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( Iqra Rabani ),서영수 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
Zinc Oxide (ZnO) nanoparticles (NPs) integrated on the surface of cellulose nanofibril (CNF) were prepared by a sol-gel reaction and its size was controlled under various synthesis conditions. ZnO-CNF hybrid as a sunscreen has merits such as skin non-penetration of ZnO nanoparticle, enhanced water solubility or dispersibility, reduced photodamage of the skin from ZnO-mediated free radical formations (photocatalytic effect). Especially, photocatalytic effect of ZnO in water was found to be completely reduced by the hybridization, where it was measured by decolouration degree of an organic dye under UV irradiation. Integrated amount of ZnO on the CNF was obtained to be up to 78 wt% of the hybrid, which indicates that the hybridization was cost-effective as for a sunscreen with high sun protection impact factor.
Iqra Ghulam Rasool,Muhammad Yasir Zahoor,Muhammad Iqbal,Aftab Ahmad Anjum,Fatima Ashraf,Hafiz Qamar Abbas,Hafiz Muhammad Azhar Baig,Tariq Mahmood,Wasim Shehzad 한국유전학회 2021 Genes & Genomics Vol.43 No.5
Background Intellectual disability (ID) is a heterogeneous disorder afecting 1–3% of the population. Elucidation of monogenic variants for ID is a current challenge. These variants can be better demonstrated in consanguineous afected families. Objective The study was designed to fnd the genetic variants of ID in consanguineous families. Methods We analyzed fve unrelated consanguineous Pakistani families afected with ID using whole exome sequencing (WES). Data was analyzed using diferent bioinformatics tools and software. Results We mapped four variants including three novels in four diferent ID known genes. Each variant is found in a different family, co-segregating with a recessive pattern of inheritance. The novel variants found are; c. 2_4del (p.?) mapped in ROS1 and c. 718G>A (p.Gly240Arg) in GRM1. Another novel causative variant, c.2673del (p.Gly892Aspfs*17) identifed in COL18A1 in a recessive form, a gene reported for Knobloch syndrome that manifests ID along with typical retinal abnormalities, and this phenotype was confrmed on reverse phenotyping. A mutation c.2134C>T (p.Arg712*) in TRAPPC9 has been found frst time in the homozygous recessive form in our enrolled three afected siblings while it was previously reported in compound heterozygous form in a Caucasian descent. While ffth family remained unsolved. Conclusion These mutations in four diferent genes with a recessive inheritance would be a contribution to the disease variant database of this devastating disorder.
Iqra Mir,Sania Aamir,Syed Rizwan Hussain Shah,Muhammad Shahid,Iram Amin,Samia Afzal,Amjad Nawaz,Muhammad Umer Khan,Muhammad Idrees 질병관리본부 2022 Osong Public Health and Research Persptectives Vol.13 No.2
The coronavirus disease 2019 (COVID-19) pandemic rapidly spread globally. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, is a positive-sense single-stranded RNA virus with a reported fatality rate ranging from 1% to 7%, and people with immune-compromised conditions, children, and older adults are particularly vulnerable. Respiratory failure and cytokine storm-induced multiple organ failure are the major causes of death. This article highlights the innate and adaptive immune mechanisms of host cells activated in response to SARS-CoV-2 infection and possible therapeutic approaches against COVID-19. Some potential drugs proven to be effective for other viral diseases are under clinical trials now for use against COVID-19. Examples include inhibitors of RNA-dependent RNA polymerase (remdesivir, favipiravir, ribavirin), viral protein synthesis (ivermectin, lopinavir/ritonavir), and fusion of the viral membrane with host cells (chloroquine, hydroxychloroquine, nitazoxanide, and umifenovir). This article also presents the intellectual groundwork for the ongoing development of vaccines in preclinical and clinical trials, explaining potential candidates (live attenuated-whole virus vaccines, inactivated vaccines, subunit vaccines, DNA-based vaccines, protein-based vaccines, nanoparticle-based vaccines, virus-like particles and mRNA-based vaccines). Designing and developing an effective vaccine (both prophylactic and therapeutic) would be a long-term solution and the most effective way to eliminate the COVID-19 pandemic.
Characterization and Comparative Evaluation of Milk Protein Variants from Pakistani Dairy Breeds
Iqra Yasmin,Rabia Iqbal,Atif Liaqat,Wahab Ali Khan,Muhamad Nadeem,Aamir Iqbal,Muhammad Farhan Jahangir Chughtai,Syed Junaid Ur Rehman,Saima Tehseen,Tariq Mehmood,Samreen Ahsan,Saira Tanweer,Saima Naz 한국축산식품학회 2020 한국축산식품학회지 Vol.40 No.5
The aim of study was to scrutinize the physicochemical and protein profile of milk obtained from local Pakistani breeds of milch animals such as Nilli-Ravi buffalo, Sahiwal cow, Kajli sheep, Beetal goat and Brela camel. Physicochemical analysis unveiled maximum number of total solids and protein found in sheep and minimum in camel. Buffalo milk contains the highest level of fat (7.45%) while camel milk contains minimum (1.94%). Ash was found maximum in buffalo (0.81%) and sheep (0.80%) while minimum in cow’s milk (0.71%). Casein and whey proteins were separated by subjecting milk to isoelectric pH and then analyzed through sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). The results showed heterogeneity among these species. Different fractions including αS1, αS2, κ-casein, β-casein and β-lactoglobulen (β-Lg) were identified and quantitatively compared in all milk samples. Additionally, this electrophoretic method after examining the number and strength of different protein bands (αS1, αS2, β- CN, α-LAC, BSA, and β-Lg, etc.), was helpful to understand the properties of milk for different processing purposes and could be successfully applied in dairy industry. Results revealed that camel milk was best suitable for producing allergen free milk protein products. Furthermore, based on the variability of milk proteins, it is suggested to clarify the phylogenetic relationships between different cattle breeds and to gather the necessary data to preserve the genetic fund and biodiversity of the local breeds. Thus, the study of milk protein from different breed and species has a wide range of scope in producing diverse protein based dairy products like cheese.
Regu Iqra Akram,Wadud Abdul,Rahman Khaleequr,Jabeen Uzma 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.1
Phyto-constituents and their efficacy vary with the age of the plant material and their affliction with environmental and storage conditions. Present study was conducted to evaluate the time dependent variation in physicochemical characters, glycyrrhi- zin content, microbial load and anti-inflammatory activity of Glycyrrhiza glabra L. root (GGR). Fresh GGR was dried and divided into three samples and stored as: sample A below 4 °C, sample B at room temperature and sample C at 40 ± 2 °C with relative humidity 75 ± 5% for six months. Afterwards, each sample was extracted in 50% alcohol and evaluated for phys- icochemical characters, glycyrrhizin content, microbial contamination and anti-inflammatory activity in histamine-induced inflammation in Wistar rats. Physicochemical characteristics exhibits less than 25% variation and qualitative analysis for plant metabolites exhibited similarity in all three samples. Glycyrrhizin was found more in sample C (5.07%) in comparison to sample B (4.52%) and A (4.72%) with variation less than 15%. As per the Ayurvedic Pharmacopeia of India these vari- ations in physicochemical parameters and glycyrrhizin content are insignificant. Sample A revealed total microbial count more than B and C. Accelerated stability data extrapolation of sample C suggests that shelf life of GGR is 2 years. Inflam- mation was significantly reduced by sample C followed by A and B in comparison to the control with residual paw volume of 0.9%, 3.22%, 20.4% and 29.7% respectively at 163 mg/kg BW dose. From the present study it can be concluded that up to two years age dependent variations in GGR is insignificant but its anti-inflammatory effect are glycyrrhizin dependent.
Rasool Iqra Ghulam,Zahoor Muhammad Yasir,Ahmed Irfan,Iqbal Muhammad,Shafqat Shehla,Anjum Aftab Ahmad,Shehzad Wasim 한국유전학회 2023 Genes & Genomics Vol.45 No.4
Background Intellectual disability (ID) is a neurodevelopmental condition, affecting 1–3% of the population. Genetic factors play a key role causing the limitation in intellectual functioning and adaptive behavior. The heterogeneity of ID makes it more difficult for genetic and clinical diagnosis. Mapping of variants through next generation DNA sequencing in consanguineous families would help to understand the molecular parthenogenesis of ID. Objective The aim of this study was to describe the genetic variants of ID in consanguineous Pakistani families. Methods We analyzed four unrelated consanguineous Pakistani families having an intellectual disability through whole exome sequencing (WES). Data was analyzed using different bioinformatics tools and software. Results We mapped four novel variants in different ID genes. Each variant is found in different family, co-segregating with a recessive pattern of inheritance. The variants found are; c.1437delG:p.Asn480Thrfs*10, mapped in FKRP, c.2041 C>A:p.Leu681Met in HIRA, c.382 C>T:p.Arg128Cys in BDH1 and c.267+1G>A:p.? identified in TRAPPC6B. Conclusions These variants help in demonstration of status and molecular basis of intellectual disability in Pakistani population leading to provision of genetic counseling services and a contribution in disease variant database.
Moeez, Iqra,Jung, Hun-Gi,Lim, Hee-Dae,Chung, Kyung Yoon American Chemical Society 2019 ACS APPLIED MATERIALS & INTERFACES Vol.11 No.44
<P>Most active materials for sodium-ion batteries suffer from the problem of low-energy efficiency in the first cycle because of the loss of active sodium ions consumed for the formation of a solid electrolyte interface. To make up for the lost sodium ion, presodiation treatments have been applied, which are effective ways to mitigate the low initial efficiency. Here, we developed a direct-contact method to achieve the presodiation for cathode and anode electrodes and demonstrated the enhanced Coulombic efficiency of the first cycle with improved cyclability and reversible capacity. Moreover, we proved the formation of a thick passivation layer at the cathode-electrolyte interface during the presodiation process; this contributes to the improved cycle stability by preventing the dissolution of the active material and its deposition on the anode surface. The direct-contact method is a simple and cost-effective way to complete presodiation, and this simple process will be widely applicable for practical battery manufacturing.</P> [FIG OMISSION]</BR>
Riaz Iqra,Qamar Obaid Ali,Jamil Farrukh,Hussain Murid,Inayat Abrar,Rocha-Meneses Lisandra,Akhter Parveen,Musaddiq Sara,Karim Muhammad Ramzan Abdul,박영권 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.11
The use of biodiesel is a proactive measure that can be implemented to reduce emissions of greenhouse gases and other adverse environmental impacts. However, one of the major setbacks to biodiesel production is its relatively higher cost compared to petroleum diesel. The optimistic solution to this is valorization of biomasses like waste chicken fat (WCF) and clay for deriving non-edible oil and catalyst respectively. Herein, we report the synthesis of clay derived SiO2 catalyst impregnated with SrO, Bi2O3, CuO and CaO. The developed catalysts were characterized by FTIR, XRD, and SEM. XRD studies confirmed the successful impregnation of active metallic oxide on SiO2 support. Further, these catalysts were employed for biodiesel production from WCF, and SrO/SiO2 was found to be most effective and efficient catalyst for biodiesel production from WCF. Hence, SrO/SiO2 was adapted to optimize the different transesterification reaction parameters such as methanol to oil ratio, catalyst loading, reaction temperature and time. The optimized conditions for maximum biodiesel yield 98.9% were found to be 65 °C in 1 h with 12:1 methanol to oil ratio and 1 wt% catalyst loading. The biodiesel produced was also analyzed by GC-MS. The obtained biodiesel yield shows that clay can be a potential, and cost-effective, catalyst source to produce biodiesel from WCF.
Redispersible Freeze-dried Quercetin-loaded Liposomal Formulations Stabilized with Lyoprotectants
윤지애,Iqra Haleem,김형민,윤새미,박기환,이재휘 대한화학회 2019 Bulletin of the Korean Chemical Society Vol.40 No.6
Enhanced physical stability of quercetin-loaded liposomes redispersed in water after freeze-drying through four different saccharides used as lyoprotectants.