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Inkeun Park,Jae Lyun Lee 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.4
After cisplatin-based chemotherapy became the standard treatment for metastatic urothelial cancer (mUC), very little progress has been made in the treatment landscape of this condition until recently. With increased knowledge about the molecular biology of mUC and advances in the field of cancer immunobiology, there has been an explosion in the number of clinical trials for mUC, and systemic treatment of mUC is rapidly changing. Despite the availability of several novel therapeutic agents, cisplatin-based cytotoxic chemotherapy remains the standard, first-line treatment option. Immune checkpoint inhibitors (ICIs), including programmed death-1 and programmed death ligand-1 inhibitors, are preferred second-line treatment options that are also used in first-line cisplatin-ineligible settings. For patients with actionable fibroblast growth factor receptor 2 (FGFR2) or FGFR3 genomic alterations, erdafitinib can be considered after platinum-based treatment. Enfortumab vedotin, a monoclonal antibody targeting nectin-4 conjugated to monomethyl auristatin E, has been approved for patients who do not respond to both cytotoxic chemotherapy and ICIs. In this review, we address the clinical trial data that have established the current standard treatments and ongoing clinical trials of various agents with different mechanisms as well as provide a brief overview of current practice guidelines and recommendations in patients with mUC.
한인근 ( Inkeun Han ) 성균관대학교 국정관리대학원 2013 국정관리연구 Vol.8 No.1
본 논문은 한국의 공·사조직에서의 성과급의 효과성을 메타분석방법으로 연구하였다. 분석결과를 통해 성과급에 관한 일반적 특징을 도출하였고, 공·사조직에서의 효과성을 비교분석하였다. 수집된 자료는 최종42편이 성과급의 효과성 분석에 사용되었다. 그리고 본 논문에서는 서로 다양한 선행연구들을 일관된 기준에 따라 분석하기 위해 가설검증비율이라는 공통된 기준으로 효과성을 분석하였다. 본 연구를 통해 밝혀진 성과급의 효과성에 관한 일반적 특징은 다음과 같다. 첫째, 한국의 공·사조직에서 성과급은 긍정적인 조직관리의 효과를 갖는다. 둘째, 정부기관에서의 성과급의 효과성은 사기업에 비해 낮다. 셋째, 공·사조직에서 성과급이 동기부여에 대해 미치는 효과성은 매우 높다. 넷째, 정부기관의 경우 성과급은 직무만족과의 관계가 높고, 사기업의 경우 성과급은 조직몰입과의 관계가 높다. 다섯째, 공·사조직에서 성과급과 성과의 관계는 동기부여나 태도와의 관계에 비해 가장 낮은 것으로 나타났다. 선행연구에 대한 이와 같은 종합적 연구는 그 표본수가 정부기관 7,426명, 사기업 45,534명에 달하기 때문에 개별 선행연구에 비해 대표성과 일반화의 수준이 높다고 볼 수 있을 것이다. This study examines the effectiveness of the performance pay at the public and the private organizations in Korea by the meta-analysis method. This study uses the rate of hypothesis test as a common criteria to analyze the previous studies which used various analysis methods and different samples. The results of this study suggest some general characteristics of the effectiveness of the performance pay; 1) the performance pay is effective in the positive organization management at both the public and the private organizations. 2) the effectiveness of the performance pay at the public organizations is lower than that at the private organizations. 3) the performance pay is highly effective in the motivation at both the public and the private organizations. 4) the relationship between the performance pay and the job satisfaction is higher at the public organizations, and the relationship between the performance pay and the organizational commitment is higher at the private organizations. 5) the relationship of the performance pay with the performance is relatively lower than the relationship with the motivation or the attitude at both the public and the private organizations. Since it is the more comprehensive study using the greater sample size with 7,426 persons at the public organizations and 45,534 persons at the private organizations compared with previous studies, this study would present more reliable representativeness and degree of generalization than the previous each study.
Fault Tree Analysis를 통한 EMB 고장의 분류 및 EMB의 고장 검출 알고리즘 개발
김인근(Inkeun Kim),한광진(Kwangjin Han),허건수(Kunsoo Huh),김명준(Myoungjune Kim),김주곤(Joogon Kim),구본경(Bongyeong Koo) 한국자동차공학회 2009 한국자동차공학회 학술대회 및 전시회 Vol.2009 No.11
Barke-by-Wire systems are lighter in weight, faster in response, easier to implement than the conventional brake systems. Because brake systems are directly related to passengers’ life, guarantee of system’s robustness are essential for implementation. In order to ensure the reliability of the Electro-Mechanical Brake(EMB), a robust dry-type BBW controller should be designed. In this study, a fault detection algorithm is designed based on classified faults. Fault Tree Analysis is used to show how the faults are occurred and how their causes are related to the basic events. In order to detect the rotor faults, magnetic flux leakage are estimated using the estimation algorithm. By choosing a proper threshold, it is shown that rotor fault can be detected.
Skull Metastasis of Gastric Gastrointestinal Stromal Tumor Successfully Managed by Surgery
Park, Inkeun,Chung, Dong Hae,Yoo, Chan Jong,Shin, Dong Bok The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.1
Gastrointestinal stromal tumors (GISTs) are rare, but are the most common mesenchymal neoplasm of the gastrointestinal tract. The most common sites of metastasis are liver and peritoneum, while bone metastasis is rare. We report on a patient with skull metastasis after seven years of treatment with imatinib for metastatic GIST. She underwent metastasectomy consisting of craniectomy with excision of the mass, and cranioplasty and continued treatment with imatinib and sunitinib, without evidence of cranial recurrence. She died of pneumonia sepsis one year after metastasectomy. Skull metastasis of GIST is a very rare presentation, and an aggressive multidisciplinary approach should be considered whenever possible.
손인근(Inkeun Son),박상준(Sangjoon Park),김용철(Yongchul Kim) 국방로봇학회 2024 국방로봇학회 논문집 Vol.3 No.1
We have been witnessing innovative improvements in unmanned autonomous robot technologies and also facing enlarged their applications in the military. Even at Ukraine-Russia war, AI(artificial intelligence)-enhanced platforms have been being operated. It is very noteworthy that there are concerns about manipulating AI technologies even though AI is still in the early stage of growth. To dispel the constantly raised fears, a few nations have announced military AI principles and following guidelines. They intended to convince their credibility in developing and operating AI capabilities in military operations. However, the main object is to show the reliability of current AI systems, which are mainly based on weak AI and so can not execute beyond on-the-loop of human interventions. This paper is to deal with following AI issues that will be publicly agendicized when AI-enhanced platforms with limited autonomy are operated in battle field. Even unmanned autonomous robots have constrained autonomy, there must be ethical challenges in real operation environments. Thus, we make an issue of military ethical challenges and propose directions for future manned and unmanned team systems and following AI ethics.