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이재설(Jaeseol Lee),고현우(Hyun-Woo Goh) 한국산업경영시스템학회 2008 한국산업경영시스템학회지 Vol.31 No.3
Mail centers play an important role such as sorting and transporting postal items in the process of postal logistics. Therefore, there is need of efficiency measurement of the facilities to reduce the inefficiency of factors. But only few attempts have so far been made at measuring the efficiency of postal logistics hubs. The purpose of this paper is to make a reasonable suggestion for the improvement of inefficient mail centers. So this study found the efficient mail centers and inefficient mail centers using data envelopment analysis(DEA) and compared inputs and outputs of the former with those of the latter.
박재설(Jaeseol Park),강연욱(Yeonwook Kang),장은주(Eun Joo Chang),오은아(Euna Oh),유경호(Kyung Ho Yu),이병철(Byuug Chul Lee) 한국언어청각임상학회 2006 Communication Sciences and Disorders Vol.11 No.3
본 연구는 혈관성 치매 환자들(VD)과 알츠하이머형 치매 환자들(DAT)의 단어 유창성을 비교하여 단어 유창성 검사에서 요구되는 인지과정인 군집화와 전환에 두 치매 집단이 어떤 결함을 지니고 있는지를 알아보고자 수행되었다. 치매 집단은 치매의 초기 단계에 속하는 37명의 VD와 44명의 DAT로 구성되었고 66명의 정상 노인(NE)이 통제집단으로 참여하였다. 대상자들에게는 의미(동물)와 음소(ㄱ,ㅇ,ㅅ) 유창성 검사를 실시하였고, 각 검사에서 4개의 점수(정반응 수, 군집 크기, 전환 수 및 오류 수)를 산출하였다. 그 결과, VD와 DAT는 모두 치매의 초기부터 단어 유창성 검사에서 정상노인들보다 현저하게 낮은 수행을 나타내지만 군집화와 전환의 결함 여부 및 결함이 나타나는 시점은 서로 다르다는 사실이 밝혀졌다. 이 결과가 VD와 DAT의 변별에 어떤 함의를 가지는지 논의하였다. The present study was conducted to examine the deficits of clustering and switching processes on the semantic and phonemic fluencies in 57 vascular dementia(VD), 44 Dementia of the Alzheimer’s Type(DAT), and 66 normal elderly(NE). All the patients were in very mild to mild level of dementia (CDR≤1.0). The subjects were given the tests of phonemic(ㄱ, ㅇ, ㅅ) and semantic fluency(animals). The following 4 types of scores were obtained from each test: (a) total number of words generated, excluding errors; (b) mean clustering size; (c) number of switches; and (d) number of errors (repetitions and intrusion). The results found that both VD and DAT, even at the early stages of dementia, showed significantly lower performance on the verbal fluency test than the NE did. The types and timing of deficits in clustering and switching processed between two dementia groups. We discussed their implications on the differentiation between VD and DAT.
기능성 탐침이 통합된 하이드로젤 원자현미경 캔틸레버의 제작
이재설(Jaeseol Lee),이정철(Jungchul Lee) 대한기계학회 2014 대한기계학회 춘추학술대회 Vol.2014 No.11
In this paper, we fabricated atomic force microscope (AFM) cantilevers with a hydrogel-poly(ethylene glycol) diacrylate (PEGDA)- and demonstrated integration of functional tips without changing the tip shape by embedding magnetic nanoparticles, plasmonic gold nanorods, and fluorescent quantum dots inside tips when the PEGDA was crosslinked within a silicone rubber mold. Fabricated hydrogel AFM cantilevers were examined with optical, fluorescent and scanning electron microscopes. The developed hydrogel AFM cantilevers would be useful for functional imaging for soft and delicate samples such as cells.
Lee, Jaeseol,Kim, Doyoon,Yoon, Yeowon,Lee, Bora,Ko, Juhee,Lee, Jungchul Institute of Electrical and Electronics Engineers 2018 Journal of microelectromechanical systems Vol.27 No.2
<P>In this letter, we report hydrogel tip attachment onto tipless silicon cantilevers by ultraviolet curing of hydrogel filled into an elastomeric tip mold, for the first time. By mechanically deforming the tip mold or changing the mold design, attachment of various tip shapes is demonstrated. Hybrid atomic force microscope cantilevers of their tip and beam being hydrogel and silicon are used for imaging various inorganic substrates and HeLa cells. Since the hydrogel tip can be selectively removed by piranha solution, hydrogel tip regeneration is also realized by removing the used hydrogel tip and re-attaching a new tip. [2018-0013]</P>
진주희,Jaeseol Park,Soh-Jeong Yang,염지영,Yisuh Ahn,백민재,Hui Jin Ryu,Byung Hwa Lee,Noh Eul Han,Kyung Hi Ryu,강연욱 대한치매학회 2018 Dementia and Neurocognitive Disorders Vol.17 No.1
Background and Purpose: Evaluating instrumental activities of daily living (IADL) is an important part of procedure to diagnose dementia. The Korean-Instrumental Activities of Daily Living (K-IADL) has been used extensively in Korea. However, its cut-off score has not been reformulated since 2002. The purpose of this study was to yield a new optimal cut-off score for the K-IADL and confirm the validity of this new cut-off score with various dementia groups. Methods: We retrospectively collected a total of 2,347 patients' K-IADL data from 6 general hospitals in Korea. These patients had mild cognitive impairment (MCI) or dementia with various etiologies for cognitive impairment. We also recruited a normal control group ( n =254) from the community. Korean-Mini Mental State Examination, Short version of the Geriatric Depression Scale, Clinical Dementia Rating, and Global Deterioration Scale were administered to all participants. Caregivers completed K-IADL and Barthel Index. Results: K-IADL scores were significantly different among dementia subgroups, but not significantly different among MCI subgroups. Based on internal consistency, correlations with other scales, and factor analysis, K-IADL showed excellent reliability and validity. The new optimal cut-off score to diagnose dementia was 0.40, which gave a sensitivity of 0.901 and a specificity of 0.916. Positive predictive value for dementia using the new cut-off score was 94.2% for Alzheimer's disease, 100% for vascular dementia, and 84% for Parkinson's disease. Conclusions: Our results illustrate that the new K-IADL cut-off score of 0.40 is reliable and valid for screening impairments of daily functioning resulting from various etiologies.
Prodromal Dementia With Lewy Bodies Manifesting as Sertraline-induced Parkinsonism: A Case Report
Kim, Jin-Hyuck,Park, Jaeseol,Yu, Kyung-Ho,Ma, Hyeo-Il,Lee, Byung-Chul,Kim, Imyel,Kim, Yun Joong Lippincott WilliamsWilkins, Inc. 2012 Alzheimer disease and associated disorders Vol.26 No.2
OBJECTIVE:: To describe a patient with prodromal dementia with Lewy bodies (DLB) manifesting as sertraline-induced parkinsonism. DESIGN:: Case report. SETTING:: Tertiary referral center. PATIENT:: A 75-year-old man who initially presented with anxiety and depression along with mild cognitive impairment, later developed drug-induced parkinsonism because of sertraline treatment, and eventually showed symptoms and signs of probable DLB. INTERVENTIONS:: Sertraline treatment for depression. MAIN OUTCOME MEASURES:: Clinical examination, magnetic resonance imaging, neuropsychologic test, and cardiac I-metaiodobenzylguanidine scintigraphy. RESULTS:: His parkinsonian symptoms, which became apparent after sertraline therapy, improved markedly after the discontinuation of the drug. When he started taking sertraline, he had no dementia but had mild cognitive impairment. However, he eventually showed most of the symptoms and signs to indicate probable DLB. CONCLUSIONS:: To our knowledge, there has been no report of sertraline-induced or aggravated parkinsonian motor symptoms in DLB patients. Our patient had a short period with neither dementia nor parkinsonism during the early stage of his illness, and this period might have been regarded as the preclinical stage of DLB in the natural course of his illness.
김근식(Keunsik Kim),김재설(Jaeseol Kim),유동주(Dong-Joo Yoo) 한국자동차공학회 2010 한국자동차공학회 학술대회 및 전시회 Vol.2010 No.11
Traditional retro-reflectors and markings have a problems of driver’s visibility for a rain and fog or surface spray conditions. Illuminated studs, so called cat’s eye system, provide benefits in reduced visibility that road delineation remains visible even under these conditions. This paper presents the design concept of cat’s eye system that ultra low energy consumption is analog circuit controlled so that just a few hours of daylight will provide enough battery power to last 14 days- more than enough to ensure the system keeps working no matter what the weather.
산소 플라즈마 식각을 이용한 20 ㎚ 이하 탐침 곡률반경 하이드로젤 켄틸레버 제작 및 고분해능 이미징
송정기(Jungki Song),이재설(Jaeseol Lee),이정철(Jungchul Lee) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11
This paper reports fabrication of sub-20 ㎚ hydrogel microcantilevers based on replica molding and O2 plasma ashing and their comparable imaging capability with silicon counterparts. First, hydrogel microcantilevers were fabricated with poly(ethylene glycol) diacrylate (PEGDA) using a polydimethylsiloxane (PDMS) cantilever mold via UV crosslinking along with capillary force induced filling into the mold. Second, Pyramid mold was integrated to the free-end of the hydrogel microcantilevers. PEGDA was dispensed into the pyramid mold, bi-axially compressed for 10~20% strain, aligned with the tipless hydrogel microcantilever, and UV cured. Third, tip radius of hydrogel microcantilevers was improved to be sub-20 ㎚ by O2 plasma ashing. Tip radius decrease depending on initial tip radius was characterized by varying the time for plasma ashing. Finally, topography of anodized aluminum oxide (AAO) (width 50 ㎛, depth 2 ㎛) was imaged in non-contact (NC) mode. Sharp hydrogel tip is shown to be free of degradation while imaging in NC mode.