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18F-FDG PET/CT Findings of Scrub Typhus
Kim, Jahae,Kwon, Seong Young,Kang, Sae-Ryung,Cho, Sang-Geon,Song, Ho-Chun Lippincott 2015 Clinical nuclear medicine Vol.40 No.10
ABSTRACT: Scrub typhus is an acute infectious disease caused by Orienta tsutsugamushi, which is clinically manifested by fever, generalized lymphadenopathy, diffuse myalgia, headache, maculopapular rash, and eschars at the site of chigger feedings. Diagnosis of scrub typhus requires compatible clinical features, history of exposure, and result of selorogic testing. In recent years, F-FDG PET/CT is seen as having increasing potential for use in examination and management of patients with infectious or inflammatory disorders. This is a PET/CT case demonstrating scrub typhus in a patient without evidence of recurrence of thyroid papillary cancer.
Kim, Jahae,Yoo, Su Woong,Kang, Sae-Ryung,Cho, Sang-Geon,Oh, Jong-Ryool,Chong, Ari,Min, Jung-Joon,Bom, Hee-Seung,Yoon, Jung-Han,Song, Ho-Chun The Korea Society of Nuclear Medicine 2012 핵의학 분자영상 Vol.46 No.4
Purpose We investigated whether PET indices measured by $^{18}F$-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) can predict prognosis in patients with operable primary breast cancer. Methods We reviewed 53 patients with operable primary breast cancer who underwent pretreatment FDG PET/CT. PET indices, maximum standardized uptake value (SUV) and metabolic tumor volume (MTV), were measured in the primary breast tumor (P), metastatic lymph nodes (N) and total tumor (T). The Cox proportional hazards model was used with age, tumor size, clinical lymph node status, method of surgery, presence or absence of neoadjuvant chemotherapy, histological type, histological grade, hormone receptors and HER2 status to predict disease-free survival (DFS) and overall survival (OS). Results Median follow-up period was 50 months (range, 17-73 months), during which 17 patients had recurrent disease and nine of whom died. The univariate analysis showed that high SUV of N ($N_{SUV}$, P=0.011), MTV of N ($N_{MTV}$, P=0.011) and MTV of T ($T_{MTV}$, P=0.045) as well as high histological grade (P=0.008), negative estrogen (P=0.045) and negative progesterone (P=0.029) receptor status were associated with shorter DFS. High $N_{SUV}$ (P=0.035), $N_{MTV}$ (P=0.035) and $T_{MTV}$ (P=0.035) as well as high histological grade (P=0.012) and negative estrogen receptor status (P=0.009)were associated with shorter OS. $N_{SUV}$, $N_{MTV}$ and $T_{MTV}$ were found to be significantly associated with high histological grade (P=0.005). However, those failed to be statistically significant prognostic factors on multivariate analysis. Conclusions PET indices seem to be useful in the preoperative evaluation of prognosis in patients with operable primary breast cancer. $N_{SUV}$, $N_{MTV}$ and $T_{MTV}$ might be considerable factors associated with patient outcome in operable breast cancer.
Yoo, Su Woong,Kim, Jahae,Chong, Ari,Kwon, Seong-Young,Min, Jung-Joon,Song, Ho-Chun,Bom, Hee-Seung The Korea Society of Nuclear Medicine 2012 핵의학 분자영상 Vol.46 No.4
Purpose This study aimed to further stratify prognostic factors in patients with stage IV non-small cell lung cancer (NSCLC) by measuring their metabolic tumor volume (MTV) using F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). Materials and Methods The subjects of this retrospective study were 57 patients with stage IV NSCLC. MTV, total lesion glycolysis (TLG), and maximum standardized uptake value (SUVmax) were measured on F-18 FDG PET/CT in both the primary lung lesion as well as metastatic lesions in torso. Optimal cutoff values of PET parameters were measured by receiver operating characteristic (ROC) curve analysis. Kaplan-Meier survival curves were used for evaluation of progression-free survival (PFS). The univariate and multivariate Cox proportional hazards models were used to select the significant prognostic factors. Results Univariate analysis showed that both MTV and TLG of primary lung lesion (MTV-lung and TLG-lung) were significant factors for prediction of PFS (P<0.001, P=0.038, respectively). Patients showing lower values of MTV-lung and TLG-lung than the cutoff values had significantly longer mean PFS than those with higher values. Hazard ratios (95 % confidence interval) of MTV-lung and TLG-lung measured by univariate analysis were 6.4 (2.5-16.3) and 2.4 (1.0-5.5), respectively. Multivariate analysis revealed that MTV-lung was the only significant factor for prediction of prognosis. Hazard ratio was 13.5 (1.6-111.1, P=0.016). Conclusion Patients with stage IV NSCLC could be further stratified into subgroups of significantly better and worse prognosis by MTVof primary lung lesion.
Brain Metastases Mimicking Hyperostosis Frontalis Interna on 99mTc HDP Bone Scintigraphy
Kang, Sae-Ryung,Kim, Jahae,Kwon, Seong Young,Min, Jung-Joon,Bom, Hee-Seung,Sohn, Myung-Hee,Song, Ho-Chun Wolters Kluwer Health, Inc. All rights reserved. 2016 Clinical nuclear medicine Vol.41 No.10
<P>Symmetric bifrontal uptake of bone-seeking agents is usually considered as the main feature of hyperostosis frontalis interna in postmenopausal elderly women. This finding is not uncommon in elderly women because of the change in their hormonal level. However, in the present case, a 66-year-old woman with intra-axial brain metastases of breast cancer showed symmetric bifrontal uptake on bone scintigraphy. Therefore, symmetric bifrontal uptake should not always be considered as a definite indicator of hyperostosis frontalis interna. Further evaluation such as SPECT/CT is needed for evaluation of brain metastases especially in cancer patients.</P>
Cho Sang-Geon,Park Ki Seong,Kim Jahae,Moon Jang Bae,Song Ho-Chun,Kang Taek Won,Yu Seong Hyeon 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.10
Objective: The assessment of cortical integrity following renal injuries with planar Tc-99m dimercaptosuccinic acid (DMSA) scintigraphy depends on measuring relatively decreased cortical uptake (i.e., split renal function [SRF]). We analyzed the additive values of the volumetric and quantitative analyses of the residual cortical integrity using single-photon emission computed tomography (SPECT) compared to the planar scintigraphy. Materials and Methods: This prospective study included 47 patients (male:female, 32:15; age, 47 ± 22 years) who had nonoperatively managed renal injuries and underwent DMSA planar and SPECT imaging 3–6 months after the index injury. In addition to planar SRF, SPECT SRF, cortical volume, and absolute cortical uptake were measured for the injured kidney and both kidneys together. The correlations of planar SRF with SPECT SRF and those of SRF with volumetric/quantitative parameters obtained with SPECT were analyzed. The association of SPECT parameters with renal function, grades of renal injuries, and the risk of renal failure was also analyzed. Results: SPECT SRF was significantly lower than planar SRF, with particularly higher biases in severe renal injuries. Planar and SPECT SRF (dichotomized with a cutoff of 45%) showed 19%–36% of discrepancies with volumetric and quantitative DMSA indices (when dichotomized as either high or low). Absolute cortical uptake of the injured kidney best correlated with glomerular filtration rate (GFR) at follow-up (ρ = 0.687, P < 0.001) with significant stepwise decreases by GFR strata (90 and 60 mL/min/1.73 m2). Total renal cortical uptake was significantly lower in patients with moderate-to-high risk of renal failure than those with low risk. However, SRF did not reflect GFR decrease below 60 mL/min/1.73 m2 or the risk of renal failure, regardless of planar or SPECT (count- or volume-based SRF) imaging. Conclusion: Quantitative measurements of renal cortical integrity assessed with DMSA SPECT can provide more clinically relevant and comprehensive information than planar imaging or SRF alone.
Cho, Sang-Geon,Jabin, Zeenat,Park, Ki Seong,Kim, Jahae,Kang, Sae-Ryung,Kwon, Seong Young,Jeong, Geum-Cheol,Song, Minchul,Kim, Jong Sang,Cho, Jae Yeong,Kim, Hyun Kuk,Song, Ho-Chun,Min, Jung-Joon,Bom, H Springer-Verlag 2017 European Journal of Nuclear Medicine and Molecular Vol.44 No.2
<P>LVMD measured by GMPS showed added prognostic value in acute MI with multivessel disease. GMPS could serve as a comprehensive evaluation imaging tool in patients with acute MI and multivessel disease.</P>
Park, Hee Jeong,Kwon, Seong Young,Cho, Sang-Geon,Kim, Jahae,Song, Ho-Chun,Kim, Sung Sun,Yoon, Yeon Hong,Park, Jin Gyoon The Korea Society of Nuclear Medicine 2016 핵의학 분자영상 Vol.50 No.4
Giant cell tumor (GCT) is a generally benign bone tumor accounting for approximately 5 % of all primary bone neoplasms. Cystic components in GCTs that indicate secondary aneurysmal bone cysts (ABCs) are reported in 14 % of GCTs. Although both of them have been described separately in previous reports that may show considerable fluorodeoxyglucose (FDG) uptake despite their benign nature, the findings of GCT with secondary ABC on $^{18}F$-FDG positron emission tomography/computed tomography (PET/CT) have not been well-known. We report a case of GCT with secondary ABC in a 26-year-old woman. $^{18}F$-FDG PET/CT revealed a heterogeneous hypermetabolic lesion in the left proximal femur with the maximum standardized uptake value of 4.7. The solid components of the tumor showed higher FDG uptake than the cystic components. These observations suggest that the ABC components in GCTs show heterogeneous metabolic patterns on $^{18}F$-FDG PET/CT.
Cho, Sang-Geon,Park, Ki Seong,Kang, Sae-Ryung,Kim, Jahae,Jun, Haeng Man,Cho, Jae Yeong,Jeong, Hae Chang,Kim, Ju Han,Jeong, Geum-Cheol,Park, Hee Jeong,Kwon, Seong Young,Min, Jung-Joon,Bom, Henry Hee-Se The Korea Society of Nuclear Medicine 2016 핵의학 분자영상 Vol.50 No.1
Purpose To evaluate the perfusion decrease in donor myocardium by collateral circulation and its correlation with angina pectoris in patients with chronic total occlusion (CTO) using myocardial perfusion single-photon emission computed tomography (MPS). Materials and Methods Thirty-six patients with single-vessel CTO without any other stenosis were included. All patients underwent MPS and coronary angiography (CAG) within 2 months. Total 72 donor arteries were evaluated for the grades of collaterals to the CTO artery using the Rentrop grading system on CAG. Perfusion defects and perfusion scores in donor and CTO territories were analyzed on MPS. Myocardial perfusion of donor and CTO territories were evaluated according to the presence of angina pectoris and the grades of collateral circulation. Results When the CTO territory was ischemic, symptomatic patients showed higher summed difference scores in the CTO territory compared to asymptomatic patients ($3.5{\pm}2.4$ vs. $1.5{\pm}0.8$ for symptomatic and asymptomatic groups respectively; p = 0.034). However, when the CTO territory was nonischemic, symptomatic patients showed higher summed stress scores (SSS, $4.3{\pm}2.9$ vs. $1.6{\pm}1.2$; p=0.032) and summed rest scores (SRS, $4.2{\pm}2.5$ vs. $1.5{\pm}1$.1; p=0.003) in the donor territories. On the per-vessel analysis, perfusion defects in donor territories were more frequent (0 % vs. 53 % vs. 86 % for Rentrop 0, Rentrop 1-2 and Rentrop 3, respectively; p<0.001) and showed higher SSS ($0.0{\pm}0.0$, $1.3{\pm}1.6$ and $2.1{\pm}1.1$ for Rentrop 0, Rentrop 1-2 and Rentrop 3, respectively; p=0.001) and SRS ($0.0{\pm}0.0$, $1.0{\pm}1.4$ and $1.7{\pm}1.2$; p=0.003) at higher Rentrop grades, but their patterns were variable. Conclusion Angina pectoris was related to either ischemia of the myocardium beyond CTO or a perfusion decrease in the donor myocardium. The perfusion decrease in donor myocardium positively correlated with the collateral grades.