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순무 동치미 제조시 젖산균 접종이 저장 중 품질에 미치는 영향
이혜정,오순덕 한국식품영양학회 2002 韓國食品營養學會誌 Vol.15 No.1
김치에서 분리된 Leuconostoc citreum IH22를 순무에 접종한 동치미와 순무동치미의 저장 중의 변화는 다음과 같다. 1. 두 시료의 pH 변화는 저장 시간의 증가에 따라 감소하는 경향을 보였으나 젖산균 접종 동치미의 pH의 감소는 control에 비해 감소의 속도가 빠른 경향을 나타냈다. 2. 총산도의 변화는 저장 시간에 따라 증가하는 경향은 두 시료 같았으나 젖산균 접종 동치미는 저장 21일 째 부터는 변하지 않았다. 3. 총균수는 두 시료 모두 21일에 최대 균수를 보인 후 감소하는 경향이었다. 4. 젖산균수는 두 시료 14일에 가장 높다가 21일 부터는 급격히 감소하는 경향을 보였다. 5. 물성도의 변화에서도 control은 경도와 파쇄성에서 저장 14일 정도에 감소하다가 다시 증가하였고, 젖산균 접종 동치미는 저장 기간과 함께 완만하게 감소하였다. 6. 관능검사 결과 순무 동치미와 젖산균 동치미는 저장 기간 동안 신만, 시원한 맛의 변화가 없는 것으로 다했고, 탄산미와 기호도는 순무 동치미가 저장 14일 때가 젖산균 접종 동치미보다 높은 것으로 나타났으며 관능 특성에서 접종한 것과 control과 차이가 있는 항목은 탄산미와 기호도가 1% 수준의 유의차를 나타냈다. This study was examined in the chemical and sensory characteristics of Korean Turnip Dongchimi when innoculated with Leuconostoc citreum IH22 and Korean turnip Dongchimi. Both of Dongchimi were at room temperature for first day and at 4℃ from 2nd to 28th day. The pH was somewhat lower in Korean turnip Dongchimi innoculated with Leuconostoc citreum IH22 than non-treated Dongchimi. As fermentation proceeded titratable acidity of both Korean turnip Dongchimi significantly increased but Korean turnip Dongchimi innoculated with Leuconostoc citreum IH22 was not changed from 21th day to 28th day. The patterns of microfloral changes of both Dongchimi were similar during fermentation and the changes were increased in the number from the beginning, but they were rapidly decreased after the optimum ripening period. The hardness and fractureability of non-treated Dongchimi decreased rapidly after 14day of fermentation followed by a little increased until 28th day also Korean turnip Dongchimi innoculated with Leuconostoc citreum IH22 decreased gradually as the fermentation progressed The evaluation of sensory quality of both of Dongchimi showed that the sour taste and fresh taste were similar but carbonated flavor and overall acceptability were higher than those of Korean turnip innoculated with Leuconostoc citreum IH22.
박순자,신정화,신정숙,정명희,안윤경 한국의류학회 2004 한국의류학회지 Vol.28 No.2
PCDD/F(Polychlirinated dibenzo-p-dioxins and dibenzofurans) in both of treated fabric and untreated fabric for working clothes of a municipal waste incineration were determinated. The treated fabric for working clothes was developed for less exposure of PCDD/F in municipal waste incinerations. The total concentrations of PCDD/F in some parts such as surface, middle layer, inside for treated and untreated fabric were investigated. The I-TEQ value of surface was 0.23370ng ·TEQ/g for treated fabric, 0.15355ng ·TEQ/g for non-treated fabric. On the other hand, the value of middle layer was 0.00077ng ·TEQ/g, 0.00177ng ·TEQ/g, respectively. The surface of the treated fabric containing high levels PCDD/F was caused by absorption of them. Therefore, PCDD/F of the treated fabric in middle layer was less I-TEQ value than that of the untreated fabric. The treated fabric makes effect on preventing PCDD/F from permeating into human body.
천마의 GABA-benzodiazepine 수용체 복합체에 대한 조절작용
하정희,이동웅,어경윤,하정상,김현주,용철순,허근 영남대학교 약품개발연구소 1998 영남대학교 약품개발연구소 연구업적집 Vol.8 No.-
Methanol extract of G. elata inhibited the binding of [³H]Ro15-1788, a selective benzodiazepine receptor antagonist, to benzodiazepine receptor of rat cortices. Saturation experiments followed by Scatchard analysis of the results showed that the inhibition of [³H]Ro15-1788 binding by G. elata. appeared to be competitive. These competitive inhibiton of the butanol fraction was observed to be higher than the methanol extract. Methanol extract of G. elata inhibited a [³H]flunitrazepam, a selective benzodiazepine receptor agonist, binding to benzodiazepine receptor. GABA significantly enhanced the inhibition of [³H]flunitrazepam binding by G. elata, and these "positive GABA shift" supported the strong possibility of agonistic activity to benzodiazepine receptor. Butanol fraction was observed to be higher than crude extract by methanol in an agonistic activity to benzodiazepine receptor, furthermore enhanced the binding of [³H]SR95531 to GABA_(A) receptor. Butanol fraction of G. elata significantly diminished the pentylenetetrazole-induced lethality of mice. From these results, it can be concluded that substance or substances with neurochemical properties characteristic of a benzodiazepine receptor agonist may be important components, and contribute to the anticonvulsant property of G. elata.
Dimethylphthalate와 Monoethanolamine의 에스테르 交換反應에 關한 硏究
孫秉淸,鄭舜旭 弘益大學校 1983 弘大論叢 Vol.15 No.2
The transesterification reaction between dimethyphthalate and monoethanolamine was kinetically investigated in the presence of various metal acetate catalyst at 110℃. The reaction was followed by the measurement of distilled methanol from the micro measuring cylinder The transeterification reaction was first-order kinetics with respect to the concentration of dimethylphthalate, monoethanolamine and catalyst. From the examination of relationship between rate constant and reciprocal absolute temperature, the activation energy has been caculated as 9.843 Kcal with cadmium acetate catalyst, 12.30 Kcal without catalyst. The highest reactives were found for electronegativity values between 1.4~1.7.
천마 성분인 4-히드록시-메톡시벤즈알데히드 및 파라-히드록시벤즈알데히드의 흰쥐에서의 약물동태
용철순,권기철,김정애,하정희,이동웅,허근 영남대학교 약품개발연구소 1999 영남대학교 약품개발연구소 연구업적집 Vol.9 No.-
Gastrodia elata (GE) is an oriental medicinal herb which has been used traditionally for the treatment of var-ious brain diseases including convulsion and epilepsy. The purpose of this study was to determine pharmacokinetic param-eters of 4-hydroxy-3-methoxybenzaldehyde (HMBA) and p-hydroxybenzaldehyde (PHBA), constituents of GE, in rats. Male rats were cannulated in the femoral vein, femoral artery, bile duct and ureter. They received a single i.v. bolus dose of either HMBA or PHBA through the femoral vein. The concentration of HMBA or PHBA in plasma, bile and urine sam-ples were analyzed by reversed-phase HPLC. HMBA and PHBA have very short half-lives, i.e. 4.03 and 2.26 minutes respectively. Most of HMBA and PHBA were thought to be eliminated through metabolism as the metabolized fraction approaches unity. Derivatives of HMBA or PHBA with longer biological half-lives should be designed to develop better anticonvulsants and more complete qualitative and quantitative understanding of the overall pharmacokinetic fate of these compounds awaits further investigation.
허근,김진숙,권태협,김정애,용철순,하정희,이동웅 영남대학교 약품개발연구소 1998 영남대학교 약품개발연구소 연구업적집 Vol.8 No.-
Gastrodia elata (GE) is a oriental medicinal herb which has been used traditionally for the treatment of various brain diseases including convulsion and epilepsy. In order to examine the mechanism of anticonvulsive effect, we treated the methanol extract of GE (500 mg/kg, P.O) to the pentylenetetrazole (PTZ)-induced convulsive rats. Methanol extracts of GE siginificantly inhibited (35%) the convulsion state as well as the level of lipid peroxidation (25%) in the brain. The ether fraction of methanol extracts among the others effectively inhibited in vitro lipid peroxidation dose dependently (5.0×10^(-6)~2.0×10^(-5) g/ml). The scavenging effect on hydroxy radicals was found in all the fractions of ether, butanol, and dichloromethane. These results suggest that the anticonvulsive effect of GE is possibly due to the antioxidative effects of the active components in GE.
프레탈^(R)정(실로스타졸 50mg)에 대한 실로졸^(R)정의 생물학적 동등성
최한곤,권기철,이승호,김학미,박병주,유봉규,이종달,이경희,하정희,우종수,박인숙,최진석,용철순 한국병원약사회 2003 병원약사회지 Vol.20 No.1
Bioequivalence of two cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and the Cilozol^(R)(Hanmi Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA, Sixteen normal male volunteers(age 20~29 years old) were divided into two groups and a randomized 22 cross-over study was employed. After two tablets containing 50㎎ of cilostazol were orally administered. blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters. The results showed that the differences in C_(max), T_(max) and AUC_(t) between two tablets were 4.99%, 1.74% and 7.68%, respectively. The powers(1-β) for C_(max), T_(max) and AUC_(t) were83.92%, 80.12% and 85.03%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilozol^(R) tablet is bioequivalent to Pletaal^(R) tablet.
Langmuir-Blodgett법을 위한 (N-docosyl quinolinium)-TCNQ(1:2) 착물의 분산용매 중에서의 안전성
정순옥(Jeoung Soon Wook),이융국(Lee Yoong Kook),손병청(Sohn Byoung Chung) 한국유화학회 1994 한국응용과학기술학회지 Vol.11 No.2
A Stability to spreading solvent, which is acetonitrile, dichloromethane, benzene, chloroform, and acetonitrile-benzene (1 : 1, v/v) of (N-docosyl quinolinium)-TCNQ(1 : 2) complex was investigated by UV-visible spectrometer and was confirmed stabilized on acetonitrile, dichloromethane, and acetonitrile-benzene(1 : 1, v/v) for 7 hours. Using buffer solution(pH≒6.0) as subphase for Langmuir-Blodgett(LB) films, it was achieved successively to fabricate the Y-type LB films of (N-docosyl quinolinium)-TCNQ(1 : 2) complex. For the identification of deposition of (N-docosyl quinolinium)-TCNQ(1 : 2) complex, UV-visible spectra was recorded on HP 8452A spectrometer.