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In vivo antimalarial activity of the endophytic actinobacteria, Streptomyces SUK 10
Mohd Shukri Baba,Noraziah Mohamad Zin,Universiti Teknologi MARA,Jalifah Latip,Florence Pethick,Iain S. Hunter,RuAngelie Edrada-Ebel,Paul R. Herron 한국미생물학회 2015 The journal of microbiology Vol.53 No.12
Endophytic bacteria, such as Streptomyces, have the potential to act as a source for novel bioactive molecules with medicinal properties. The present study was aimed at assessing the antimalarial activity of crude extract isolated from various strains of actinobacteria living endophytically in some Malaysian medicinal plants. Using the four day suppression test method on male ICR strain mice, compounds produced from three strains of Streptomyces (SUK8, SUK10, and SUK27) were tested in vivo against Plasmodium berghei PZZ1/100 in an antimalarial screen using crude extracts at four different concentrations. One of these extracts, isolated from Streptomyces SUK10 obtained from the bark of Shorea ovalis tree, showed inhibition of the test organism and was further tested against P. berghei-infected mice for antimalarial activity at different concentrations. There was a positive relationship between the survival of the infected mouse group treated with 50 μg/kg body weight (bw) of ethyl acetate-SUK10 crude extract and the ability to inhibit the parasites growth. The parasite inhibition percentage for this group showed that 50% of the mice survived for more than 90 days after infection with the parasite. The nucleotide sequence and phylogenetic tree suggested that Streptomyces SUK10 may constitute a new species within the Streptomyces genus. As part of the drug discovery process, these promising finding may contribute to the medicinal and pharmaceutical field for malarial treatment.
An Oxepinoflavone from Artocarpus elasticus with Cytotoxic Activity Against P-388 Cells
Iqbal Musthapa,Lia D. Juliawaty,Yana M. Syah,Euis H. Hakim,Jalifah Latip,Emilio L. Ghisalberti 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.2
A new oxepinoflavone, artoindonesianin E1 (1), was isolated from the wood of Artocarpus elasticus,along with four known prenylated flavones: artocarpin (2), cycloartocarpin (3), cudraflavones A (4) andC (5). The structure of the new compound was identified by spectroscopic methods. Upon cytotoxic evaluation against murine leukemia P-388 cells, the new compound showed IC50 5.0 μg/mL.
Chemical Properties and Toxicology Studies of Fucoidan Extracted from Malaysian Sargassum binderi
Seng Joe Lim,Wan Aida Wan Mustapha,Mohamad Yusof Maskat,Jalifah Latip,Khairiah Haji Badri,Osman Hassan 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.suppl1
Fucoidan is a sulfated polysaccharide that consists mainly of fucose and is found in brown seaweeds. In this study, fucoidan was extracted from Sargassum binderi (Fsar) from Malaysia and subsequently characterized in terms of composition, structure and toxicology. It was found that the molecular weight, polydispersity index, monosaccharide profile and degree of sulfation of Fsar differed from those of commercial food-grade fucoidan (Fysk). NMR analysis suggested that the main structure of Fsar was →3)fuc-2-OSO3 −(1→3)fuc-2-OSO3 −(1→. A cytotoxicity study employing up to 200 mg/mL Sargassum binderi extract showed that cell inhibition was less than 50% (IC50), while acute toxicity results classified S. binderi as category 5 (unclassified) according to the OECD Guideline 423, as no mortality was observed at the highest dosage (2,000 mg/kg). Both toxicity results showed that this material is safe to be consumed. The chemical characteristics and non-toxicity of Fsar demonstrate its potential in biological and food product applications.