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- 저자 : Jaehyun;Om, (검색결과 2 건)
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Effect of Apoptosis Induction of Ailanthus altissima on Human Lung Carcinoma Cells
Yu-Jin Hwang,Hye-Im Woo,Inhye Kim,Dong-Sik Park,Jaehyun Kim,Ae-Son Om,Kyung-A Hwang 경상대학교 농업생명과학연구원 2011 농업생명과학연구 Vol.45 No.5
We investigated the inhibitory effects of solvent extracts from Ailanthus altissima in A549 human lung cancer cell. A. altissima has been recognized as a traditional healthy food due to its various biological activities against hypertension, strokes, fever, pain, neuralgia, inflammation, and cancer effects. Recently, it has been reported that the extracts of various wild vegetables show strong anti-cancer properties by induction of apoptosis. However, the mechanisms of their cytotoxicity in human lung cancer cells have been poorly understood. The present study was investigated the effects of solvent extracts from A. altissima on cell growth and apoptosis on A549 human lung cancer cells. A treatment of A. altissima inhibited the growth of A549 cells in a dose-dependent manner by inducing apoptosis. Especially, the chloroform fraction showed the highest anti-cancer effect among five kinds of fractions. And also, induction of apoptosis by chloroform fraction were associated with down-regulation of Bcl-2, and up-regulation of pro-apoptotic Bax expression. From these results, A. altissima may have a therapeutic potential in human lung cancer cells and as a functional food.
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Antioxidative and Anticancer Activities of Korean Wild Edible Vegetables
Woo, Hye-Im;Hwang, Yu-Jin;Kim, Inhye;Park, Dong-Sik;Kim, Jaehyun;Om, Ae-Son;Hwang, Kyung-A 한양대학교 2011 韓國 生活 科學 硏究 Vol.31 No.2
The purpose of this study was performed to evaluated cytotoxicity of the water extract of five wild edible vegetables on five kinds of human cancer cells lines to provide as a fundamental data to be utilized for cancer chemopreventive agents. The total phenolics content of Ailanthus altissima, Patrinia saniculaefolia, Tetragonia tetragonoides, Aster yomena and Valeriana fauriei extracts were 73, 57, 32, 66, and 47 ㎎ GAE/g, respectively. In the α,α-diphenyl-β-picrylhydrazyl (DPPH) radical scavenging assay, Ailanthus altissima and Aster yomena the highest DPPH radical scavenging activity which were 45.1 and 45.8% at 100 ug/ml, respectively. The growth inhibitory activity of human cancer cells on HeLa, MKN-45 and NCI-H460 were 59, 66 and 60% in Patrinia saniculaefolia extract at 100 ㎍/㎖, respectively. In human colon cancer cell (HT29), Aster yomena extract showed 43.5% inhibitory activity at 100 ug/ml. The growth of human breast cancer cell (MCF-7) was inhibited 85.1% at 100 ug/ml by Ailanthus altissima extract.
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