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The Superiority of Jensen-Suh's Equation to Cruickshank's One for the Anisotropic Thermal Factor
Choo, Geum-Hong,Kim, Moon-Jib,Lee, Jin-Ho,Jensen, William P.,Suh, Il-Hwan 충남대학교 기초과학연구소 2000 忠南科學硏究誌 Vol.27 No.1
Jensen-Suh's equation for the atomic anisotropic thermal factor Exp[-2π^(2)(h^(2)(u_(x)^(2)/α^(2))+k^(2)(u_(y)^(2)/b^(2))+l^(2)(u_(z)^(2)/c^(2)) 2hk(u_(x)/a)(u_(y)/b)+2lk(u_(z)/c)(u_(x)/a)] and Cruckshank's one exp[-2π^(2)(U_(11)h^(2)a^(*2)+U_(22)k^(2)b^(*2)+U_(33)k^(l)c^(*2)+2U_(12)hka^(*)b^(*)+2U_(23)klb^(*)c^(*)+2U_(31)lhc^(*)b^(*)] are found to be identical provided U_(11)=u_(x)^(2) sin^(2)β^(*)sin^(2)γ, U_(22)=u_(y)^(2) sin^(2)γ^(*)sin^(2)α, U_(33)=u_(z)^(2) sin^(2)α^(*)sin^(2)β, U_(12)=u_(x)u-(y)sinαsinβsin^(2)γ^(*), U_(23)=u_(y)u-(z)sinβsinγsin^(2)α^(*), U_(31)=u_(z)u-(x)sin γ sinαsin^(2)β^(*), and it is much easier to derive and understand Jensen-Suh's equation rather than Cruickshank's one.
North-Holland Pub. Co ; Elsevier Science Ltd 2010 Discrete mathematics Vol.310 No.21
This paper discusses an attempt at identifying a property of circuits in (nonplanar) graphs resembling the separation property of circuits in planar graphs derived from the Jordan Curve Theorem. If G is a graph and C is a circuit in G, we say that two circuits in G form a split of C if the symmetric difference of their edges sets is equal to the edge set of C, and if they are separated in G by the intersection of their vertex sets. Garcia Moreno and Jensen, A note on semiextensions of stable circuits, Discrete Math. 309 (2009) 4952-4954, asked whether such a split exists for any circuit C whenever G is 3-connected. We observe that if true, this implies a strong form of a version of the Cycle Double-Cover Conjecture suggested in the Ph.D. thesis of Luis Goddyn. The main result of the paper shows that the property holds for Hamilton circuits in cubic graphs.
Jensen, Helene H.,Login, Fré,dé,ric H.,Park, Ji-Young,Kwon, Tae-Hwan,Nejsum, Lene N. Elsevier 2017 Biochemical and biophysical research communication Vol. No.
<P><B>Abstract</B></P> <P>Aberrant levels of aquaporin-5 (AQP5) expression have been observed in several types of cancer, including breast cancer, where AQP5 overexpression is associated with metastasis and poor prognosis. In cultured cancer cells, AQP5 facilitates cell migration and activates Ras signaling. Both increased cell migration and Ras activation are associated with cancer metastasis, but so far it is unknown if AQP5 also affects these processes <I>in vivo</I>. Therefore, we investigated if high AQP5 expression in breast cancer tissue correlated with increased activation of Ras and of Rac1, which is a GTPase also involved in cell migration. This was accomplished by immunohistochemical analysis of invasive ductal carcinoma of breast tissue sections from human patients, followed by qualitative and quantitative correlation analysis between AQP5 and activated Ras and Rac1. Immunohistochemistry revealed that activation of Ras and Rac1 was positively correlated. There was, however, no correlation between high AQP5 expression and activation of Ras, whereas a nonsignificant, but positive, tendency between the levels of AQP5 and activated Rac1 levels was observed. In summary, this is the first report that correlates AQP5 expression levels to downstream signaling partners in breast cancer tissue sections. The results suggest Rac1 as a potential downstream signaling partner of AQP5 <I>in vivo</I>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Subcellular AQP5 localization is altered in human breast cancer. </LI> <LI> Correlation analysis of GTPase activation and AQP5 in human breast cancer. </LI> <LI> Positive tendency for correlation between Rac-GTP and AQP5 in human breast cancer. </LI> <LI> Ras-GTP and Rac1-GTP positively correlated in human breast cancer. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Disruption of Established Bacterial and Fungal Biofilms by a Blend of Enzymes and Botanical Extracts
Jensen Gitte S.,Cruickshank Dina,Hamilton Debby E. 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.6
Microbial biofilms are resilient, immune-evasive, often antibiotic-resistant health challenges, and increasingly the target for research into novel therapeutic strategies. We evaluated the effects of a nutraceutical enzyme and botanical blend (NEBB) on established biofilm. Five microbial strains with known implications in chronic human illnesses were tested: Candida albicans, Staphylococcus aureus, Staphylococcus simulans (coagulase-negative, penicillin-resistant), Borrelia burgdorferi, and Pseudomonas aeruginosa. The strains were allowed to form biofilm in vitro. Biofilm cultures were treated with NEBB containing enzymes targeted at lipids, proteins, and sugars, also containing the mucolytic compound N-acetyl cysteine, along with antimicrobial extracts from cranberry, berberine, rosemary, and peppermint. The post-treatment biofilm mass was evaluated by crystal-violet staining, and metabolic activity was measured using the MTT assay. Average biofilm mass and metabolic activity for NEBB-treated biofilms were compared to the average of untreated control cultures. Treatment of established biofilm with NEBB resulted in biofilm-disruption, involving significant reductions in biofilm mass and metabolic activity for Candida and both Staphylococcus species. For B. burgdorferi, we observed reduced biofilm mass, but the remaining residual biofilm showed a mild increase in metabolic activity, suggesting a shift from metabolically quiescent, treatment-resistant persister forms of B. burgdorferi to a more active form, potentially more recognizable by the host immune system. For P. aeruginosa, low doses of NEBB significantly reduced biofilm mass and metabolic activity while higher doses of NEBB increased biofilm mass and metabolic activity. The results suggest that targeted nutraceutical support may help disrupt biofilm communities, offering new facets for integrative combinational treatment strategies.
Translating Integer Factoring into Graph Coloring
Jensen, Tommy Rene Department of Mathematics 2016 Kyungpook mathematical journal Vol.56 No.2
This paper gives for every positive integer n an explicit construction of a graph G with fewer than $15{\log}^2n-{\frac{5}{2}}{\log}n+28$ vertices, such that there exists a nontrivial factoring of n if and only if G is 3-colorable.
The role of aquaporin-5 in cancer cell migration: A potential active participant
Jensen, H.H.,Login, F.H.,Koffman, J.S.,Kwon, T.H.,Nejsum, L.N. Pergamon 2016 The international journal of biochemistry & cell b Vol.79 No.-
Emerging data identifies the water channel aquaporin-5 as a major player in multiple cancers. Over-expression of aquaporin-5 has been associated with increased metastasis and poor prognosis, suggesting that aquaporin-5 may enhance cancer cell migration. This review aims to highlight the current knowledge and hypothesis regarding downstream signaling partners of aquaporin-5 in relation to cancer cell migration. The molecular mechanisms that link aquaporin-5 to cell migration are not completely understood. Aquaporin-5 may promote cell movement by increasing water uptake into the front of the cell allowing local swelling. Aquaporin-5 may also activate extracellular-regulated kinases, increasing proliferation and potentially stimulating the migration machinery. Thus, further studies are warranted to identify the underlying mechanisms and signaling pathways. This will reveal whether aquaporin-5 and downstream effectors could be targets for developing new cancer therapeutics.
The Phase Problem In X-Ray Crystallography
Jensen, William P.,Suh, Il-Hwan 충남대학교 기초과학연구소 1995 忠南科學硏究誌 Vol.22 No.1
In the past half-century the phase problem in x-ray crystallography has received much attention. Many methods have been developed to overcome this problem. These methods include the heavy atom method, isomorphous replacement and anomalous dispersion techniques, and direct methods. Direct methods have played a significant role in the determination of many important "small molecule" structures and will possibly play a significant role in helping to solve "large molecule" structures in the near future.
Jensen, Joseph B.,Blakeslee, John P.,Gibson, Zachary,Lee, Hyun-chul,Cantiello, Michele,Raimondo, Gabriella,Boyer, Nathan,Cho, Hyejeon IOP Publishing 2015 The Astrophysical journal Vol.808 No.1
<P>We present new calibrations of the near-infrared (near-IR) surface brightness fluctuation (SBF) distance method for the F110W (J(110)) and F160W (H-160) bandpasses of the Wide Field Camera 3 Infrared Channel (WFC3/IR) on the Hubble Space Telescope. The calibrations are based on data for 16 early-type galaxies in the Virgo and Fornax clusters observed with WFC3/IR and are provided as functions of both the optical (g(475)-z(850)) and near-infrared (J(110)-H-160) colors. The scatter about the linear calibration relations for the luminous red galaxies in the sample is approximately 0.10 mag, corresponding to a statistical error of 5% in distance. Our results imply that the distance to any suitably bright elliptical galaxy can be measured with this precision out to about 80 Mpc in a single-orbit observation with WFC3/IR, making this a remarkably powerful instrument for extragalactic distances. The calibration sample also includes much bluer and lower-luminosity galaxies than previously used for IR SBF studies, revealing interesting population differences that cause the calibration scatter to increase for dwarf galaxies. Comparisons with single-burst population models show that as expected, the redder early-type galaxies contain old, metal-rich populations, while the bluer dwarf ellipticals contain a wider range of ages and lower metallicities than their more massive counterparts. Radial SBF gradients reveal that IR color gradients are largely an age effect; the bluer dwarfs typically have their youngest populations near their centers, while the redder giant ellipticals show only weak trends and in the opposite sense. Because of the population variations among bluer galaxies, distance measurements in the near-IR are best limited to red early-type galaxies. We conclude with some practical guidelines for using WFC3/IR to measure reliable SBF distances.</P>