信號交叉路의 交通特性과 左回轉 禁止에 따른 運營效果에 관한 硏究

홍익상,공창환,정우영,임채문 대구대학교 산업기술연구소 1993 産業技術硏究 Vol.12 No.-

This study analyzed the characteristics of the operation of left turns at intersections of the streets in Taegu City. The points of the study were as follows: increase of traffic capacity, decrease of delay time, and to do so this study aims at seeking a way for the most appropriate signal cycle and an effective way to operate intersections. The following are the results: 1st The arterials of Taegu City have a high rate of left turns, and yet are not divided into specific functions, which impairs the efficient use of the functions. It is required that a study be made on the way of utilizing the left turn to the maximum of the operational functions of signalized intersections. 2nd As traffic volume and left turn ratio increase, it was revealed that the optimum signal cycle and delay increased, adoption of efficient lanes was analysed to be most effective at the intersection which have a great of traffic volume and a high or rate of left turns. 3rd On the independent intersection in Taegu city, when left turn is prohibited, it may give poor approaches, but according to analyses this will bring a phenomenal decrease in the optimum signal cycle and delay.

세포브러쉬와 면봉도말법에 의한 부인과 세포학적 검사의 효율비교

김정란,김성숙,배한익,김용탁,심재철,임문환,윤혜원,이상식 동국대학교 경주대학 1993 東國論集 Vol.12 No.-

A study was undertaken to evaluate the efficiency of the sytobrush compared with the cotton swab for obtaining cells from the uterine cervix. In 300 patients, the cytobrush technique was employed and in control 300 patients was smeared by the cotton swab. In 12 out of 300 patients(4%) endocervical cells were found on the cotton swab technique. A total of 252 out of 300 cytobrush sampler specimen(84%) contained endocervical cells. With the X²method for statistical comparison, the difference in endocervical cell yield between the cotton swab and the cytobrush sampler was significantly different(p<0.01). This was particularly true in older patients. We conclude from study that the cytobrush sampler is of value for obtaining as adequate cervical cytologic specimen.

한중노선의 저가항공사 진출전략 -춘추항공(春秋航空)을 중심으로-

문익환 ( Ik Hwan Moon ),안세진 ( Se Jin An ),유용재 ( Yong Jae Yoo ) 한국유통물류정책학회 2015 유통물류연구 Vol.2 No.2

세계항공운송시장의 경쟁체제가 점차 심화되는 가운데, 아시아·태평양지역 여객운송시장 에서도 저가항공사(LCC)가 새로운 주역으로 부상하고 있다. 말레이지아의 에어아시아(Air Asia)와 일본의 피치(Peach) 등 해외 국제선 경험이 풍부한 LCC외에 최근에는 자국내시장 이 거대한 중국 LCC가 파격적인 운임으로 공격적 영업을 하면서 우리나라를 중심으로 한 동북아 LCC 시장의 경쟁은 더욱 더 치열해질 것으로 예상된다. 항공시장에서도 중국은 아시아 항공시장에서의 중요한 변수가 되고 있다. 2015년12 월 한중 FTA의 국회비준통 과로한. 중간의 무역 및 항공교류는그 어느때 보다 관심이 고조 되고 있으며. 중국은 현재한국의 최대 수출국이자 최대 수입국으로 현재국내 한중 노선의 항공시장 규모는 꾸준히 커져가고 있다. 중국의 LCC 시장을 이끌고 있는 춘추항공(Spring Airlines)은 2013년 제주-상하이에 이어 2014년 인천-상하이노선의 정기노선을 취항하였는데, 인천-상하이노선을 운항하는 LCC는 춘추항공이 처음이지만 향후 중국노선에서의 LCC 간의 경쟁은 더욱 심화될 전망이다. 이처럼 국내항공시장은 저비용항공사가 출항한지 10년을 넘어서면서 국.내외적으로 큰 변화를 맞고 있음에도 불구하고, 거대 자본력과 국제선 운항 노하우를 가진 외국계 LCC에 대응할만한 경쟁력 제고방안이 미흡한 실정이다. 국내 LCC들도 외국 LCC들로부터 국내 시장의 보호를 넘어선 해외진출을 가속하기 위한 보다 구체적인 경쟁전략 수립이 필요하며, 이를 지원하기 위한 여러가지의 정책적 지원이 요구된다. Recently low-cost carriers are becoming major players in the world aviation market. Especially they achieved great success in US and European Market. Asia and Pacific region is now targeted as a potential market by low-cost carriers. Several aviation companies already entered into the market like Japan, Republic of China and so on. Considering this, the Republic of Korea needs to seek for various political support and strategies to expand their low-cost carrier market share. Among those is building a strategic partnership with aviation companies of China. It will help to develop and seize the opportunity in low-cost carrier market.

구강내 미생물, pH, 완충용액과 충치와의 관계

정문진 ( Moon Jin Jeong ) , 김익환 ( Ik Hwan Kim ) , 최치원 ( Chi Won Choi ) 조선대학교 구강생물학연구소 2004 Oral Biology Research (Oral Biol Res) Vol.28 No.2

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A New Soybean Cultivar with Lodging Resistance and Adaptability for Mechanized Harvesting, "Shingi"

Jung Kyung Moon,Keum Yong Park,Hong Tae Yun,Yeong Ho Lee,Min Jung Seo,Sun Lim Kim,Yong Hwan Ryu,Suk Ha Lee,Ja Hwan Ku,Jae Hwan Roh,Jung Soo Park,Ik Jae Kim,Soo Kyeong KimMoon 한국육종학회 2005 한국육종학회지 Vol.37 No.2

P285 : Gene expression profiling in melasma in Korean women

( Ik Jun Moon ),( Bo Young Chung ),( Tai Kyung Noh ),( Sang Hwa Yang ),( Il Hwan Kim ),( Mi Woo Lee ),( Tae Jin Yoon ),( Sung Eun Chang ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: There has been a paucity of data about the difference in the expression of the genes between the malasma lesional skin and normal adjacent one. Objectives: Our aim was to identify novel genes involved in the pathogenesis of melasma. Methods: We performed a microarray analysis and confirmed the results on the quantitative real-time polymerase chain reaction (qRT-PCR) in Korean women with melasma. Results: There were 334 genes which degree of expression showed a significant difference between the melasma lesional skin and normal adjacent one. Of these, five genes were confirmed on qRT-PCR. In the melasma lesional skin, there were down-regulation of genes involved in the PPAR signaling pathway and up-regulation of genes involved in neuronal component and the functions of stratum corneum barrier. Conclusion: This result suggests that the pathogenesis of melasma might be associated with novel genes involved in the above signaling pathway in Korean women

Replacement techniques to reduce animal experiments in drug and nanoparticle development

Ik Sup Jin,Moon Sup Yoon,Chun‑Woong Park,Jin Tae Hong,Youn Bok Chung,Jin‑Seok Kim,Dae Hwan Shin 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.3

Background Animals have been used for the testing of new drugs and nanoparticles to determine their safety and effectiveness before application in humans. Numerous drugs and nanoparticles have been developed through animal tests, and development in medical nanotechnology is progressing rapidly. However, a good experiment requires many animals. The primary measures to reduce animal experiments include reducing the number of animals used in each experiment and replacing laboratory animals with inanimate, cellular, or inferior animals to reduce sacrifices. Area covered Developing nanoparticles using simulations rather than experiments may be another alternative. Instead of animals, human cells or animal-derived organs, tissues, or cells could be used in experiments. These methods allow rapid toxicity and efficacy testing at low cost. However, the disadvantage of these methods is that they cannot accurately replicate the complex interrelationships between human organs, biological reactions to specific routes of administration, or toxicity of substances resulting from metabolic processes. To overcome these shortcomings of in vitro tests, new technologies such as organoids and organ-on-chips are progressing. These can be used to quickly examine the efficacy of newly developed drugs and nanoparticles and can be useful in developing patient-tailored agents. Expert opinion These technologies offer some promise but it is still difficult to entirely replace animal experiments. However, the scope of methods to replace experimental animals is widening, suggesting the potential to refine, reduce, and ultimately replace animal testing.

마우스 복강 대식세포의 Prostaglandin 합성에 미치는 Bacterial Lipopolysaccharide의 영향

문창현,김지영,최소연,박정미,어수익,이수환 아주대학교 의과학연구소 1996 아주의학 Vol.1 No.1

Production of inflammatory mediators by the host in response to bacterial lipopolysaccharide (LPS) is generally believed to be responsible for the pathogenesis of septic shock. One of the mediators associated with septic shock sequelae are arachidonic acid metabolites, including prostanoids and leukolrienes. Prostaglandin H synthase (PGHS) is a rate-limiting enzyme in prostanoid synthesis of which there were very recently reported two different isotypes. Their activities and expressions are known to be regulated by different mechanisms. Also, differences in response to stimulators have been shown for the different cell types. Even in the macrophage populations, there have been reported diverse profiles of prostanoid synthesis. These discrepancies might be due to the differences in the underlying regulation mechanisms, but presently, little information is available regarding these. Thus, in order to get insights into these discrepancies, firstly, we compared the characteristics of LPS-induced prostanoid production in alveolar macrophages and mouse peritoneal macrophages and secondly, we examined whether variations of glucose concentration affect LPS-induced prostanoid synthesis and PGHS-2 activity in both cell types. Overall responses to LPS were qualitatively similar between both cell types, and LPS-induced TXB2 production was attenuated in high glucose media.

Eupatilin Inhibits Hepatic Fibrosis by Blocking TGF-β1 /non-Smad Signaling

Moon Kee MAENG,Byung Soo YOON,Ik Hwan KIM 한국생물공학회 2018 한국생물공학회 학술대회 Vol.2018 No.4

성인남성의 혈청 DHEAS(Dehydroepiandrosterone Sulfate) 농도와 건강수준에 관한 연구 : 일부 대학병원 건강검진 대상자를 중심으로

문성환,박상화,김응익,한정호 대한보건협회 1998 대한보건연구 Vol.24 No.1

본 연구의 목적은 한국인 성인남성에서 연령에 따른 혈청 DHEAS 농도의 변화 양상을 관찰하고, 혈청 DHEAS 농도와 성인병 진단에 이용되는 혈액화학적 검사치, 건강수준 및 생활습관과의 관련성을 조사하여 DHEAS 농도가 건강수준의 지표가 되는가를 확인하고자 하였다. 연구대상은 1997년 5∼7월 사이에 서울시내 1개 대학병원의 건강검진 프로그램을 이용하여, 면담 당시 일상적인 사회활동이 가능하고 일반적으로 건강한 23∼80세 사이의 성인 남성 235명(건강검진 결과 정상 판정자 129명 및 질환 의심자 106명)을 대상자로 선정하였다. 1. 전체 대상자 중 건강검진 결과 정상으로 판정받은 129명의 대상자에서 5세 단위로 나눈 연령군별 혈청 DHEAS 농도는 40세 미만에서는 180∼195μg/100㎖로 유의한 차이가 없었으나, 40세 이상에서 연령이 증가함에 따라 점차 감소하는 경향을 보여 70세 이상 군에서는 51.2±28.3μg/100㎖이었고, 연령군별로 유의하였다. 연령과 혈청 DHEAS 농도와의 회귀분석 결과 년간 DHEAS 농도 감소율은 1.14% 정도이었다. 2. 전체 235명의 대상자에서 연령, 혈액화학적 분석치, BMI 및 생활습관 변량과 혈청 DHEAS 농도와의 단순 및 부분 상관관계 분석 결과 유의한 상관관계를 보이는 변량은 연령(r=-0.564), 수축기 혈압(r=0.141), r-CTP(r=-0.189), 흡연양(r=0.162), GOT(r=0.135), GPT(r=-0.144)인 것으로 나타났다. 그러나 BMI, 확장기 혈압, 혈색소 농도, 혈당, 혈청 총 콜레스테롤 농도와 음주 및 운동량에서는 유의한 상관관계가 관찰되지 않았다. 3. 연령과 흡연양을 보정한 후 각종 혈액화학적 분석치, BMI 및 혈압의 정상 및 비정상 범위별 혈청 DHEAS 농도 평균치의 차이를 분석한 결과 혈색소(F ratio=3.140, p=0.045)의 경우를 제외하고는 유의한 차이가 관찰되지 않았다. 4. 연령과 흡연양을 보정한 후 일상적인 생활습관의 군별 평균 혈청 DHEAS 농도의 차이를 분석한 결과에서는 음주 여부에 따라 유의한(p=0.048) 차이가 관찰되었으나, 주당 음주량, 흡연 여부와 하루 흡연양 및 운동 여부와 주당 운동시간에 따른 군별 평균 DHEAS 농도의 차이는 유의하지 않았다. 5. 과거병력, 성인병에 의한 가족사망력, 건강검진 판정 및 대상자 자신이 평가하는 건강수준의 군별 평균 DHEAS 농도의 차이를 연령과 흡연량을 보정한 후 분석한 결과에서는 성인병에 의한 가족사망력이 없는 경우와 대상자 자신이 평가하는 건강수준이 좋은 경우에 평균 혈청 DHEAS 농도가 유의하게 높은 것으로 관찰되었다. 6. 이상의 연구결과는 비록 성인병의 위험인자로 알려진 혈액화학적 분석치 대부분에서는 혈청 DHEAS 농도에 유의한 차이를 보여 수지는 못하였으나 의사의 건강검진 판정이나 대상자 본인이 인식하는 건강수준 및 혈청 효소활성과는 유의한 연관성을 보임으로써 혈청 KHEAS 농도가 인체의 건강수준과 관련이 있을 가능성을 제시하였다. In recent years, relationships of dehydroepiandrosterone sulfate(DHEAS) with decreased risks of diabetes, cardiovascular disease, and other age-related degenerative diseases have been postulated. To examine the association of blood chemistry values, smoking and drinking behaviors, physical activity, and other variables related to health status with circulating DHEAS levels, the serum DHEAS concentrations were measured cross-sectionally in generally healthy 235 Korean adult males(23 to 80 years old) participated in health examination program of a university hospital from May to July. 1997. The results are as follows: 1. In 129 normal subjects, the mean of serum DHEAS in age groups of <40 yr were 179.9~195.2㎍/100㎖, and then significantly(F=8.626, p=0.0000) declined steadily as age increased(40~44 yr, 171.4±75.8㎍/100㎖; 45~49 yr, 125.7±63.5㎍/100㎖; 50~54 yr, 114.4±79.1㎍/100㎖; 55~59 yr, 103.0±52.9㎍/100㎖; 60~64 yr, 77.0±35.9㎍/100㎖; 65~69 yr, 65.4±35.5㎍/100㎖; 70-yr 51.2±28.2㎍/100㎖). The result of linear regression analysis showed that the serum DHEAS levels were decreased at the average rate of 1.14% per year. 2. Simple and partial correlation analysis of the various blood chemistry values, smoking and drinking behaviors showed that the serum DHEAS levels were correlated negatively with age and serum GPT and ??-GTP activities, and positively with systolic blood pressure, GOT and smoking behavior(packs per day). 3. In comparisons between groups divided by the cut off values in blood chemistry, BMI and blood pressure, the age- and smoking-adjusted mean DHEAS levels showed significant(p=0.045) difference only in hemoglobin concentration. 4. In comparisons between groups divided by the categories of health behavior and status, the age- and smoking-adjusted mean DHEAS levels showed significant difference by drinking(p=0.048), family history of death from diseases(p=0.050), perceived health status(p<0.035).