The Time Course Effects of Conjugated Linoleic Acids on Body Weight, Adipose Depotsand Lipid Profiles in the Male ICR Mice Fed Different Fat Sources

Hwang, Yun Hee,Kang, Keum Jee 덕성여자대학교 대학원 2005 덕성여자대학교 대학원 논문집 Vol.7 No.-

This study examined the time course effects of conjugated linoleic acids(CLA) on the body weight, lipid depots and lipid profilesof ICR male mice using two different sources of fats in the diet. Ninety eight mice weighing 25 to 30g were divided into four groups: beef tallow (BT) and fish oil (FO), beef tallow with CLA supplementation (BTC), and fish oil with CLA supplementation (FOC) group. Eight to nine mice in each group were fed with the experimental diets for 1,2 or 4 weeks, respectively. All mice were fed experimental diets containing 12% of total dietary fat (w/w) with or without 0.5% CLA (w/w). CLA supplementation did not affect the body weight. The weight of epididymal and visceral fats were significantly lower in BTC compared to those in BT groups during the periods examined (p<0.05), whereas they were significantly lower in FOC than those in FO only at 4 weeks (p<0.05). The levels of triglycerides in the plasma were significantly decreased in the BTC group than in BT group throughout the experimental periods (p<0.05). But, FOC was only effective at 4 weeks as compared to FO. The levels of total cholesterol and HDL-C weresignificantly increased in the BTC than in BT during the entire period (p<0.05), whereas there were no difference between FO and FOC on the levels of total cholesterol and HDL-C. The levels of free fatty acids (FFA) were significantly decreased in BTC than in BT at 1 and 4weeks and in FOC only at4 weeks as compared to FO (p<0.05). Taken these results together, CLA was more effective in the beef tallow diet in lowering the epididymal and visceral fat weights and triglyceride level rather than fish oil diet with CLA. Furthermore, the effect became clearer at 4 weeks than at one week of the experiment.

쑥 급여 돼지고기의 냉장저장 중 품질특성

김일석,진상근,송영민,하경희,김회윤,남기윤,류현지,하지희 한국국제농업개발학회 2004 韓國國際農業開發學會誌 Vol.16 No.4

쑥 분말 사료를 암돼지 및 거세돈에 첨가하여 그 수준에 따라 0%(T1, 암돼지, T2; 거세돈)와 1.5%(T3; 암돼지, T4, 거세돈)로 각 구별 45두씩 배치, 42일간 급여하여 생산된 돈육의 육질특성은 다음과 같다. 도체중량과 등지방두께는 73가 가장 낮았으며, 도체등급에서는 처리구간 유의차가 없었다(P>0.05). 쑥 분말 급여시 암돼지간(T1과 T3)에서는 조회분, 거세돈간(T2와 T4)에는 조지방 및 조회분 함량이 유의적으로 증가하였다(P<0.05). pH는 저장기간에 증가함에 따라 모든 처리구에서 감소하였으며, 쑥 분말 급여 처리구(T3와 T4)에서다소 높은 pH값을 나타내었다 드립감량은 처리구간에 일정한㎏/㎠경향을 나타내지 않았지만 저장기간이 경과함에 따라 높아졌다. 전단가(shear force, ㎏/㎠)는 T1을 제외한 모든 처리구에서 저장기간이 길어짐에 따라 감소하였다. 명도와 적색도는T3가 T1 보다 다소 높은 수치를 보였으나, 거세돈간(T2와 T4)에서는 오히려 낫게 나타났다. 저장기간이 증가함에 따라 TBARS와 VBN값은 공히 유의적으로 증가하였으며(P<0.05),쑥 분말 급여 처리구(T3 및 T4)에서 유의적으로 더 높게 나타났다(P<0.05). 지방산 분석결과, 포화지방산(saturated fatty acids)은 대조구에 비해 쑥 분말 첨가수준 증가에 따라 포화지방산은 높아지고 상대적으로 불포화지방산(unsaturated fatty acids)은 낮아지는 경향이 있었으나 유의차는 없고, 콜레스테롤의 경우에도 동일하게 유의적인 차이가 없었다. 전체적인 기호도는 신선육 및 조리육 공히 처리구가 낮은 점수를 얻었다. 향후 쑥 분말 급여에 대한 보다 많은 연구가 진행되어야 할 것으로 판단된다. This study was carried out to investigate the feeding effects of mugwort powder on meat quality characteristics for 42 days. The results obtained were as follows; Carcass weight(㎏) and backfat thickness(㎜) of T3 showed the lowest compared with other treatments. Grade scores were not significantly differ among the all treatments. In the proximate composition, crude ash content was higher(P<0.05) in the T3 than that of T1, while, crude fat and crude ash contents in T4 were higher(P<0.05) than those of T2. pH values were tended to low as storage period extended, in particular, those values slightly higher in the T3 and T4. Drip loss(%) was tended to increase during storage. Shear force(㎏/㎠) in all samples showed the decreased during the storage, except for Ti. L^(*) and a^(*) of T3 were slightly higher than those of T1, while, T4 was lower than T3. TBARS and VBN of all samples were significantly increased(P<0.05) as storage period extended, those values significantly higher(P<0.05) in the T3 and T4. There were no differences in saturated fatty acids, unsaturated fatty acids and cholesterol of pork meat between control(T1 and T2) and treatments(T3 and T4). The sensory score of pork samples fed with mugwort power were lower than that of control(T1 and T2) in both fresh and cooked meat. Further studied are needs on the pigs fed with mugwort powder.

급성골수백혈병에 대한 관해유도화학요법 후의 Granulocyte Colony-stimulating Factor의 효과

윤환중,최지영,전의건,길준영,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Granulocyte colony-stimulating factor(G-CSF) have been shown to hasten the recovery of neutropenia following anti-cancer chemotherapy. There are controversial opinions on the use of G-CSF in acute myelogenous leukemia(AML) because clonogenic studies have shown that G-CSF stimulates leukemic colonies as well as granulocyte colonies. In this study, we evaluated the effectiveness and safety of recombinant human G-CSF after induction chemotherapy with DAV regimen(Ara-C 100mg/㎡ day 1-8, Doxorubicin 45mg/㎡ day 3-5, VP-16 100mg/㎡ day 6-8) in 9 patients with AML. G-CSF therapy(200 ㎍/㎡/day) was begun 2 days after the end of chemotherapy and continued for 10 days. 17 AML patients who recieved the same chemotherapy before the onset of this study were used as historical control. G-CSF shortened the duration of granulocytopenia (less than 500/㎣) significantly (13 vs 23 days, p<0.001), but it had no effect on platelet recovery. Although the incidence of febrile episodes was almost the same, the duration of febrile episodes was shorter in the group treated with G-CSF( 5 vs 12 days, p=0.03). There was no evidence that G-CSF accelerated the regrowth of leukemic cells and the complete remission rates between the 2 groups were not different. These results show that G-CSF accelerates the recovery of granulocytopenia and shortens the febrile days after chemotherpy in patients with AML, without affecting the regrowth of leukemic cells.

Gutte-percha 또는 Resilon을 사용한 근관충전이 상아세관 내의 Enterococcus faecalis에 미치는 영향

지상욱,김의성,,정일영,유윤정 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.5

목적은 근관충전이 상아세관 내에 남아있는 세균에 미치는 영향을 알아보고 가터퍼차와 resilon의 밀폐 능력을 상아세관 내에 남아있는 세균의 생존 여부를 통하여 비교하는 것이다. 발치된 우전치로 치아시편에 E. faecalis를 접종하고 제1군은 음성대조군, 제 2군은 양성대조군, 제3군은 ZOE 계통의 근관전색제와 가터퍼차, 제 4군은 레진 계통의 근관전색제와 가터퍼차, 제 5군은 레진 계통의 근관전색제와 resilon으로 근관 충전하였다. 각 시편은 1, 2, 3주 및 4주간 보관한 뒤 round bur로 근관 내를 삭제하여 얻은 상아질을 배양하고 혼탁도를 측정하였다. 1. Nail varnish로 상아세관을 완전히 밀폐한 경우, 상아세관 내의 E. faecalis의 수는 가터퍼차 및 resilon으로 근관 충전 한 경우보다 통계적으로 유의차 있게 감소하였다 (p<0.05). 2. 레진 계통의 근관전색제와 resilon으로 근관충전 한 군에서는 시간의 흐름에 따라 상아세관 내의 E. faecalis의 수가 유의차 있게 감소하였다(p<0.05). 3. 가터퍼차와 resilon으로 근관충전한 군 사이에 상아세관 내에 남아 있는 E. faecalis의 생존 정도는 통계학적 유의차가 없었다 (p>0.05). The purpose of this study was to observe the effect of canal filling on the bacteria left in the dentinal tubules and to compare the sealing ability between Gutta-percha and Resilon. The bovine dentin block models were prepared. E. faecalis was inoculated to dentin blocks and incubated. The dentin blocks were divided into 5 groups. Group 1 was the negative control. Group 2 was the positive control. Group 3 was filled with ZOE based sealer and Gutta-percha, Group 4 with resin based sealer and Gutta-percha, and Group 5 with resin based sealer and Resilon. After 24 hour, the blocks were incubated at 37℃ for 1, 2, 3 and 4 weeks on BHI agar plates. The internal dentin portion of the blocks was removed using ISO 027, 029, 031, 035 round burs and the dentin chips were incubated at 37℃ for 24 hour. Following incubation, the optical density of the medium was measured. The data were statistically analysed using repeated measures ANOVA and one-way ANOVA and one-way ANOVA. The results were as follows, 1. There was statistically significant reduction in the number of E. faecalis of the group where dentinal tubules were completely sealed with nail varnish in comparison with the groups obturated with gutta-percha or resilon (p < 0.05). 2. In group 5, the number of E. faecalis in the dentinal tubules decreased significantly with time (p<0.05), whereas in Group 3 and 4, there was no reduction in its number (p>0.05). 3. Under the conditions of this experiment, E. faecalis survived up to 4 weeks after obturation with gutta-percha or resilon (p>0.05).

소독제에 의한 콕시디움오오시스트의 포자형성 억제효과

이윤세,지차호 충북대학교 동물의학연구소 2005 Journal of Biomedical and Translational Research Vol.6 No.2

본문참조

FCL(5-FU, Carboplatin, Leucovorin) 항암 화학요법에서 Gm-CSF의 효과

최지영,김현수,김종숙,박상준,윤환중,조덕연,남상륜,김삼용 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

Background: One of the major side effects of cancer chemotherapy is myelosuppression. Neutropenia and/or thrombocytopenia are dose-limiting factors in chemotherapy. Colony-stimulating factor induces proliferation and functional maturation of hematopoietic progenitor cells. GM-CSF is primarily active on progenitor cells of granulocytic and monocytic lineage. Methods: Fifteen patients with histologically proven malignancy diagnosed at Chungnam National University Hospital from January 1993 to August 1995 were included in this study. We could evaluate the clinical efficacy of GM-CSF in 13 patients undergoing FCL(5-FU, Carboplatin and Leucovorin) chemotherapy; the first cycles involved no GM-CSF while the second cycles involved GM-CSF on day 6 through 15 of chemotherapy. Results: 1) The subjects were fifteen patients in all, there were five patients with head and neck cancer, which was the most common types of maligancy. There were four patients with colon cancer, two patients with stomach cancer, and one patient with breast cancer, gallbladder cancer, cervix cancer and cholangiocarcinoma respectively, two patients, who did not complete two cycles of chemotherapy were excluded. 2) Age distribution was from 38 years to 78 years with a median age of 57. 3) In FCL chemotherapy cycles with GM-CSF, the duration of neutropenia(<500/μL) was 0.5±0.3 day, while FCL chemotherapy cycles without GM-CSF, it was 2.9±0.7 day(P=0.008). 3) There was no significant difference in platelet count between the two chemotherapy cycles(P=0.133). 4) Febrile duration without GM-CSF was 4.9±2.1 day, but with GM-CSF the duration was 1.3±0.7 day, which was significantly different(P=0.003). The duration of antibiotics use with GM-CSF was 1.7±1.2 day and without GM-CSF was 6.8±3.2 day, also significantly different(P=0.002). But hospital stay between the two cycles were not significantly different(P=0.064). Conclusion: GM-CSF was effective in preventing or restoring bone marrow depression after FCL chemotherapy.

학문 분야별 감성의 적용사례 분석 연구

장지혜,이윤희,연태경,강혜은,이연숙 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

The purpose of this study was to analyze application cases of human sensibility in various fields. Nowadays in various fields human sensibility and ergonomic have been studied using variety of methods. Studies on human sensibility have been widely carried in various field such as design and making instruments, selling products and marketing skills even if environmental design fields and human interface by computers. The results have been well applied in of industry. Therefore, understanding rationality. Through this study, ways of creating and measuring environment to improve our living quality, and living places can be developed. From such a viewpoint, this study did the following; First, it reviewed the literatures of studies and results of the tests for application of human sensibility in various field, and organized contents of studies and measurement tools which were used in the studies or tests. Second, it summarized the measurement methods of human sensibility according to three parts; physiological measurement, psychological measurement, and physical measurement. This study was expected to braden the sight on research methodologies and relevant applicable areas.

도시화에 따른 지표수 관리기법

최윤영,정광옥,지홍기 영남대학교 지역발전연구소 1997 새마을지역개발연구 Vol.20 No.-

This study is aimed at the development of management of surface water in the urban environment. In the civilization process of riverside, natural and humane environment has changed continually, and there are more frequent changes in flux and quantity of surface flow in civilized riverside than in natural riverside. Civilization concerned with the concentration of population and activity and expanding the range of urban area changed natural environment, and humane activity in urban area caused appearance of new hydrologic cycle system. This study defined the concept of urban environment and the role of river and investigated the change of natural environment caused by the civilization of urban area, the change of recharge from surface flow fluxing characteristics in urban river, and flux for suggesting the organization system of surface flow in urban river. To make the device which reasonably organize the surface water flow insurance in urban environment, this study systematically suggests the surface water flow management on flood-control, water-use and environmental aspect. To make the device which synthetically manage the surface water flow in urban river, this study suggests urban river synthetically management model which aims for harmony with nature which contains the concept of amenity, connecting with space, devotion to local for river development and preservation.

중소하천유역에서 개념적 유출모형의 민감도 분석을 통한 매개변수 추정기법의 비교

김지학,허창환,최윤영 충주대 산업과학기술연구소 1999 産業科學論文集 Vol.7 No.2

A Sensitivity analysis on the model parameters involved in the O'Donnell model is made to demonstrate the effect of each parameter on the magnitude of daily runoff for small to medium sized watershed. In the structure of O'Donnell model, the sub-tank is installed in O'Donnell's model in rainfall-runoff process to give lag effect. This model uses three parameter calibration methods, trial & error method, Powell method and Rosenbrock method, in estimating parameters in order to estimate parameters of the model. And as a consequence of calibration, Rosenbrock method was most suitable among three methods. The O'Donnell type model is dealt with time variant system in which rainfall- runoff process of basin is indicated as API's function. Index of API's function is used to calibrate the infiltration coefficient(βi) and runoff coefficient (α2i) of the model. The calculated values of applied hydrologic system by O'Donnell type model are closer to observed values compared with SSARR model values.

小兒 驚風의 鍼灸治療에 對한 文獻的 考察

朴志修,金允姬,柳同烈 대전대학교 한의학연구소 2001 혜화의학회지 Vol.10 No.1

Infantile Convulsion, one of common emergency symptoms in pediatrics, arises from sudden derangement of the central nerve system, and can cause a sudden loss of consciousness and spasm. It falls into three categories; Acute Infantile cnvulsion, Chronic Infantile convulsion and Chronic Spleen convulsion. According to research, approximately 6~7% of all babies undergo spasm more than once. Since the treatment must be done immediately, acupuncture & moxibustion treatment can be one of the most important treatments in this particular case. Therefore, the focus of this study is on how acupuncuture & moxibustion can be utilized in the treatment of Infantile Convulsion, and the literary findings are as follows: 1. The meridian points used on acute infantile convulsion are Sugu(GV26), T´aech´ung(Liv3), Hapkok(LI4). 2. The meridians used on acute infantile convulsion are Governor Vessel(GV), Bladder Meridian(BL), Stomach Meridian(ST). 3. The meridian points used on accompanied symptoms with acute infantile convulsion are Haenggan(Liv2), Yangnungch´on(Liv3) on spasm, Paek´oe(GV14) on opisthotonus, Kokchi(LI11), Taech´u(GV14) on fever, Nogung(P8), Yongch´on(K1) on fainting spell, Chok-samri(S36) on body weakness. 4. The meridian points used on chronic infanitle convulsion are Shinguol(CV8), Ch´onchj´u(S25), T´aech´ung(Liv3), Kwanwon(CV4), Ch´ukt´aek(L5). 5. The meridians used on chronic infantile convulsion are Conception Vessel(CV), Governor Vessel(GV), Stomach Meridian(ST). 6. The meridian points used on accompanied symptoms with chronic infantile convulsion are Ch´onchj´u(S25), Kolli(CV11) on diarrhea, Taenung(P7), Shinmun(H7) on fainting spell, Kansu(B18), T´aech´ung(Liv3) on spasm. 7. The meridian points and meridians are Paek´oe(GV14), Sangsung(GV23), Sugu(GV26) of Governor Vessel(GV) and Chonjung(CV16), Shinguol(CV16) of Conception Vessel(CV) and Taedon(Liv1), Changmun(Liv13).