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Postoperative radiation therapy following the incomplete resection of a non-small cell lung cancer
Park, Jaehyeon,Song, Si Yeol,Kim, Su Ssan,Kim, Sang-We,Kim, Woo Sung,Park, Seung-Il,Kim, Dong Kwan,Kim, Yong-Hee,Park, Jongmoo,Lee, Sang-Wook,Kim, Jong Hoon,Ahn, Seung Do,Choi, Eun Kyung The Korean Society for Radiation Oncology 2014 Radiation Oncology Journal Vol.32 No.2
Purpose: To review the results of postoperative radiation therapy (PORT) for residual non-small cell lung cancer (NSCLC) following surgical resection and evaluate multiple clinicopathologic prognostic factors. Materials and Methods: A total of 58 patients, who completed scheduled PORT for positive resection margin, among 658 patients treated with PORT from January 2001 to November 2011 were retrospectively analyzed. Radiation therapy was started at 4 to 6 weeks after surgery. Chemotherapy was also administered to 35 patients, either sequentially or concurrently with PORT. Results: The median age of patients was 63 years (range, 40 to 82 years). The postoperative pathological stage I NSCLC was diagnosed in 10 (17.2%), stage II in 18 (31.0%), and stage III in 30 patients (51.7%). Squamous cell carcinoma was identified in 43, adenocarcinoma in 10, large cell in 1, others in 4 patients. Microscopic residual disease (R1) was diagnosed in 55 patients (94.8%), and the remaining three patients were diagnosed with gross residual disease (R2). The median dose of PORT was 59.4 Gy (range, 50.0 to 64.8 Gy). Chemotherapy was administered to 35 patients (60%), and the median follow-up time was 22.0 months (range, 6.0 to 84.0 months). The 3-year locoregional relapse-free survival and distant metastasis-free survival rates were 82.1% and 52.9%, respectively. The median overall survival was 23.8 months (range, 6.0 to 84.1 months), and the 3-year overall survival rate was 58.2%. Chemotherapy did not influence the failure pattern or survival outcome. Conclusion: PORT is an effective modality for improving local tumor control in incompletely resected NSCLC patients. Major failure pattern was distant metastasis despite chemotherapy.
Postoperative radiation therapy following the incomplete resection of a non-small cell lung cancer
Jaehyeon Park,MD,Si Yeol Song,MD,PhD,Su Ssan Kim,MD,PhD,Sang-We Kim,MD,PhD,Woo Sung Kim,MD,PhD,Seung-Il Park,MD,PhD,Dong Kwan Kim,MD,PhD,Yong-Hee Kim,MD,PhD,Jongmoo Park,MD,Sang-wook Lee,MD,PhD,Jong H 대한방사선종양학회 2014 Radiation Oncology Journal Vol.32 No.2
Purpose: To review the results of postoperative radiation therapy (PORT) for residual non-small cell lung cancer (NSCLC) following surgical resection and evaluate multiple clinicopathologic prognostic factors. Materials and Methods: A total of 58 patients, who completed scheduled PORT for positive resection margin, among 658 patients treated with PORT from January 2001 to November 2011 were retrospectively analyzed. Radiation therapy was started at 4 to 6 weeks after surgery. Chemotherapy was also administered to 35 patients, either sequentially or concurrently with PORT. Results: The median age of patients was 63 years (range, 40 to 82 years). The postoperative pathological stage I NSCLC was diagnosed in 10 (17.2%), stage II in 18 (31.0%), and stage III in 30 patients (51.7%). Squamous cell carcinoma was identified in 43, adenocarcinoma in 10, large cell in 1, others in 4 patients. Microscopic residual disease (R1) was diagnosed in 55 patients (94.8%), and the remaining three patients were diagnosed with gross residual disease (R2). The median dose of PORT was 59.4 Gy (range, 50.0 to 64.8 Gy). Chemotherapy was administered to 35 patients (60%), and the median follow-up time was 22.0 months (range, 6.0 to 84.0 months). The 3-year locoregional relapse-free survival and distant metastasis-free survival rates were 82.1% and 52.9%, respectively. The median overall survival was 23.8 months (range, 6.0 to 84.1 months), and the 3-year overall survival rate was 58.2%. Chemotherapy did not influence the failure pattern or survival outcome. Conclusion: PORT is an effective modality for improving local tumor control in incompletely resected NSCLC patients. Major failure pattern was distant metastasis despite chemotherapy.
Park, Jaehyeon,Kim, Ka Young,Kim, Chaelin,Lee, Ji Ha,Kim, Ju Hyun,Lee, Shim Sung,Choi, Yeonweon,Jung, Jong Hwa The Royal Society of Chemistry 2018 Polymer chemistry Vol.9 No.29
<P>Correction for ‘A crown-ether-based moldable supramolecular gel with unusual mechanical properties and controllable electrical conductivity prepared by cation-mediated cross-linking’ by Jaehyeon Park <I>et al.</I>, <I>Polym. Chem.</I>, 2018, DOI: 10.1039/c8py00644j.</P>
Generation of Locally Optimal Trajectories against Moving Obstacles using Gaussian Sampling
Jaehyeon Park,H.Jin Kim 제어로봇시스템학회 2016 제어로봇시스템학회 국제학술대회 논문집 Vol.2016 No.10
Differential Dynamic Programming (DDP) can effectively solve an optimal control problem; however, it cannot deal with temporally changing environments such as an appearance of a moving obstacle. In this paper, we present the segmentation of locally optimal trajectories under an environment with a moving obstacle. The agent finds locally optimal trajectories by sampling Gaussian samples according to its existing incomplete policy. After one episode of the agent movement is over and if this episode performs better than the previous one, the policy is reinforced by learning the trajectories of the episode. We show that the algorithm successfully generates the locally optimal trajectories to avoid moving obstacles, and the performance of the resulting policy is improved as the episode progresses. These results would help apply reinforcement learning to robotics in two respects: learning the policy with a small number of iteration by reusing DDP policy, and taking action against changing environments. Because a real-world robot has to deal with a variant environment and has a limit of iterations for policy learning, these two results would help to settle the reinforcement learning issues for robotics.
Hybrid Fuel Preparation Combining Glycerol-Derived Hydrogel and Coal and Its Characterization
Park, Se-Joon,Lee, Dong-Wook,Lee, Young-Joo,Bae, Jong-Soo,Hong, Jai-Chang,Kim, Joeng-Geun,Park, Jaehyeon,Park, Jae Hyeok,Shin, Jong-Seon,Choi, Young-Chan American Chemical Society 2013 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.52 No.46
<P>A number of countries are mixing wood biomass with coal in existing coal-fired power plants according to the implementation of renewable portfolio standard (RPS) and cap-and-trade systems; problems arise due to mixing of the two fuels which have different combustion reactivities. In the previous work, research on glycerol impregnated hybrid fuel (Hybrid Coal by Korea Institute of Energy Research; HCK) was conducted for the diversification of bioliquid and issues to be resolved through further study in the application of glycerol to Hybrid Coal were noted. As a solution, a hydrogel having a small quantity of poly vinyl alcohol (PVA) added to glycerol was applied in the present work. PVA allowed the solidification of glycerol and contributed to the binding energy being stronger among glycerol derivatives and the surface of coal pore; thus, the fuel loss by readsorption of water can be inhibited by setting hydrogel into coal pores.</P>
Park, Jae Hyeok,Lee, Chang-Ha,Joo, Ji Bong,Bae, Dal-Hee,Shun, Dowon,Moon, Jong-Ho,Park, Young Cheol,Shin, Jong-Seon,Choi, Young-Chan,Jung, Doo-hwan,Park, Jaehyeon Taylor Francis 2016 Drying technology Vol.34 No.9
<P>Upgrading low-rank coal (LRC) through various strategies is always an important issue. Here, we report the production of hybrid coals and an evaluation of their characteristics for use as a fuel in power plants. The hybrid coals (HCKs) were prepared by a combination of drying and biomass impregnation into an Indonesian LRC followed by a precarbonization process. We used a top-spray fluidized-bed reactor for drying, biomass impregnation, and precarbonization to produce hybrid coals that have improved fuel characteristics in terms of heating value, moisture readsorption, and combustion patterns. A systematic study reveals that experimental parameters, such as a bed temperature, bioliquid spraying procedure, and precarbonization temperature strongly influence the characteristics of the resulting hybrid coal, meaning that they have an important role in upgrading LRC. In particular, the hybrid coal prepared by a process of simultaneous drying and bioliquid spraying followed by precarbonization at 200-300 degrees C showed high contents of fixed carbon, an improved heating value, lower moisture adsorption, and single combustion patterns in which the characteristics were dramatically upgraded for practical use as a fuel in power plants. In addition, the simultaneous process using a fluidized-bed reactor has great potential because it can achieve process simplification, reduce manufacturing costs, and handle coal particles easily.</P>
Non-coplanar whole brain radiotherapy is an effective modality for parotid sparing
Park, Jaehyeon,Park, Jae Won,Yea, Ji Woon Yeungnam University College of Medicine 2019 Yeungnam University Journal of Medicine Vol.36 No.1
Background: The purpose of this study was to evaluate the efficacy and feasibility of non- coplanar whole brain radiotherapy (NC-WBRT) for parotid sparing. Methods: Fifteen cases, previously treated with WBRT were selected. NC-WBRT plans were generated. The beam arrangement for the non-coplanar plans consisted of superior anterior, right, and left beams. After generation of the non-coplanar plans a field-in-field technique was applied to the bilateral parallel opposed beams in order to reduce maximum dose and increase dose homogeneity. The NC-WBRT plans were subsequently compared with the previously generated bilateral WBRT (B-WBRT) plans. A field-in-field technique was also used with the B-WBRT plans according to our departmental protocol. As per our institutional practice a total dose of 30 Gy in 10 fractions of WBRT was administered 5 days a week. Results: The mean dose to the parotid gland for the two different plans were 16.2 Gy with B-WBRT and 13.7 Gy with NC-WBRT (p<0.05). In the NC-WBRT plan, the V5Gy, V10Gy, V15Gy, V20Gy, and V25Gy of the parotid were significantly lower (p<0.05) than those of the B-WBRT plan. The $D_{max}$ of the lens was also lower by 10% with NC-WBRT. Conclusion: The use of NC-WBRT plans could be a simple and effective method to reduce irradiated volumes and improve the dose-volume parameters of the parotid gland.