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Iseul Yu,Suk Joong Yong,Won-Yeon Lee,Sang Ha Kim,Hyun Lee,Ju Ock Na,Deog Kyeom Kim,Yeon-Mok Oh,이지호 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.5
Background/Aims: Patients with bronchiectasis often present with respiratory symptoms caused by chronic rhinosinusitis (CRS). However, studies on the prevalence of CRS and its relationship with bronchiectasis are limited. Methods: The baseline characteristics of patients with bronchiectasis recruited from the Korean Multicenter Bronchiectasis Audit and Research Collaboration were analyzed. CRS diagnosis was determined by a physician, on the basis of medical records, upper airway symptoms, and/or radiologic abnormalities. Questionnaires for quality of life, fatigue, and depression were administered when patients were stable for a minimum of 4 weeks after the bronchiectasis exacerbation. Results: The prevalence of CRS was 7.1% (66/931). Patients with CRS were significantly younger than those without CRS (60.5 ± 10.7 years vs. 64.6 ± 9.3 years, p = 0.001). Idiopathic bronchiectasis was more common in patients with CRS compared to those without CRS (53.0% vs. 36.0%, p = 0.006). Lung function, inflammatory markers, exacerbations, bronchiectasis severity, and scores for quality of life, fatigue, and depression did not differ between the two groups. In a logistic regression analysis, CRS was associated with age of bronchiectasis diagnosis (odds ratio [OR], 0.96; 95% confidence interval [CI], 0.94 to 0.99; p = 0.003) and idiopathic bronchiectasis (OR, 1.95; 95% CI, 1.12 to 3.34; p = 0.018). Conclusions: The prevalence of CRS was relatively low. CRS was not associated with the severity or clinical outcomes of bronchiectasis. Early diagnosis and idiopathic etiology were associated with CRS. Our findings reflect the low recognition of CRS in the clinical practice of bronchiectasis and highlight the need for awareness of CRS by adopting objective diagnostic criteria.
Seismo-acoustic characterization of the 2018 Ambae eruption, Vanuatu
Iseul Park,Arthur Jolly,Robin Matoza,Ben Kennedy,Geoff Kilgour,Richard Johnson,Esline Garaebiti,Sandrine Cevuard 대한지질학회 2021 대한지질학회 학술대회 Vol.2021 No.10
Ambae (also called Manaro Voui or Aoba) is a basaltic shield volcano in the Vanuatu archipelago. Recently, this volcano resumed a new eruptive episode from 2017 and released various seismic and acoustic activity associated with phreatic/phreatomagmatic/magmatic eruptions. To observe the activity, we installed a multi-station network comprising seven broadband seismic stations and four 3-element acoustic arrays during the 2018 eruptive phase. The observed seismic signals mostly consist of volcanic tremor and explosion quakes, which are related to volcanic fluid movement. The corresponding acoustic (infrasound) signals have relatively low frequency (< 1 Hz) and affect the seismic data in a very-long-period band as ground-coupled airwaves. The infrasound waves during volcanic explosions show strong coherence over all the arrays, and these coherent signals are used to detect previously unreported volcanic explosions based on a reverse-time-migration method. During the detected explosions, seismic source locations ascend and then descend, which might be interpreted as the propagation of a pressure front, bubble activity, and two superimposed source locations. No preceding study for Ambae’s eruption has been completed, hence this study using novel seismo-acosutic dataset may be useful to improve the local monitoring system and future work.
( Iseul Yu ),( Ji-ho Lee ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0
Background Patients with bronchiectasis often present with symptoms as a result of comorbidities. Respiratory symptoms caused by chronic rhinosinusitis (CRS) are commonly seen in patients with bronchiectasis. However, a study on prevalence of CRS and its relationship with bronchiectasis is scarce. Methods Baseline characteristics of patients with non-cystic bronchiectasis recruited from the Korean Multicenter Bronchiectasis Audit and Research Collaboration were analyzed. Diagnosis of CRS was determined by physician based on the medical record, upper airway symptoms, and/or radiologic abnormality. Questionnaires for quality of life, fatigue, and depression were inquired when patients were stable at least 4 weeks after the exacerbation of bronchiectasis. Pulmonary function test and history of exacerbations within 1 year of enrollment were collected. Results A total of 931 patients with bronchiectasis were included. Onset age of bronchiectasis was 57.5 ± 11.1 for patients with CRS, which was significantly lower than 61.4 ± 9.4 years for patients without CRS (p=0.002). Idiopathic bronchiectasis was higher for patients with CRS compared to patients without CRS (53.0% versus 36.0%, p=0.006). Predicted FEV1% did not differ between two groups: 68.3 ± 21.1 % for patients with CRS and 66.8 ± 19.1 % for patients without CRS (p=0.589). Exacerbation frequency, bronchiectasis severity and scores for quality of life, fatigue, and depression did not differ significantly between two groups. In a binary logistic regression, CRS was associated with onset age (OR 0.97, 95% CI: 0.94-0.99, p=0.020) and idiopathic bronchiectasis (OR 2.30, 95% CI: 1.25-4.23, p=0.007). Conclusions Prevalence of CRS was relatively low. Early onset age and idiopathic bronchiectasis were factors associated with CRS. Further study for the prevalence of CRS and its impact on bronchiectasis is warranted.
A Case of Acute Fibrinous and Organizing Pneumonia
( Iseul Yu ),( Sang-ha Kim ),( Sung Min Ko ),( Soon-hee Jung ),( Ji-ho Lee ),( Seok Jeong Lee ),( Myoung Kyu Lee ),( Won-yeon Lee ),( Suk Joong Yong ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Acute fibrinous and organizing pneumonia (AFOP) is a rare type of acute lung injury. AFOP can be misdiagnosed with pneumonia or tuberculosis, because there is no characteristic clinical feature. Case presentation A 80-year-old man was hospitalized in May 2021 with exertional dyspnea for 14dyas. Before admission, he had taken levofloxacin at a local clinic for 10 days, but there was no benefit. On admission day, His blood pressure was 132/76 mmHg, heart rate was 82 beats/min, respiratory rate was 18 breaths/min, temperature was 37.0 °C and oxygen saturation 93% in room air. Initial laboratory data included a white blood cell count of 8.98 X /L, C-reactive protein 9.75 mg/dL, serum procalcitonin 0.13 ng/mL. Electrolytes, hepatorenal function, and respiratory virus ware normal. The blood cultures revealed no growth, besides sputum TB-PCR and acid-fast bacilli smear & culture were all negative. Autoimmune antibody profiles were within normal limits. A chest computed tomography (CT) scan showed consolidation and ground-glass opacity in the right lower lobe with small amount pleural effusion. We treated him with an empirical antibiotic therapy (cefoperazone/sulbactam plus levofloxacin) for community acquired pneumonia. But his symptoms and chest X-ray was getting worse, so we exchanged levofloxacin for clarithromycin. Despite of antibiotics change, his clinical status worsened with fever. CT guided transthoracic needle biopsy was done on day 12 and histologic examination revealed AFOP. On day 14, we started on intravenous methylprednisolone 1mg/kg (75mg) daily. His general conditions (fever, dyspnea) and chest X-ray were improved. The patient discharged on day 26 with oral methylprednisolone 32mg daily. He is on tapering dose of steroid in outpatient follow-up.