나노 소재 기반의 전기장 투과 전극에 관한 연구동향

이재형,신재혁,이상일,박원일,Lee, Jae Hyung,Shin, Jae Hyeok,Lee, Sang Il,Park, Won Il 한국마이크로전자및패키징학회 2020 마이크로전자 및 패키징학회지 Vol.27 No.1

The 'field-effect' underlies the operation of most conventional electronic devices. However, effective control and implementation of the field-effect in semiconductor devices are limited due to screening of the electric-field by conducting electrodes. Thus far, the electronic devices have necessarily been designed to avoid or minimize the electric-field screening effect. As an alternative approach to this, a new type of conducting electrodes which would be transparent to both visible light and electric-field while being electrically conductive have been developed. Here, we define these electrodes as 'electric-field transparent electrodes' and provide a review on related work. Particular attention is paid to the material selection and design strategies to enhance the electric-field transparency of the electrodes while maintaining good electrical conductivity and optical transparency. We then introduce potential applications of the electric-field transparent electrodes in electronic and optoelectronic devices.

Genome sequence of Veillonella atypica KHUD-V1 isolated from a human subgingival dental plaque of periodontitis lesion

이재형,신승윤,이한,양석빈,장은영,류재인,이진용,문지회,Lee, Jae-Hyung,Shin, Seung-Yun,Lee, Han,Yang, Seok Bin,Jang, Eun-Young,Ryu, Jae-In,Lee, Jin-Yong,Moon, Ji-Hoi The Microbiological Society of Korea 2019 미생물학회지 Vol.55 No.1

본 논문에서는 한국인 만성 치주염 환자의 치은연하치태에서 분리된 Veillonella atypica KHUD-V1의 유전체 서열을 보고한다. 다른 V. atypica 균주와 달리, KHUD-V1에서는 프로 파지 및 이와 관련된 것으로 추정되는 여러 병독성 인자가 확인되었다. V. atypica KHUD-V1 균주 및 이 균주의 유전체 서열정보는 Veillonella의 유전체 다양성을 진화론적 관점에서 이해하고, V. atypica의 병독성 및 유전적 다양성에 기여하는 프로파지의 역할을 연구하는데 유용할 것이다. Here we report the genome sequence of Veillonella atypica strain KHUD-V1 isolated from subgingival dental plaque of Korean chronic periodontitis patients. Unlike other V. atypica strains, KHUD-V1 carries two prophage regions and prophage remnants, as well as several genes homologous to prophage-associated virulence factors, such as virulence-associated protein E, a Clp protease, and a toxin-antitoxin system. The isolate and its genome sequence obtained here will aid to understand the diversity of the genome architecture of Veillonella within an evolutionary framework and the role of prophages that contribute to the genetic diversity as well as the virulence of V. atypica.

변위 시계열 데이터를 이용한 교량거더의 Flutter 계수 추정기법에 관한 연구

이재형,민원,이용재,Lee, Jae Hyung,Min, Won,Lee, Yong Jae 한국강구조학회 2001 韓國鋼構造學會 論文集 Vol.13 No.5

교량의 내풍 안전성을 평가하기 위해서는 플러터 계수(Flutter Derivatives)의 안정적 추정이 필요하다. 본 논문에서는 풍동실험에서 얻어지는 시간영역에서의 데이터중 변위 시계열데이터를 이용해서 플러터 계수를 구하는 동특성 계수 측정기법 2가지를 검토하였다. 검토된 MITD(Modified Ibrahim Time Domain) 방법과 AKF(Adaptive Kalman Filtering) 방법은 2차원단면모형 실험으로부터 동시에 8개의 플러터 계수를 산출할 수 있는 유용한 방법이다. 제안된 방법의 실제상황에서의 적용성을 검토하기 위해서 Bandlimited Gausian white noise을 가상의 데이터에 첨가하여 수학적 시뮬레이션으로 잡음에 대한 안정성을 검증해 보았다. 그 결과 교량의 플러터 해석에서는 본 연구에서 검증된 MITD 방법을 통한 플러터 계수의 산출이 추전된다. The wind resistant design of long-span bridges has urged a special attention to the prevention of the flutter occurrence Therefore calculation of flutter derivatives is indispensable to this prediction. A used system identification method must identify all the flutter derivatives from noisy experimental data In this paper MITD(Modified Ibrahim Tim Domain) method and AKF (Adaptive Kalman Filter) method are applied to extract flutter derivatives from section-model tests. The robustness and reliability of proposal SI methods under a high signal-to-noise ratio is demonstrated through numerical simulation for windtunnel test.

설하 신경 마비로 인한 설마비 환자 치험 1례

이재형,한성준,이엄지,이정은,남성욱,하나연,김진성,Lee, Jae-hyung,Han, Seong-jun,Lee, Eom-jee,Lee, Jung-eun,Nam, Seong-uk,Ha, Na-yeon,Kim, Jin-sung 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.5

Hypoglossal nerve palsy is an uncommon neurologic disorder. We report a 67-year-old Korean male with tongue paralysis due to hypoglossal nerve palsy. He had complaints associated only with tongue paralysis and was treated with herbal medicine and electric acupuncture for 12 days. We evaluated his tongue paralysis severity by a numeric rating scale (NRS) and the angle of tongue deviation. After 12 days of treatment, the NRS score showed improvement of his complaints, and the angle of tongue deviation was decreased. Korean medicine could therefore be an effective treatment choice for hypoglossal nerve palsy.

Alginate Lyase 생산 균주 Pseudomonas sp. N7151-6의 분리 및 특성

이재형,배민지,김양춘,남수완,Lee, Jae-Hyung,Bae, Min-Ji,Kim, Yang-Choon,Nam, Soo-Wan 한국미생물·생명공학회 2009 한국미생물·생명공학회지 Vol.25 No.4

해운대 연안에서 그람 음성균이면서 알긴산 분해효소를 생산하는 세균을 분리하였다. 분리된 N7151-6 균주의 성장을 위한 최적 온도는 $30^{\circ}C$, 최적 pH는 8.0으로 조사되었다. 또한 0-7%(w/v) NaCl 농도에서도 성장 가능하다. 16S rDNA 염기 서열 분석과 생화학적 분석에 의해 이 균주는 Pseudomonas 속으로 동정되어 Pseudomonas sp. N7151-6으로 명명하였다. Pseudomonas sp. N7151-6에서 생산하는 알긴산 분해효소를 한외여과(ultrafilteration; MWCO=30 kDa) 방법에 의해 부분정제하였다. 분리된 효소의 최적 pH는 7.0으로 최적 온도는 $30^{\circ}C$로 조사 되었다. pH 5.0에서 9.0까지 이 효소는 안정하였으며, $23^{\circ}C$에서 $37^{\circ}C$까지의 범위에서도 안정성을 보여주었다. 알긴산 분해효소의 전체 활성은 110 unit/L이었다. A Gram-negative, alginate lyase-producing bacterium was isolated from the Haeundae Coast, Korea. The isolated strain N7151-6 produced alginate lyase. The optimal temperature and pH for growth were found to be $30^{\circ}C$ and pH 8.0, respectively. This strain can be grown at the NaCl concentration of 0-7% (w/v). Analysis of 16S rDNA sequence and physiological profiling indicated that the strain N7151-6 belonged to Pseudomonas sp. The enzyme alginate lyase produced by Pseudomonas sp. N7151-6 was partially purified by ultrafiltration (MWCO= 30 kDa). The optimum pH and temperature for the activity of the purified enzyme were found to be 7.0 and $30^{\circ}C$, respectively. The enzyme was stable at the pH range of 5.0-9.0 and temperature range of $23-30^{\circ}C$. The total activity of alginate lyase produced was reached about 110 unit/L.

망막색소상피세포에서 포도당이 반응성산소종의 생성에 미치는 영향

이재형,김재우,Jae Hyung Lee,MD,Jae Woo Kim,MD,PhD 대한안과학회 2010 대한안과학회지 Vol.51 No.2

Purpose: To investigate the effect of high glucose (HG) on the production of reactive oxygen species (ROS) in retinal pigment epithelial (RPE) cells. Methods: ARPE-19 cells were exposed to low glucose (5 mM) and high glucose (HG, 25 mM) for three days. Additionally, 50 μM N-acetyl cysteine (NAC) and 100 μM L-arginine were co-exposed. Productions of nitric oxide (NO), ROS, and superoxide were determined by Griess assay, DCFH-DA assay, and modified cytochrome c assay, respectively. Results: HG increased production of NO, ROS, and superoxide. HG-induced cells increased production of superoxide and ROS but were suppressed by NAC and L-arginine (substrate for NO production) as an antioxidant. Conclusions: HG increased ROS production in RPE cells. Thus, HG may cause cellular dysfunction and damage by inducing oxidative stress in RPE cells. J Korean Ophthalmol Soc 2010;51(2):276-281

간헐성 외사시에서 수술시기에 따른 수술결과 비교

이재형,강남여,Jae Hyung Lee,MD,Nam Yeo Kang,MD 대한안과학회 2013 대한안과학회지 Vol.54 No.2

Purpose: To investigate how the constancy of intermittent exotropia affects postoperative motor and sensory outcomes. Methods: A retrospective analysis was conducted of 44 patients with intermittent exotropia (IXT group) and 16 patients with constant exotropia with a previous history of intermittent exotropia (CXT group). All patients were followed up for more than 1 year postoperatively. Successful postoperative motor alignment was defined as within 8 prism diopters of exo- or esotropia at 6 meters and 33 centimeters. Successful sensory outcome (bifixation) was considered as stereoacuity ≤60 seconds of arc. The influence of constancy, age at surgery, duration of strabismus, preoperative gross stereopsis, preoperative distant deviation, and preoperative distant fusion to surgical outcomes were evaluated using logistic regression analysis. Results: Mean age at surgery and follow-up periods was 9.34 years and 37.8 months in the IXT group, and 10.19 years and 45.7 months in the CXT group. Successful motor alignment rates of the IXT and CXT groups were 65.9% and 48.3%, respectively. Postoperative bifixation rates of the IXT and CXT groups were 70.5% and 12.5%, respectively. The IXT group showed significantly better successful sensory outcome (p = 0.000), but no significant difference in motor outcome (p = 0.121). Constancy and preoperative distant fusion were associated with post-operative bifixation in univariate regression analysis (p = 0.001, 0.025, respectively). However, only the constancy was strongly associated with successful sensory outcome in multivariate regression analysis with an odds ratio of 20.138 (p = 0.008). Conclusions: Surgical correction of intermittent exotropia during the intermittent period showed better sensory outcome than in constant deviation period.

POD를 이용한 구조기본단면 주변 비정상흐름장 특성에 관한 연구

이재형,마츠모토 마사루,Lee, Jae-Hyung,Matsumato, Masaru 한국강구조학회 2008 韓國鋼構造學會 論文集 Vol.20 No.6

본 연구에서는 구조적 기본단면인 사각단면중에서 B/D=2,3,4,5 단면을 대상으로 단면주위 흐름상태가 단면의 공기력 특성에 미치는 영향을 살펴보고, 정지/진동하는 B/D=4 사각실린더 주위의 비정상압력장에 POD해석을 도입함으로써 흐름패턴에 따른 POD해석의 고유벡터를 규정하고 실린더 주위 흐름장 안에 공존하는 서로 다른 흐름패턴의 상호간섭과 물리적 모드분해에 관하여 검토하였다. POD해석의 고유벡터 비교를 통해서 칼만와류는 박리버블에 의해서 거의 영향받지 않지만 칼만와류는 단면후류부에서 박리버블의 발달에 상당히 간섭하고 있음을 확인하 였다. 변장비(B/D=2,34,5) 변화에 따른 ${dC_L/d\alpha}$, ${H_1^{*}}$의 정(+)부(-)의 차이, 즉 갤로핑현상에 대한 안정/불안정성은 박리전단층의 재부착에 깊은 관련이 있는 것으로 판단되며 B/D=3,4에서 시간평균적으로 재부착하던 주위흐름장이 칼만와류의 방출을 제어하면 재부착하지 않는 것으로 생각된다. 즉, 칼만와류의 억제는 후류부에서 박리전단층의 곡률이 작아지도록 간섭하고 단면에 있어서 elongation효과를 나타낸다. In this study, the effect of an unsteady flow field around a body of aerostatic/aerodynamic forces were investigated using rectangular cylinders (B/D = 2, 3, 4, 5). Proper orthogonal decomposition (POD) was introduced to the analysis of the fluctuating pressure field that was measured on the stationary/oscillatory B/D=4 rectangular cylinder, and the characteristics of the proper functions with flow patterns were identified. In addition, the physical decoupling and interactions in the different co-existing flow patterns were investigated through POD. The comparison with the identified proper function associated with a particular flow pattern revealed that the Karman vortex is almost not affected by the separation bubble, but that the Karman vortex considerably interferes in the development of the separation bubble around the trailing edge. It can be considered that the Karman vortex induces the increment of the curvature of the substantial separated flow.

마리나 개발 적정수요와 입지선정의 중요도에 관한 연구

이재형,Lee, Jae-Hyung 해양환경안전학회 2012 해양환경안전학회지 Vol.18 No.5

본 연구는 현재 지방자치단체에서 개발 예정중인 마리나와 관련하여 우리나라에 필요한 마리나의 적정수요와 마리나 개발시 입지의 중요도를 심층적으로 분석한 후 정부 및 각 지방자치단체에게 연구의 결과를 제공하고자 하는데 목적을 두며 연구의 결론은 다음과 같다. 첫째, 국내의 마리나 개발 시 적정 수요는 대략적으로 49개 정도로 나타났다. 자세하게 언급하면 지역을 광역권으로 구분한 후, 마리나를 구간별로 네트워크화시켜 연안역 마리나의 개념으로 개발을 하여야 하며, 반드시 대형, 중형, 소형 마리나의 구분을 하여야 한다. 권역별로 10개는 대형(리조트형)마리나를 수도권(2), 충청권(1), 전라권(2), 경상도(3), 강원권(1), 제주권(1) 등에 개발하고, 17개는 중형(레포츠형)마리나를 수도권(3), 충청권(2), 전라권(2), 경상권(6), 강원권(2), 제주권(2) 등에 개발을 하여야 한다. 그리고 22개의 소형(지역 거점형)마리나는 수도권(2), 충청권(1), 전라권(6), 경상권(9), 강원권(2), 제주권(2) 등에 개발해야 한다. 둘째, 국내에 적합한 마리나 개발 입지의 중요도는 마리나 관련 전문가 그룹이 제시한 5개(접근성, 시장성, 이용성, 타당성, 자연환경)요인을 대상으로 종합적인 중요도를 분석한 결과 1순위는 이용성으로 나타났고, 2순위는 접근성, 3순위는 자연환경, 4순위는 시장성, 5순위는 타당성 요인으로 나타났다. The research aims to provide its results to each municipal corporation after an in-depth analysis of its optimum demand and also the significance of post-development location selection. The research results, related to the future development of Marina from the municipal corporation, are as follows: There are approximately 49 proper domestic demands after the Marina development. In further detail, there must be a development of the coastal zone Marina concept after classifying the regions to their Metropolitan areas and networking the Marina to each section. Moreover, the classification of the Marinas to small, medium, and large size is of absolute necessity. Regionally, 10 large Marinas must be developed for metropolitan area (2), Chungcheong area (1), Jeolla area (2), Gyeongsang Provinces (3), Gangwon area (1), and Jeju (1). The 17 mid-sized leisure sports Marinas must be developed for metropolitan area (3), Chungcheong area (2), Jeolla area (2), Gyeongsang Provinces (6), Gangwon area (2), and Jeju (2). The rest of 22 small Marinas must be developed for metropolitan area (2), Chungcheong area (1), Jeolla area (6), Gyeongsang Provinces (9), Gangwon area (2), and Jeju (2). In addition, there is an evident result of significant importance in the domestic positions of appropriate Marina development. A group of professionals suggested five key factors contributed to the importance including accessibility, marketability, usability, validity, and natural environment. The results, aimed to show comprehensive importance based on the five factors, ranks in the following order from highest to lowest: usability, accessibility, natural environment, marketability, and validity.

Logic 공정 기반의 비동기식 1Kb eFuse OTP 메모리 IP 설계

이재형,강민철,김려연,장지혜,하판봉,김영희,Lee, Jae-Hyung,Kang, Min-Cheol,Jin, Liyan,Jang, Ji-Hye,Ha, Pan-Bong,Kim, Young-Hee 한국정보통신학회 2009 한국정보통신학회논문지 Vol.13 No.7

본 논문에서는 로직 공정 기반의 저전력 eFuse OTP 메모리 셀을 제안하였다. eFuse OTP 메모리 셀은 프로그램과 읽기 모드에 최적화되도록 각각의 트랜지스터를 사용하였으며, WL과 BL의 기생적인 커패시턴스를 줄이므로 읽기 모드에서의 동작 전류를 줄였다. 그리고 저전력, 저면적의 eFuse OTP 메모리 IP 설계를 위하여 비동기식 인터페이스, 분리된 I/O, 디지털 센싱 방식의 BL 감지 증폭기 회로를 사용하였다. 모의실험 결과 읽기 모드에서의 동작전류는 VDD, VIO 각각 349.5${\mu}$A, 3.3${\mu}$A로 나왔다. 그리고 동부하이텍 0.18${\mu}$m generic 공정으로 설계된 eFuse OTP 메모 리 IP의 레이아웃 면적은300 ${\times}$557${\mu}m^2$이다. We propose a low-power eFuse one-time programmable (OTP) memory cell based on a logic process. The eFuse OTP memory cell uses separate transistors optimized at program and read mode, and reduces an operation current at read mode by reducing parasitic capacitances existing at both WL and BL. Asynchronous interface, separate I/O, BL SA circuit of digital sensing method are used for a low-power and small-area eFuse OTP memory IP. It is shown by a computer simulation that operation currents at a logic power supply voltage of VDD and at I/O interface power supply voltage of VIO are 349.5${\mu}$A and 3.3${\mu}$A, respectively. The layout size of the designed eFuse OTP memory IP with Dongbu HiTek's 0.18${\mu}$m generic process is 300 ${\times}$557${\mu}m^2$.