고려시대 혼인형태에 대한 재검토

이정란 ( Lee Jeong Lan ) 고려대학교 역사연구소 2003 사총 Vol.57 No.-

Polylysine을 입힌 배양면이 GH₃ 뇌하수체 종양 세포에 미치는 영향에 관한 연구

김정진,백상호,황덕호,황영일,이왕재,이병란 대한해부학회 1998 Anatomy & Cell Biology Vol.31 No.3

사람의 비후성 반흔에서 면역조직화학기법에 의한 형질전환인자 알파와 표피성장인자 발현의 차이에 관한 면역조직화학적 연구

박영란,김현곤,김종중,문정석,송준섭,설경수,정윤영 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Background and Objectives: Transforming growth factor-α (TGF-α) and epidermal growth factor (EGF) are polypeptides which interact with the epidermal growth factor receptor (EGFR) to produce their biological effects. The aim of the present investigation was to elucidate the immunolocalization of TGF-α and EGF in normal human skin, hypertrophic scar with skin graft on soft tissue defect, and postburn hypertrophic scar without graft. Methods: The data presented in this paper focused attention on differences of expression between two kinds of hypertrophic scars in relation to skin graft using immunohistochemistry. Formalin-fixed and paraffin-embedded tissues from 3 normal skin tissues, 3 hypertrophic scars after skin graft and 8 postburn hypertrophic scars without graft were immunolabelled with antibodies directed against TGF-α and EGF. Results: In normal epidermis of skin, strong TGF-α immunoreactivity (IR) was observed in all epidermal layers except the stratum (S.) basale, whereas EGF was immunopositive in a few cells over all epidermal layers. The staining for TGF-α was found in cell membrane, and EGF was seen either diffuse cytoplasmic or peripheral part of cells in normal epidermis. In hypertrophic scar after six months postoperation, TGF-α IR was observed in the upper part of S. spinosum and S. corneum, whereas EGF was diffusely expressed in the S. spinosum, also its intensity was slightly increased compared to normal skin. In hypertrophic scar without skin graft, very strong expression of EGF was detected in the S. spinosum and S. corneum, and intensity of EGF was increased when compared to normal skin and postoperative hypertrophic scar. EGF and TGF-α coexisted in the cells of S. spinosum in normal skin as well as hypertrophic scars. Double-labeled cells were increased in postburn hypertrophic scar compared to normal skin and postoperative hypertrophic scar. In addition, intensity of EGF and TGF-α double IR was the strongest in postburn hypertrophic scar. Conclusion: These results indicate that EGF may have a more complex regulatory role not only in the early stages of wound healing but also in hypertrophic scar.

흰쥐 시상에서 Epidermal growth factor receptor면역반응 신경세포의 생후 발달에 관한 연구

박영란,정윤영,김종중,문정석,오재욱,정영욱,김주수 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Background and Objectives : Epidermal growth factor receptor (EGFR), a 170-kDa transmembrane glycoprotein, appears to mediate epidermal growth factor (EGF) activity. Transforming growth factor-α and EGF produce their biological effects in numerous systems by stimulating the EGFR In this study, we examine the postnatal development of EGFR immunoreactivity in the different regions of the thalamus of the rat Materials and Methods : The present study is based on 28 postnatal cases of rat thalamus ranging from the day of birth, postnatal day 0 (P0) to 30 days (P3, P5, P10, P15, P20, P30), and these cases were compared with adult rat thalamus. Cryostat sections were processed free-floating with monoclonal antibody by immunohistochemistry Results : EGFR immunoreactivity in the thalamus of the rat showed very different patterns according to postnatal ages and thalamic areas. EGFR-immunoreactive cells appeared in the first two postnatal weeks, except the ventral posterior thalamic nuclei. In the early postnatal days, EGFR-immunoreactive cells appeared thalamic midline structures, increased progressively in the first two postnatal weeks, and followed mediolateral gradient. The mature patterns of EGFR-immunoreactive cells were achieved at P20 Conclusion : These data indicate that the maturation of EGFR-immunoreactive cells requires a relatively prolonged period of time to achieve an adult configuration. Many growth factors probably play protective or neurotrophic roles at EGFR-immunoreactive neurons of thalamus both young and adult rats In addition to difference in time of appearance in thalamic nuclei and developing pattern with mediolateral gradient suggest that EGFR-immunoreactivities are correlated with the appearance of the related functional.

리튬 연관성 무증상 갑상선 기능저하증에 대한 연구

김정란,이선우 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.2

Lithium is a mainstay in the treatment of bipolar disorder. It is well-known to suppress thyroid function varying from overt hypothyroidism to subclinical, or asymptomatic hypothyroidism. While lithium-induced overt hypothyroidism has been well studied. subclinical hypothyroidism is less well understood. Thus, this paper has two aims : (1) to evaluate the effect of lithium and clinical features in patients with bipolar I disorder who are taking lithium maintenance therapy and (2) to review subclinical hypothyroidism. We included 2% patients(men : 9, women : 13). who met criteria for bipolar I disorder in DMS-Ⅳ and are taking lithium as mood stabilizer. Five with subclinical hypothyroidism were identified after examination of T3. T1. and TSH(thyroid stimulating hormone). However. we did not find any difference in clinical variables. such as age. sex. subtype of bipolar disorder. or exposure duration of lithium. between patients with subclinical hypothyroidism and patients with euthyroid. we suggest that lithium-induced subclinical hypothyroidism can be underdiagnosed in practice in spite of interfering the treatment of bipolar disorder. Further systematic and well-designed studies are needed in the future.

중원지역의 설화를 동화화하기 위한 연구 및 개발

김정란,유소영,박혜숙,박용식 건국대학교 중원인문연구소 1999 중원인문논총 Vol.19 No.-

This study describes the research and development of fairy tales from the folk tales in Joung-Won area. The need for this problem was assessed through the special training course of fairy tale writing sponsored by Cho-Bang. The first step was the study of the suitable definition and types of fairy tales. Assuming that the problem in defining the field of folk tales is the lack of common agreement in the labels, definitions and standard classification models of folk tales, literature related to these areas were reviewed. The application of this research and development will be the fairy tale writing. The next step was therefore to select the folk tales suitables to the fairy tale writing and to explore the Joong-Won area related to these stories. By this study we found that Joon-Won area's folk tales have few supernatural, fantastic elements which are the common characteristics of fairy tales. Considering the lack of these characteristics, we selected and wrote the story of "General Shin Lip", "the funny stories", "the story of the Castle Mago"(from the Nam mountain folk tales), "princess Ari and prince Koko"(from the folk tales of Kye-Myung mountain), etc... We found the development of the fairy tales a meaningful and rewarding work and experience. Our purpose to gain the basic knowledge in the development of this field has been met. But these fairy tales need to be visualized to be published. We should prepare for the implementation of practical application of this study and development: contact with a higher administrator in Joong Won area, discussion on the support possibility, visual production, addition of necessary materials, etc... Only the surface has been touched in this study. But the authors hope that in the near future, we will be able to create the new cultural work needed in the Joon-Won area.

한국판 신체변형장애 척도개발을 위한 예비연구

김정란,지익성,신석철 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

연구목적 : 본 연구의 목적은 신체변형장애의 진단 및 심한 정도를 평가하는 자기 보고형 검사인 한국판 신체변형 장애 척도(BDDE-SR)를 개발하고 한국 청소년내의 신체 불만족에 대한 자료를 얻고자 하는데 있었다. 방 법 : 한국판 BDDE-SR을 대전 시내 남녀 고등학생 417명을 대상으로 설문을 하였고. 이 중 100명을 선정하여 6주 간격후 재검사를 하였다. 결 과 : 1) 전체 점수에 대한 검사-재검사 신뢰도(Pearson 상관계수)는 0.883(p〈0.001)으로 만족할 만한 신뢰도를 보였으며, 각 문항에 대한 검사-재검사 신뢰도는 통계적으로 유의하였다(Spearman 상광계수 범위:0.159∼0.761). 2) 내적 일치도는 Cronbach's α0.922(p〈0.01)로 높은 신뢰도를 보였다. 3) Varimax 회전에 의한 요인 분석의 결과, 5개의 요인을 추출하였는데, 제1요인은 고통과 당황인자, 제2요인은 자기 의식 및 부정적 평가 인자, 제3요인은 회피인자, 제4요인은 가리기 인자, 그리고 제5요인은 비교 인자였다. 4) 한국 청소년의 신체 불판족에 대한 자료에서, 전체 점수는 여학생 집단에서 52.4±24.8로 남학생집단의 37.7±20.6보다 유의하게 높았다. 남녀 고등학생을 합하여 가장 만족하지 못하는 신체부위는 허리-배(6.8%), 코(6.4%), 다리전체(6.0%), 치아와 눈(각각 5.9%) 순이었다. 결 론 : 이 결과들은 한국판 BDDE-SR이 신체변형장애의 평가를 위한 신뢰할 만한 도구임을 입증하는 것이며, 향후의 연구들에서 신체변형장애 환자군을 대상으로한 임상 자료를 얻고 한국판 BDDE-SR의 타당도 검증이 시행되어야 할 것으로 생각된다. Objective : The purposes of this study were to develop a Korean version of the Body Dysmorphic Disorder Examination-Self Report(BDDE-SR) and to get informations about the body dissatisfaction of the Korean adolescents. Method : A Korean version of the BDDE-SR was applied to 417 Korean high school adolescents. Retest was conducted with 6-week interval in 100 adolescents. Results : 1) Test-retest reliability of the total scores(Pearson's correlation coeffciency) was 0.883(p〈0.001) and test-retest reliabilities of each item also showed high correlation (Spearman's correlation coefficency range : 0.159-0.761). 2) Internal consistency by Cronbach's alpha of 0.922(p〈0.001) was very much high. 3) Five factors were extracted by factor analysis with the Varimax rotation. They were 'the distressing and embarrassment factor','the self-consciousness and negative self-evaluation factor','the avoidance factor','the camouflage factor', and'the comparison factor'. 4) The total score of BDDE-SR of girls was statistically higher(52.4±24.8) than that of boys(37.7±20.6). The most dissatisfied body part was abdomen (6.8%), nose (6.4%), entire leg (6.0%), teeth (5.9%) and eyes (5.9%) in all the subjects. Conclusion : These results indicate that a Korean version of the BDDE-SR is a reliable instrument for the assessment of Body Dysmorphic Disorder (BDD). The authors suggest that future researches should be directed to obtaining clinical of the patients with BDD and should test the validity of a Korean version of the BDDE-SR.

불어 알파벳 연구(1) : 알파벳 기원과 형태의 변천

金貞蘭 건국대학교 중원인문연구소 1998 중원인문논총 Vol.18 No.-

L'ecriture constitue l'invention la plus importante faite par l'homme. Avec elle, on passe de la prehistoire a l'histoire. Mais depuis que le rejet du systeme graphique hors de la langue a ete radicalise par les courants dominant du structuralisme, les etudes sur l'ecriture etait considerees comme celle d'un travestissement de la langue. Peu d'etudes sont donc faites sur l'ecriture. Le but de notre etude est de nous occuper de savoir quand sont nees et d'ou viennent les lettres d'alphabet du francais. Par la recherche historique nous avons trouve que les lettres ont nee de l'image. Ainsi la premiere consonne de l'alphabet phenicien est-elle notee par un dessin qui represente une tete de boeuf. Le premier peuple a ecrire fut le peuple sumerien qui vivait en Irak 4,000 ans avant Jesus-Christ. Le premier vertable alphabet, lettres mises ensemble pour fabriquer des mots, apparut en Syrie, 1300 ans avant Jesus-Christ. Ainsi nous avons vu que le passage de l'alphabet des Pheniciens au Grecs et puis aux Latins. Au VIIIe siecle avant Jesus-Christ, les grecs sont emprunte aux Phenicien et de l'alphagrec, ils ont adapte lessignes a leur systeme lingustique. Or les Grecs parlaient une langue indo-europeenne dans laquelle les voyelles jouaient un role important. Et les Pheniciens u'utilsaient que dees consonnes. Les Grecs ont donc detourne de leur voyelles. Par exemple, l'alpha qui a note le [a] et qui le note encore dans le francais: le <a> est donc une vieille tete de boeuf phenicienne. Cette sorte adaptation et ce detoumement semblent possibles lorsque le peuple qui emprunte l'alphabet ne connit pas precedemmment l'ecriture. Par contre, lorsqu'une langue n'ajamais ete ecrite, et qu'elle se trouve sous l'influence d'une langue ecrite prestigieuse, il est sans doute difficile de modifier l'alphabet prestigieux pour l'adapter a la transcription de cet idiome sans lustre. C'est ce qui s;est prodit pour la langue francsaise et l'alphabet latin(C'est la raison que, sauf quelques lettres et usages nouveaux, proprement francais(le j, le v, les accents et signes auxilaires, etc.), les Francais n'ont jamais cree les signes qui leur auraient ete absolument necessaires pour transcrire avec exactitude les sons de leur langue). Les Latins ont emprunte l'alphabet grec. Au temps de l'Empire romain, l'alphabet comptait 21 lettres. J, U, W, Y, et Z furent ajoutes ensuite. Cet alphabet resta en vigueur tres lontemps. Au moyen Age, le latin etait la langue des erudits et de l'Eglise. L'alphabet utilise aujourd'hui en France est donc inspire de l'alphabet latin.

설화의 동화화에 대한 연구(1) : 뻬로의 「빨강 모자 Le petit Chaperon rouge」 Le petit Chaperon rouge de Charles Perrault

김정란 건국대학교 중원인문연구소 2001 동화와 번역 Vol.1 No.-

Perrault a transforme les recits populaires qui l'ont inspire, et ses adaptations ont eu du succes. L'objet de notre etude est de repondre aux questions d'ou vient ls succes de ses adaptations. Qulle est la difference entre les recits de Perrault et ceux de la tradition orale? Pour realiser notre objectif, nous avons utilise la grammaire transformationnelle et generative. Pour les transformationnalistes, la grammaire est un ensemble restreint de regles qui rendent compte de l'engendrement d'un ensemble infini de phrases, obtenues par transformation a partir d'un ensemble restreint de phrases abstraites simples. De la meme maniere les contes merveilleux ont aussi besoin d'une theorie qui peut render compte de l'engendrement d'un ensemble infini a partir d'un ensemble fine de regles. En examinant d'abord la theorie fondamentale de Chomsky, nous avons trouve les 6 rehles suivantes: l'addition, le deplacement, le changement des formes, la repetition, et les conditions restreintes. Nous avons d'abord obseve que les contes de Perrault ne sont pas la notation simple des recits populaires comme il reclame lui-meme, mais que c'est une sorte de la creation de quelqu'un qui a une vision et des aspirations pour le future. L'additon du titre "Le petit Chaperon rouge" par exemple, qui est absent dans les recits populaires, est une creation significative de perrault qui eclaire bien le theme du conte, l'avertissement. La suppression jouait aussi un role important. Dans les contes populaires, la fillette s'echappe et rentre chez elle saine et sauve, mais dan "Le petit Chaperon rouge", le recit s'arrete au moment ou la fillette est avalee par le loup. Perrault a aussi supprime le motif du repas cannibale de la fillette, la scene du deshabillage progressif, et la question du loup a l'enfant sur le chemin qu'elle va prendre: celui des aiguilles ou celui des epingles, etc.. Ces suppressions sont en general consideerees dome une incomprehension de la vie rurale chez l'auteur. Mais nous avons trouve que ces suppressions ont aussi une relation avec le theme de l'avertissement. Les contes ne sont pas pouratnt qu'un ensemble de regles. C'est une oeuvre litteraire qui cherche a toucher le Coeur de l'homme. La simplicite naive du style de Perrault, comme l'utilisation de la narration orale, des archaisms et des repetitions, etc. est la marque d'un talent et d'une esthetique tres reflechis qui n'est pas donnee a tout le monde. Le succes des adaptations des recits populaires est donc venu de l'effort de Perrault lui-meme, ecrivain et chancelier de l'Academie Francaise. Son adaptation etait la creation de quelqu'n qui avait une vision et des aspirations pour le future de la literature et de son pays.

國際情勢分析 : 體系理論의 適用을 中心으로 With Application of Systems Theory

趙貞蘭 숙명여자대학교 대학원원우회 1983 원우논총 Vol.1 No.-

Ⅰ. Introduction International political phenomena are made up of the interactions among the nations in the aim of their national interests. International political phenomena can be understood as a system based upon a system theory. We'll analyze the international political systems by decades up to now since World War. Ⅱ. Ⅱ. Theoretical Framework International situation is characterized by the dominant trends of the period. Especially, it is determined by the following four variables. 1) political variable : The changes of political domain and numbers of political actors. 2) economic variable : The changes of economic order 3) military variable : The degree of military equilibrium and the adven of new weapons 4) ideological variable: The firmness of ideology These four independent variables result in the dependent variable, the international political systems. In short, the international political system is characterized to the extent which variables of the four have more strong influence. Ⅲ. Transformations of International Political Systems 1. International political system of 1950's : Cold War System 2. International political system of 1960's : Collapsed Cold War System 3. International political system of 1970's : Detente System 4. International political system of 1980's : De-Detente System Ⅳ. Conclusion International situation is influenced by the political, economic, military and ideological milieu that the international political systems have. For this reason international political system has been transformed and will be transformed continuously.