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Jack M. Harrowfield 고신대학교 자연과학연구소 2008 고신대학교 자연과학연구소 논문집 Vol.15 No.-
The work described above is no more than a fragment of contemporary chemistry illustrating some steps in its evolution. The ability to form grids from appropriately designed ligands, for example, has led to syntheses using functionalised ligands which provide larger, spatially oriented arrays of the functional groups [25] with the potential for selective interactions with other molecules, thus leading to even larger aggregates which may be of importance in catalysis, analysis or even medical therapy [28,30). There is a need for new methods to detect and quantify weak interactions between chemical species [31], driven by the increasing complexity of the systems studied, and their development should lead to even greater sophistication of synthetic systems [32], some of which may even challenge the efficacy of Nature in ensuring the survival of mankind.
Jack Jr., Clifford R.,Garwood, Michael,Wengenack, Thomas M.,Borowski, Bret,Curran, Geoffrey L.,Lin, Joseph,Adriany, Gregor,Grö,hn, Olli H. J.,Grimm, Roger,Poduslo, Joseph F. Wiley Subscription Services, Inc., A Wiley Company 2004 Magnetic resonance in medicine Vol.52 No.6
<P>One of the cardinal pathologic features of Alzheimer's disease (AD) is the formation of senile, or amyloid, plaques. Transgenic mice have been developed that express one or more of the genes responsible for familial AD in humans. Doubly transgenic mice develop “human-like” plaques, providing a mechanism to study amyloid plaque biology in a controlled manner. Imaging of labeled plaques has been accomplished with other modalities, but only MRI has sufficient spatial and contrast resolution to visualize individual plaques noninvasively. Methods to optimize visualization of plaques in vivo in transgenic mice at 9.4 T using a spin echo sequence based on adiabatic pulses are described. Preliminary results indicate that a spin echo acquisition more accurately reflects plaque size, while a T<SUB>2</SUB>* weighted gradient echo sequence reflects plaque iron content, not plaque size. In vivo MRI–ex vivo MRI–in vitro histologic correlations are provided. Histologically verified plaques as small as 50 μm in diameter were visualized in living animals. To our knowledge this work represents the first demonstration of noninvasive in vivo visualization of individual AD plaques without the use of a contrast agent. Magn Reson Med 52:1263–1271, 2004. © 2004 Wiley-Liss, Inc.</P>