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Biosensors and their Applications in Food Safety: A Review
Jannat Yasmin,Mohammed Raju Ahmed,조병관 한국농업기계학회 2016 바이오시스템공학 Vol.41 No.3
Background: Foodborne pathogens are a growing concern with respect to human illnesses and death. There is an increasing demand for improvements in global food safety. However, it is a challenge to detect and identify these harmful organisms in a rapid, responsive, suitable, and effective way. Results: Rapid developments in biosensor designs have contributed to the detection of foodborne pathogens and other microorganisms. Biosensors can automate this process and have the potential to enable fast analyses that are cost and time-effective. Various biosensor techniques are available that can identify foodborne pathogens and other health hazards. Conclusions: In this review, biosensor technology is briefly discussed, followed by a summary of foodborne pathogen detection using various transduction systems that exhibit specificity for particular foodborne pathogens. In addition, the recent application of biosensor technology to detect pesticides and heavy metals is briefly addressed.
Jannat, Susoma,Ali, Md Yousof,Kim, Hyeung-Rak,Jung, Hyun Ah,Choi, Jae Sue The Korean Society of Food Science and Nutrition 2016 Preventive Nutrition and Food Science Vol.21 No.3
The aim of this study was to investigate the protective effects of juice powders from sweet orange [Citrus sinensis (L.) Osbeck], unshiu mikan (Citrus unshiu Marcow), and mini tomato (Solanum lycopersicum L.), and their major flavonoids, hesperidin, narirutin, and rutin in tert-butyl hydroperoxide (t-BHP)-induced oxidative stress in HepG2 cells. The increased reactive oxygen species and decreased glutathione levels observed in t-BHP-treated HepG2 cells were ameliorated by pretreatment with juice powders, indicating that the hepatoprotective effects of juice powders and their major flavonoids are mediated by induction of cellular defense against oxidative stress. Moreover, pretreatment with juice powders up-regulated phase-II genes such as heme oxygenase-1 (HO-1), thereby preventing cellular damage and the resultant increase in HO-1 expression. The high-performance liquid chromatography profiles of the juice powders confirmed that hesperidin, narirutin, and rutin were the key flavonoids present. Our results suggest that these fruit juice powders and their major flavonoids provide a significant cytoprotective effect against oxidative stress, which is most likely due to the flavonoid-related bioactive compounds present, leading to the normal redox status of cells. Therefore, these fruit juice powders could be advantageous as bioactive sources for the prevention of oxidative injury in hepatoma cells.
Comparison of Analysis Methods for Vigor of Naturally Aged Pepper Seeds using FT-NIR Spectroscopy
( Jannat Yasmin ),( Mohammed Raju Ahmed ),( Collins Wakholi ),( Santosh Lohumi ),( Byoung-kwan Cho ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Physiological and biochemical deterioration of naturally aged seed is very common as enzymatic activity is changed over time. Seed vigor is also reduced due to this degradation. The main purpose of this study was to investigate the discrimination between viable and non-viable naturally aged pepper seeds. In this study, Fourier transform near-infrared (FT-NIR) spectroscopy was used for spectral data acquisition in the spectral range of 4000-10000 cm<sup>-1</sup> at the interval of 4 cm<sup>-1</sup> spectral resolution with total 32 successful scans. After applying different preprocessing methods, spectral angle mapper (SAM) technique was employed as a blind source separation (BSS) tool. This technique investigated the spectral difference between a viable and non-viable seed. Afterwards, the partial least square discriminant analysis (PLS-DA) model was developed using multivariate data analysis. All the samples were set to a germination test to identify the viable and non-viable seed and the result was used to make calibration and validation data set. The PLS-DA model provided a good result with performance accuracy of 91% for calibration and 85% for prediction. The SAM technique and the beta coefficient derived from PLS-DA showed some spectral difference between viable and non-viable seeds that might be a reason to vary the germination ability of the seed. The results demonstrate the possibility of using the FT-NIR spectroscopic technique with chemometrics to separate seeds based on their viability, which is very important in the seed industry.
Biosensors and their Applications in Food Safety: A Review
( Jannat Yasmin ),( Mohammed Raju Ahmed ),( Byoung-kwan Cho ) 한국농업기계학회 2016 바이오시스템공학 Vol.41 No.4
Foodborne pathogens are a growing concern with respect to human illnesses and death. There is an increasing demand for improvements in global food safety. However, it is a challenge to detect and identify these harmful organisms in a rapid, responsive, suitable, and effective way. Results: Rapid developments in biosensor designs have contributed to the detection of foodborne pathogens and other microorganisms. Biosensors can automate this process and have the potential to enable fast analyses that are cost and time-effective. Various biosensor techniques are available that can identify foodborne pathogens and other health hazards. Conclusions: In this review, biosensor technology is briefly discussed, followed by a summary of foodborne pathogen detection using various transduction systems that exhibit specificity for particular foodborne pathogens. In addition, the recent application of biosensor technology to detect pesticides and heavy metals is briefly addressed.
Susoma Jannat,Anand Balupuri,Md Yousof Ali,홍승수,최천환,최윤혁,구진모,김우정,임재윤,김주은,Abinash Chandra Shrestha,함하늘,이기호,김동민,강남숙,박길홍 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
We extracted 15 pterosin derivatives from Pteridium aquilinum that inhibited β-site amyloid precursor protein cleaving enzyme 1 (BACE1) and cholinesterases involved in the pathogenesis of Alzheimer’s disease (AD). (2R)-Pterosin B inhibited BACE1, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with an IC50 of 29.6, 16.2 and 48.1 μM, respectively. The Ki values and binding energies (kcal/mol) between pterosins and BACE1, AChE, and BChE corresponded to the respective IC50 values. (2R)-Pterosin B was a noncompetitive inhibitor against human BACE1 and BChE as well as a mixed-type inhibitor against AChE, binding to the active sites of the corresponding enzymes. Molecular docking simulation of mixed-type and noncompetitive inhibitors for BACE1, AChE, and BChE indicated novel binding site-directed inhibition of the enzymes by pterosins and the structure−activity relationship. (2R)-Pterosin B exhibited a strong BBB permeability with an effective permeability (Pe) of 60.3×10−6 cm/s on PAMPA-BBB. (2R)- Pterosin B and (2R,3 R)-pteroside C significantly decreased the secretion of Aβ peptides from neuroblastoma cells that overexpressed human β-amyloid precursor protein at 500 μM. Conclusively, our study suggested that several pterosins are potential scaffolds for multitarget-directed ligands (MTDLs) for AD therapeutics.
Nonplanar Ion-acoustic Shock Waves in a Multi-ion Plasma with Nonextensive Electrons and Positrons
N. Jannat,M. Ferdousi,A. A. Mamun 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.67 No.3
The basic features of ion-acoustic shock waves (IASHWs) in a multi-ion nonextensive plasma (containing positive light ions, negative heavy ions, as well as nonextensive electrons and positrons) have been rigorously investigated in a nonplanar geometry. The standard reductive perturbation method has been employed to derive the Modified Burgers (MB) equation. The combined effects of the electron and positron nonextensivity, and the ion kinematic viscosity significantly have been found to modify the basic properties of these electrostatic shock structures. The properties of the cylindrical and the spherical IASHWs are observed to differ significantly from those of onedimensional planar waves. The findings obtained from this theoretical investigation may be useful in understanding the characteristics of IASHWs both in space and laboratory plasmas.
Biosensors and their Applications in Food Safety: A Review
Yasmin, Jannat,Ahmed, Mohammed Raju,Cho, Byoung-Kwan Korean Society for Agricultural Machinery 2016 바이오시스템공학 Vol.41 No.3
Background: Foodborne pathogens are a growing concern with respect to human illnesses and death. There is an increasing demand for improvements in global food safety. However, it is a challenge to detect and identify these harmful organisms in a rapid, responsive, suitable, and effective way. Results: Rapid developments in biosensor designs have contributed to the detection of foodborne pathogens and other microorganisms. Biosensors can automate this process and have the potential to enable fast analyses that are cost and time-effective. Various biosensor techniques are available that can identify foodborne pathogens and other health hazards. Conclusions: In this review, biosensor technology is briefly discussed, followed by a summary of foodborne pathogen detection using various transduction systems that exhibit specificity for particular foodborne pathogens. In addition, the recent application of biosensor technology to detect pesticides and heavy metals is briefly addressed.