급성 진행형 국소 신경학적 증상을 보인 쯔쯔가무시병 1예에서 고용량 스테로이드의 사용

최현철,위성헌,이소연,김상일,박성경,정연주,정소령,전정수,강문원 대한감염학회 2002 감염 Vol.34 No.6

Functional Group Effects of Chemically Modified Microcrystalline Methyl Cellulose on Polymer Composites

Jeong Jae Wie(위정재) 한국고분자학회 2023 한국고분자학회 학술대회 연구논문 초록집 Vol.48 No.2

Association between blood viscosity in preeclampsia and combined fetal growth restriction

( Jeong Ha Wie ),( Sin Young Kim ),( Hyun Sun Ko ),( In Yang Park ),( Jong Chul Shin ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: This study was done to assess the relationship between blood viscosity in normal pregnancies and those complicated with preeclampsia and FGR. Methods: A case-control study involving 60 women with FGR, and 354 uncomplicated women. The FGR group was further subdivided into normotensive and hypertensive women. The blood sampling obtained just before delivery. We compared the maternal blood viscosity and umbilical cord blood viscosity between the three groups. Results: Age, BMI, and maternal weight were comparable in the groups, while gestational age at delivery as well as fetal outcome parameter were statistically significant unfavourable in patients with hypertensive FGR. The mean of the systolic viscosity in women with hypertensive FGR was significantly greater than those with normotensive FGR and uncomplicated women ( 4.696 (±1.044) mP vs4.220 (±0.704)mP, 4.350(±0.824)mP, respectively, p=0.007). The mean oxygen delivery index in women with hypertensive FGR was significantly lower than other 2 group. (8.309(±1.312) vs 8.537(±1.399) vs 8.779(±1.0438), respectively, p=0.045). Conclusion: Increased blood viscosity may be associated with the hypertensive FGR. However, further validation of these findings with more robust multicenter prospective and longitudinal characterization of blood rheology in pregnancy should be carried out.

Shape-Reconfigurable Electronics and Energy Storage

Jeong Jae Wie(위정재) 한국고분자학회 2022 한국고분자학회 학술대회 연구논문 초록집 Vol.47 No.2

Effect of recombinant human epidermal growth factor against scar formation after Cesarean section : a randomized controlled trial

( Jeong Ha Wie ),( Sin Young Kim ),( Woo Jeng Kim ),( Su Been Hong ),( Ji Young Kwon ),( In Yand Park ),( Ji Hye Jo ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: Recombinant human epidermal growth factor(rhEGF) is a cicatrizant that promote wound healing though formation of scar tissue and is used to treat a diabetic foot ulcer. This study aimed to evaluate the effect of topical rhEGF on hypertrophic scar formation by applying it to Cesarean scar. Methods: We conducted a randomized placebo-controlled trial evaluating the efficacy of the rhEGF on hypertrophic scar formation after Cesarean section. Women who underwent Cesarean section by single obstetrician from Apr 2019 to Dec 2019 were randomized. The degree of hypertrophic scar was compared between the rhEGF application group and placebo group at postpartum 6 and 12 week, respectively. Efficacy was determined by modified Vancouver scar scale(mVSS). Results: 64 women were randomized into two arms, 33 topical rhEGF applied group and 31 placebo group. There was no significant difference by maternal age, BMI, nulliparity, hypertension, diabetes, and multifetal pregnancy. There was no significant difference in mVSS evaluated between the two group at postpartum 6 weeks. At postpartum 12 weeks, the rhEGF applied group had better mVSS than the placebo group, with median of 7.0 (Interquartile range(IQR) 6.0-9.0) versus 6.0(IQR 5.0-7.5), respectively (p=0.013). The difference was statistically significant in pigmentation of the mVSS (p<0.001). Conclusion: Applying topical rhEGF to a cesarean scar seems to have the effect of reducing the pigmentation of the scar. Using topical rhEGF might be useful for improving the cosmetic outcomes of Cesarean scar.

Cerclage for sonographic short cervix in singleton gestations without prior spontaneous preterm birth

( Jeong Ha Wie ),( Ji Sun Lee ),( Ji Young Kwon ),( Hyun Sun Ko ),( In Yang Park ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: The aim of this study was to quantify the efficacy of cervical cerclage in preventing preterm birth (PTB) in singleton pregnancies with a short midtrimester cervical length (CL) on transvaginal sonography (TVS) and without prior spontaneous PTB. Methods: This was a retrospective cohort study of women with singleton pregnancy for midtrimester (16+0~27+6weeks) short cervix with CL <25 mm. Out study consisted of women delivered at Seoul St. Marys and Eunpyeong St. Marys hospital between Jan 2013 and Dec 2019. The decision to perform cerclage was based on individual physician preference. Demographic data; information on CL status; medical, obstetric, and social history; cerclage vs no cerclage; and neonatal outcomes were compared. Primary outcome was PTB <37weeks. Secondary outcome was PTB <34 weeks and prolongation of pregnancy latency . The risk of PTB was separately analyzed by dividing the CL into 10, 15, 20, and 25mm or less, respectively. Results: A total of 213 women with short cervix before 27+6weeks of gestation were identified. Among the women with shortened CL <25 mm, 107 women (50.2%) had cervical cerclage. The mean gestational age at delivery was not significantly different between women who performed cerclage (37.0 weeks) vs. those who did not (36.3 weeks). In women with a CL of less than 20mm, the rate of PTB < 37, 34 weeks were significantly lower in the cerclage group : 36.6% vs 19.2%, 21.4% vs 8.0%, respectively (p=0.038, 0.037). The rate of spontaneous PTB < 37 weeks remained significantly after controlling for confounders (adjusted odds ratio 0.37,95% CI 0.16-0.86) The risk of PTB <37 weeks were significantly lower in the cerclage group in women with a CL less than 15mm (odds ratio(OR) 0.26, 95% CI 0.07-0.93). In women with a short CL less than 15 and 10mm before 25 weeks of gestation, the risk of PTB < 37 weeks were significantly lower in the cerclage group (OR[95% CI] 0.14[0.04-0.52], 0.13[0.02-0.89], respectively). The risk of sPTB were higher in the cerclage group(35.0% vs. 25.0%) in women with CL >20mm. Conclusion: In singleton gestations without prior spontaneous PTB but with CL<25mm before 27+6 weeks of gestation, cerclage does not seem to prevent preterm delivery. However, in these pregnancies, cerclage seems to be efficacious at lower CLs, such as 20mm or less, requiring further studies in these subgroups. Given the low quality of evidence, further welldesigned RCTs are needed to confirm the findings of this study.

Untethered Photo-Fueled Soft Robots by Liquid Crystalline Polymers

Jeong Jae WIE,M. Ravi SHANKAR,Timothy J. WHITE 한국고분자학회 2016 한국고분자학회 학술대회 연구논문 초록집 Vol.41 No.2

≪靈樞·本神≫편을 통해 본 정신 기능의 발생과 층차에 대한 고찰

정창현(Jeong Chang-hyun),위보영(Wie Bo-young),추면(Zou Mian) 대한한의학원전학회 2020 대한한의학원전학회지 Vol.33 No.1

Objectives : We analyzed the descriptions of Doek(德)·Qi(氣)·Saeng(生)·Jeong(精)·Sin(神)·Hon(魂)·Baek(魄)·Sim(心)·Ui(意)·Ji(志)·Sa(思)·Ji(智)·Ryeo(慮)․Ji(智) which are the concepts mentioned in the beginning of the ≪Lingshu·Benshen≫. Methods : We reinterpreted this verse in ≪Lingshu·Benshen≫ from the viewpoint of evolution and development of mental function and considered it in relation to the knowledge of modern psychology and brain science. Results & Conclusions : The reproductive essence of the parents are combined, primitive essence(元精) is created and simultaneously primitive spirit is born. Primitive spirit first differentiates into Hon and Baek. Hon and Baek are instinctive mental functions. Up to this point, because the process is completed before birth, primitive spirit, Hon, and Baek are innate spirit. Ui, Ji, Sa, Ryeo and Ji are the rational thinking abilities as mental functions that develop actively after birth. This is called conscious spirit and acquired spirit. Analyzing the contents of <Benshen>, it can be said that the mental function is divided into four layers of primitive spirit-Baek-Hon-conscious spirit.

Omega-3 fatty acids incorporated colloidal systems for the delivery of <i>Angelica gigas</i> Nakai extract

Lee, Jeong-Jun,Park, Ju-Hwan,Lee, Jae-Young,Jeong, Jae Young,Lee, Song Yi,Yoon, In-Soo,Kang, Wie-Soo,Kim, Dae-Duk,Cho, Hyun-Jong Elsevier 2016 Colloids and Surfaces B Vol.140 No.-

<P><B>Abstract</B></P> <P>Omega-3 (ω-3) fish oil-enriched colloidal systems were developed for the oral delivery of <I>Angelica gigas</I> Nakai (AGN) extract (ext). By constructing a pseudo-ternary phase diagram, the composition of oil-in-water (o/w) microemulsion (ME) systems based on ω-3 (oil), Labrasol (surfactant), and water was determined. AGN ext was dissolved into the ME system and <SMALL>D</SMALL>-α-tocopherol polyethylene glycol 1000 succinate (TPGS) was added to the ME formulation in order to enhance the mucosal absorption of the pharmacologically active ingredients in the AGN ext. The droplet size of AGN-loaded MEs was 205–277nm and their morphology was spherical. The release of major components of AGN, decursin (D) and decursinol angelate (DA), from ME formulations in pH 1.2 and 6.8 buffers was significantly greater (<I>P</I> <0.05) than that from the AGN suspension group. The pharmacokinetic properties of AGN-loaded MEs in rats were evaluated by measuring decursinol (DOH) concentrations in plasma after oral administration. TPGS-included ME (F2) resulted in significantly greater (<I>P</I> <0.05) systemic exposure of DOH than that with ME without TPGS (F1), AGN ext+TPGS, and AGN in suspension. Severe toxicity of F1 and F2 on the intestinal epithelium was not observed by histological staining. The colloidal carriers described herein are promising delivery systems for oral administration of AGN ext.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Colloidal carriers for <I>Angelica gigas</I> Nakai (AGN) ethanol extract were developed. </LI> <LI> Omega-3 (ω-3)/Labrasol/TPGS/water-based oil-in-water microemulsion (ME) was prepared. </LI> <LI> MEs provided the enhanced release of decursin and decursinol angelate. </LI> <LI> Oral bioavailability of decursinol from ME group was higher than suspension group. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

품종별 포도씨의 식물성 스테롤 및 지방산 조성 분석

위민정(Minjung Wie),장성호(Sungho Jang),정미리(Miri Jeong),윤재민(Jaemin Yoon),정헌상(Heon-Sang Jeong),이준수(Junsoo Lee) 한국식품영양과학회 2009 한국식품영양과학회지 Vol.38 No.4

본 연구는 국내에서 재배되고 있는 포도씨 14종에 대한 식물성 스테롤의 함량과 지방산 조성을 분석하였다. 포도씨의 식물성 스테롤의 함량은 그 품종별로 차이가 있었으나 14품종의 포도씨 모두 β-sitosterol(64.9~119.3 ㎎/100 g)의 함량이 가장 높게 나타났다. 지방산 조성의 비율은 palmitic(16:0, 6.8~16.8%), palmitoleic(16:1, 0.1~0.2%), stearic(18:0, 4.7~5.2%), oleic(18:1, 16.6~26.1%), linoleic(18:2, 16.6~20.1%), linolenic acid(18:3, 0.3~0.5%) 및 arachidic acid(20:0, 0.3~0.5%)로 분석되었다. 국내에서 재배되고 있는 포도씨 14종의 식물성 스테롤과 지방산의 조성은 유사하였으나 그 함량에는 차이가 있었다. 14품종의 포도씨 중 국내에서 가장 많이 경작되고 있는 Campbell early는 식물성스테롤의 함량과 지방산 조성에 있어서 비교적 우수한 함량을 보였다. 따라서 Campbell early를 가공함으로써 포도씨유 등과 같은 우수한 품질의 가공품 생산이 가능할 것으로 기대된다. In this study, phytosterol content and fatty acid composition of grape seeds from fourteen different cultivars produced in Korea were determined. Although the total phytosterol contents depended upon the cultivars, the major phytosterol was β-sitosterol (64.9~119.3 ㎎/100 g) in all samples. The fatty acid composition of the grape seeds were analyzed as palmitic (16:0, 6.8~16.8%), palmitoleic (16:1, 0.1~0.2%), stearic (18:0, 4.7~5.2%), oleic (18:1, 16.6~26.1%), linoleic (18:2, 16.6~20.1%), linolenic acid (18:3, 0.3~0.5%) and arachidic acid (20:0, 0.3~0.5%). Campbell early, the mainly produced and consumed cultivar in Korea, contained relatively high phytosterol content compared to other samples and high proportion of unsaturated fatty acids. Therefore, the seeds from Campbell early might be used for functional oil production and as food ingredients.