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태아 쥐와 임신 쥐의 간에서 Protein Carboxyl Methylation
전길자,최혜정,이준승 이화여자대학교 생명과학연구소 1990 생명과학연구논문집 Vol.1 No.-
Protein carboxyl methyltransferase(EC 2.1.1.77) which has specificities for the protein containing abnormal asparty residues is investigated in lysosome, mitochondria, peroxisome in liver of fetus, pregnant rat and vacuole vesicles in beet root. The level of this enzyme in brain cytosol of normal rat was almost same as that in brain cytosol of pregnant rat. But in liver cytosol, PCM activity of fetal rat was increased 17-fold more than that of normal rat. Total enzyme activities in lysosome, mitochondria and peroxisome of fetal and pregnant rat were not changed. But the total methylatability of fetal rat were increased about 2-fold comparing to pregnant rat. Vacuole vesicles showed the enzyme activities and methylatabilities.
태아 쥐와 임신 쥐의 간에서 Protein Carboxyl Methylation
전길자,최혜정,이준승 梨花女子大學校 韓國生活科學硏究院 1990 韓國生活科學硏究院 論叢 Vol.46 No.-
Protein carboxyl methyltransferase(EC 2.1.1.77) which has specificities for the protein containing abnormal aspartyl residues is investigated in lysosome, mitochondria, peroxisome in liver of fetus, pregnant rat and vacuole vesicles in beet root. The level of this enzyme in brain cytosol of normal rat was almost same as that in brain cytosol of pregnant rat. But in liver cytosol, PCM activity of fetal rat was increased 17-fold more than that of normal rat. Total enzyme activities in lysosome, mitochondria and peroxisome of fetal and pregnant rat were not changed. But the total methylatability of fetal rat were increased about 2-fold comparing to pregnant rat. Vacuole vesicles showed the enzyme activities and methylatabilities.
Development and Evaluation of the Elderly Health Mileage Program to Promote Exercise
June, Kyung Ja,Kim, Hee Gerl,Park, Bohyun 한국보건간호학회 2017 韓國保健看護學會誌 Vol.31 No.3
Purpose: The purpose of this study was to develop a Health Mileage Program (EHMP) to promote exercise amongst the elderly and assess the feasibility of the program. Methods: A literature review to identify the effects of exercise in the elderly was conducted. Relevant cases were investigated and in-depth interviews with exercise instructors were conducted, after which the EHMP was developed based on the assessment and tested in three regions. The outcome was evaluated using indicators such as attendance rate, number of participants, proportion of participants who received health education, and proportion of participants who measured their physical and mental status. Results: Based on assessment, we developed an EHMP composed of four steps. Following application of the EHMP in three regions, ≥80% of the participants received incentives. Additionally, ≥85% of participants underwent measurement of their physical and mental status. The proportion of participants who received health education differed among regions. Conclusion: The EHMP program increased participation and interest in exercise programs for the elderly. However, there is concern regarding availability due to regional differences in resources related to elderly exercise; therefore, it will be necessary to invest in infrastructure, including facilities, and knowledgeable instructors.
호암상 수상 기념특강 : Progression and chemoprevention of hepatocellular carcinoma
( Ja June Jang ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.2
Epidemiological and experimental data have demonstrated that the process of carcinogenesis is progressive and multistage in nature. Model systems in animals exhibit this property of cancer development for several organ systems. The rodent liver is one of the most extensively studied models of carcinogenesis. The evolution of hepatic neoplasia is a slow process leading from the normal state via preneoplasia to benign and malignant neoplasia. On the histological level, hepatic preneoplasia usually emerges as foci of altered hepatocytes (FAH) which can be perfectly integrated in the normal liver parenchyma and have no obvious neoplastic nature. The early emergence of FAH seems to be a general phenomenon of hepatocarcinogenesis in all species, no matter how this process has been elicited. In rodent liver treated with various chemical carcinogens, most of phenotypes have been shown to represent successive stages in an ordered sequence of cellular changes, progressing from glycogenic, clear and acidophilic cell foci, through intermediate, mixed and basophilic cell populations, to hepatocellular adenomas and carcinomas, the fast growing variants of which consist of glycogen-poor, basophilic cells. Following curative treatment for hepatocellular carcinoma (HCC), 50%-90% of postoperative death is due to recurrent disease. Chemoprevention, the use of natural or synthetic chemical agents to reverse, suppress or prevent carcinogenesis is considered an important way for confronting HCC. Any agent which can prevent a new HCC from developing in the background of chronic liver diseases after curative treatment, will improve the prognosis of HCC patients.