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鄭長均,安日會 圓光大學校 韓醫學硏究所 1995 원광한의학 Vol.5 No.1
We understand the meaning of The SoPoongTang's using and compared with western medical treatment of cerebral thrombosis, so except that The SoPoongTang is effective of preventing early cerebral thrombosis' degeneration. therefore, we had prescribed the estract of The SoPoongTang in 47 early cerebral thrombosis patients for a week from April, 1994 to December, 1994 and the result was as follows; 1. We observed recovering rates after a week; Headache 40%, Dizziness 87.5%, Insomnia 505, Neck stiffness 83.3%, Redface 755, Palpitation 100%; Avearge recovering rates 68.8%. 2. We observed the states of consciousness after a week; There were increasing from 41 patients to 43 patients in Gr-4 and decreasing from 5 patients to 3 patients in Fr-3. 3. We observed the states of swallowing after a week; There were increasing from 37 patients to 44 patients in having G.D. decreasing from 7 patients to 3 patients in having S.D and from 6 patients to 0 patients in having L.D. 4. We observed the states of motor weakness after a week. Upper Limb - There were degeneration in 12 patients(25.5%), changelessness in 25 patients(53%), and improvement in 10 patients(21%) Lower Limb - There were degeneration in 5 patients(10.6%), changelessness in 31 patients (66%), and improvement in 11 patients(23.4%) As a result, The SoPoongTang has effect in preventing of the most serious neurological symptoms-hemiplegia, bysphsia, metal disorder in early cerebral thrombosis. Additionally I recommend that we should compare and reserch three cases; independent priescription group(which are) used Urokinase, Heparine, etc. at the begining of Cerebral thrombosis in western medicine; a tretment group which are given combination of Western and Oriental medicine silmultaneously; and this study.
골격근 근형질세망의 ATP유도 ^45Ca-uptake에 대한 Thapsigargin및 Vanillylnonanamide의 영향
황의강,배소현,홍장희,허강민,김진회,이재흔,석정호 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2
To investigate the effect of thapsigargin(THP) and vanillylnonanamide(VN), derivative of capsaicin, on the ATP-induced ^45Ca-uptake in the sarcoplasmic reticulum(SR) of the skeletal muscle, the SR vesicles were prepared from the back muscle of the rabbit, and ^45Ca-uptake was carried out. The results as follows: ATP-induced ^45Ca-uptake of skeletal muscular SR was significantly increased by 1 mM ATP. It was significantly blocked by 5 μM THP, but slightly decreased by 20 μM VN. The combined effect of THP and VN on the 45Ca-uptake of the SR vesicles was much potentiated than the sum of each effect of them. The above results suggest that the action of VN, being slightly influential to ATP-induced Ca-uptake but potentiating the effect of THP on the Ca-uptake, might be related with direct perturbation of the SR membrane or exposure of the THP-binding site.
NsMADS1, a Member of the MADS Gene Family Nicotiana sylvestris
Jang, Seong-Hoe,An, Gyu-Heung The Botanical Society of Korea 1999 Journal of Plant Biology Vol.42 No.1
A cDNA clone, NsMADS1, was isolated from Nicotiana sylvestris. Sequence homology analysis indicated that the gene is a member of the SQUA subfamily. Its transcript was detectable primarily in reproductive organs, especially in sepals and carpels. When the gene was expressed ectopically in tobacco plants, no phenotypic alteration was observed. Thus, NsMADS1 appears to be a new member of the MADS gene family.
The Effectiveness and Safety of Direct-Acting Antivirals for HCV Infection during Clinical Practice
( Hoe Soo Jang ),( Sung Kyun Na ),( Eun Kwang Choi ),( Byung-cheol Song ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: This study assessed the real-world experience for efficacy and safety of direct-acting antivirals (DAAs) for patients with HCV infection. Methods: This retrospective study analyzed 127 patients with HCV infection (genotype 1b, n=77; genotype 1a, n=1; mixed with genotype 1a/1b n=1; genotype 2, n=48) who were treated with DAAs. In patients with genotype 1b without NS5A RAV (n=64), daclatasvir and asunaprevir (DCV+ASV) therapy was introduced. In patients with genotype Ib harbouring NS5A RAV (n=13), a patient infected with genotype 1a, a patient with mixed genotype 1a/1b (n=1) and a patients with genotype 1b whose NS5A RAV were not available, were treated with sofosbuvir and ledipasvir (SOF+LDV). Genotype 2 patients (n=48) were treated with sofosbuvir and rivabirin (SOF +RBV). Results: Of the 127 patients (male, n=63 [49.6%]; mean age, 62.9 years; liver cirrhosis 47 [37%]), 66 patients (52.0%) were interferon- experienced. In genotype I patients, SVR12 was achieved in 59 (92.2%) in DCV+ASV group. Among 5 patients without SVR12, virologic breakthrough occurred in a patient and virologic relapse occurred in 4 patients (6.3%). In SOF+LDV group, SVR12 occurred in all patients. In SOF +RBV group, SVR12 was achieved in 46 patients (95.8%). In genotype 1 patients treated with DCV+ASV, 2 patients early stopped the treatment because of economic problem (n=1) and virolgic breakthrough (n=1). In genotype 2 patients, 3 patients (SVR12, n=1, no SVR12, n=2), all were over 70 year old, stopped the medication due to gastrointestinal troubles (n=2) or pruritus (n=1). During or after DAA treatment, hepatocellular carcinoma developed in 2 patients (1 in DCV+ASV group and 1 in SOF +RBV group) whose ages were over 75 years. Conclusions: DAAs provide high rate of SVR12 and safety in patients with HCV infection. However, in some older patients, especially ribavirin containing regimen is not tolerable and HCC can develop during or after DAAs treatment.
( Hoe Soo Jang ),( Hyung Ho Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The aim of this study is to investigate the characteristics of pleural effusion and to identify the factors associated with the occurrence of pleural effusion of adult scrub typhus patients which are currently unclear. Methods: We conducted a retrospective analysis of the medical records of the confirmed adult scrub typhus patients between January 2004 and December 2011 at Chosun University Hospital in South Korea. 445 confirmed adult scrub typhus patients were divided into two groups for comparison: the patients group without pleural effusion (n=352) and with effusion (n=93). And data of 18 patients with examined pleural effusion were summarized. Results: Multivariate analysis demonstrated that following four factors were signifi-cantly associated with the occurrence of pleural effusion of scrub typhus as independent risk factors: older age (odd ratio[OR] = 1.03, p = 0.037); male sex (OR = 1.92, p = 0.020); presence of underlying heart failure (OR = 2.63, p = 0.039, CI = 1.05-6.56); lower albumin (OR = 0.11, p = <0.001). Most of the effusions were bilateral location (88%) and small in size (91%). The mean pleural fiuid WBC count was 1619.7/mm3, and the differential count showed a predominance of mononuclear cell in 11 patients. Effusion of 11 patients (61.1%) was classified as exudates by Light`s criteria. The mean pleural fiuid total protein was 2.30 ± 0.58 g/dL, and the mean pleural fiuid LDH was 275.8 ± 101.6 U/L. The mean pleural fiuid pH was 7.43 ± 0.82. The mean ADA was 32.5 ± 20.9 U/L, and ADA was above 35 U/L in 8 patients (44.4%). Conclusions: This study provides first data regarding the factors associated with the occurrence of pleural effusion and the characteristics of pleural effusion of adult scrub typhus.
장회수 ( Hoe-soo Jang ),정종훈 ( Jong-hun Chung ),김조아 ( Joa Kim ),한선애 ( Sun Ae Han ),윤나라 ( Na-ra Yun ),김동민 ( Dong-min Kim ) 대한내과학회 2016 대한내과학회지 Vol.90 No.3
치쿤구니야는 치쿤구니야바이러스에 의해 발생하는 감염증으로 모기에 의해 사람에게 전염되며 임상적으로 2-7일간지속되는 발열, 관절통, 두통, 반점구진상 발진 등을 일으킨다. 본 증례의 경우 수리남에 다녀온 여행력이 있는 환자에서 증상 발생 15일째 시행한 효소결합면역흡착법(ELISA) 그리고 간접면역형광항체법상 음성이었으나 23일째 재시행한 항체검사상 치쿤구니야가 진단되었다. 이에 IgM 항체가 형성되는 시기가 증상 발생 후 5일 이후부터 형성되므로 임상적으로 치쿤구니야가 의심되는 경우 반드시 추적 검사가 필요할 것으로 사료된다. Chikungunya infection is caused by an arbovirus transmitted by the Aedes mosquito. A 19-year-old man who had traveled to the Republic of Surinam to perform volunteer work complained of a fever, arthralgia, articular stiffness, and a skin rash on both the arm and trunk. Chikungunya fever was diagnosed using a Chikungunya virus specific IgM antibody in an enzyme-linked immunosorbent assay (ELISA) using blood samples obtained during follow-up visits. In this report, we describe a case of imported Chikungunya fever that presented with arthralgia and a skin rash, with islands of normal skin, that occurred following travel to Surinam, South America. (Korean J Med 2016;90:262-265)