국소재발된 두경부종양의 무고정틀 정위적 분할방사선치료

김인아(In Ah Kim),최일봉(Ihl Bhong Choi),장지영(Ji Young Jang),강기문(Ki Mun Kang),조승호(Seung Ho Jho),김형태(Hyung Tae Kim),이경진(Kyung Jin Lee),최창락(Chang Rak Choi) 대한두경부종양학회 1998 대한두경부 종양학회지 Vol.14 No.2

Background & Objectives: Frameless fractionated stereotactic radiotherapy(FFSRT) is a modification of stereotactic radiosurgery(SRS) with radiobiologic advantage of fractionation without losing mechanical accuracy of SRS. Local recurrence of head and neck cancer at or near skull base benefit from reirradiation. Main barrier to successful palliation is dose limitation secondary to normal tissue tolerance. We try to evaluate the efficacy and safety of FFSRT as a new modality of reirradaton in these challenging patients. Materials & Methods: Seven patients with recurrent head & neck cancer involving at or near skull base received FFSRT from September 1995 to November 1997. Six patients with nasopharyngeal cancer had received induction chemotherapy and curative radiation therapy. One patient with maxillary sinus cancer had received total maxillectomy and postoperative radiation therapy as a initial treatment. Follow-up ranged from 11 to 32 months with median of 24 months. Three of 7 patients received hyperfractionated radiation therapy(1.1-1.2Gy/fraction, bid, total 19.8-24Gy) just before FFSRT. All patients received FFSRT(3-5Gy/fraction, total 15-30Gy/5-10fractions). Chemotherapy(cis-platin 100mg/m(2)) were given concurrently with FFSRT in four patients. Second course of FFSRT were given in 4 patients with progression or recurrence after initial FFSRT. Because IF(irregularity factor; ratio of surface area of target to the surface area of sphere with same volume as a target) is too big to use conventional stereotactic RT using multiple arc method for protection of radiation damage to critical normal tissue, all patients received FFSRT with conformal method using irregular static ports. Results: Five of 7 patients showed complete remission in follow-up CT &/or MRI. Three of these five patients who developed marginal, in-field, and out-field recurrences, respectively. Another one of complete responders has been dead of G-I bleeding without evidence of local recurrence. One partial responder who showed progressive disease 15 months after initial FFSRT has received additional FFSRT, and then he is well-being with symptomatic improvement. One minmal responder who showed progression of locoregional disease 9 months after 1st FFSRT has received 2nd FFSRT, and then he is alive with stable disease. Five of 7 case had showed direct invasion to skull base and had complaint headache and various symptoms of cranial nerve involvement. Four of these five case showed improvement of neurologic symptoms after FFSRT. No significant neurologic complicaltion related to FFSRT was observed during follow-up periods. Tumor volumes were ranged from 3.9 to 50.7 cc and surface area ranged from 16.1 to 114.9cm(2). IF ranged from 1.21 to 1.74. The average ratio of volume of prescription isodose shell to target volume was 1.02 that indicated the improvement of target coverage and dose distribution with FFSRT with conformal method compared to target coverage with FFSRT with multiple arc method. Conclusion: Our initial experience suggests that FFSRT with conformal method was relatively effective and safe modality in the treatment of recurrent head and neck cancer involving at or near skull base. Treatment benefit included good palliation of symptoms and reasonable radiographic response. However, more experience and additional follow-up are needed to better assess its ultimate role in treating these challenging patients.

상륙이 고지방식이 흰쥐의 체지질 변화에 미치는 영향

노성택,김인락 대한본초학회 2001 大韓本草學會誌 Vol.16 No.1

The purpose of this experimental study is to find wheather Phytolaccae Radix is effective or not in hyperlipidemia rat. During 8 weeks 30 rats were fed with high fat diet for inducing hyperlipidemia. The contents of serum total cholesterol, trilyceride free fatty acid, phospholipid and weight were measured in each groups, in the induced hyperlipidemic rat experiments. 1. The increase of weight tended to be decreased. 2. The increase of total cholesterol in the serum tended to be decreased. 3. The content of triglyceride in the serum tended to be decreased. 4. The content of free fatty acid in the serum tended to be decreased. 5. The content of phospholipid in the serum tended to be decreased, but was not significant difference. According to above these results, Phytolaccae Radix have shown to be capable of cure and prevent for an hyperlipidemia.

Monoamine Oxidase 의 활성 변화에 의한 기미론 연구

黃今熙,마진열,金仁洛 대한본초학회 1999 大韓本草學會誌 Vol.14 No.1

To explain the theory of KIMI which is the theory of therapeutics in oriental medicine, the monoamine oxidase(MAO) activities were determined in the brain and liver of mouse which was orally adminstered cold and hot drugs, and forced swimming in cold and hot water. The MAO plays a central role in the metabolism of many amines including the neurotransmetter monoamines. MAO is a flavoprotein found exclusively in the mitochondrial outer membrane, occuring in the MAO-A and MAO-B subtypes. MAO-A deaminates serotonin and noradrenaline, whereas MAO-B prefers penylethylamine and benzylamine as substrates. Serotonin is important neurotransmetter for the control of body temperature. Coptis japonica Makino was selected as the cold drug, and Radix Aconiti lateralis preparata was as the hot drug. Coptis japonica Makino elevated the MAO-A activity which was increased by cold stress, whereas it inhibited the MAO-B activity which was increased by cold stress. Coptis japonica Makino elevated the MAO-A activity which was decreased by heat stress, whereas it inhibited the MAO-B activity which was increased by heat stress. Radix Aconiti lateralis preparata inhibited the MAO-A activity which was increased by cold stress, whereas it inhibited the MAO-B activity which was increased by heat stress.

계피의 부위별 cinnamic acid 와 cinnamic aldehyde 정량

이태희,문정호,김인락 대한본초학회 2001 大韓本草學會誌 Vol.16 No.2

In order to prove which layer of Cinnamomi cortex had been used in Oriental medicine, the contents of cinnamic acid and cinnamic aldehyde as indexd component on 3 different layers of Cinnamomi Cortex were analysed respectively The results were: 1. The cinnamic acid contents of Cassiae Cortex Interior was 0.135%, inner bark layer, 0.031%, peridium, 0.023%, and average, 0.068%. 2. The cinnamic aldehyde contents of Cassiae Cortex Interior was 1.686%, inner bark layer 0.139%, peridium, 0.183%, and average, 0.696%. From the above results, it is suggested that the main part of Cinnamomi Cortex showed pharmacological activity is its interior.

桂枝湯의 氣味 표준화 연구(Ⅰ)

金仁洛 현곡학회 1997 제3의학 Vol.2 No.2

This study was conducted to standardize the "Ki-Mi" of Kye-Ji Tang in the 1 of 'Treatise on Febrile Diseases o and the results were as follows : 1. The medicinal plants used are processed with hot water right after picking. 2. One seung(升) of water equals to 10cc. 3. One yang(兩) equals to 6 grams. 4. Medicinal plants are shattered to the size of beans by the process call Boo-Jeor(부저). 5. Kye-Ji Tang, which is composed with 5 medicinal plant(Cortex Cinnamom 18g; Radix Paeoniae : 18g; Radix Glycyrrhizae : 12g; Rhizoma Zingiberis : 1~ Fructus Ziziphi Jujubae : 18g), is prepared by adding 490c:c water to above medicinal plants and boiled to 210cc. After boiling, the residue is discarded a the extract is taken orally 3 times a day as one dosage of 70cc. It recommended that 20 minitues after taking of Kye-Ji Tang, the additional upt of rice porridge might enhance the pharmacological effect of Kye-Ji Tang.

에너지 敎育의 敎材開發에 관한 硏究Ⅰ

崔宗洛,洪仁植 경북대학교 과학교육연구소 1981 科學敎育硏究誌 Vol.5 No.-

The energy crises in Korea has been a serious problem in the economic development In this paper, the present status of the crisis is discussed, and then the contents and the methods of the energy education is also discussed. The contents of education, eighteen items in the cognitive domain, seven items in the affective domain, and eight items of the skills are selected. The learing and teaching method of the education, inquiry method is recommended so that the students are able to acquire the best knowledges and skills of energy control through their real experience.

한약재의 보관 , 절단 , 수치 , 전탕법에 관한 연구 1 : 육계 Cortex Cinnamomi

金仁洛,黃今熙,朱慧庭 대한본초학회 1998 大韓本草學會誌 Vol.13 No.2

To improve the quality control of frequantly used oriental medicinal plants, the stroage, cutting, processing and decokting methods of Cinnamomum cassia were examined. The contents of cinnamic acid and cinnamaldehyde of Cinnamomum cassia were analysed by HPLC at various conditions as the standard components. Standard components decreased in aerobic condition more than in anaerobic storage condition. The cinnamic acid decreased and the cinnamaldehyde increased during the aerobic and anaerobic storage condition. Especialy, cinnamaldehyde was conciderably increased at aerobic storage condition. The soaking and steaming processing for easy cutting resulted in the loss of the standard components. The best decokting conditions which were determined by the yield of cinnamic acid were as follows : the size was below 0.5㎝, soaking time was 90 minutes, decokting time was 15 minutes after boiling.

한약재의 절단 , 수치 , 전탕법에 관한 연구 Ⅲ : 厚朴 Cortex Magnoliae

金仁洛,黃今熙,朱蕙庭 대한본초학회 1999 大韓本草學會誌 Vol.14 No.1

To improve the quality control of frequantly used oriental medicinal plants, the cutting, processing and decokting methods of Magnolia obovata were examined. The contents of magnolol of Magnolia obovata were analysed by HPLC at various conditions as the standard component. The content of magnolol increased about 3% in baked Magnolia obovata. The soaking and steaming processing for easy cutting resulted in the loss of the standard components about 10%. The best decokting conditions which were determined by the yield of magnolol were as follows : the size was below 0.5㎝, soaking time was 0 minutes, decokting time was 75 minutes after boiling.

기미론에 대한 문헌적 연구

김인락 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

Kimi(氣味) means five tastes(五味), sour, bitterness, sweetness, ho taste and astringency, and four conditions(四氣), cold, hot, warm and cool, in the oriental medicine. This is defined based on yn-yang 5 evolutive phases(陰陽五行), and 5 evolutive phases on the change of season. Four seasons, spring, summer, autumn, winter are clearly different but, the rainy season(辰夏) is not. In the theory of Ki(氣), not worn not hot(平) is included in addition to the four conditions that is because the rainy season is not differentiated clearly. Kimi have relations to the four seasons, that is, warm and hot taste is considered as spring, hot and astringency as summer, not worm not hot and sweetness as rainy season, cool and sour as autumn, and cold and bitterness as winter. 4 conditions can be classified more detail, because the changes of the seasons are continuous. In the action mechanisms, Gardeniae Fructus reduces Heat of Insufficiency Type of the upper class of medicinal herbs, and Rhel Rhizoma reduces Exessive Heat(實熱) of the under class of the. The assay methods for four groups medicines can be developed in three ways according to the indicators as follows. First, by the indicator which defines cold-acting medicine(寒性藥) such as Rhei Rhizoma, Coptidis Rhizoma, Scutellariae Radix, Gardeniae Fructus and is differentialted clearly from Hot-acting medicine(熱性藥) at the same time. Second, when the medicines are classified into another four groups as Drugs for Dispelling Internal Cold, Drugs for Regulatings Ki Flow(理氣藥), by the indicator which satisfies each group and is differentiated from other groups, at the same time. Third, by the indicator which has to be defined for each medicinal herb for four classification, individually.

선박적용을 위한 장주기 광섬유 격자 압력센서의 기초연구

손경락(Kyung Rak Sohn),최영길(Young Gil Choi),장세인(Se In Jang),최재윤(Jae Yun Choi) 한국마린엔지니어링학회 2005 한국마린엔지니어링학회 학술대회 논문집 Vol.2005 No.-

we present a pressure sensor based on the mechanically formed long-period fiber gratings. The attenuation properties of an output power as a function of an external pressure is able to apply to the in-line fiber pressure sensors for the vessels.