Contagions and Ways of Seeing

Chung-jen Chen(Chung-jen Chen) 19세기영어권문학회 2011 19세기 영어권 문학 Vol.15 No.2

It is generally agreed that the great discovery of bacteria and a series of related breakthroughs around the mid nineteenth century onward forced a transformation in medical discourse. Doctors and medical scientists decisively transformed the nature of medical examination and human perception. Through microscopic lenses, human eyes saw what was once invisible; through policy making, human hands explored the previously unreachable. In order to highlight uncleanness as a health threat, sources of contamination and transmission were presented in forms perceivable to the observer. This newly constructed narrative of contagion was transnational and transcontinental in its essence as the dominant figure in the formation of such medical breakthroughs came from Louis Pasteur, the French biologist and chemist. In light of Pasteur’s germ theory, this paper attempts to read slum narratives of Charles Booth and examine the formation of how a Pasteurian way of seeing the invisible contagions turned to a set of moralistic criteria in investigating potentially infectious individuals. Just as the visualization of bacterial invasion consolidates boundaries between health and disease, sanitation and filth, morality and immorality, country and the city, domestic and native, disease transmission was endowed with a penetrating moralist vision in which what is foreign and filthy are regarded as intimidating to the health and integrity of the race.

A 138.24-MHz Continuous-Time Band-Pass Sigma Delta Modulator for Digital IF Application

Jen-Shiun Chiang,Ming-Hung Tu,Hsin-Liang Chen,Yu-Chen Sung 대한전자공학회 2005 ITC-CSCC :International Technical Conference on Ci Vol.2005 No.3

Probability Density Function for the Critical Current Asymmetry of a HTS dc SQUID

Jen-Tzong Jeng,C. H. Wu,H. C. Yang,H. E. Horng,J. C. Chen,K. H. Huang,K. L. Chen,S. H. Liao,Y. C. Lin 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.5I

A dc SQUID consisting of grain boundary Josephson junctions may often be asymmetric owing to the large critical-current spread. In this work, the probability density function (PDF) for the critical-current asymmetry of high-transition-temperature-superconductor (HTS) dc SQUID was investigated. To model the critical-current spread in the grain boundaries, we assumed that the barrier thickness of the Josephson junction fluctuated according to a log-Weibull distribution. The resultant PDF for the critical-current spread that fits the histogram data of critical currents reported in literature was the gamma distribution. With the proposed distribution function, the corresponding PDF for the critical-current asymmetry parameter of a HTS dc SQUID was derived and compared with the experimental result. The proposed gamma distribution function is useful in modeling devices, such as the SQUID array and the superconducting quantum interference grating, consisting of many grain-boundary Josephson junctions.

A phase I/II and pharmacogenomic study of pemetrexed and cisplatin in patients with unresectable, advanced gastric carcinoma

Chen, Jen-Shi,Chao, Yee,Bang, Yung-Jue,Roca, Enrique,Chung, Hyun C.,Palazzo, Felipe,Kim, Yeul H.,Myrand, Scott P.,Mullaney, Brian P.,Shen, Li J.,Linn, Carlos Lippincott Williams Wilkins, Inc. 2010 ANTICANCER DRUGS Vol.21 No.8

This phase I/II study was conducted to determine the maximum recommended dose of pemetrexed when given in combination with a fixed dose of cisplatin, and the efficacy, toxicity and association of 5,10-methylenetetrahydrofolate reductase (MTHFR) variants with this pemetrexed--cisplatin combination, in patients with unresectable, advanced gastric carcinoma. Patients 18–70 years of age, with stage IV disease or post-surgery recurrence, no earlier palliative chemotherapy, 0 or 1 Eastern Cooperative Oncology Group performance status, were included. The cisplatin dose was 75 mg/m. In phase I, the initial dose of pemetrexed was 600 mg/m, escalated in 100 mg/m increments. In phase II, efficacy, including overall response rate, overall survival, as well as toxicity and MTHFR pharmacogenetics were investigated. Phase I enrolled 16 patients; 700 mg/m was defined as pemetrexed recommended dose. Thirteen serious adverse events were reported; the most common grade 3/4 toxicities were haematologic (10 of 13, 76.9%). Phase II enrolled 73 patients, 69 qualified for safety and 68 for efficacy analysis; 65 for pharmacogenomic analysis. Overall response rate was 23.5% (14.1%, 35.4%), disease control rate 55.9%, median overall survival 11.8 months (95% confidence interval, 7.2–18.5 months), progression-free survival 4.9 months (95% confidence interval, 2.8–7.1 months), and median response duration 5.4 months. Patients with MTHFR A1298C variants had median overall survival of 6.6 months, significantly shorter than patients with the wild type (median 18.5 months, P=0.001). The pemetrexed--cisplatin combination in patients with advanced gastric cancer generates modest efficacy and a manageable toxicity profile. The reduced overall survival in patients with MTHFR A1298C polymorphism variants deserves further investigation.

COMMITMENT TO EXCELLENCE : NUCLEAR PERSPECTIVE IN REPUBLIC OF CHINA

CHEN JEN-HWA Korea Atomic Industry Forum 1986 원자력산업 Vol.6 No.5

Ultraviolet-assisted synthesis of encapsulating adhesives and their application for lifetime improvement of organic light emitting diodes

Chen-Ming Chen,Ming-Hua Chung,Tsung-Eong Hsieh,Bohr-Ran Huang,Huai-En Hsieh,Fuh-Shyang Juang,Yu-Sheng Tsai,Mark O. Liu,Jen-Lien Lin 한국물리학회 2009 Current Applied Physics Vol.9 No.4

The lifetimes of organic light emitting diodes (OLEDs) have been successfully enhanced with the modulation of LiF thickness and the utilization of encapsulating adhesives, which have been successfully and quickly synthesized with UV irradiation. Experimental results demonstrate that LiF and lab-made encapsulating adhesives can block the invasion of moisture as well as oxygen in the atmosphere into the OLEDs so that the lifetimes of devices with their encapsulation are 18-folds longer than those without encapsulation. The lifetimes of organic light emitting diodes (OLEDs) have been successfully enhanced with the modulation of LiF thickness and the utilization of encapsulating adhesives, which have been successfully and quickly synthesized with UV irradiation. Experimental results demonstrate that LiF and lab-made encapsulating adhesives can block the invasion of moisture as well as oxygen in the atmosphere into the OLEDs so that the lifetimes of devices with their encapsulation are 18-folds longer than those without encapsulation.

Screening, Purification, and Characterization of an Extracellular Prolyl Oligopeptidase from Coprinopsis clastophylla

Jen-Tao Chen,Mei-Li Chao,Chiou-Yen Wen,Wen-Shen Chu 한국미생물학회 2012 The journal of microbiology Vol.50 No.4

Culture filtrates of 22 mushrooms were screened for extracellular prolyl oligopeptidase activity. Four strains with relatively high enzyme activity were all from inky cap mushrooms. The production of Coprinopsis clastophylla prolyl oligopeptidase was associated with the growth of the fungus and the enzyme was not released by cell lysis. The enzyme was purified 285-fold to a specific activity of 52.05 U/mg. It was purified to a single band on a native polyacrylamide gel. However, the enzyme separated into three bands on a sodium dodecyl sulfate-polyacrylamide gel with mobility corresponding to molecular weights of approximately 84,60, and 26 kDa. The results of tandem mass spectrometric analysis revealed that the 60 kDa protein was likely a degradation product of the 84 kDa protein. The isoelectric point of the purified enzyme was 5.2. The purified enzyme had an optimal pH and temperature of 8.0 and 37°C, respectively. Diisopropyl fluorophosphate (DFP), p-chloromercuribenzoaic acid (PCMB), Hg2+, and Cu2+ strongly inhibited C. clastophylla prolyl oligopeptidase. This enzyme is a serine peptidase and one or more cysteine residues of the enzyme are close to the active site.

“The Best Thing America Gave Me” : Creative Nostalgia and Identity Politics in A Good Fall

Chen, Chung-jen 21세기영어영문학회 2013 21세기영어영문학회 학술대회 Vol.2013 No.09

Ha Jin’s A Good Fall is a collection of short stories about lives of Chinese immigrants clustered in Flushing, the second largest Chinatown in New York. This book features a cast of Chinese immigrants with diverse socioeconomic backgrounds. Each story presents a unique way of developing lives in a new society and of formulating a new identity. Their diasporic experience is constructed through their varied attempts to seek a new identity. Meanwhile, their bonds with the motherland in the host country are displaced, unsettled, and repositioned. Stories of immigrants lead easily to questions of what to keep, what to adopt and what to discard. If reflection comes with sentimental attachment or emotional associations, this kind of memory is usually called nostalgia. And as nostalgia touches on politicized, historicized, and nationalized concerns, it provides an opportunity to examine the contested and heterogeneous makings of diaspora, as well as its historical experience, and hopefully, it offers a perspective of who they are now and who they are becoming. Nostalgia of this sort is effective, giving rise to agency with self-awareness and self-determination when facing questions of cultural assimilation. Nostalgia may also initiate a constructive process of consolidating identity in diaspora. Nostalgia can be creative in establishing, realizing, or consolidating a diasporic identity; this I call creative nostalgia. This article explores the complicated fabrication of a shared memory among Chinese immigrants in the microcosm of Flushing. I argue that A Good Fall is about a sort of creative nostalgia, where the old life clashes with new routines, and shared memory is recollected in terms of all that has been lost and gained. This paper also examines the shaping of new identity, as memory of the homeland is resurrected culturally through interactions with the living reality of a new world. The common practice of memory sustains a bond to the past in the form of creative nostalgia, while it helps to transform the process of cultural integration into a blend of unsettled new identities.

Optimal Lot-sizing and Pricing with Markdown for a Newsvendor Problem

Chen, Jen-Ming,Chen, Yi-Shen,Chien, Mei-Chen Korean Institute of Industrial Engineers 2008 Industrial Engineeering & Management Systems Vol.7 No.3

This paper deals with the joint decisions on pricing and ordering for a monopolistic retailer who sells perishable goods with a fixed lifetime or demand period. The newsvendor-typed problem is formulated as a two-period inventory system where the first period represents the inventory of fresh or new-arrival items and the second period represents the inventory of items that are older but still usable. Demand may be for either fresh items or for somewhat older items that exhibit physical decay or deterioration. The retailer is allowed to adjust the selling price of the deteriorated items in the second period, which stimulates demand and reduces excess season-end or stale inventory. This paper develops a stochastic dynamic programming model that solves the problem of preseason decisions on ordering-pricing and a within-season decision on markdown pricing. We also develop a fixed-price model as a benchmark against the dual-price dynamic model. To illustrate the effect of the dual-price policy on expected profit, we conduct a comparative study between the two models. Extension to a generalized multi-period model is also discussed.

Seismic behavior of structures isolated with a hybrid system of rubber bearings

Chen, Bo-Jen,Tsai, C.S.,Chung, L.L.,Chiang, Tsu-Cheng Techno-Press 2006 Structural Engineering and Mechanics, An Int'l Jou Vol.22 No.6

The enlargement of interest in base isolators as an earthquake-proof design strategy has dramatically accelerated experimental studies of elastomeric bearings worldwide. In this paper, a new base isolator concept that is a hybrid system of rubber bearings is proposed. Uniaxial, biaxial, and triaxial shaking table tests are also performed to study the seismic behavior of a 0.4-scale three-story isolated steel structure in the National Center for Research on Earthquake Engineering in Taiwan. Experimental results demonstrate that structures with a hybrid system of rubber bearings composed of stirruped rubber bearings and laminated rubber bearings can actually decrease the seismic responses of the superstructure. It has been proved through the shaking table tests that the proposed hybrid system of rubber bearings is a very promising tool to enhance the seismic resistance of structures. Moreover, it is demonstrated that the proposed analytical model in this paper can predict the mechanical behavior of the hybrid system of rubber bearings and seismic responses of the base-isolated structures.