자주적 학습의 관련 요인에 관한 이론적인 고찰

박재규 釜山敎育大學 1985 부산교육대학 논문집 Vol.21 No.1

1. The subject and purpose of the study . The criteria of the facts relative to independent learning are formed theoretically. . The problems of independent learning are analyzed according to the criteria. . The improved methods of independent learning are inquired. 2. The method of the study The improved method is discussed from the viewpoint of the theory by applying liter-ature research and the factual method of investigation, finding the criteria of the process of research in the theoretical reseach, and finding the problems in the factual method of investigation. 3. The results of the study . The criteria relative to independent learning are formed. . Theachers' view of value, teaching theory and skill, and the lack of creative effort are considered the problem of independent learning. ◆ The improved method . Teachers' value of view should be varied independently by group discussion of teachers and workshop of the life norm of the group of teachers. . Teaching theory and skill should be improved by cultivating theory and skill by the way of the practical investigation on classroom teaching. . Creative efforts should be got by cultivating self-confidence through systemic reserch activities and varying the tachers' view of value. 4. Conclusion . The criteria of the relevant are facts contributed to the generalization of inderendent learning. . It is needed that we must much more concerned with the generalization of independent learning.

유치원 교육과정 신체 발달 영역의 수업 목표의 세분화와 교재화

박재규 釜山敎育大學 1984 부산교육대학 논문집 Vol.20 No.1

The purpose of this paper is to clarify the teaching object in the area of the body development of preschool curriculum and to make materials for teaching toward it. The topics discussed in this paper include the classification of teaching; (① some features and learning ways essential for the body development, ② individualizing them above for general criteria of development, : and ③ making the object for us to observe) and making materials for teaching central to concrete activities (① maintaining constant relationship with teaching object ② with concrete activities relevant to learning ways, and ③ in the context). The study period is Gen. 4, 1984 to Nov. 30, 1984. I have drawn the first tentative plan, corrected and supplemented it through the discussion aboutit with 58 teachers of preschool including 236 children of preschool with correction and supplementation through the discussion about the data with 58 teachers of preschool. As the process of this study, they are the specifying and the making materials for teaching of teaching object for a sense, those for the ability the exercise and the body control, and those for the ability of health and safety. In conclusion, it is hoped that when the teachers in service of preschool try to organize learning activities according to the curriculum with reference to the criteria relevent to establishing teaching object and making materials for teaching, they will give a small contribution to normal operation of curriculum.

Mycophenolic Acid가 PDGF에 의해 증식 유도된 흰쥐 혈관평활근 세포에서 NAD(P)H Oxidase, 세포내 활성산소족 및 Mitogen-activated Protein Kinases에 미치는 영향

박제현,하헌주,김명수,허규하,김유선 이화여자대학교 약학연구소 2004 藥學硏究論文集 Vol.- No.14

Background: Vascular smooth muscle cell (VSMC) proliferation plays an important role in the development and progression of chronic allograft vasculopathy as in atherosclerosis. We already reported that mycophenolic acid (MPA) inhibited VSMC proliferation, cellular reactive oxygen species (ROS) and mitogen-activated protein kinases (MAPK) in human VSMCs. In this study, we examined further molecular mechanisms involved in the anti-proliferative effect of MPA in rat VSMCs. Methods: Primary rat VSMCs were stimulated with PDGF-BB 10 ng/mL in the presence or absence of MPA and various kinds of cell signaling inhibitors. Cell proliferation was assessed by [H³]-thymidine incorporation, NAD(P)H oxidase subunits mRNA expression by RT-PCR, dichlorofluorescein-sensitive cellular ROS by FACS, and the activation of PDGF receptor-β (Tyr 751), racl, and MAPK by Western blot analysis. Results: PDGF increased cell proliferation and cellular ROS, activation of PDGF receptor-β (Tyr 751), racl, expression of p22phox and MOX1 mRNA, ERK 1/2, and p38 MAPK, compared to control. MPA inhibited up-regulation of racl phosphorylation, p22phox and MOX1 mRNA expression, cellular ROS, and phosphorylation of ERK 1/2 and p38 MAPK. However, MPA did not affect PDGF receptor-β (Tyr 751) activation. Wortmannin, diphenyleniodonium (DPI), trolox, and NAC, each inhibited PDGF-induced ERK 1/2 and p38 MAPK activation. PD98059 and p38 MAPK inhibitor also inhibited PDGF-induced cell proliferation. Conclusion: These results suggest that MPA inhibits PDGF-induced VSMC proliferation through inhibiting NAD(P)H oxidase-dependent cellular ROS leading to ERK 1/2 and p38 MAPK activation. 배경 : 혈관평활근 세포의 증식은 장기이식 후 발생하는 혈관경화증이나 동맥경화증의 발생과 진행에 중요한 역할을 한다. Mycophenolic acid (MPA)는 강력한 면역억제제로서 혈관평활근 세포의 증식도 억제한다. 본 연구는 사람의 혈관평활근 세포에서 MPK가 세포증식에 관여하는 신호전달계인 활성산소족과 mitogen-activated protein kinases(MAPK) 활성화를 억제하는 기존의 연구결과를 바탕으로, PDGF에 의해 증식 유도된 흰쥐 혈관평활근 세포에서 MPA가 세포의 증식을 억제하는 기전을 검색하였다. 방법 : 일차 배양한 흰쥐 혈관평활근 세포를 PDGF-BB 10 ng/mL로 자극하였고, MPA를 비롯한 여러 종류의 신호전달 억제제는 PDGF를 투여하기 1시간 전에 투여하였다. 세포증식은 [H³]-thymidine incorporation으로, NAD(P)H oxidase subunit의 mRNA 표현은 RT-PCR로, dichlorofluorescein에 민감한 세포내 활성산소족은 FACS 방법으로, 그리고 PDGF 수용체-β (Tyr 751), racl 및 MARK 활성하는 Western blot으로 각각 분석하였다. 결과 : PDGF는 PDGF 수용체-β (Tyr 751)의 활성화 및 NAD(P)H oxidase subunit 중 racl의 활성화와 p22phox와 MOX1의 mRNA 표현을 대조군에 비하여 유의하게 증가시켰다. MPA는 PDGF 수용체의 활성화에는 영향을 주지 않았으나, racl의 활성화, p22phox와 MOX1의 mRNA 표현의 상향 조절, 세포내 활성산소족, 그리고 ERK 1/2와 p38 MAPK의 활의한 EFK 1/2와 p38 MAPK 활성화와 세포 증식을 억제하였다. PD98059와 p38 MAPK 억제제는 PDGF에 의한 혈관평활근 세포의 증식을 억제하였다. 결론 : 본 연구결과는 MPA가 NAD(P)H oxidase를 억제함으로써 세포내 활성산소족 생산과, MAPK 활성화를 억제함으로써 PDGF에 의하여 유도되는 혈관평활근 세포의 증식을 억제함을 시사하였다.

유치원 교육과정 사회성·정서발달 영역의 수업목표 세분화와 교재화

박재규 釜山敎育大學 1981 부산교육대학 논문집 Vol.17 No.1

The subject and purpose this study The content of education of the written curriculum notified by the Ministry of Education is so basic and general that it is difficult for field teachers to organize and instruct those into learning activity. Therefore, this study is aim at specializing the content of education in order to embody step by step and organize into learning activity the content of education in the field of development of sociality and emotion of curriculum which will be reformed the yer of 1982. The subject of this study is as follows: (1) to find category which the aim of teaching and teaching materials can be embodied (2) to establish the aim teaching and teaching materials according to the cotegory The method of this study: (1) to find the category of specification of the content of education on the basis of literature research and invesitigation of the fact of children life (2) to revise the first tentative plan after discussing it with 40 field teachers of preschool (3) for 6 teachers to apply the first tentative plan the 240 children (4) to revise again materials gained by experimental application after discussing them with 40 field teachers of preschool The result and conclusion of this study. The domain which the content of curriculum was specified and materialized into the aim of teaching is as follows: There are 5 items of individual and home life part, 9 items of group life and 6 items of national life in the field of sociality development. In the field of emotion development are 6 items of positive attitude and 7 items of accomplishment feeling. It may be concluded that the specified aim of teaching and teaching mateials can be judged as a pertinent data in order to instruct learning activity systematically accrding to curriculum and as reference materials useful for this field of study in the future.

뇌하수체경을 침범한 Histiocytosis X : 증례 보고 Case Report

조병규,왕규창,양세원,지제근,김인원,최길수 대한신경외과학회 1989 Journal of Korean neurosurgical society Vol.18 No.7-12

A case of histiocytosis X with the involvement of pituitary stalk in a 5 year old boy was described. He presented with diabetes insipidus and the endocrinological study showed growth hormone deficiency. On computerized tomography and magnetic resonance imaging, the pituitary stalk was abnormally thick. Overlooking of the skull lesion on plain X-ray film led to an erroneous diagnosis of 'germ cell tumor'. Gross total removal of the lesion and chemotherapy were performed. In the differential diagnosis of suprasellar masses, this disease entity should be included. The importance of histological diagnosis of the infundibular lesion in cases of central diabetes insipidus is also emphasized.

地方別 너도방동산이(Cyperus Serotinus Rottb.)의 生態的 特性

金帝圭,姜炳華 건국대학교 1978 論文集 Vol.8 No.1

This experiment was conducted in Suweon to compare the ecological characteristics of Cyperus serotinus Rottb. collected from the seven different locations in Korea. The results are summarized as follows : The number of tubers of C. serotinus collected from Kwangsan, Cheonju, Iri, Milyang, Suweon, Chinju and Chilgok was 313, 206, 183, 165, 148, 143 and 135 per pot, respectively. The number of shoots was highest in C. serotinus collected from Kwangsan. 2. All C. serotinus flowered under the Suweon climatic conditions except the C. seritinus collected from Kwangsan. 3. The dry weights of tubers of C. surotinus collected from Suweon, Milyang, Iri, Chilgok, Chinju, Cheonju and Kwangsan were 0.12, 0.07, 0.06, 0.06, 0.06, 0.04 and 0.04g per tuber, respectively. 4. Tuberization was earliest in C. serotinus collected from Suweon. 5. The first withering was observed in C. serotinus collected from Suweon (October 23), but C. serotinus from Kwangsan did not wither until November 1.

유치원 교육과정 언어발달 영역의 수업 목표의 세분화와 교재화

박재규 釜山敎育大學 1982 부산교육대학 논문집 Vol.18 No.1

1. Purpose This study was sttempted to specify and materialize the contents of language curriculum which is generally stated in terms of the behavioral level. 2. Procedure 1) The theoretical background for the study was established through the docments and the several preceded practical researches, 2) the first tentative plan (specification frame) of the classification and materialization was made by the researcher, 3) the implement and revison of the tentative plan were made by the 40 co-researchers through the analytic discussion, 4) the tentative plan was applied by six kindergarten classes 5) and finally, the tentative plan, analysing the results, was revised and implemented through the discussion with 40 kindergarten teachers. 3. Results and Siscussion Results: 1) Classification and Specification of the educational objectives in the field of language education are made for the kindergarten level, 2) and the objectives were materialized for the individualized prescription of the language education Discussion: Even though this study has several limitation, it will surely be the useful reference for the kindergarten teachers in field language education.

뇌하수체 종양 제거술 시행 후 뒤늦게 발생한 횡문근 융해증과 동반된 중추성 열

장제혁,최규남,김일환,노은지,김윤정,유충헌,고정해,박봉수,김태균,권민정,이순희,박정현 인제대학교 2008 仁濟醫學 Vol.29 No.-

Body temperature is controlled by thermoregulatory center of the hypothalamus. We report a case of 24 years old man with central fever. He was subjected to a partial excision of pituitary tumor compressing optic chiasm four years ago. He has received hormonal therapy for panhypothyroidism after removal of pituitary tumor. And He received gamma knife operation for partially contrast-enhancing masses in suprasellar and both hypothalamic areas that is probably postoperatively remnant or recurrent tumor of pituitary adenoma. One year after gamma knife operation, he presented with a febrile syndrome of unknown origin including rhabdomyolysis. All usual investigations proved negative. We diagnosed him as central fever with rhabdomyolysis. He received medical ICU care with cooling bed, ice pack. And his symptom improved. Postoperative hyperthermia may result following resection of the pituitary tumor. When central fever is suspected taking note of past history, a quick recognition of course of fever can help reduce the using of unnecessary antibiotics and hospital stay.

요배부 수술 실패 증후군에서 자기공명영상의 이용

이준규,안재성,권순태,김환정,정제택 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

This study was compared pre-operative MRI finding with operative finding on 36 cases with the failed back surgery syndrome (FBSS) retrospectively. The purpose of this study was to determine the accuracy of the MRI on the FBSS including early complications such as hematoma of infection. Of the 51 patients with FBSS, we analyzed pre-operative MRI finding compared with operative finding on 36 cases excluding nonunion, instability, metal failure and pseudoarthrosis who underwent an operation for the FBSS from December 1994 to June 1997. There were 25 men (69.4%) and 11 women (30.6%), aged from 16 to 68 years (average 43.6 years). These were divided into 5 sub-groups and calculated sensitivity, specificity and positive predictability. MRI accuracy in recurred disc was 84%, scar adhesion, recurred or developed stenosis, infection and hematoma 100% each and all, overall accuracy of the MRI 93%, respectively. Average interval of re-operation in FBSS WAS 4.3 years. In the 18 cases (50%), symptoms persist without pain-free interval after first operation. Early complications including hematoma and infection are easily detected with MRI. Especially if patient complains of severe leg pain or neurologic deficit, it is a good diagnostic procedure to check the MRI. The MRI is a useful method for evaluation of most cases of the FBSS, but it has limitations to evaluate recurred disc or scar adhesion only in T1, T2 weighted image. Therefore Gd-DTPA enhancement is necessary for the accurate diagnosis.

생활규범의 자율적인 선택결정이 도덕적인 행위에 미치는 영향

박재규 釜山敎育大學 學生指導硏究所 1983 學生指導硏究 Vol.4 No.-

Abstract The subject of this study is concerned with the influence of self-determination of life rule on moral behavior. Hypothesis is that there would. be an meaningful influence on moral behavior if one selected for oneself life rule as the followings:1. In the environment of moral for individual, 1)Learners make rules for themselves in the way that they consult theachers 2)Learners make rules for themselves when theachers offer more than two opinions. 3)Learners make rules for themselves after they offer their opinions each other.2. In the environment of moral conflict among them, 1)Learners make rules in cooperation with them, 2)Learners aprange for themselves the conflict between two of them. As for reseach method, the subjects of this study are one chss(60 persons)in the second grade, one class (60 persons) in the third grade one class (60 persons) in the forth grade of a elementary school in Pusan. This research period is March, 1983 through October, 1983. As regards the condition control, the subjects werenot persuaded of reward and punishment during This research period.In the result and discussion, the research data showed p<0.05 for thesecond grade, p<0.01 for the thirdgrade and p<0.01 for the fourth grade in immoral behavior. So it is found that moral behavior is meaningful in change on the hypothesis above. Finally, it was concluded that the hypothesis in this study appears to be valid to change moral behavior for children meaningfully.