http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jayamani, A.,Sengottuvelan, N.,Kang, S.K.,Kim, Y.I. Elsevier 2014 INORGANIC CHEMISTRY COMMUNICATIONS Vol.48 No.-
The mononuclear nickel(II) complexes (1-3) of ligands bappz [1,4-bis(3-aminomethyl)piperazine] and its Schiff bases L<SUP>1</SUP> with 5-methyl salicylaldehyde; and L<SUP>2</SUP> with 5-bromosalicylaldehyde have been synthesized and characterized. The single crystal X-ray study showed that the complex 1 crystallized in the orthorhombic Pbca space group with distorted square planar geometry. The ligands and their nickel(II) complexes presented good binding propensity to bovine serum albumin protein (BSA). The strong binding interaction of the prepared complexes with calf thymus DNA (CT-DNA) was confirmed by absorption, fluorescence, circular dichroism spectral analysis and molecular docking studies in the order as follows: 3>2>1. The Schiff bases and their Ni(II) complexes were also screened for antimicrobial activity. All the complexes exhibited higher antimicrobial activity than free ligands.
Jayamani, A.,Sengottuvelan, N.,Kang, S.K.,Kim, Y.I. Pergamon Press 2015 Polyhedron Vol.98 No.-
The copper(II) complexes [Cu(bpy)<SUB>2</SUB>(ClO<SUB>4</SUB>)](ClO<SUB>4</SUB>) (1), [Cu(bpy)<SUB>2</SUB>(Cl)](ClO<SUB>4</SUB>) (2), [Cu(bpy)<SUB>2</SUB>(CH<SUB>3</SUB>COO)](ClO<SUB>4</SUB>) (3), [Cu<SUB>2</SUB>(bpy)<SUB>2</SUB>(μ-OH)<SUB>2</SUB>(μ-ClO<SUB>4</SUB>)<SUB>2</SUB>] (4) and [Cu<SUB>2</SUB>(bpy)<SUB>2</SUB>(μ-OH)(μ-H<SUB>2</SUB>O)(μ-CH<SUB>3</SUB>COO)](ClO<SUB>4</SUB>)<SUB>2</SUB> (5) (where bpy=2,2'-bipyridine) have been synthesized and characterized by single crystal analysis, elemental analysis and spectroscopic methods. Complexes 2 and 4 crystallize in the monoclinic P2<SUB>1</SUB>/n and C2/m space groups respectively, and the other complexes crystallize in the triclinic P1@? space group. The molecular Hirshfeld surfaces and fingerprint plots of the complexes were investigated. Complexes 1-3 exhibit one quasi-reversible and complexes 4 and 5 exhibit two quasi-reversible redox cyclic voltammetric responses near the cathodic region in DMF. Binding studies of the complexes with BSA and ctDNA showed good binding affinity. Cleavage of pBR322 DNA by the complexes shows efficient oxidative cleavage in the presence of MPA through the formation of singlet oxygen. The complexes were also screened for their antimicrobial activities, which indicated that the complexes exhibit a zone of inhibition like that of standard drugs.
Jayamani, A.,Thamilarasan, V.,Sengottuvelan, N.,Manisankar, P.,Kang, S.K.,Kim, Y.I.,Ganesan, V. Pergamon 2014 Spectrochimica acta. Part A, Molecular and biomole Vol.122 No.-
The mononuclear copper(II) complexes (1&2) of ligands L<SUP>1</SUP> [N,N'-bis(2-hydroxy-5-methylbenzyl)-1,4-bis(3-iminopropyl)piperazine] or L<SUP>2</SUP> [N,N'-bis(2-hydroxy-5-bromobenzyl)-1,4-bis(3-iminopropyl) piperazine] have been synthesized and characterised. The single crystal X-ray study had shown that ligands L<SUP>1</SUP> and L<SUP>2</SUP> crystallize in a monoclinic crystal system with P2<SUB>1</SUB>/c space group. The mononuclear copper(II) complexes show one quasireversible cyclic voltammetric response near cathodic region (-0.77 to -0.85V) in DMF assignable to the Cu(II)/Cu(I) couple. Binding interaction of the complexes with calf thymus DNA (CT DNA) investigated by absorption studies and fluorescence spectral studies show good binding affinity to CT DNA, which imply both the copper(II) complexes can strongly interact with DNA efficiently. The copper(II) complexes showed efficient oxidative cleavage of plasmid pBR322 DNA in the presence of 3-mercaptopropionic acid as reducing agent through a mechanistic pathway involving formation of singlet oxygen as the reactive species. The Schiff bases and their Cu(II) complexes have been screened for antibacterial activities which indicates that the complexes exhibited higher antimicrobial activity than the free ligands.
Jayamani, Arumugam,Thamilarasan, Vijayan,Ganesan, Venketasan,Sengottuvelan, Nallathambi Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.12
A nickel(II) complex $[Ni(H_2biim)_2(H_2O)_2](ClO_4)_2{\cdot}H_2O$ (1) of biimidazole ligand has been synthesized and characterized (Where $H_2biim$ = 2,2'-biimidazole). The single crystal X-ray diffraction of the complex shows a dimeric structure with six coordinated psudo-octahedral geometry. The cyclic voltammograms of complex exhibited one quasireversible reduction wave ($E_{pc}=-0.61V$) and an irreversible oxidation wave ($E_{pa}=1.28V$) in DMF solution. The interaction of the complex with Calf-Thymus DNA (CT-DNA) has been investigated by absorption and fluorescence spectroscopy. The complex is an avid DNA binder with a binding constant value of $1.03{\times}10^5M^{-1}$. The results suggest that the nickel(II) complex bind to CT-DNA via intercalative mode and can quench the fluorescence intensity of EB bind to CT-DNA with $K_{app}$ value of $3.2{\times}10^5M^{-1}$. The complex also shown efficient oxidative cleavage of supercoiled pBR322 DNA in the presence of hydrogen peroxide as oxidizing agent. The DNA cleavage by complex in presence of quenchers; viz. DMSO, KI, $NaN_3$ and EDTA reveals that hydroxyl radical or singlet oxygen mechanism is involved. The complex showed invitro antimicrobial activity against four bacteria and two fungi. The antimicrobial activity was nearer to that of standard drugs and greater than that of the free ligand.
Arumugam Jayamani,Vijayan Thamilarasan,Venketasan Ganesan,Nallathambi Sengottuvelan 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.12
A nickel(II) complex [Ni(H2biim)2(H2O)2](ClO4)2·H2O (1) of biimidazole ligand has been synthesized and characterized (Where H2biim = 2,2'-biimidazole). The single crystal X-ray diffraction of the complex shows a dimeric structure with six coordinated psudo-octahedral geometry. The cyclic voltammograms of complex exhibited one quasireversible reduction wave (Epc = −0.61 V) and an irreversible oxidation wave (Epa = 1.28 V) in DMF solution. The interaction of the complex with Calf-Thymus DNA (CT-DNA) has been investigated by absorption and fluorescence spectroscopy. The complex is an avid DNA binder with a binding constant value of 1.03 × 105 M−1. The results suggest that the nickel(II) complex bind to CT-DNA via intercalative mode and can quench the fluorescence intensity of EB bind to CT-DNA with Kapp value of 3.2 × 105 M−1. The complex also shown efficient oxidative cleavage of supercoiled pBR322 DNA in the presence of hydrogen peroxide as oxidizing agent. The DNA cleavage by complex in presence of quenchers; viz. DMSO, KI, NaN3 and EDTA reveals that hydroxyl radical or singlet oxygen mechanism is involved. The complex showed invitro antimicrobial activity against four bacteria and two fungi. The antimicrobial activity was nearer to that of standard drugs and greater than that of the free ligand.
Thamilarasan Vijayan,Arumugam Jayamani,Mani Pugazhenthi,Azam Nasirian,Jinheung Kim,Gopinath Kasi 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.11
Tridentate NNO donor Schiff base ligand and its mixed ligand zinc(II) complexwere synthesized stoichiometrically and characterized by electronic, infrared,mass spectral techniques and elemental analysis. To understand the DNA bindingability, the complex was investigated by various analytical and spectroscopictechniques in presence of calf thymus DNA (CT-DNA). The bindingstudies showed that the zinc complex interacts with DNA by groove bindingmode with intrinsic binding strength of 2.11 105 M1 and with bovine serumalbumin the complex showed dynamic quenching attributed for changes inthe secondary structure of BSA with efficient interaction. The MCF-7 cell linestudies of the zinc(II) complex with 90.8 μM IC50 value revealed that the complexis effective for the breast cancer cell line and has a potential as anticancerdrug. Furthermore, the tridentate ligand and its mixed ligand zinc complexwere screened for antibacterial and antifungal activities, which showed betterantimicrobial activity for complex.
Pathophysiology and Grading of the Ventral Displacement of Dorsal Spinal Cord Spectrum
Amarnath Chellathurai,Suhasini Balasubramaniam,Sathyan Gnanasihamani,Sukumar Ramasamy,Jayamani Durairajan 대한척추외과학회 2018 Asian Spine Journal Vol.12 No.2
Study Design: A retrospective study of the ventral displacement of dorsal spinal cord (VDDSC) spectrum pathophysiology and grading. Purpose: This study aimed at examining the pathophysiology of VDDSC between D3 and D7, using magnetic resonance imaging (MRI) correlation and severity grading. Overview of Literature: The pathologies that lead to VDDSC were previously discussed in various articles. We attempted to group these pathological conditions under a single spectrum, and grade them according to their severity. Methods: We reviewed the MRI images of the dorsal spines of 1,350 patients over a period of 4 years (February 2013–February 2017); all MRI images were analyzed by two experienced radiologists. Results: Of the 1,350 patients, 28 exhibited VDDSC between D3 and D7. Additional findings included ventral transdural herniation of the spinal cord (n=10), anterior spinal cord adhesion (n=7), arachnoid web (n=6), and arachnoid cyst (n=5). Conclusions: We grouped the pathologies that lead to VDDSC at the thoracic level into a single spectrum of varying severity and graded VDDSC, from mild to severe.
Variation of optimization techniques for high dose rate brachytherapy in cervical cancer treatment
Ahmad Naqiuddin Azahari,Ahmad Tirmizi Ghani,Reduan Abdullah,Jayapramila Jayamani,Gokula Kumar Appalanaido,Jasmin Jalil,Mohd Zahri Abdul Aziz 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.4
High dose rate (HDR) brachytherapy treatment planning usually involves optimization methods todeliver uniform dose to the target volume and minimize dose to the healthy tissues. Four optimizationswere used to evaluate the high-risk clinical target volume (HRCTV) coverage and organ at risk (OAR). Dose-volume histogram (DVH) and dosimetric parameters were analyzed and evaluated. Better coveragewas achieved with PGO (mean CI ¼ 0.95), but there were no significant mean CI differences than GrO(p ¼ 0.03322). Mean EQD2 doses to HRCTV (D90) were also superior for PGO with no significant meanEQD2 doses than GrO (p ¼ 0.9410). The mean EQD2 doses to bladder, rectum, and sigmoid weresignificantly higher for NO plan than PO, GrO, and PGO. PO significantly reduced the mean EQD2 doses tobladder, rectum, and sigmoid but compromising the conformity index to HRCTV. PGO was superior inconformity index (CI) and mean EQD2 doses to HRCTV compared with the GrO plan but not statisticallysignificant. The mean EQD2 doses to the rectum by PGO plan slightly exceeded the limit from ABSrecommendation (mean EQD2 dose ¼ 78.08 Gy EQD2). However, PGO can shorten the treatment planningprocess without compromising the CI and keeping the OARs dose below the tolerance limit.