유기주석 노출에 의한 Mysid, Neomysis awatschensis의 독성 영향

지정훈,김상규,황운기,강주찬 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.4

Tests for the toxicity of tributyltin (TBT) were conducted on mysid collected from Dadepo beach, Pusan, Korea. The toxic effects of tributyltin on the survival, growth and oxygen consumption of the mysid, Neomysis awatschensis have been evaluated. Mysids were exposed to several concentrations of TBT (0, 0.56, 1.15, 3.07 and 6.12 ㎍/L) for 6 weeks. Survival rate was decreased with increases in concentration and exposure time and the reduction of more than 40% occurred at TBT concentration greater than 1.15 ㎍/L after 6 weeks. Growth rate was significantly decreased at concentrations greater than 1.15 ㎍/L Oxygen consumption rate was also decreased in a concentration-dependent way and significantly decreased to 39, 47 and 69% of the control at 1. 15, 3.07 and 6.12 ㎍/L, respectively. These results indicate that the contamination of aquatic environment by TBT has the potential to significantly reduce coastal and estuaries recruitment of mysid.

Gutte-percha 또는 Resilon을 사용한 근관충전이 상아세관 내의 Enterococcus faecalis에 미치는 영향

지상욱,김의성,,정일영,유윤정 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.5

목적은 근관충전이 상아세관 내에 남아있는 세균에 미치는 영향을 알아보고 가터퍼차와 resilon의 밀폐 능력을 상아세관 내에 남아있는 세균의 생존 여부를 통하여 비교하는 것이다. 발치된 우전치로 치아시편에 E. faecalis를 접종하고 제1군은 음성대조군, 제 2군은 양성대조군, 제3군은 ZOE 계통의 근관전색제와 가터퍼차, 제 4군은 레진 계통의 근관전색제와 가터퍼차, 제 5군은 레진 계통의 근관전색제와 resilon으로 근관 충전하였다. 각 시편은 1, 2, 3주 및 4주간 보관한 뒤 round bur로 근관 내를 삭제하여 얻은 상아질을 배양하고 혼탁도를 측정하였다. 1. Nail varnish로 상아세관을 완전히 밀폐한 경우, 상아세관 내의 E. faecalis의 수는 가터퍼차 및 resilon으로 근관 충전 한 경우보다 통계적으로 유의차 있게 감소하였다 (p<0.05). 2. 레진 계통의 근관전색제와 resilon으로 근관충전 한 군에서는 시간의 흐름에 따라 상아세관 내의 E. faecalis의 수가 유의차 있게 감소하였다(p<0.05). 3. 가터퍼차와 resilon으로 근관충전한 군 사이에 상아세관 내에 남아 있는 E. faecalis의 생존 정도는 통계학적 유의차가 없었다 (p>0.05). The purpose of this study was to observe the effect of canal filling on the bacteria left in the dentinal tubules and to compare the sealing ability between Gutta-percha and Resilon. The bovine dentin block models were prepared. E. faecalis was inoculated to dentin blocks and incubated. The dentin blocks were divided into 5 groups. Group 1 was the negative control. Group 2 was the positive control. Group 3 was filled with ZOE based sealer and Gutta-percha, Group 4 with resin based sealer and Gutta-percha, and Group 5 with resin based sealer and Resilon. After 24 hour, the blocks were incubated at 37℃ for 1, 2, 3 and 4 weeks on BHI agar plates. The internal dentin portion of the blocks was removed using ISO 027, 029, 031, 035 round burs and the dentin chips were incubated at 37℃ for 24 hour. Following incubation, the optical density of the medium was measured. The data were statistically analysed using repeated measures ANOVA and one-way ANOVA and one-way ANOVA. The results were as follows, 1. There was statistically significant reduction in the number of E. faecalis of the group where dentinal tubules were completely sealed with nail varnish in comparison with the groups obturated with gutta-percha or resilon (p < 0.05). 2. In group 5, the number of E. faecalis in the dentinal tubules decreased significantly with time (p<0.05), whereas in Group 3 and 4, there was no reduction in its number (p>0.05). 3. Under the conditions of this experiment, E. faecalis survived up to 4 weeks after obturation with gutta-percha or resilon (p>0.05).

Pipemidic Argininate 및 Pipemidic Acid β-Cyclodextrin Inclusion Complex의 장관흡수실험

智雄吉,羅成範 충남대학교 약학대학 의약품개발연구소 1986 藥學論文集 Vol.2 No.-

Pipemidic argininate and pipemidic acid β-cyclodextrin inclusion complex was examined for the absorption by rat intestin in situ recirculation. The absorption rate constant was pipemidic acid 0.096hr^-1, pipemidic argininate 0.276hr^-1 and pipemidic acid β-cyclodextrin inclusion complex 0.221hr^-1. The absorption rat of pipemidic argininate and it's complex turned out to be greater than that of pipemidic acid. And the absorption mechanism of pipemidic argininate was examined by everted sac of rat intestin, 0.1mM drug buffer solution was incubated in serosal and mucosal for 30 minutes, and the result showed that drug concentration of serosal was 0.144mM, concentration of mucosal was 0.0897mM. Through this study it is infered that the absorption mechanism was a special transport.

uT 컴퓨팅 환경에서의 에이전트 시스템 적용 사례

지경환,김성태,양정진 가톨릭대학교 자연과학연구소 2005 자연과학논문집 Vol.26 No.-

유비쿼터스 시대의 컴퓨팅은 사용자의 의향과 상황을 인지해 동적으로 목표를 설정하고 자동으로 협력해 목표를 달성하게 된다. 앞으로 곧 다가올 새로운 컴퓨팅 환경에서 주된 역할을 하게 될 개체인 에이전트와 이들이 상호 협력하는 기반구조인 다중 에이전트 시스템에 관하여 활발히 연구가 진행 중이다. 본 연구는 uT 컴퓨팅 환경에서 응용될 수 있는 에이전트 시스템의 적용 사례들을 분석하고 기존 연구의 방향, 목적, 장단점을 파악하여 앞으로의 에이전트 연구에 도움이 될 수 있는 기술적 근거를 조사하고 uT 컴퓨팅 환경에서 다중 에이전트 시스템 설계를 위한 방법론을 모색한다. Computing in ubiquitous era introduces that a goal is dynamically set by recognizing user's intention and situational information and that the goal is achieved better through collaborative wok by different components. Agents are the components that take critical roles in the new computing era, the study of multi-agent systems, that is, working through interaction and collaboration among agents is actively pursued along with the current demand. Our work focuses on the case studies of multi-agent system applications in ubiquitous computing environment. The study of the analysis enables us to extract rational direction of multi-agent system research in the future and the methodology of developing multi-agent system in ubiquitous computing environment.

Clonixin Argininate의 약제학적 연구

智雄吉,羅成範 충남대학교 약학대학 의약품개발연구소 1986 藥學論文集 Vol.2 No.-

To increase the bioavailability of clonixin, clonxin argininate was prepared and compared with clonxin by determining solubility, pKa, lipid-water partition coefficient, dissolution rate and in vivo tests. The results are summerized as followings; 1) The solubility of clonixin argininate was increased by 20 times in water, about 1.2 times in pH 1.2 and pH 8.0 buffer solution, and about 1.8 times in pH 6.8 buffer solution compared with that of clonixin. 2) pKa values of clonixin, clonixin lysinate and clonixin argininate were 6.32, 7.20 and 7.45, respectively. 3) The lipid-water partition coefficient of clonixin argininate was increased more than that of the clonixin in n-hexane, carbon tetrachloride, chloroform, methylene chloride, and n-butanol, but the partition coefficient of clonixin was increased more than that of clonixin argininate in benzene/pH 1,2 buffer solution, ether/pH 8.0 buffer solution, and about 5 min. in pH 6.8 buffer solution. T_60% of clonixin lysinate was about 1.5min. in water, about 1.8 min. in pH 6.8 buffer solution, and about 8min. in pH 1.2 buffer solution. But T_60% of clonixin was about 96 min. in pH 6.8 buffer solution, over 2 hours in water and pH 1.2 buffer solution. 5) Anti-inflammatory effect of clonixin argininate was lapse of time. 6) Analgesic effect of clonixin argininate was increased by 1.5 times more than that of clonixin and the effect of clonixin argininate was nearly identical with that of clonixin lysinate. 7) The absorption rates (Ka) of clonixin, clonixin lysinate and clonixin argininate were 0.169hr^01, 0.652hr^-1 and 0.723 hr^-1 in situ, respectively.

Pipemidic Argininate의 藥劑學的 硏究

智雄吉,羅成範 충남대학교 약학대학 의약품개발연구소 1985 藥學論文集 Vol.1 No.-

Pipemidic acid, 8-ethyl-5,8-dihydro-5-oxo-2 (1-piperazinyl)-pyrido [2,3-d] pyrimidine-6-carboxylic acid is a synthetic antibacterial agent structurally related to nalidixic acid. Pipemidic acid is insoluble drug in water, which is aimed at increasing solubility to improve upon the bioavailability in case of oral administration. Then writer was reacted by the basic amino acid, arginine, into the pipemidic acid, produced the pipemidic argininate and examined for solubility, dissolution rate, apparent partition coefficient and antibacterial activity. The results were summerized as followings. (1) The solubility of pipemidic argininate has been increased by 2~6 times more than that of pipemidic acid in each solvents. (2) In dissolution test, the time required to dissolve 60% (T_60%) of pipemidic argininate was about 1.5 minutes in each solvent. But pipemidic acid was over 120 minutes in each solvent. (3) The lipid-water partition coefficient against pipemidic argininate was generally greater than that of pipemidic acid. (4) In Vitro antibacterial activity, namely, the MIC values of pipemidic acid and pipemidic argininate were same against for Bacillus subtillis and Escherichia coli. But against Staphylococus aureus, Pseudomonas aeruginosa and Proteus vulgaris, pipemidic argininate was much lower than that of pipemidic acid.

비이온성 미셀용액과 수중유형 마이크로에멀젼계의 특성 및 수단 Ⅳ의 가용화

지웅길,황성주,장은옥,현종목 충남대학교 약학대학 의약품개발연구소 1995 藥學論文集 Vol.11 No.-

The O/W microemulsion systems were made from 2 or 4% (w/w) oil (soybean oil, olive oil or isopropyl myristate) and 10, 15 or 20% (w/w) Brij 96. They were compared with micellar solution of equivalent surfactant concentration in therms of physicochemical properties, and the solubilization of sudan IV. They were characterized by dynamic light scattering, stability, surface tension, viscosity and rheogram. The mean diameters of O/W microemulsion systems were 10~15 nm, and those of Brij 96 micellar solutions were 18~19 nm. Both of them were monodisperse systems. The O/W microemulsion systems showed Newtonian flow and their apparent viscosities were lower than those of micellar solutions. The surface tensions of O/W microemulsion systems were increased or decreased depending on the types of oil used, when compared with those of micellar solutions. The O/W microemulsion systems were very stable, and did not show any flocculation or aggregation. Their mean diameters were not changed after three months. But oxidation was observed in microemulsions without nitrogen gas at high temperature. There was a significant improvement in the sudan IV solubilization in microemulsion compared with that in the micellar solution containing equivalent concentration of surfactant. The size distribution and mean diameters of O/W microemulsions were not changed when sudan IV was solubilized.

Hydrophone 응용을 위한 壓電 Ceramics/Polymer Composites의 誘電 및 壓電 特性에 관한 연구

池相良 경북전문대학교 1990 慶北專門大學 論文集 Vol.9 No.-

In this syudy Composites with 0-3 connectivity were habricated with PbTio3 powder and PMMA polymer for hydrophone application, and the dielectric and piezoelectric properties as a function of PbTio3 volume fraction were investigated. Also, a modified cubic model was introduced to explain the influence of the PbTio3 volume fraction. In terms of the modified cubic model, Calculated theoretical the dielectric constant and piezoelectric coefficient of the composites, and compared the calculated value with measured value, so that the result are as follows: 1. At the form factor n=0.36, the measured dielectric constant value agree with the calculated value 2. At 70 vol.% of PbTio3, Figure of merit of the composites was 325 (x10 ㎡/n)

토목공학과 교육과정 개발연구

成基泰,金知學,李興吉,辛逸善,金芳植,閔彰東 忠州大學校 1996 한국교통대학교 논문집 Vol.31 No.2

For resonable curriculum modification and development corresponding with training to competent high-level, engineering as educational object of industrial university this research was carried out as following process ; 1. Collection and analysis of present curriculum in civil engineering department of domestic industrial university including the curriculum of foreign industrial university. 2. Organization of advisory committee for insustry school cooperation and visiting insustry and interview. 3. Organization of all Korea Civil Engineering Department chief committe. 4. Result of research through the questionnaire for all Korea representative industry and academic could be summarized as follows : 1) Wide contact between college education and industry field should be strengthened, and field experiment education was strengthened to consider of ability, and construction management was edited compulsory major. 2) For the adapting trend of variety and subdivision of construction skill EDPS education was edited compulsory 3) The curriculum was endeavoured to fundamental science. 4) The curriculum enlarged the range of the optional subject which is able to manage the flexible curriculum for characterization of each local industrial university and endeavoured consideration of field adapting ability by classifing the civil design into Construction design and integration, Hydraulic design and integration, Earth design and integration. 5) The curriculum of academic theories and experiments were unificated into single subject for the purpose of flexible management 6) The curriculum was edited in the ration which is 20 to 80 between liberal and majoring arts in presentation on the basis of all accounts of opinion from the academic and field worker, and emphasized the importance of language education editing industrial English conversation because of demand of much ability along with foreign advance of construction technique. 7) The curriculum was emphasized in the necessity of the field experimental trained based on the information by all opinion. By operationg this curriculum, it is expected that the relationship between industry and academic will be efficiently considered.

담도에 국한되어 증상을 유발한 석회쓸개즙 2 예

윤성우,이지영,하경호,이수경,한나,배효근,박선자 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Limy bile is a rare condition characterized by excessive precipitation of calcium carbonate in the gallbladder or bile duct. Recently we experienced two cases with obstructive jaundice in which limy bile in the common bile duct but not in the gallbladder for one case, and in the common bile duct and intra hepatic duct but not in the gallbladder for another case. The patients were treated by endoscopic sphincterotomy. Here, we report the cases and review the literature.