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RISS 인기검색어
- 검색키워드
- 저자 : Jayavanth (검색결과 3 건)
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MULTI-SHAPE ERYTHROCYTE IMAGING AND THEIR DEFORMABILITY ANALYSIS IN A MICROFLUIDIC ENVIRONMENT
Sanjay Jayavanth,Bock Choon Pak 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.5
In their long journey through the cardiovascular circuit, erythrocytes are coerced to shape transform and assume different shapes on account of varying flow conditions in different blood vessels. The present work was aimed to visualize these erythrocyte shape transformations by an invitro microcirculatory model, and assess multi-shape erythrocyte deformability. The model uses an in-house fabricated, inexpensive disposable micro flow channel to mimic certain invivo conditions and a fast frame video microscopic system for imaging the shape changes in erythrocytes. Results show the multi-shape transformation of erythrocyte christened as discoidal shape, the asymmetrically deformed ‘hat’ and ‘bullet-like’ shapes, and the axially deformed ‘slipper’ and ‘spindle-like’ shapes. Specific erythrocytes showed the shape transition and transformation while passing through the observed window. The obtained erythrocyte shapes very analyzed for deformability index using image processing techniques that varied significantly (p<0.001) for different shapes as compared with the resting shape.
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Multi-shape erythrocyte deformability analysis by imaging technique
Sanjay Jayavanth,이동환,박복춘 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.4
In their extensive circulation through the cardiovascular circuit, erythrocytes are forced to transform and assume different shapes depending on the varying flow conditions in different blood vessels. The present work aims to visualize various erythrocyte shape transformations by an in vitro microcirculatory model, and to visualize multi-shape erythrocyte deformability. The model used an in-house fabricated and inexpensive disposable micro flow channel to mimic certain in vivo conditions, and a fast frame rate video microscopic system to visualize the shape changes in erythrocytes. Results have shown the multi-shape transformation of erythrocytes as resting discoidal shape, asymmetrically deformed ‘hat’ and ‘bullet-like’ shapes, and axially deformed ‘slipper- and spindle-like’ shapes. Specific erythrocytes demonstrated shape transition and transformation while passing through the observed window. The obtained erythrocyte shaper were thoroughly analyzed based on the deformability index. Findings from the image processing techniques were significant (P<0.001) for the different shapes compared with the resting shape. The simple glass in-house fabricated microfludic channel allowed for multi-shape erythrocyte deformability characterization, many of which manifest in human circulation.
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Evidence for Erythrocyte Aggregational Pathology
Sanjay Jayavanth,Bock Choon Pak 한국유체기계학회 2006 유체기계 연구개발 발표회 논문집 Vol.- No.-
Erythrocyte aggregation is a physiological assemblage of red blood cells into neat stack like structure as though cells were placed one over / beside another like coins. Such stack of RBC interconnects to form three-dimensional networks often referred to as rouleaux in presence of plasma proteins aided by low flow. These neatly looking erythrocyte aggregates can turn into ugly, haphazard clump of cells under pathological conditions. Aggregational pathology can thus hamper blood flow, increase flow resistance and some times cause occlusion of blood vessels afflicting the microcirculatory rheology. This paper presents recent research report evidencing aggregational pathology in disease condition obtained through an in-vitro microhemofludic visualization system (μHVS). In a study conducted on normal and malaria infected subjects, erythrocyte aggregation showed irregular shapes and compactness aggregates when compared to the normal ones. Specific erythrocyte aggregates were rolling about themselves showing little or no deformation. While the aggregates of normal samples showed porous rouleaux network changing shape and orientation. Such deformation of rouleaux network was not seen among the clumped cells of parasitized samples. Erythrocytes were found adhering to each other and formed clumps tending toward agglutination. These results showed the extent to which microrheologic dysfunction could occur in severe cases of a specific disease.
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