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      • KCI등재

        A Cluster-Based Relay Station Deployment Scheme for Multi-Hop Relay Networks

        Jau-Yang Chang,Yun-Wei Chen 한국통신학회 2015 Journal of communications and networks Vol.17 No.1

        Multi-hop relay networks have been widely considered as a promising solution to extend the coverage area and to reduce the deployment cost by deploying the relay stations (RSs) in mobile communication systems. Suitable deployment for the RSs is one of the most important features of the demand nodes (DNs) to obtain a high data transmission rate in such systems. Considering a tradeoff among the network throughput, the deployment budget, and the overall coverage of the systems, efficient RS deployment schemes and corresponding algorithms must be developed and designed. A novel cluster-based RS deployment scheme is proposed in this paper to select the appropriate deployment locations for the relay stations from the candidate positions. To make an ideal cluster distribution, the distances between the DNs are calculated when deploying the RSs. We take into account the traffic demands and adopt a uniform cluster concept to reduce the data transmission distances of the DNs. On the basis of the different candidate positions, the proposed scheme makes an adaptive decision for selecting the deployment sites of the RSs. A better network throughput and coverage ratio can be obtained by balancing the network load among the clusters. Simulation results show that the proposed scheme outperforms the previously known schemes in terms of the network throughput and the coverage ratio. Additionally, a suitable deployment budget can be implemented in multi-hop relay networks.

      • KCI등재

        Dynamically Alternating Power Saving Scheme for IEEE 802.16e Mobile BroadbandWireless Access Systems

        Jau-Yang Chang,Yu-Chen Lin 한국통신학회 2012 Journal of communications and networks Vol.14 No.2

        Power saving is one of the most important features that extends the lifetime of portable devices in mobile wireless networks. The IEEE 802.16e mobile broadband wireless access system adopts a power saving mechanism with a binary truncated exponent algorithm for determining sleep intervals. When using this standard power saving scheme, there is often a delay before data packets are received at the mobile subscriber station (MSS). In order to extend the lifetime of aMSS, the battery energy must be used efficiently. This paper presents a dynamically alternating sleep interval scheduling algorithm as a solution to deal with the power consumption problem.We take into account different traffic classes and schedule a proper sequence of power saving classes. The window size of the sleep interval is calculated dynamically according to the packet arrival rate. We make a tradeoff between the power consumption and packet delay. The method achieves the goal of efficiently reducing the listening window size, which leads to increased power saving. The performance of our proposed scheme is compared to that of the standard power saving scheme. Simulation results demonstrate the superior performance of our power saving scheme and its ability to strike the appropriate performance balance between power saving and packet delay for aMSS in an IEEE 802.16e mobile broadband wireless access system.

      • SCIESCOPUSKCI등재

        Dynamically Alternating Power Saving Scheme for IEEE 802.16e Mobile Broadband Wireless Access Systems

        Chang, Jau-Yang,Lin, Yu-Chen The Korea Institute of Information and Commucation 2012 Journal of communications and networks Vol.14 No.2

        Power saving is one of the most important features that extends the lifetime of portable devices in mobile wireless networks. The IEEE 802.16e mobile broadband wireless access system adopts a power saving mechanism with a binary truncated exponent algorithm for determining sleep intervals. When using this standard power saving scheme, there is often a delay before data packets are received at the mobile subscriber station (MSS). In order to extend the lifetime of a MSS, the battery energy must be used efficiently. This paper presents a dynamically alternating sleep interval scheduling algorithm as a solution to deal with the power consumption problem. We take into account different traffic classes and schedule a proper sequence of power saving classes. The window size of the sleep interval is calculated dynamically according to the packet arrival rate. We make a tradeoff between the power consumption and packet delay. The method achieves the goal of efficiently reducing the listening window size, which leads to increased power saving. The performance of our proposed scheme is compared to that of the standard power saving scheme. Simulation results demonstrate the superior performance of our power saving scheme and its ability to strike the appropriate performance balance between power saving and packet delay for a MSS in an IEEE 802.16e mobile broadband wireless access system.

      • KCI등재

        Enhanced Phase Relaxation in a Hybrid Ferromagnet/Semiconductor System

        Kuang Yao Chen,Chun-Kai Yang,N. Aoki,Y. Ochiai,Y. Ujiie,K. A. Cheng,Li-Hung Lin,C. F. Huang,Yu-Ru Li,Yen Shung Tseng,Po-Tsun Lin,Jau-Yang Wu,Sheng-Di Lin,C.-T. Liang 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.1

        Hybrid ferromagnet/semiconductor systems have been the focus of considerable attention because of the transport properties of two-dimensional electron systems and their potential applications to magnetic storage and sensing devices. We use the weak localization effect to probe the dephasing mechanism at low temperatures. In our study, the zero-temperature phase-relaxation rate can be enhanced in a hybrid ferromagnet/semiconductor system, which may be due to the inhomogeneous magnetic field emanating from the Ni film. The result may improve understanding of the issue of zero-temperature dephasing in disordered systems. Hybrid ferromagnet/semiconductor systems have been the focus of considerable attention because of the transport properties of two-dimensional electron systems and their potential applications to magnetic storage and sensing devices. We use the weak localization effect to probe the dephasing mechanism at low temperatures. In our study, the zero-temperature phase-relaxation rate can be enhanced in a hybrid ferromagnet/semiconductor system, which may be due to the inhomogeneous magnetic field emanating from the Ni film. The result may improve understanding of the issue of zero-temperature dephasing in disordered systems.

      • A pivotal role of matrix metalloproteinase‐3 activity in dopaminergic neuronal degeneration via microglial activation

        Kim, Yoon Seong,Choi, Dong Hee,Block, Michelle L.,Lorenzl, Stefan,Yang, Lichuan,Kim, Youn Jung,Sugama, Shuei,Cho, Byung Pil,Hwang, Onyou,Browne, Susan E.,Kim, Soo Yul,Hong, Jau,Shyong,Flint Bea Federation of American Society for Experimental Bi 2007 The FASEB Journal Vol.21 No.1

        <P>Recent studies have demonstrated that activated microglia play an important role in dopamine (DA) neuronal degeneration in Parkinson disease (PD) by generating NADPH-oxidase (NADPHO)-derived superoxide. However, the molecular mechanisms that underlie microglial activation in DA cell death are still disputed. We report here that matrix metalloproteinase-3 (MMP-3) was newly induced and activated in stressed DA cells, and the active form of MMP-3 (actMMP-3) was released into the medium. The released actMMP-3, as well as catalytically active recombinant MMP-3 (cMMP-3) led to microglial activation and superoxide generation in microglia and enhanced DA cell death. cMMP-3 caused DA cell death in mesencephalic neuron-glia mixed culture of wild-type (WT) mice, but this was attenuated in the culture of NADPHO subunit null mice (gp91(phox-/-)), suggesting that NADPHO mediated the cMMP-3-induced microglial production of superoxide and DA cell death. Furthermore, in the N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-injected animal model of PD, nigrostriatal DA neuronal degeneration, microglial activation, and superoxide generation were largely attenuated in MMP-3-/- mice. These results indicate that actMMP-3 released from stressed DA neurons is responsible for microglial activation and generation of NADPHO-derived superoxide and eventually enhances nigrostriatal DA neuronal degeneration. Our results could lead to a novel therapeutic approach to PD.</P>

      • KCI등재

        Probing Insulator-quantum Hall Transitions by Current Heating

        Kuang Yao Chen,N. Aoki,Y. Ochiai,K. A. Cheng,Li-Hung Lin,C. F. Huang,Yu-Ru Li,Yen Shung Tseng,Chun-Kai Yang,Po-Tsun Lin,Jau-Yang Wu,Sheng-Di Lin,C.-T. Liang 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.1

        We report a magneto-transport study on the two-dimensional electron system (2DES) in an Al- GaAs/GaAs heterostructure. The direct insulator to quantum Hall conductor transition is observed at low temperatures by increasing the magnetic field B perpendicular to the 2DES. We can also observe the transition by varying the current I and find a relation Te~Ia between electron effective temperature Te and current. Here, a denotes the exponent for the power law. The exponent a, however, can have different values on the two sides of the transition point, which indicates different inelastic scattering mechanisms in the low-field insulator and in the quantum Hall conductor. We report a magneto-transport study on the two-dimensional electron system (2DES) in an Al- GaAs/GaAs heterostructure. The direct insulator to quantum Hall conductor transition is observed at low temperatures by increasing the magnetic field B perpendicular to the 2DES. We can also observe the transition by varying the current I and find a relation Te~Ia between electron effective temperature Te and current. Here, a denotes the exponent for the power law. The exponent a, however, can have different values on the two sides of the transition point, which indicates different inelastic scattering mechanisms in the low-field insulator and in the quantum Hall conductor.

      • KCI등재

        Dextromethorphan Protect the Valproic Acid Induced Downregulation of Neutrophils in Patients with Bipolar Disorder

        Ru-Band Lu,Yun-Hsuan Chang,Sheng-Yu Lee,Tzu-Yun Wang,Shu-Li Cheng,Po See Chen,Yen Kuang Yang,Jau-Shyong Hong,Shiou-Lan Chen 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.1

        Objective: Valproic acid (VPA) is an anticonvulsant and commonly long term used as a mood stabilizer for patients with mood disorders. However its chronic effects on the hematological changes were noticed and need to be further evaluated. In this study, we evaluated, in Taiwanese Han Chinese patients with bipolar disorders (BD), the chronic effects of VPA or VPA plus dextromethorphan (DM) on the hematological molecules (white blood cell [WBCs], red blood cells [RBCs], hemoglobin, hematocrit, and platelets). Methods: In a 12-week, randomized, double-blind study, we randomly assigned BD patients to one of three groups: VPA plus either placebo (VPA+P, n = 57) or DM (30 mg/day, VPA+DM30, n = 56) or 60 mg/day (VPA+DM60, n = 53). The Young Mania Rating Scale and Hamilton Depression Rating Scale were used to evaluate symptom severity, and the hematological molecules were checked. Results: Paired t test showed that the WBC, neutrophils, platelets and RBCs were significantly lowered after 12 weeks of VPA+P or VPA+DM30 treatment. VPA+DM60 represented the protective effects in the WBCs, neutrophils, and RBCs but not in the platelets. We further calculated the changes of each hematological molecules after 12 weeks treatment. We found that combination use of DM60 significantly improved the decline in neutrophils induced by the long-term VPA treatment. Conclusion: Hematological molecule levels were lower after long-term treatment with VPA. VPA+DM60, which yielded the protective effect in hematological change, especially in the neutrophil counts. Thus, DM might be adjunct therapy for maintaining hematological molecules in VPA treatment.

      • KCI등재

        ALDH2 Gene: Its Effects on the Neuropsychological Functions in Patients with Opioid Use Disorder Undergoing Methadone Maintenance Treatment

        Po-Wei Lee,Tzu-Yun Wang,Yun-Hsuan Chang,Sheng-Yu Lee,Shiou-Lan Chen,Ze-Cheng Wang,Po See Chen,Chun-Hsien Chu,San-Yuan Huang,Nian-Sheng Tzeng,I Hui Lee,Kao Chin Chen,Yen Kuang Yang,Jau-Shyong Hong,Ru-B 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.1

        Objective: Patients with opioid use disorder (OUD) have impaired attention, inhibition control, and memory function. The aldehyde dehydrogenase 2 (ALDH2 ) gene has been associated with OUD and ALDH2 gene polymorphisms may affect aldehyde metabolism and cognitive function in other substance use disorder. Therefore, we aimed to investigate whether ALDH2 genotypes have significant effects on neuropsychological functions in OUD patients undergoing methadone maintenance therapy (MMT). Methods: OUD patients undergoing MMT were investigated and followed-up for 12 weeks. ALDH2 gene polymorphisms were genotyped. Connors’ Continuous Performance Test (CPT) and the Wechsler Memory Scale-Revised (WMS-R) were administered at baseline and after 12 weeks of MMT. Multivariate linear regressions and generalized estimating equations (GEEs) were used to examine the correlation between the ALDH2 genotypes and performance on the CPTs and WMS-R. Results: We enrolled 86 patients at baseline; 61 patients completed the end-of-study assessments. The GEE analysis showed that, after the 12 weeks of MMT, OUD patients with the ALDH2 *1/*2+*2/*2 (ALDH2 inactive) genotypes had significantly higher commission error T-scores (p = 0.03), significantly lower hit reaction time T-scores (p = 0.04), and significantly lower WMS-R visual memory index scores (p = 0.03) than did patients with the ALDH2 1 */*1 (ALDH2 active) genotype. Conclusion: OUD patients with the ALDH2 inactive genotypes performed worse in cognitive domains of attention, impulse control, and memory than did those with the ALDH2 active genotype. We conclude that the ALDH2 gene is important in OUD and is associated with neuropsychological performance after MMT.

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