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      • SCISCIESCOPUS

        Sensing threshold control for fair coexistence of heterogeneous systems in open spectrum

        Jemin Lee,Hano Wang,Sungtae Kim,Daesik Hong IEEE 2009 IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS Vol.8 No.12

        <P>A critical problem in open-spectrum communications is fairness with respect to the coexistence of heterogeneous systems with different resource units and traffic models. In addition, the sensing performances of different systems can also lead to unfair resource utilization between systems. To address this problem, we derive a continuous-time Markov chain model to show the effect of sensing performance on system coexistence. The analysis derived from this model is then used as the basis for a sensing threshold control (STC) scheme to achieve fairness. The proposed STC determines the sensing threshold for each system as a way of balancing resource utilization among systems, while guaranteeing target detection probability. Numerical results on the amount of resource utilization by each system demonstrate that the proposed STC achieves a full degree of fairness.</P>

      • A case of triamcinolone induced fat atrophy treated by Polydeoxyribonucleotide (PDRN) injection

        ( Jemin Kim ),( Sooyie Choi ),( Young In Lee ),( Jihee Kim ),( Ju Hee Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

        Atrophy of the skin and subcutaneous tissue is one of the well-known side effects of local injection of corticosteroid. Generally, most cases can be spontaneously improved within a year. However, some lesions may persist yet little has been reported about the treatment. A 26-year-old man presented with linear, atrophic scar with telangiectasia on the right knee. He received arthroscopic reduction and fixation due to anterior cruciate ligament fracture 10 months ago. One month after the surgery, intralesional triamcinolone was injected for the treatment of widening scar. Skin and subcutaneous atrophy developed after the injection, and the condition had not improved for 9 months. We decided to consider polydeoxyribonucleotide(PDRN) injection into the lesion. After 3 sessions of treatments, atrophic site became almost flat and the associated paresthesia was remarkably improved. PDRN is a novel component derived from the germ cells of salmon species, which is a mixture of deoxyriboneucleotides with molecular weights between 50-1,500 kDa. Enhanced wound healing and angiogenesis are well-established characteristics of PDRN. Clinically, PDRN has been shown to improve pressure ulcer, diabetic ulcer, and tendon injury. In vitro treatment of adipose tissue-derived stem cells resulted in adipogenic induction. Therefore, we consider PDRN can be useful treatment modality for the treatment of corticosteroid-induced skin and fat atrophy.

      • Investigation of Cytochrome P450 Genes Related to Saponin Biosynthesis in Platycodon grandiflorum Using RNA-Seq Analysis

        Jemin Yoo,Yurry Um,Yi Lee 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

        Platycodon grandiflorum is a herbal flowering perennial plant belongs to Campanulaceae family. The saponins derived from P. grandiflorum were termed platycosides and platycodin D, which is the most abundant saponin in the plant and pharmacologically active component, was intensively studied. Platycodin D is synthesized from triterpenoids by several enzymes including cytochrome P450. Cytochrome P450 is known to exist in superfamily in plant kingdom and essential roles in saponin biosynthetic pathway by hydroxylation or oxidation of triterpene skeletons. However, the key genes of P450 involved in biosynthesis of saponin was not identified because of its low conservation rate in amino acid sequence level among plant species and gene superfamilies. Recently, next generation sequencing (NGS) technology is rapidly developed as a method to discover target genes. In this study, we tried to identify P450 genes involved in saponin biosynthetic pathway from the various tissues of P. grandiflorum using RNA-seq analysis. The sequencing was performed using Illumina Hi-Seq platform after cDNA library preparation. The produced reads were assembled using CLC Genomics Workbench software (CLC Bio, Inc.). We obteined 122,663 contigs and found out 191 putative P450 genes. The phylogenetic relationship was analyzed and putative genes related to platicoside biosysthesis were selected and cloned for further analysis.

      • Analysis of Phylogenetic Relationship in Platycodon grandiflorum using RAPD Molecular Marker

        Jemin Yoo,So Hyeon Park,Yurry Um,Yi Lee 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

        Platycodon grandiflorum is a perennial herbal plant belongs to Campanulaceae family. It has very important genetic value as a major plant in Asterids order. The major ingredients are platycosides, terpenoid saponins. In Korean industrial plants market, it was produced 5,633 tons in 2013, and the total amount of production was less than only five species, omija, ginger, raspberry, yam and deodeok. P. grandiflorum is called ‘Gilgyung’ and is used as a fresh vegetable and an ornamental plant. Nowadays, various components of P. grandiflorum were already published. But, genetic research is in the starting stage. In this study, 11 cultivars; 1. MariesⅡ, 2. Hakone double white, 3. Hakone double blue, 4. Fuji white, 5. Fuji pink, 6. Fuji blue, 7. Astra white, 8. Astra pink, 9. Astra blue, 10. Astrasemi double blue, 11. Jangback, were analyzed using 60 Operon Universal RAPD primers. The results were phylogenetically analyzed and related to the morphological characteristics of the cultivars.

      • Effects of Enzyme Type and Molar Ratio on Enzymatic Synthesis of Hydroxybutyrate Methyl Ester

        Jemin SON,Kyeonga KIM,Seungmee LEE,Hah Young YOO,Chulhwan PARK 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10

        Ketone bodies are energy supplements produced from fatty acids by the liver under energy restriction conditions. In recent studies, several clinical effects, such as the increase of cardiac energetics and potential uses as a treatment for cancer and cardiovascular disease, are observed when the ketone body concentration in the blood is maintained over 0.5 mM. Appropriate ingestion ways of ketone bodies are investigated, and ketone esters were recognized as the most effective ingestion way. Hydroxybutyrate methyl ester, one of ketone esters, can effectively increase ketone body concentration in the blood with fewer doses than other options and are shown several clinical effects as ketone bodies and also as itself. Through ingestion of hydroxybutyrate methyl ester, the learning and memory was improved and further, the possibility for the treatment of Alzheimer’s disease was also observed. But still, only few studies are investigated the production of hydroxybutyrate methyl ester. Therefore, the conditions for the production of hydroxybutyrate methyl ester based on enzymes were designed under the consideration of productivity.

      • KCI등재

        A Comparative Study between Conservative and Surgical Treatments of Triangular Fibrocartilage Complex Injury of the Wrist with Distal Radius Fractures

        Jemin Im,Sung Jin Kang,이승준 대한정형외과학회 2021 Clinics in Orthopedic Surgery Vol.13 No.1

        Background: Triangular fibrocartilage complex (TFCC) injury is common in distal radius fractures. The purpose of this study was to compare the conservative and surgical treatments of TFCC injury of the wrist associated with distal radius fractures. Methods: A retrospective study was conducted on 39 patients who received treatment for TFCC injury with distal radius fractures. All patients were treated using a volar locking plate for distal radius fractures. Twenty-six patients who received conservative treatment for TFCC through long arm splinting were classified into group 1, and 13 patients who received surgical treatment for TFCC were classified into group 2. The splint was maintained for 6 weeks in both groups. For clinical evaluation, the range of motion (ROM) of the wrist joint, patient-rated wrist evaluation (PRWE) score, Disabilities of the Arm, Shoulder and Hand (DASH) score, and grip strength were measured. Distal radioulnar joint (DRUJ) stability was evaluated through a stress load test and graded between grade 0 and 3 intraoperatively after fixation and at the final follow-up. Results: In group 1, the average DASH score was 11.1 ± 4.4, the average PRWE score was 10.2 ± 4.6, the grip strength was 89.4% relative to the unaffected side, the average ROM of the wrist joint was 65° ± 7.0° for extension, 51.5° ± 8.1° for flexion, 86° ± 5.1° for supination, and 85° ± 5.2° for pronation, and DRUJ stability at the final follow-up was grade 0 in 58.62%, grade 1 in 31.03%, grade 2 in 10.34%, and grade 3 in 0%. In group 2, the average DASH score was 13 ± 5.0, the average PRWE score was 12.4 ± 3.7, the grip strength was 87.3% relative to the unaffected side, and the average ROM of the wrist joint was 60° ± 9.8° for extension, 53.1° ± 7.0° for flexion, 85° ± 5.3° for supination, and 86.8° ± 4.5° for pronation. At the final follow-up, DRUJ stability was grade 0 in 66.67%, grade 1 in 25%, grade 2 in 8.3%, and grade 3 in 0%. The 2 groups showed no statistically significant differences in DASH score, PREW score, grip strength, ROM, and final follow-up DRUJ stability. Conclusions: There were no statistically significant differences in the clinical outcomes between the surgical and conservative treatment groups. Therefore, when normal radiological indices are achieved after treatment of distal radius fractures, DRUJ stability can be obtained by conservative treatment.

      • SCISCIESCOPUS

        Spectrum-Sharing Transmission Capacity

        Jemin Lee,Andrews, J. G.,Daesik Hong IEEE 2011 IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS Vol.10 No.9

        <P>This paper analyzes spectrum sharing between multiple systems. The efficiency of spectrum sharing is determined primarily by interference, which is a function of the spatial densities of the transmitters in systems dependent on the chosen spectrum sharing method. One method is underlay, which allows all systems to concurrently use the whole spectrum, and the other is overlay, in which a system only utilizes its own assigned spectrum. We define the spectrum-sharing transmission capacity (S-TC) as the number of successful transmissions per unit area subject to outage probability constraints for each system. To prevent some systems from monopolizing access to the spectrum, we also propose a fair coexistence constraint and derive the optimal spatial densities and relative transmission powers both with and without this constraint in terms of the sum S-TC. Through analytical results, the overlay and underlay methods are compared, verifying that the overlay method is generally preferred, and the underlay method is equally good only for optimal transmission power ratios under a fair coexistence constraint.</P>

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