Girder의 강성을 고려한 복합 재료 교량 상판의 구조 거동

원치문,박제선,이정호,심도식 江原大學校 産業技術硏究所 1998 産業技術硏究 Vol.18 No.-

Many of the bidge and building floor systems, including the girders and cross-beams, also behave a similar special orthotropic plates. Such plates are subject to the concentrate masses in the form of traffic loads, or the test equipments such as the accelerator in addition to their own masses. Analysis of such problems is usually very difficult. Most of the bridge slabs on girders have large aspect ratios. Finite difference method is used for this purpose, in this paper. The reuslt is compared with that of the beam theory.

Pulmonary inflammation caused by silica dioxide nanoparticles in mice via TXNIP/NLRP3 signaling pathway

Je‑Oh Lim,Je‑Won Ko,Tae‑Yang Jung,Woong‑Il Kim,So‑Won Pak,In‑Sik Shin,Won‑Kee Yun,Hyoung‑Chin Kim,Jeong‑Doo Heo,Jong‑Choon Kim 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3

Background Silica dioxide nanoparticles (SiONPs) have been used for various medical applications, including therapeutics and imaging, and the use of SiONPs has increased gradually over the years. However, despite an increase in the use of SiONPs, not much is known about mechanism of action of SiONPs and their pulmonary toxicity. Objective The present study investigated the pulmonary toxicity of SiONPs and explored the underlying mechanism of action, primarily focusing on thioredoxin-interacting protein (TXNIP)/NOD-like receptor pyrin domain-containing 3 (NLRP3) in SiONPs-treated mice. We investigated the toxic effects of SiONPs in the lung of BALB/c mice administered 5, 10, and 20 mg/kg SiONPs for 3 days. Results Exposure to SiONPs markedly increased inflammatory cell counts, including those of neutrophils and macrophages, and levels of inflammatory mediators, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α in a dose-dependent manner in the bronchoalveolar lavage fluid. Moreover, the inflammation was verified upon histopathological analysis. In addition, exposure to SiONPs increased the expression of TXNIP in a dose-dependent manner and, in turn, upregulated NLRP3 inflammasome proteins, which subsequently induced IL-1β production. Conclusion Collectively, exposure to SiONPs induced inflammation in the lungs of mice, which resulted in the activation of IL-1β production via the TXNIP-NLRP3 axis. Our results provide useful information on the pulmonary toxicity induced by SiONPs and provide insights into the underlying mechanism of action.

鹿茸藥鍼이 骨形成에 미치는 影響

한상원,최제용,이윤호 대한침구학회 2001 대한침구의학회지 Vol.18 No.5

Objective : Bone homeostasis is maintained by balance of bone formation and resorption. Therefore, bone related diseases arose by disturbance of this balance between osteoblast and osteoclast activities. To develop a successful screening system of the therapeutic components based on oriental medicine is essential to set out systematic approach for that purpose. Methods : This study was perforated Sprague-Dawley rat femur for bony defects(φ 5㎜) by the fissure bur. And experimetal group were treated with Cervi Pantotricuhum Cornu injection at both She`nshu~(BL23) & Da`zhu`(BL11)(0.2㎖). This was evaluated by radiography and histological analysis with in situ hybridization. Results : Cervi Pantotricuhum Cornu Herbal Acupuncture has weak effect on bony defect healing and this was evaluated by X-ray taking and histological analysis with in situ hybridization. Osteocalcin gene expression was not changed by Cervi Pantotricuhum Cornu Herbal Acupuncture in bony defects animal model. Conclusion : Taken together this study show that the Cervi Pantotricuhum Cornu herbal-acupuncture has a weak effect healing of bony defects, this type of approach might give a good chance to explore the favorable effects of Cervi Pantotricuhum Cornu herbal-acupuncture on bone tissue.

시멘트 콘크리트의 건조수축균열 특성

박제선,윤경구,이주형,김태환,정원경 강원대학교 부설 석재복합신소재 제품연구센터 2000 석재연 논문집 Vol.5 No.-

콘크리트는 본질적으로 인장강고와 휨강도가 약하며 취성적 성질을 나타내는 결점을 가지고 있으므로 이를 보강할 목적으로 콘크리트에 섬유를 혼입한 섬유보강 콘크리트가 크게 각광받고 있다. 특히 폴리프로필렌 섬유보강은 모르타르 및 콘크리트가 건조나 동해에 의해 수축될 때 구속에 의해 발생되는 인장응력 및 균열을 제어하고 인성의 증가와 충격, 마모, 피로에 대한 저항성, 내구성을 증대시키는 장점을 가지는 것으로 보고 되고 있다. 1축으로 구속된 건조수축의 구속으로 인한 조강형 콘크리트의 잔류응력을 선형모델을 이용하여 예측할 수 있었고 조강형 콘크리트에 섬유보강으로 인한 건조수축 제어효과는 일반큰코리트에 비해 효과가 매우 큰 것으로 나타났다. 따라서 폴리크로필렌 섬유의 혼입으로 인해 콘크리트의 균열제어가 가능하며, 균열 폭이 큰 균열보다는 많은 미세 균열을 유도하는 것을 알 수 있었다. 섬유보강 조강형 큰크리트의 동결융해저항특성은 거의 동해의 손상을 받지 않으며 좋은 내구성을 유지하고 있는 것으로 나타났다. 이는 불규칙하게 배향된 섬유가 공극수의 이동을 효과적으로 제어함으로써 메트릭스 내의 팽창압으로 인한 파괴를 최대한 줄였기 때문이라고 보여진다. 표면손상과 박리저항에 매우 우수하며 저항성을 증진시키는 효과가 뛰어남을 확인할 수 있었다. 따라서, 내구적 측면의 유지, 보수에 있어서도 섬유보강은 그 효과가 큰 것으로 나타났다. To improve the brittle nature of concrete, discrete fibers can be adapted in concrete. Since polypropylene fiber has many advantages in many points on its chemical stability and good durability, its usages have been increased gradually. It has been reported than polypropylene fibers can not only control restrained tensional stresses and cracks, but also increase toughness, resistance to impact, corrosion, fatigue, and durability. Although the polypropylene fiber reinforced concretes with ordinary cement have been studied so much, those with very early strength concretes have not studied at all. Therefore, it is necessary to initiate and conduct the researches for the polypropylene fiber reinforced very early strength concretes which has enough workability and durability. This study of polypropylene fiber reinforced very early strength concrete focused on the investigation each material's effect into strength development with analysis of restrained shrinkage properties with one-dimensional concrete members. The results showed that more optimized mixture combinations could be selected in very early strength concrete by incorporating polypropylene fibers, keeping in same strength levels at urgent repair works. The formation of needle-shape ettringite helps the early strength development, specially at flexural and this enables the repaired concrete structures or pavements to be opened to traffic after 3 hours of concrete placement. A residual stress of early strength concrete caused by one-dimensional restrained drying shrinkage was predicted from linear model. the control of shrinkage crack by fiber reinforcement at early strength concrete was better than that of ordinary portland cement concrete because of bridging effect of fiber at early age and resulting of more hair cracks rather than fewer wider cracks. As a results, this dissertation clearly validated the fiber reinforcement on the strength development and durability of polypropylene fiber reinforced very early strength concrete, and characteristic of restrained shrinkage. The proposed optimized concrete mixtures might be satisfactory applied at the repair works in fields, because of its durability and crack control capacity against freeze-thaw and contraction at early age, respectively.

물라이트로 부터 용융 알루미늄의 치환 반응에 의한 Al₂O₃-Al 복합체의 제조

배원태,김용진,김승제 慶尙大學校生産技術硏究所 1996 生産技術硏究所論文集 Vol.12 No.-

Al₂O₃-Al composites were produced by displacement reaction method, which was carried out by immersing the mullite preform which was prepared by cutting and polishing the commercial sintered mullite in molten aluminum. The change of physical and mechanical properties such as bulk density, porosity, water absorption, 4-point MOR, hardness, fracture toughness of Al₂O₃-Al composites with the variation of the reaction temperature and time were investigated. Microstructure and the phases of this composite were also investigated by SEM and XRD analysis. A1₂O₃-Al composites which was produced at 1000℃ for 24 hours showed porosity of 2.07%, water absorption of 0.35%, bulk density of 3.43g/cm3, 4-point MOR of 287.97MPa, hardness of 593.6kg/mm2 and ?? of 8.64MPa·??. The microstructure of this composites showed three dimensionally co-continuous of alumina which provides wear resistance and high stiffness and aluminum which acts as a toughening phase. The exact shape of the preform is retained and a net-shaped A1₂O₃-Al composite was produced.

우심방과 우심실의 거대 심장 혈관종 1예

김제열,조상호,김건일,허경림,김현숙,조구영,최영진,이원용,임종윤 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Cardiac tumors, especially the primary tumors involving any part of the heart are extremely rare and its relative incidence has been reported to be approximately 0.02%. We report a patient with huge cardiac hemangioma who complained of shortness of breath, general weakness, and dizziness, Imaging study by echocardiography and computed tomography of thorax revealed a huge lobulating mass like a bunch of grapes in the right chamber of heart. The surgical exploration of thorax was performed and a histological diagnosis of spindle cell hemangioma was obtained by microscopy. The patient was treated by surgical resection of the tumor and doing well after surgery. Our experience indicated that prompt diagnosis and treatment of cardiac hemangioma is imperative for patients' prognosis.

수면주기 지연 증후군 1례

박원명,김제헌 大韓神經精神醫學會 1992 신경정신의학 Vol.31 No.1

Whereas insomnia (disorders of initiating and maintaining sleep) and hypersomnia(disorders of excessive somnolence) have been studied for many centuries, physicians only recently become aware of that the sleep-wake rhythm itself can also be disturbed. Indeed, at this time we can only dimly perceive the importance of circadian rhythm for healthful sleeping. Not only do our internal circadian rhythm have to be properly entrained to the 24-hour cycling of this planet, but it also seems crucial that an individual's usual bedtime hours be properly located within that individual's circadian rhythm. Delayed sleep phase syndrome is one of disorders of the sleep-wake schedule, which usually arises from mismatches between the patient's circadian rhythm and society's timetable. We experienced a case of salary man who developed delayed sleep phase syndrome for about one year. He had considerable difficulty in falling asleep at appropriated time in the night and increasing difficulty in awakening in the next morning. When not on a strict schedule(eg, weekends, holidays), he had a normal sleep pattern and after a sleep of normal length awaked spontaneously and felt refreshed. Polysomnographic recordings performed in our department for 3 consecutive nights demonstrated that he was noted only a delayed pattern of sleep and awaking time. There was no evidence of significant organic diseases except hepatitis type B. Past history revealed no previous psychiatric disorders and no family history of psychiatric disorders.

野冬靑果가 實驗的 糖尿에 미치는 影響에 관한 免疫組織化學的 硏究

柳濟原,李學仁,金蓮燮 대한본초학회 1999 大韓本草學會誌 Vol.14 No.1

This experiment was performed into investigate the effect of Syzygii cumini Fructrs on the diabetic rats induced by STZ. Experimental diabetes was induced by 55㎎/㎏ of STZ. injection and administered Syzygii cumini Fructrs extract during 14days after STZ injection. Glucagon and insulin granules in Langerhans islets were stained by use of immunohistochemical method and observed the relative amount of the each granules in Langerhans islet by light microscope and image analysis ststem. The results obtained are as follows: 1. Area % of insulin granules in Langerhans islets in Syzygii cumini Fructrs raised and showed the statistically significant difference with the control group at 14th day. 2. Area % of glucagon granules in Langerhans islets in Syzygii cumini Fructrs decreased and showed the statistically significant difference with the control group at 7th and 14th day. To conclude, it can be inferred that Syzygii cumini Fructrs has a control effect on glucagon and insulin granules in Langerhans islets of diabetic rats induced by STZ.

鹿茸藥鍼液의 DNA chip을 利用한 遺傳子 發顯 分析

한상원,서정철,이윤호,최제용 大韓鍼灸學會 2003 대한침구의학회지 Vol.20 No.3

Objective : Bone homeostasis is maintained by balance of bone formation and resorption. Therefore, bone related diseases arose by disturbance of this balance between osteoblast and osteoclast activities. To develop a successful screening system the therapeutic components based on oriental medicine is essential to set up systematic approach for that purpose. The purpose of this study is to the know the gene expression using cDNA microarray assay. Methods : Cervi Pantotricuhum Cornu Herbal-acupuncture extract was prepared by boiling. human osteosarcoma cells(HOS) were treated with Cervi Pantotricuhum Cornu Herbal-acupuncture solution. Then mRNA was extracted and cDNA microarray assay was performed. Results : Human osteosarcoma cells(HOS) treated with Cervi Pantotricuhum Cornu Herbal-acupuncture solution(500㎍/㎖) showed that thioredoxin, TAFII31 and two novel genes were increased. However many genes decreased their expression by Cervi Pantotricuhum Cornu Herbal-acupuncture. Conclusions : This type of approach will give a good chance to explore the favorable effects of Cervi Pantotricuhum Cornu Herbal-acupuncture. Futher study is needed for investigating the effect of Cervi Pantotricuhum Cornu Herbal-acupuncture.

한국인 젊은 여성의 심미적인 안면 연조직 형태에 관한 두부 X-선 계측학적 연구

우제경,성재현,권오원 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.2

본 연구에서는 대구에서 활동하고 있는 모델과 심미적인 안모를 가졌다고 추천받은 68명의 젊은 여성을 대상으로 하여 두부X-선 사진, 정모 사진과 측모 실루엣 사진을 채득하였다. 두부X-선 사진의 연조직 측모선만을 사용한 3명씩의 측모 실루엣을 FH plane이 평행하게 한 장에 그려서 제작한 사진을 경북대학교 미술학과 재학생 7명과 교정 전공의 15명에게 평가하게 하였으며 정모 사진을 교정 전공의만 평가하게 하였다. 아주 좋은 경우를 9점, 좋은 경우를 7점 보통인 경우를 5점, 좋지 않은 경우를 3점으로 처리토록 하였다. 측모 실루엣에서 교정 전공의와 미대생의 심미안간의 상관관계, 교정 전공의가 평가한 정모와 측모의 심미성간의 상관관계, 교정 전공의가 평가한 측모 실루엣의 평균 점수가 5점 이상인 38명의 측모 계측항목과 측모 심미성간의 상관관계를 분석하여 다음과 같은 결론을 얻었다. 1. 측모 실루엣에서 교정 전공의와 미대생의 심미안간의 상관관계는 유의성있게 나타났다(r=0.67, P=0.0001). 2. 교정 전공의가 평가한 정모와 측모의 심미성간의 상관관계는 유의성있게 나타났다(r=0.26, P=0.0381). 3. 측모 실루엣과 상관관계가 유의성있게 나타난 항목은 Na-Pog to N′, BNV to Pog′, BNV/B′-Pog′, Ls-Li-Pog′, Li-B′-Pog′, Z angle이었다.(P<0.05). 4. 측모 계측항목의 평균치 및 표준편차를 구하였다. Cephalometric radiographs, frontal photographs and profile silhiuette phogographs of 68 young adult female who were model or were recommended to have esthetic face were used in this study. 7 Students in department of Art of Kyungpook national university and 15 orthodontists estimated profile slides which were made of 3 profile silhouettes in parallel with FH plane. Profile silhouettes were made of soft tissue profile line of cephalometric radiograph. Only orthodontists estimated frontal photographs. Students and Orthodontists score 9 in excellent case, score 7 in good case, score 5 in average case, score 3 in poor case. Correlation analysis between orthodontists` esthetic concept and Artists` esthetic concept, between frontal view esthetics and profile view esthetics which estimated by orthotontists. between profile view esthetics and profile measurements which consisted of measurements of 38 female who were scored above 5 mean score in profile silhouette by orthodontists were done. And the finding in this study indicated the following 1. Correlation between orthodontists` esthetic concept and Artists` esthetic concept in profile silhouette was significant(r=0.67, P=0.0001). 2. Correlation between frontal view esthetics and profile view esthetics which estimated by orthodontist was significant(r=0.26, P=0.0381). 3. Measurements which had significant correlation between profile measurements and profile view esthetics were Na-Pog to N′, BNV to Pog′, BNV/B′-Pog′, Ls-Li-Pog′, Li-B′-Pog′and Z angle(P<0.05). 4. Mean and standard deviation of profile measurements of 38 female were obtained.