Everolimus-Eluting Stent Implantation for Unprotected Left Main Coronary Artery Stenosis

PRECOMBAT-2 Investigators,Kim, Y.H.,Park, D.W.,Ahn, J.M.,Yun, S.C.,Song, H.G.,Lee, J.Y.,Kim, W.J.,Kang, S.J.,Lee, S.W.,Lee, C.W.,Park, S.W.,Jang, Y.,Jeong, M.H.,Kim, H.S.,Hur, S.H.,Rha, S.W.,Lim, D.S. Elsevier 2012 JACC. Cardiovascular interventions Vol.5 No.7

Objectives: This study sought to evaluate the safety and efficacy of second-generation drug-eluting stents (DES) for patients with unprotected left main coronary artery (ULMCA) stenosis. Background: The clinical benefit of second-generation DES for ULMCA stenosis has not been determined. Methods: The authors assessed 334 consecutive patients who received everolimus-eluting stents (EES) for ULMCA stenosis between 2009 and 2010. The 18-month incidence rates of major adverse cardiac or cerebrovascular events (MACCE), including death, myocardial infarction (MI), stroke, or ischemia-driven target vessel revascularization (TVR), were compared with those of a randomized study comparing patients who received sirolimus-eluting stents (SES) (n = 327) or coronary artery bypass grafts (CABG) (n = 272). Results: EES (8.9%) showed a comparable incidence of MACCE as SES (10.8%; adjusted hazard ratio [aHR] of EES: 0.84; 95% confidence interval [CI]: 0.51 to 1.40; p = 0.51) and CABG (6.7%, aHR of EES: 1.40; 95% CI: 0.78 to 2.54; p = 0.26). The composite incidence of death, MI, or stroke also did not differ among patients receiving EES (3.3%), SES (3.7%; aHR of EES: 0.63; 95% CI: 0.27 to 1.47; p = 0.29), and CABG (4.8%; aHR of EES: 0.67; 95% CI: 0.29 to 1.54; p = 0.34). However, the incidence of ischemia-driven TVR in the EES group (6.5%) was higher than in the CABG group (2.6%, aHR of EES: 2.77; 95% CI: 1.17 to 6.58; p = 0.02), but comparable to SES (8.2%, aHR of EES: 1.14; 95% CI: 0.64 to 2.06; p = 0.65). Angiographic restenosis rates were similar in the SES and EES groups (13.8% vs. 9.2%, p = 0.16). Conclusions: Second-generation EES had a similar 18-month risk of MACCE for ULMCA stenosis as first-generation SES or CABG. (Evaluation of Outcomes of EES Implantation for Unprotected Left Main Coronary Artery Stenosis [PRECOMBAT-2]; NCT01348022)

Radiological Characteristics of the Havar Foil in the Cyclotron Target

Dong gun Jang,Sang hwa Shin,Chang lak Kim,Gyeong hyeon Gwak2 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2

The cyclotron is an apparatus used for the production of radioactive isotopes through nuclear reactions, resulting in the inevitable emission of neutrons. Consequently, surrounding components become activated. The purpose of this study was to investigate the radiological characteristics of Havar foil, a periodic replacement part of the Targetry system. In this study, radioactivity and radiation dose were calculated based on the time of Havar foil replacement and equipment dismantling. The time to dismantle the equipment was set at one year after the equipment was shut down, based on the recently used 1g of Havar foil. All simulations were performed using the FLUKA program. First, in the simulation results, 11 elements (Re, W, Tc, Nb, Cu, Ni, Co, Fe, Mn, Cr, V) were converted into 36 radioisotopes by activation based on the replacement period. Based on radioactivity levels, major isotopes included 52Mn (77.63%), 56Co (13.36%), 96Tc (2.4%), and 95Tc (1.80%). Based on radiation dose rates, 52Mn (82.66%) and 56Co (13.45%) exhibited the highest levels. Furthermore, the dose rates at distances of 10 cm, 50 cm, and 100 cm were found to be 1.36E+1 mSv/hr, 2.24E+00 mSv/hr, and 8.80E-01 mSv/hr, respectively. Second, as of the time the equipment was dismantled, 20 radioactive isotopes of 10 elements, excluding short-lived nuclides, were generated. In terms of radioactivity, 56Co (45.83%), 55Fe (19.73%), 57Co (14.48%), and 54Mn (13.50%) were prominent. Regarding radiation dose rates, 56Co (92%) and 54Mn (7.32%) exhibited higher levels. Dose rates at distances of 10 cm, 50 cm, and 100 cm were calculated at 5.31E-01 mSv/hr, 8.80E-02 mSv/hr, and 3.47 E-02 mSv/hr, respectively. Third, according to the radioactive waste classification standards in the replacement and decommissioning stages, Havar foil was predicted to be low-level radioactive waste in terms of radioactivity. In addition, it was derived that a cooling period of approximately 12 years is necessary to satisfy the allowable dose for clearance level waste. In conclusion, Havar foil, which is periodically generated as radioactive waste, can cause radiation exposure to replacement workers. Therefore, special and careful management is required for the Havar foil of the cyclotron.

Effect of Linearized Contact Spring in Track Dynamic System

강영종,JeongHun Kim,JungBum Jang2,한상윤 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.4

In recent years, a number of researches into dynamic characteristics of the noise and vibration in the railway have been performed. Since the high frequency vibration, which occurs in the irregularity(roughness) of the wheel and rail running surfaces, causes the track noise in railway system, analytic study with measurement of the vibration for the wheel and rail is needed. So, the algorithm and program for the vibration analysis in the track system were developed as a part of the analytic study. In this study, evaluation for the effect of the linearized contact spring in track dynamic system was studied with the developed program. In addition, analytical study for the comparison between hysteretic and viscous damping in this system was performed. The result shows that both the linearized contact spring stiffness and damping of track system are important factors in track dynamic analysis model.

신이식환자에서 Thiopurine Methyltransferase의 활성이 Azathioprine 치료에 미치는 영향

조주연,배균섭,유경상,이소영,장인진,신상구,김상준,하종원,안규리 大韓臨床藥理學會 2000 臨床藥理學會誌 Vol.8 No.1

Capsule endoscopy in small bowel tumors: A multicenter Korean study

Cheung, Dae Young,Lee, In‐,Seok,Chang, Dong Kyung,Kim, Jin Oh,Cheon, Jae Hee,Jang, Byung Ik,Kim, Yong‐,Sik,Park, Cheol Hee,Lee, Kwang Jae,Shim, Ki‐,Nam,Ryu, Ji‐,Kon,Do, Jae&#x2 Blackwell Publishing Asia 2010 Journal of gastroenterology and hepatology Vol.25 No.6

<P><B>Abstract</B></P><P><B>Background and Aim: </B> Capsule endoscopy (CE) has proven to be highly effective at detecting small bowel lesions in a variety of clinical conditions, but studies concerning the practical impact of CE on small bowel tumors are still scarce, especially in the Asian population. The aim of this study was to evaluate the diagnostic and therapeutic impact of CE in the field of small bowel tumors.</P><P><B>Methods: </B> CE records consecutively pooled from the beginning of use of CE in Korea, October 2001 until April 2008, in 14 centers throughout Korea were reviewed. Clinical information and CE video images of small bowel tumors were analyzed.</P><P><B>Results: </B> A total of 1332 cases undergoing CE were reviewed with all clinical indications. Small bowel tumors were diagnosed with CE in 57 (4.3%) of 1332 patients. The tumors were malignant in 33 cases, and included three adenocarcinomas, eight lymphomas, 20 gastrointestinal stromal tumors, and two metastatic cancers. The most frequent indications for CE in malignant tumors were obscure gastrointestinal bleeding, followed by abdominal pain and weight loss. Thirty of 57 tumors were identified exclusively by CE (diagnostic impact = 30/57), and they were smaller in size (mean, range: 14.3 mm, 2–35 mm) compared to the other tumors detected in radiological studies (48.7 mm, 10–110 mm). Seven patients underwent surgical resection (therapeutic impact = 7/57).</P><P><B>Conclusion: </B> CE effectively identifies small bowel tumors that are undetectable by conventional radiological studies (diagnostic impact = 52.6%) and can critically change the therapeutic course (therapeutic impact = 12.3%).</P>

Paleostress of the Joseon and Pyeongan Supergroups in South Korea using the New Calcite Strain Gauge (NCSG)

( Bo An Jang ),( Chin Surk Ko ),( Jung Han Kim ),( Cheong Bin Kim ),( Seong Seung Kang2 ) 대한지질공학회 2014 지질공학 Vol.24 No.3

Limestone bodies under the tectonic environment have experienced various tectonic processes, and also changed the stress state. In this study, calcite twins found in limestones of the Joseon Supergroup and Pyeongan Supergroup in the northeastern part of the Ogcheon Belt, South Korea were measured, then the paleostress (i.e., the maximum shortening axis) was reconstructed using the new calcite strain gauge (NCSG) technique. The average twin thickness and average twin intensity increase as the total twin strain increases. We utilize the appearance of twins, the average twin thickness and average twin intensity, and the total twin strain to estimate that the observed calcite twins were produced at temperatures of < 200oC in the Joseon Supergroup and 170oC in the Pyeongan Supergroup. In the Joseon Supergroup, the dominant direction of the maximum shortening axis WNW-ESE to NW-SE; NE-SW shortening is also observed. The maximum shortening axes in the Pyeongan Supergroup are oriented NW-SE and NE-SW. The NE-SW direction of maximum shortening is associated with the occurrence of the Songrim orogeny of the Paleozoic to Early Jurassic, and the NW-SE direction of maximum shortening correlates to the Daebo orogeny of the Early Jurassic to Late Jurassic. It is thus concluded that the paleostress across the study area changed from NE-SW to NW-SE during the Mesozoic.

Exploring potential biomarker responses to lithium in Daphnia magna from the perspectives of function and signaling networks

Hyo Jeong Kim1,2,Jun Hyuek Yang,Hyun Soo Kim,Yeo Jin Kim,Wonhee Jang,Young Rok Seo,W. Jang,Y. R. Seo 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.1

I ntensive usage of electronic appliances containing lithium batteries causes an accumulation of e-trash. Environmental exposure to lithium batteries contaminates ecosystems. In air and water, the batteries form lithium hydroxide (LiOH) on their surfaces. LiOH enters the aquatic environment and contaminates the aquatic ecosystem by being absorbed into biological organisms. In this study, in order to identify meaningful potential biomarkers that appear in response to lithium, we measured significantly up- and down-regulated genes after LiOH exposure by conducting a microarray. In addition, we explored the functions of differentially expressed daphnia genes, and we conducted a comparative analysis in other species, Daphnia spp. to humans, then analyzed the signaling pathways using the human gene set derived from daphnia sequences that are differentially expressed in response to LiOH using the NCBI-BLAST tool and Pathway studio. As a result, we identified signaling pathways and suggested several potential biomarkers that are up- or down-regulated in response to lithium. This study may contribute to the development of a biomonitoring system which can detect the ecotoxicity of lithium. Furthermore, lithium toxicity in humans can be predicted, so the study may also provide potential biomarkers of lithium exposure in humans.

A comparison of the BISAP score and serum procalcitonin for predicting the severity of acute pancreatitis

( Byung Geun Kim ),( Myung Hwan Noh ),( Choong Heon Ryu ),( Hwa Seong Nam ),( Su Mi Woo ),( Seung Hee Ryu ),( Jin Seok Jang ),( Jong Hun Lee ),( Seok Ryeol Choi ),( Byeong Ho Park2 ) 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.3

Background/Aims: The bedside index of severity in acute pancreatitis (BISAP) is a new, convenient, prognostic multifactorial scoring system. As more data are needed before clinical application, we compared BISAP, the serum procalcitonin PCT), and other multifactorial scoring systems simultaneously. Methods: Fifty consecutive acute pancreatitis patients were enrolled prospectively. Blood samples were obtained at admission and after 48 hours and imaging studies were performed within 48 hours of admission. The BISAP score was compared with the serum PCT, Ranson`s score, and the acute physiology and chronic health examination (APACHE)-II, Glasgow, and Balthazar computed tomography severity index (BCTSI) scores. Acute pancreatitis was graded using the Atlanta criteria. The predictive accuracy of the scoring systems was measured using the area under the receiver-operating curve (AUC). Results: The accuracy of BISAP (≥ 2) at predicting severe acute pancreatitis was 84% and was superior to the serum PCT (≥ 3.29 ng/mL, 76%) which was similar to the APACHE-II score. The best cutoff value of BISAP was 2 (AUC, 0.873; 95% con- fidence interval, 0.770 to 0.976; p < 0.001). In logistic regression analysis, BISAP had greater statistical significance than serum PCT. Conclusions: BISAP is more accurate for predicting the severity of acute pancreatitis than the serum PCT, APACHE-II, Glasgow, and BCTSI scores.