation in FBSS WAS 4.3 years. In the 18 cases (50%), symptoms persist without pain-free interval after first operation. Early complications including hematoma and infection are easily detected with MRI. Especially if patient complains of severe leg pain or neurologic deficit, it is a good diagnostic procedure to check the MRI. The MRI is a useful method for evaluation of most cases of the FBSS, but it has limitations to evaluate recurred disc or scar adhesion only in T1, T2 weighted image. Therefore Gd-DTPA enhancement is necessary for the accurate diagnosis.

Symposium on Strategy for Drug Research and Development : Apicidin , a Histone Deacetylase Inhibitor , as a Potential Anticancer Agents

(Jeung Whan Han) 서울시립대학교 산업기술연구소 2002 국제학술SYMPOSIUM논문집 Vol.10 No.1

Regulation of mitogen-activated p70s6k

Jeung Whan Han,Hyang Woo Lee 대한약학회 1997 大韓藥學會 總會 및 學術大會 Vol.1997 No.1

Apicidin as Potential Antiproliferative Agent

Jeung-Whan Han,Seong Hoon Ahn,Hoi Young Lee,Yin-Won Lee,Hyang-Woo Lee 대한약학회 2000 大韓藥學會 總會 및 學術大會 Vol.49 No.-

Disciplinary Session9 / Sport Biomechanics : Development Methodology for Teaching Sport Skill / Kinematic Analysis of the Motion of One Hand Jump Shoot in Basketball

(Jeung Whan Oh),(Dong Jin Lee) 한국체육학회 1999 New Millennium and Sport Vision ABSTRACTS Vol.- No.-

Poster Session 2 / G-7 : Effects of dietary restriction and aging on protein carboxyl methylation in rat testis

(Jeung Whan Han),(Hyang Woo Lee),(Sung Youl Hong),(Sang Hyung Bong),(Hae Yyoung Chung),(Byung Pal Yu) 한국생화학분자생물학회 (구 한국생화학회) 1999 생화학분자생물학회 춘계학술발표논문집 Vol.- No.-