http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Iida, M.,Fujii, S.,Uchida, M.,Nakamura, H.,Kagami, Y.,Agusa, T.,Hirano, M.,Bak, S.M.,Kim, E.Y.,Iwata, H. Elsevier/North Holland Biomedical Press 2016 Aquatic toxicology Vol.177 No.-
<P>2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces a broad spectrum of toxic effects including craniofacial malformation and neural damage in fish embryos. These effects are mainly mediated by the aryl hydrocarbon receptor (AHR). However, the mode of action between TCDD-induced AHR activation and adverse outcomes is not yet understood. To provide a comprehensive picture of the AHR signaling pathway in fish embryos exposed to TCDD, red seabream (Pagrus major) embryos were treated with graded concentrations of TCDD (0.3-37 nM) in seawater, or with a mixture of TCDD and 500 nM CH223191, an AHR-specific antagonist. The transcriptome of red seabream embryos was analyzed using a custom-made microarray with 6000 probes specifically prepared for this species. A Jonckheere-Terpstra test was performed to screen for genes that demonstrated altered mRNA expression levels following TCDD exposure. The signals of 1217 genes (as human homologs) were significantly altered in a TCDD concentration-dependent manner (q-value < 0.2). Notably, the TCDD-induced alteration in mRNA expression was alleviated by co-exposure to CH223191, suggesting that the mRNA expression level of these genes was regulated by AHR. To identify TCDD-activated pathways, the microarray data were further subjected to gene set enrichment analysis (GSEA) and functional protein-protein interaction (PPI) network analysis. GSEA demonstrated that the effects of TCDD on sets of genes involved calcium, mitogen-activated protein kinase (MAPK), actin cytoskeleton, chemokine, T cell receptor, melanoma, vascular endothelial growth factor (VEGF), axon guidance, and renal cell carcinoma signaling pathways. These results suggest the hypotheses that TCDD induces immunosuppression via the calcium, MAPK, chemokine, and T cell receptor signaling pathways, neurotoxicity via VEGF signaling, and axon guidance alterations and teratogenicity via the dysregulation of the actin cytoskeleton and melanoma and renal cell carcinoma signaling pathways. Furthermore, the PPI network analysis indicated that the adverse outcome pathways of TCDD in the embryos might be propagated through several hub genes such as cell division control protein 42, phosphoinositide-3-kinase regulatory subunit 1, and guanine nucleotide binding proteins. Understanding these pathways potentially allows for exploring the adverse outcome pathway of the effects of TCDD on the red seabream embryos. (C) 2016 Elsevier B.V. All rights reserved.</P>
A Way to Utilize Movies Through Exceptional Examples of English Comparatives and Imperatives
Iida. Yasuhiro 영상영어교육학회 2016 영상영어교육 (STEM journal) Vol.17 No.4
Recent mechanical improvement in classroom facilities allows teachers to use movies as teaching material for students studying English as a foreign language. Movies help students to understand the rules of English linguistics such as grammar and sound patterns by providing them with specific real-life utterances. Unlike general textbooks, movies also provide a wide variety of interesting English examples that appear to go against the general rules. In this paper, we first divide English examples found in movies into two types: supporting examples (SptEx) that exemplify the rules of English; and exceptional examples (ExpEx) that superficially break the rules. Then, by showing a way to utilize movies via both the SptEx and the ExpEx, this paper argues that a reciprocally-related teaching method helps teachers to deepen students’ understanding of English and even broaden their linguistic views. Furthermore, it is demonstrated that this method can be applied to various fields of English linguistics such as syntax and morphology, and also to a number of English sentence types. Among others, this paper focuses on comparative and imperative sentences. In addition, several potential issues related to collecting ExpEx from movies and build up a database of examples are pointed out.
Expression mechanism of tryptophan hydroxylase 1 in mouse islets during pregnancy.
Iida, Hitoshi,Ogihara, Takeshi,Min, Mun-kyeong,Hara, Akemi,Kim, Yeong Gi,Fujimaki, Kyoko,Tamaki, Motoyuki,Fujitani, Yoshio,Kim, Hail,Watada, Hirotaka Journal of Endocrinology (Ltd. by Guarantee) 2015 Journal of molecular endocrinology Vol.55 No.1
<P>Serotonin signaling plays key roles in augmentation of pancreatic β-cell function during pregnancy. Increased expression of tryptophan hydroxylase 1 (Tph1), a rate-limiting enzyme for serotonin synthesis by lactogenic hormones, is involved in this phenomenon. To investigate its mechanisms, we here performed 5'-RACE and identified β-cell-specific transcription initiation sites for Tph1. Prolactin enhanced the expression of mRNA containing these exons; however, reporter gene plasmids containing the proximal 5'-flanking region of these exons did not show prolactin responsiveness in MIN6 cells. Prolactin-induced Tph1 expression was inhibited by a Jak2 inhibitor and was partially inhibited by an MEK1/2 or PI3K inhibitor. Therefore, we analyzed interferon γ-activated sequences (GAS) and found GAS-A about 9-kbp upstream of the transcription start site. The reporter gene plasmid containing the GAS-A region linked to a heterologous promoter showed increased promoter activity by prolactin, which was inhibited by the forced expression of a dominant-negative mutant form of Stat5A and a Jak2 inhibitor. Chromatin immunoprecipitation analysis showed that prolactin treatment augmented Stat5 binding to the GAS-A region in MIN6 cells, as well as in isolated mouse islets, and that Stat5 recognized the GAS-A region in pregnant mouse islets. In addition, the transactivation activity of Stat5 was enhanced by prolactin through the Erk and PI3K pathways in MIN6 cells. Finally, serotonin expression was attenuated in islets of β-cell-specific Stat5-deficient mice compared with that of control littermates during pregnancy. Our findings suggest that prolactin-induced Tph1 expression is mediated by the activation of Jak2/Stat5, Erk, and PI3K pathways in β cells.</P>
INTER COMM 93 - '전기통신 표준에 전세계적인 합의를 이루는 방안'
Iida Tokuo 한국정보통신기술협회 1993 국제전기통신표준화소식 Vol.27 No.-
전기통신 전반에 걸친 최신 기술과 미래를 전망해 보는 정책들이 발표되는 ''INTER COMM 93''이 지난 2월 22일부터 25일까지 캐나다 뱅쿠버에서 개최되었다. 본 특집에서는 이번 심포지움을 통하여 발표되었던 내용중 관심있는 주제를 모아 정리하여 보았다.
Learning English via Cross-Cutting Observations: With Tag Questions and Movies
Iida, Yasuhiro 영상영어교육학회 2019 영상영어교육 (STEM journal) Vol.20 No.4
This paper proposes a method to help ESL learners improve their knowledge of English grammar and broaden their understanding of the English language. One important key feature of the method is careful observation of the independently-taught rules of English grammar from one specific sentence type, which I call “cross-cutting observations”. It encourages ESL learners to see the close relation between aspects of English language learning and the application of different grammar rules, such as the imperative sentence construction, pronoun usage, adverb usage, etc., by highlighting in particular the properties of tag questions in English (e.g., Tom likes sushi, doesn’t he?). Furthermore, this paper provides suggestions as to the potential use of authentic English examples in movies (and also TV dramas) as a rich source of learning and teaching material which typical English textbooks for ESL learners may lack. The paper concludes by encouraging ESL learners desiring to widen their understanding of English forms and usage (specifically as seen from the aspect of tag questions) by tapping into authentic and natural English in movies. Overall, this paper is an attempt to bridge English education, English linguistics and movies as an effective means to engage ESL learners.
Evaluation of Reduction Effect in Traffic Accidents Based on Time Series Reliability Model
Ryota IIDA,Makoto MOCHIZUKI,Yoshiki NII,Dejan ORSAG,Keisuke SUZUKI,Kiichi YAMADA 대한인간공학회 2016 대한인간공학회 학술대회논문집 Vol.2016 No.06
In recent years, various kinds of research related to alarm systems which prevent traffic accidents has been reported. However, there are few which evaluated the effects of reducing driver’s reaction time during unpredictable risks on decreasing traffic accidents. In this study, a methodology for estimating the collision mitigation ratio is discussed, using a collision-prevention system that supplies aroma to drivers whose cognitive attentiveness has decreased due to a prolonged driving. First, we investigated driving action at intersections during use of the system in a driving simulator. The results showed that reaction time to the crossing vehicle was significantly reduced when a driver used the aroma-supplying collision-prevention system. In addition, a system that doesn’t supply aroma could cause a decrease in driver’s attentiveness. The Time Series Reliability Model, which is a driver-model considering the driver’s time-series cognitive status, is constructed and the collision mitigation ratio is estimated. The results suggested that the collision ratio increased during the use of a system that presents only information, since the driver depended on the system information and the driver’s safety confirmation actions were inhibited. Meanwhile, the collision ratio decreased during the use of the aroma-supplying system since reaction time to the crossing vehicle was reduced by an effect on stress reduction. It can be concluded that traffic accidents at intersections are reduced by using the aroma-supplying system.