複合生藥製劑의 止血作用및 摘出子官筋에 미치는 影響(第4) : 壽脾煎 및 歸脾양에 대하여 On Soo-Bi-Jeon and Kwi-Bi-Tang

殷載淳,李東熙,黃甲洙 又石大學校 1990 論文集 Vol.12 No.-

These experiments were conducted to investigate the pharmacological difference between Soo-Bi-Jeon and Kwi-Bi-Tang extract,, clinically used in gynecology, on the hemostasis and the contractile force of the isolated uterine muscle. For this purpose, the effects of the extracts on the bleeding time in mouse tail and prothrombin time in vitro were estimated. Forthermore, its activity on the isolated uterine muscle in rats were investigated. The results obtained were as following; The bleeding time and prothrombin time were significantly shortened compared with the control group in all samples, The uterotonic action produced by Kwi-Bi-Tang(Sample II), Sample III and IV (the same component crude drugs between not blocked by atropine (10^(-7)M) and cyproheptadine (10^(-7)M). but inlhibited by pretreatment of verapamil (10^(-7)M). On the oter hand, Soo-Bi-Jeon(Sample I) extract relaxed the uterine muscle.

Al-Fe-Ni 공정복합합금의 응고속도에 따른 전기저항의 변화

이재갑,조현기 경북대학교 산업기술연구소 1988 産業技術硏究誌 Vol.17 No.-

Numerous researchs have been investigated concerning the mechanism of unidirectionally solidification and the relationships between microstructure and growth rate in eutectic alloys. Although it is expected that the anisotropic microstructure associated with eutectic should produced the interesting electrical properties, almost all studies on eutectic composite alloy have been investigated about morphology, mechanical properties and thermal stability. In the present study, changes of electrical resistivity according to cooling rate in Al-Fe-Ni eutectic composite alloy is investigated. The obtained results are as follows; As cooling rate(R) increased, electrical resistivity of Al-Fe-Ni eutectic composite alloy at 520℃ increased with increaseing of fineness of eutectic fibers and formation of cellular structure. The higher the cooling rate, the higher the temperature dependence of electrical resistivity and the lower the stability of eutectic composite alloy, respectively.

慶尙南道 一部 地域 農業從事者의 農夫症에 關한 調査硏究

朴在甲 인제대학교 지역사회의학연구소 1995 硏究論文集 Vol.1 No.-

Recently, the rural Korea has been markedly changed in accordance with the development of agricultural technology and advanced economic growth. New cultivation methods have been used widely at present. Health problems among farmers working in vinyl house are increased due to long working hours in hot and humid environment. A questionnaire survey was conducted during the period from November 1992 to April 1993 to investigate the prevalence of Farmer's Syndrome and the frequencies of complaining symptoms related to the so called Vinyl House Disease. 281 farmers who worked at the vinyl house(141) or open fields(140) in Chinyang Gun and Changyoung Gun were surveyed. The results were as follows: 1. Fatigue was the most common complained symptom (92.9%) of vinyl house workers, which was followed by numb limbs(85.1%), shoulder stiffness (83.7%) and headache( 82.4%). 2. Average Farmer's syndrome scores were 4.35 in total, 4.89 in farmers worked in vinyl house and 3.82 in open fields. Average score of Farmer's syndrome of female workers( 4. 79) was much higher than that of male workers(3. 93). 3. The prevalence of farmer's syndrome of women working in vinyl house was 291 per 1000 and 209 in men. The prevalence of farmer's syndrome of women in open field was 157 per 1000 and 86 in men. 4. The longer the working hours, the more complained numb limbs(r=0.2401, P$lt;0.01), lumbago(r=0.1814, P$lt;0.05) and shoulder stiffness(r=0.1484, P$lt;0.05). The more exposure to pesticides, the more complaints with dizziness(r=0.1437, P$lt;0.05) and insomnia(r=0.1817. P$lt;0.05). 5. The shorter the time between pesticide spray and reentry into vinyl house the more common shoulder stiffness(r=0.2641, P$lt;0.01), dyspnea(r=0.1450, P$lt;0.05) and dizziness(r=0.1766, P$lt;0.05).

능이버섯의 藥理作用에 관한 硏究

殷載淳,이중원,黃甲洙 又石大學校 1990 論文集 Vol.12 No.-

The pharmacological effects of Sarcodon aspratus extract were investigated. The extract promoted contraction of isolated stomach and ileum, and this contraction was blocked by atropine(7×10^-7M) and cyproheptadine (1.5×10^-7M). The maximum effective dose of the extract was 1.5×10^-3g/㎖. The extract promoted the peristaltic movement of small intestine, and this movement was blocked by atropine. The extract accelerated the secretion of histamine in serum and gastric acid. The serum glucose and total cholesterol levels in alloxan-induced mice were significantly decreased by oral administration of the extract for 7 days. The pharmacological effects of the extract on the central nervous system were little.

국내 시판 항생제의 허가 용량 및 용법의 적정성에 대한 고찰 : 국내 약제사용설명서(package insert)와 미국 Physicians' Desk Reference의 비교 Comparison of Domestic Package Inserts with Physicians' Desk Reference

이재갑,이연주,황병연,정혜원,정성주,김성범,정희진,김우주,김민자,박승철 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

목적 : 국내 시판중인 항생제의 1일 투여량과 투여간격의 적정성을 확인하고 적응증 및 중증도에 따른 항생제 용량 제시 여부를 확인하기 위하여 항생제 시판시 KFDA의 허가사항을 담은 약제사용설명서을 미국 FDA 공인 약제에 대한 사용지침으로 쓰이고 있는 PDR(Physicians' Desk Peference)과 비교하였다. 방법 : PDR에 등재되어 있는 항생제 중에서 시럽 및 도포용 항생제를 제외한 총 61종에서, 국내에 시판되어 있는 51종 항생제의 약제사용설명서를 대상으로 1일 투여량, 투약횟수, 적응증 및 중증도에 따른 설명 정도를 비교하였다. 결과 : 1) 1일 투여량 비교 : 비교 가능한 전체 항생제에서, 약제사용설명서가 PDR보다 적은 용량을 제시한 경우는 경구용 8종, 주사용 11종으로 총 19종(37%)였으며, 많은 용량을 제시한 경우는 경구용만 2(4%)종이었고, 동일하거나 비슷한 용량을 제시한 경우는 경구용 15종, 주사용 15종으로 총 30(59%)종이었다. 약제사용설명서에서 적은 용량이 제시된 항생제 중 경구용인 cefdnir, cefixime, cefpodoxime, ofloxacin, levofloxacin, norfloxacin(6종), 주사용인 cefazolin, cefotetan, ceftizoxime, meropenem (4종) 등 반수이상의 약제가 일본제약회사로부터 국내에 수입된 약들이었으며 일본의 약제 사용설명서와 동일한 용량을 제시한 것을 알 수 있다. 2) 투여간격 비교 : 비교가능한 항생제 51종 중에서 국내약제사용설명서가 PDR과 동일한 투약횟수, 투여간격을 제시한 항생제는 30종(59%)이었다. 국내 약제사용설명서가 PDR보다 적은 투약횟수, 긴 투여간격을 제시한 항생제는 9종(17%)이었다. 오히려 많은 투약횟수, 짧은 투여간격을 제시한 항생제가 12종(24%)이나 되었다. 경구용만 비교하였을 경우 국내 약제사용설명서가 PDR보다 적은 투약횟수를 제시한 항생제는 없었으며, 동일하세 제시한 경우는 15종, 빈번한 투약횟수를 제시한 경우는 10종이었다. 주사용 항생제에서 국내 약제사용설명서가 PDR보다 긴 투여간격을 제시한 항생제는 9종, 동일한 경우는 15종, 짧은 투여간격을 제시한 경우는 2종이었다. 3) 적응증 및 중증도에 따른 비교 : 약제사용설명서에서 적응증 또는 중증도에 따른 용량에 대한 설명이 부족한 경우는 경구용 13종, 주사용 7종으로 총 20종(39%)이었으며, PDR에서는 경구용 1종, 주사용 2종으로 총 3종(6%)이었다. 결론 : 항생제에 첨부되는 약제사용설명서 및 약제사용설명서를 바탕으로 편집되는 의약품집이 항생제를 처방하는 의사들이 용법과 용량을 결정함에 있어 참고 역할을 하고 있으나, 국내의 시판 허가사항을 담은 약제사용설명서가 많은 수에서 적응증 또는 중증도에 따른 1일 투여량과 투여간격에 대한 정확한 정보를 제공하고 있지 못하고 있다. Background : The appropriate usage of antibiotics needs informations such as its effectiveness for a given infection, administration route, the amount of effective dose, and the dose intervals. In this study, in order to find any significant discrepancy regarding to the details of explanation of the necessary information for appropriate antibiotic usages, we compares informations about 51 antibiotics, one from package inserts in Korea and the other from physician's desk reference (PDR) certified by FDA in the United States of America. Materials and Methods : Package inserts about antibiotics, only oral or parenteral agent, wereperused to collect three categories of data: the recommended dosage, dose interval, and adjustment of dose to indications or the severity of infection. These data available in Korea were compared with 61 antibiotics (32 oral and 29 parenteral agents) cited in PDR. Results : Package inserts for 51 antibiotics were gathered, because the remaining 10 antibiotics in PDR are not domestically commercialized. Among data on antibiotics comparable with those in PDR, 59% (30 cases: 15 oral and 15 parenteral agents) suggested the dose similar to that of PDR, 37% (19 cases: 8 oral and 11 parenteral agents) recommend less dose, and 4% in only 2 oral agents showed more dose. About half of the drugs recommending lower dosage were imported from Japanese pharmaceutical company, and the recommended doses of these antimicrobial agents were similar to those in Japan. About 59% (30 cases: 15 oral and 15 parenteral agents) directed dose interval or duration similar to those of PDR and 17% (9 parenteral agents) suggested less administration or longer duration. Surprisingly, in contrast to only 6% (3 cases) of PDR, 24% (12 cases : 10 oral and 2 parenteral agents) recommended more administration or shorter duration. About 39% (24 cases: 13 oral and 7 parenteral agents) revealed no information for dose adjustment commons to indications or the severity of infection. Conclusion : This study revealed that many guidelines in Korea recommend lower doses and/or unreasonable dose intervals. In future studies, improved antibiotic usage guidelines should be established based on pharmacokinetic and pharmacodynamic researches, on the aspect of optimal dosage, dose interval, and dose adjustment commensurate to the indications and the severity of the infection.

Midfacial degloving approach을 이용한 양측성 상악골절제술의 치험례

오재권,류동목,이상철,김여갑,이백수 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6

Maxillary cancer accounts for only 0.3% of all cancers and tumors of the nose and paranasal sinuses are 80% of maxillary neoplasms. The complexes of midfacial anatomical landmarks make the extension of the maxillary cancer more easy. In 1826 since Lazar first made unilateral maxillectomy for the maxillary cancer, various developments were evoluated and in the surgical approach of these lesions most oral & maxillofacial surgeons have used the vestibular approach or Weber-Fergusson approach and also unilateral lesions are common but bilateral lesons are rare. In 1992 Sjovall introduced the bilateral maxillectomy and for the preventions of the facial scar, In 1927 Portmann and Retrouvey reported the sublabial approach and In 1979 Price reported the midfacial degloving approach and in 1981 Allen and Siegel used the term "Midfacial degloving approach". Unlike the previous used Weber-Fergusson approach and Caldwell-Luc method, midfacial degloving method can make the intraoral approach of midfacial structure exposure without facial incision and has populated gradually for the removal of tumors and facial plastic surgery. In this case, two male pt. with bilaterally extensive malignant neoplasm on maxillary sinus was treated with pre or post op. radiotherapy and then underwent the bilateral subtotal maxillectomy via midfacial degloving approach and relatively satisfactory results were obtained.

치아의 순(협)설 경사도 변화에 따라 파노라마 방사선 사진에 나타난 치아 길이 및 각도 변화

최갑림,임성훈,김광원,김재덕 대한치과교정학회 2007 대한치과교정학회지 Vol.37 No.2

파노라마 방사선 사진은 치아 및 주위 조직에 대한 많은 정보를 제공해 주며 교정치료 동안에도 치근의 근원심 경사도나 길이 평가를 위해 흔히 이용되고 있지만 파노라마 방사선 사진에서 보이는 치아의 근원심 각도와 길이는 순(협)설 경사도에 의해 영향을 받는 것으로 알려져 있다. 따라서 본 연구에서는 치아의 근원심 경사도를 정상교합자의 평균 근원심 각도로 유지하면서 순(협)설 경사도만 변화시킬 때 파노라마 방사선 사진에서 각 치아의 근원심 경사도와 길이가 어떻게 변화되는지 알아보고자 하였다. 성인 정상 교합자 30명의 평균 악궁을 기초로 하여 아크릴 모델을 제작한 후 치아를 대신하는 와이어를 정상 근원심 및 순(협)설 경사도(I°)로 식립하고 여기에 순(협)설 경사도만 I-15°에서 I+15°까지 5°씩 변화시켜 파노라마 방사선 사진을 촬영한 후 방사선 사진에 나타난 와이어의 길이와 각도를 각각 계측하였다. 와이어를 정상 근원심 및 순(협)설 각도로 식립했을 때 방사선 사진에서 계측된 길이는 중절치, 측절치, 견치의 경우 실제 길이의 111% ~ 117%의 확대율을 보였고, 소구치와 대구치에서는 121% ~ 125%의 확대율을 보였다. 이 때 근원심 경사도는 그대로 유지하면서 순(협)설 경사도만 I-15°(순측경사)에서 I+15°(설측경사)로 변화시킨 경우 중절치 (p < 0.01)와 측절치 (p < 0.05)에서만 유의한 확대율 증가를 보였다. 파노라마 방사선 사진에서 치아의 경사도는 대부분 실제 근원심 경사도보다 더 크게 즉 원심경사된 것으로 계측되었고, 이러한 원심경사 경향은 측절치와 견치에서 가장 크게 나타났으며, 제1, 2소구치의 I+10°, I+15° 그룹과 제1, 2대구치의 I+15° 그룹에서만 실제 근원심 각도보다 더 작게, 즉 근심 경사된 것으로 계측되었다. 또한 순(협)설 경사도의 변화에 따라 파노라마 방사선 사진에서 모든 치아의 근원심 각도가 유의한 변화를 보였는데, 순(협)설 경사도가 작아질수록, 즉 순(협)측 경사될수록 파노라마 방사선 사진에서 더 원심경사되어 나타났다. 따라서 파노라마 방사선 사진에서 중절치와 측절치의 치아 길이와 모든 치아의 근원심 경사도를 평가할 때 치아의 순(협)설 경사도에 따라 영향을 받기 때문에 이를 고려해야 할 것이다. Objective: The purpose of this study was to examine how the mesio-distal angulation and the length of each tooth changes on panoramic radiograph at different bucco-lingual inclinations. Methods: After constructing an acrylic model based on the mean arch of 30 adults with normal occlusion, the wire was placed in the center of the teeth on the acrylic model. First, the wire was implanted in normal angulation and inclination and a panoramic radiograph taken. After changing the inclination from I-15° to I+15° by 5°, a panoramic radiograph was taken again and the mesio-distal angle and wire length on the panoramic radiograph were assessed. Results: When the wire was implanted at the normal angulation and inclination, the length measured in the panoramic radiograph was magnified 111 ~ 117% from the original length in the anterior region and 121 ~ 125% in the posterior region. Only the central and lateral incisors showed significant length differences when the inclination was changed from I-15° to I+15° at fixed angulation. When the inclination was changed from I-15° to I+15°, the angulation of most teeth on panoramic radiograph appeared to be more disto-angulated than in reality, and the lateral incisor and canine showed the largest difference. Only I-15°, I+15° groups of premolars and I+15° group of molars showed more mesio-angulation than in reality. As the labio(bucco)lingual inclination of all teeth were decreased, tooth angulation in the panoramic radiograph appeared to be more disto-angulated. Conclusion: The labio-liugual inclination of teeth should be considered because it affects panoramic image of teeth, such as length of incisors and angulation of other teeth.

적응가변구조 방법을 이용한 DC MOTOR 제어에 관한 연구

하재해,한창훈,조용갑,최부귀 동아대학교 공과대학 부설 한국자원개발연구소 1994 硏究報告 Vol.18 No.1

Direct methods and indirect methods for the adaptive control of linear plant, DC motor, are currently well known. Recently, methods for combining direct and indirect methods have also been suggested. In this note the latter method is combined with the variable structure method. New adaptive laws are suggested which overcome the principal draw-backs of the variable structure method. While the direct and indirect components of the new method assure stability, the variable structure component improves the transient response of the system. Simulation results are presented to show that the overall system is asymptotically stable in the ideal case, and exhibits robustness and improved performance in the presence of perturbations.

초음파를 이용한 해저 목표물 탐지와 패턴인식에 관한 연구

김재갑 順天靑巖大學 1999 論文集-順天靑巖大學 Vol.23 No.-

In general, the experienced diver go into the water to find out Pan Shell which is spontaneously generated and brought up at the depth of 25-30 meters in the slime along the bank of an inlet of western and southern sea. However, this searching system has caused some problems in terms of economical efficiency and riskiness of diver. To overcome such problems and enhance the competence capability of fishermen, a new Pan Shell searching system is required. If an onboard searching system as a substitute of the way of diving into the deep water to identify the existence of Pan Shell is developed, it would be greatly beneficial to fishermen. The purpose of this research is to develop a new searching system of Pan Shell by making use of 50-200 Khz Ultra Sonic Signal, A/D Converter and computer process program. Based on the fact that Sonic Signal between the soft part of slime and the hard part of sand, pebble and Pan Shell is different, the possibility of this system have been approved in some degree by this time of research. However, to utilize this new system, further research on the establishment of data base and sample data is required. With the theoretical knowledge, the systematic research on the searching capability of Ultra Sonic Signal will be continued to identify the influence against the sea water subject. In this research, signal will be analyzed according to the influence range, power and sensitiveness of Ultra Sonic Generator. In addition, the radius of Ultra Sonic Signal will be included. The experimental field work will be executed at Nockdong, Pulkyo and other places well known as a habitat of Pan Shell.

뇌의 신경교종과 수막종에서 성장촉진 인자와 증식세포핵항원(PCNA)에 관한 연구

심재갑,김인선,구병삼 고려대학교 의과대학 1992 고려대 의대 잡지 Vol.29 No.1

A recent revolutionary study in molecular biology leads to understand that growth factors are necessary for normal development and the function of the cells. It has also found that many of the growth factors or their respective receptors are related to products of transforming viral genes and normal cellular counterparts called proto-oncogenes. The activation of proto-oncogenes results in growth factor secretion or growth factor receptor expression. The concommitant expression of growth factors and of their receptors results in autocrine growth stimulation, related to the development of human cancers. In this study, the presence of estrogen receptor (ER-D_(5)) and epidermal growth factor receptor(EGFR). expression of c-myc protein. and the positivity of proliferating cell nuclear antigen (PCNA) were evaluated in 26 cases of low grade (13) and high grade (7) astrocytomas and glioblastoma multiforme (6), and 22 cases of meningiomas, by immunohistochemical staining on paraffin sections. The results are summerized as follows : 1. ER-D_(5) was positive in 9 among 22 cases of meningioma (40.9%), and in 4 among 26 cases of astrocytoma and glioblastoma multiforme (19.2%). 2. EGFR was positive in 20 of 22 meningiomas (90.9%), and 20 of 26 astrocytomas and glioblastoma multiforme than in low grade tumors. 3. C-myc protein was positive in all, except one, meningiomas and all malignant astrocytomas and glioblastoma multiforme. However, it was only positive in 8 among 13 cases of low grade astrocytoma (61.5%). The positivity was higher in the meningotheliomatous type of meningiomas than in other histologic types, and also higher in malignant astrocytomas and glioblastoma multiforme than in low grade astrocytomas. 4. The PCNA-positive cells were absent or rarely seen in one case of meningiomas and 8 of 13 cases of low grade astrocytomas. The proportion of positive cells was higher in the meningotheliomatous type of meningiomas than in others, and higher in malignant astrocytomas and glioblastoma multiforme than in low grade astrocytomas. 5. There was a positive correlation between the expressibility of EGFR, c-myc protein, and PCNA. The degree of positivity was higher in malignant forms of glial tumors.