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Ee Jean Lim,Khi Yung Fong,Jingqiu Li,Hong Hong Huang,Kenneth Chen,Kae Jack Tay,Christopher Wai Sam Cheng,Henry Sun Sien Ho,Nye Thane Ngo,John Shyi Peng Yuen 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.2
Purpose: To perform a retrospective review of the clinicopathological features of patients with conventional and non-conventional renal cell carcinoma (cRCC and ncRCC). Materials and Methods: A large prospectively maintained uro-oncological registry was accessed to extract clinicopathological data of patients diagnosed with renal tumors who subsequently underwent nephrectomy from 1990–2019. Demographics and operative parameters were extracted. Analyses of overall survival (OS) and cancer-specific survival (CSS) were performed using the Kaplan–Meier method. Cox proportional-hazards analysis was used to identify risk factors which influenced survival. Results: There were a total of 1,686 consecutive nephrectomies which was retrieved, with 1,286 cRCC and 400 ncRCC. The commonest ncRCC subtypes were papillary (n=198, 11.7%), clear cell papillary (n=50, 3.0%) and chromophobe (n=49, 2.9%) RCC. Kaplan–Meier estimates of OS were higher in cRCC (0.74; 95% confidence interval [CI], 0.71–0.78) than ncRCC (hazard ratio, 1.47; 95% CI, 1.16–1.87). Among individual subtypes, chromophobe RCC had the highest 5-year OS (0.90; 95% CI, 0.79–1.0). Among ncRCC subtypes, acquired cystic RCC demonstrated the highest association with end-stage renal failure and hypertension, with the highest CSS. MiT family translocation RCC had the youngest mean age at presentation (45.6±12.8 y) and excellent CSS. Factors associated with increased OS in the entire cohort included shorter operative time, partial nephrectomy and lower tumor stages. Conclusions: This study provides a comprehensive contemporary overview of ncRCCs which are yet poorly characterized, in comparison to cRCCs. Data from this study would contribute towards tailored patient counseling and healthcare resource planning.
Towards Distributed Trustworthy Traceability and Accountability
Jörn Erbguth,Jean-Henry Morin 한국경영정보학회 2016 한국경영정보학회 학술대회논문집 Vol.2016 No.11
Digital traces play an increasingly important role in our society. Whether in the context of regulatory compliance, contractual exchanges or simply for general interactions, people need to be able to document trustworthy facts. Most approaches today rely either on Trusted Third Parties, at best, or more generally on collecting such traces after problems occur in ways where their authenticity may be arguable (fabricated, doctored). Blockchain technology offers an interesting alternative to the problem by allowing documenting transactions in a distributed consensus ledger with transparency and immutability properties. This paper proposes a new approach to the problem leveraging blockchain technology towards providing a framework for distributed trustworthy logging of digital facts and traces on the blockchain as they happen or are needed before problems arise. Disintermediation of such processes is likely to significantly help raise trust and accountability in many aspects of our interactions, whether online or offline.
Meyer Mikael,Prost Solène,Farah Kaissar,Denis Jean-Baptiste,Dufour Henry,Blondel Benjamin,Fuentes Stéphane 대한척추외과학회 2020 Asian Spine Journal Vol.14 No.3
Study Design: Observational study.Purpose: The actual sanitary crisis led to a massive mobilization of the sanitary system toward intensive care units and management of coronavirus disease 2019 (COVID-19) patients. However, some patients still require spinal interventions. The present study aimed to assess the impact of the COVID-19 pandemic on spine surgical in a moderate COVID-19 cluster region.Overview of Literature: Previous studies have reported screening and management of patients with spinal conditions during the COVID-19 pandemic. However, to date, knowledge, no observational study on spine surgeries during the pandemic has not been reported.Methods: Between March 17, 2020 and April 17, 2020, information on spine surgical activity was prospectively collected at our institution. This surgical activity related to the first month of confinement in France was compared to the activity during the same period in 2019 to evaluate the impact of the COVID-19 pandemic on surgical activities.Results: In order to reduce the contamination rate of patients and medical staff during hospitalization, the spine department was completely reorganized. Non-urgent elective spine surgeries were cancelled. When considering the global amount of surgeries procedures during the first month of confinement, a decrease of almost 50% was observed in the number of surgical procedures. During the study period, 62 patients were eligible for spine surgery. The numbers of patients managed for tumor and infectious cases were stable, while a considerable reduction was observed in the number of trauma and degenerative cases. During the follow-up period, two patients were tested as COVID+ during the postoperative course, and no cases of medical or paramedical staff contamination were reported using polymerase chain reaction-testing.Conclusions: During the COVID-19 pandemic, it is possible to maintain spine surgical activity. Each surgical procedure must be discussed and organized with all the caregivers involved. Indications for surgery must be in line with the scientific guidelines and adapted to each healthcare facility.
Renaud Sabatier,Véronique Diéras,Xavier Pivot,Etienne Brain,Henri Roché,Jean-Marc Extra,Audrey Monneur,Magali Provansal,Carole Tarpin,François Bertucci,Patrice Viens,Christophe Zemmour,Anthony Gonçalv 대한암학회 2018 Cancer Research and Treatment Vol.50 No.4
Purpose Eribulin is approved for advanced breast cancers refractory to anthracyclines and taxanes. Efficacy according to sensitivity to previous therapies has been poorly explored. Materials and Methods Safety data were collected prospectively and we retrospectively collected efficacy data from the five French centres that participated in the Eribulin E7389-G000-398 expanded access program. Our main objectives were exploration of safety and analysis of eribulin efficacy (progression- free survival [PFS] and overall survival [OS]) according to sensitivity to the last microtubule-inhibiting agent administered. Results Median eribulin treatment duration was 3.3 months for the 250 patients included in this prospective single-arm study. Two hundreds and thirty-nine patients (95.6%) experienced an adverse event (AE) related to treatment including 129 (51.6%) with grade 3 AEs. The most frequently observed toxicities were cytopenias (59.6% of included patients), gastrointestinal disorders (59.2%), and asthenia (56.4%). The most frequent grade 3-4 AE was neutropenia (37.2% with 4.8% febrile neutropenia). Median PFS and OS were 4.6 and 11.8 months, respectively. Patients classified as responders to the last microtubule-inhibiting therapy had a longer OS (hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.51 to 0.94; p=0.017), and tended to display a better PFS (HR, 0.78; 95% CI, 0.58 to 1.04; p=0.086). OS improvement was still significant in multivariate analysis (adjusted HR, 0.53; 95% CI, 0.35 to 0.79; p=0.002). Conclusion This work based on a prospective study suggests that identification of patients likely to be more sensitive to eribulin could be based on their previous response to microtubules inhibitors.
The Brownfield of the Eiffel Tower Steel Mill: A Highly Contaminated but Well-Functioning Ecosystem
Pierre Lucisine,Michael Danger,Vincent Felten,Delphine Aran,Sonia Henry,Hermine Huot,Antoine Lecerf,Gabriel Moinet,Jean-Louis Morel,Serge Muller,Johanne Nahmani,Florence Maunoury-Danger 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6