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      • Determining Nursing Student Knowledge, Behavior and Beliefs for Breast Cancer and Breast Self-examination Receiving Courses with Two Different Approaches

        Karadag, Mevlude,Iseri, Ozge,Etikan, Ilker Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.9

        Background: This study aimed to determine nursing student knowledge, behavior and beliefs for breast cancer and breast self-examination receiving courses with a traditional lecturing method (TLM) and the Six Thinking Hats method (STHM). Materials and Methods: The population of the study included a total of 69 second year nursing students, 34 of whom received courses with traditional lecturing and 35 of whom received training with the STHM, an active learning approach. The data of the study were collected pre-training and 15 days and 3 months post-training. The data collection tools were a questionnaire form questioning socio-demographic features, and breast cancer and breast self-examination (BSE) knowledge and the Champion's Health Belief Model Scale. The tests used in data analysis were chi-square, independent samples t-test and paired t-test. Results: The mean knowledge score following traditional lecturing method increased from $9.32{\pm}1.82$ to $14.41{\pm}1.94$ (P<0.001) and it increased from $9.20{\pm}2.33$ to $14.73{\pm}2.91$ after training with the Six Thinking Hats Method (P<0.001). It was determined that there was a significant increase in pre and post-training perceptions of perceived confidence in both groups. There was a statistically significant difference between pre-training, and 15 days and 3 months post-training frequency of BSE in the students trained according to STHM (p<0.05). On the other hand, there was a statistically significant difference between pre-training and 3 months post-training frequency of BSE in the students trained according to TLM. Conclusions: In both training groups, the knowledge of breast cancer and BSE, and the perception of confidence increased similarly. In order to raise nursing student awareness in breast cancer, either of the traditional lecturing method or the Six Thinking Hats Method can be chosen according to the suitability of the teaching material and resources.

      • Parotid Gland Tumours in Turkish Population: Analysis of 165 Patients

        Derin, Serhan,Erdogan, Selvet,Almac, Ahmet,Ulubil, Arif,Iseri, Mete,Aydin, Omer,Keskin, I Gurkan,Oran, Abdulkadir,Kuru, Fatma Demir Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8

        Background: Retrospective data on 165 patients who presented with a parotid mass and underwent surgery in our clinics during 2000-2009 were examined. The obtained data (demographic data, surgical procedures, histopathological diagnoses) were compared to similar studies to make contributions to the literature. Materials and Methods: Patients were classified according to their histopathological diagnosis. Surgical procedures and patient follow-up were clarified. The results are presented as means and standard deviations. Results: Of the 165 masses, 134 (81.3%) were benign and 31 (18.7%) were malignant. Pleomorphic adenoma was the most common benign tumour (79 patients, 59%). Lymphoma and adenoid cystic carcinoma were equally common and were the most common malignant parotid gland tumours (both 6 patients, 19.3%). The most frequent surgical procedure was superficial parotidectomy (92 patients, 55.7%), and the most commonly encountered surgical complication was facial paralysis (12 patients, 7.2%). Conclusions: Our data are generally in line with the literature but lymphoma was more common than in most previous reports. Although the number of cases was low, the high incidence of parotid gland lymphoma was remarkable.

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        Identification of aquifer system in the whole Red River Delta, Vietnam

        Duong Du Bui,Akira Kawamura,Thanh Ngoc Tong,Hideo Amaguchi,Naoko Nakagawa,Yoshihiko Iseri 한국지질과학협의회 2011 Geosciences Journal Vol.15 No.3

        The Red River Delta is one of two biggest deltas in Vietnam. People living in the delta depend entirely on groundwater for their domestic water. However, the aquifer system in the whole Red River Delta remains poorly understood due to the lack of available data. Recently, we were nominated to construct a hydrogeological database. Using these valuable data contained in this database, this paper comprehensively analyzed the best number of 778 boreholes including well logs and their hydrogeological parameters obtained from pumping tests for the first time in order to identify the entire aquifer system and characterize hydrogeological conditions in the whole delta for potential groundwater resources. Great efforts have been made to establish and analyze hydrogeological maps, cross sections, and contour maps of main aquifers’ thickness and transmissivity. As for the results, we found that groundwater mainly exists in Quaternary unconsolidated sediments as porous water forming the topmost Holocene unconfined aquifer (HUA) and the shallow Pleistocene confined aquifer (PCA) sandwiching the Holocene-Pleistocene aquitard (HPA), while cleft and karst water exist in consolidated Neogene formations and Mesozoic rocks constituting the Neogene water bearing layer (NWL) and Mesozoic fractured zones (MFZ), respectively. PCA is almost entirely distributed over the delta. It serves as the highest groundwater potential and the most important aquifer for water supply. HUA is also widely distributed about 88% over the delta and has a high groundwater potential. NWL and MFZ, placed below PCA but exposed on the surface outside the delta, are minor sources for local domestic water supply only. These findings are indispensable for further groundwater analyses needed to ensure the sustainable groundwater development for the high-security water requirements in the delta, but have never been completed sufficiently before due to the unavailability of large-scale basic data sets

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        Clinical and genetic analyses in syndromic intellectual disability with primary microcephaly reveal biallelic and de novo variants in patients with parental consanguinity

        Mercan Sevcan,Akcakaya Nihan Hande,Salman Baris,Yapici Zuhal,Ozbek Ugur,Sibel Aylin Ugur Iseri 한국유전학회 2023 Genes & Genomics Vol.45 No.1

        Background Syndromic intellectual disability (ID) with accompanying primary microcephaly is a group of rare neurodevelopmental disorders exhibiting extreme genetic and clinical heterogeneity. This layered heterogeneity can partially be resolved by unbiased genetic approaches targeting the genome with next generation sequencing (NGS) technologies, including exome sequencing (ES). Objective This study was performed to dissect the clinical and genetic features in five distinct IDM cases. Methods Singleton or trio ES approach followed by in-depth variant analysis using alternative inheritance models was performed. Results We have identified biallelic loss of function variants in genes WDR62 and AP4M1 in three families, together with de novo missense variants in genes SOX11 and TRIO in two families. ES based haplotype analysis in two cases upon identification of an identical WDR62 variant in the homozygous state in two cases was suggestive of a small shared haplotype of 0.1 Mb. Additionally, we have shown a paternal origin for the de novo variant in TRIO via a polymorphic tag SNP, which enlightens the mutational mechanism for this variant. Conclusion In populations with high parental consanguinity, an autosomal recessive inheritance pattern for data analysis is usually the most obvious choice. Therefore, heterozygous variants may be overlooked in standard NGS analyses in consanguineous families. Our findings underlie the importance of using multiple inheritance models in NGS data analysis.

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        The Healing Effects of Autologous Mucosal Grafts in Experimentally Injured Rabbit Maxillary Sinuses

        Murat Topdag,Ahmet Kara,Esma Konuk,Necdet Demir,Murat Ozturk,Sebla Calıskan,Deniz Ozlem Topdag,Arif Ulubil,Ibrahim Gurkan Keskin,Mete Iseri 대한이비인후과학회 2016 Clinical and Experimental Otorhinolaryngology Vol.9 No.1

        Objectives. Healing processes of the nose and paranasal sinuses are quite complex, and poorly understood. In this study, we aimed to compare the effect of mucosal autologous grafts on the degenerated rabbit maxillary sinus mucosa with spontaneous wound healing. It is hypothesized that mucosal grafts will enhance ciliogenesis and improve the morphology of regenerated cilia. Methods. Ten female New Zealand rabbits were included in the study. They underwent external maxillary sinus surgery through a transcutaneous approach. A total of 20 maxillary sinuses were randomly divided into 2 groups: ‘spontaneous healing group’ and ‘autologous graft group.’ The animals were sacrificed at the 14th day after the surgery. Scanning electron microscope (SEM), and light microscope were used for the evaluation. Results. Cellular composition of the graft group is better than the spontaneous healing group. The graft group had larger areas covered with ciliary epithelium than the spontaneous healing group, and the mean length of the cilias were also longer. Additionally, there were wider cilia with abnormal morphology areas in the spontaneous healing group. Conclusion. In our opinion, covering of the denuded areas with a graft improves re-epithelization, and may prevent the early complications after sinus surgeries.

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