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Ihn, Kyong,Hyung, Woo Jin,Kim, Hyoung-Il,An, Ji Yeong,Kim, Jong Won,Cheong, Jae-Ho,Yoon, Dong Sup,Choi, Seung Ho,Noh, Sung Hoon The Korean Gastric Cancer Association 2012 Journal of gastric cancer Vol.12 No.4
Purpose: To evaluate the technical feasibility and oncologic safety, we assessed the short-term and long-term outcomes of laparoscopic resection of the small bowel gastrointestinal stromal tumors smaller than 5 cm by comparing those of open surgery by subgroup analysis based on tumor size. Materials and Methods: From November 1993 to January 2011, 41 laparoscopic resections were performed among the 95 patients who underwent resection of small intestine ${\leq}10$ cm in diameter. The clinicopathologic features, perioperative outcomes, recurrences and survival of these patients were reviewed. Results: The postoperative morbidity rates were comparable between the 2 groups. Laparoscopic surgery group showed significantly shorter operative time (P=0.004) and duration of postoperative hospital stay (P<0.001) than open surgery group and it was more apparent in the smaller tumor size group. There were no difference in 5-year survival for the laparoscopic surgery versus open surgery groups (P=0.163), and in 5-year recurrence-free survival (P=0.262). The subgroup analysis by 5 cm in tumor size also shows no remarkable differences in 5-year survival and recurrence-free survival. Conclusions: Laparoscopic resection for small bowel gastrointestinal stromal tumors of size less than 10 cm has favorable short-term postoperative outcomes, while achieving comparable oncologic results compared with open surgery. Thus, laparoscopic approach can be recommended as a treatment modality for patients with small bowel gastrointestinal stromal tumors less than 10 cm in diameter.
Isolation of a New Phenylpropanoid from Codonopsis ussuriensis
Lee, Ihn-Rhan,Seo, Eun-Kyong The Pharmaceutical Society of Korea 1990 Archives of Pharmacal Research Vol.13 No.4
A new phenylpropanoid was isolated from the roots of Codonopsis ussuriensis (Rupr. et Maxim) Hemsley. It was coloress crystals, mp. 140-142.deg.C and was elucidated as 4-(3-ethoxy-1-propenyl)-2, 6-dimethoxyphenyl-$\beta$-D-glucopyranoside on basis of spectral data analysis.
췌장 베타세포에서 인터루킨-1beta로 유도한 인슐린 의존형 당뇨병 실험 모델
이인순(Ihn Soon Lee),이인자(In Ja Rhee),김경태(Kyong Tai Kim) 대한약학회 1998 약학회지 Vol.42 No.4
To establish prediabetes in vitro/ model concerning the etiology of Insulin Dependent Diabetes Mellitus (IDDM) in cellular level we have designed experimental prediabefic model in pancreatic beta cells. RINm5F, HIT-T15 and isolated rat islets were chosen as pancreatic beta cells. Since interleukin-1beta-induced beta cell cytotoxicity has been implicated in the autoimmune cytotoxicity of IDDM, we used inteleukin-1beta as diabetogenic agent. For establishment of prediabetic in vitro model, the degree of beta cell deterioration was determined by cell proliferation, insulin release and morphological appearance. Cell proliferation, insulin release and morphology were changed dose-dependently in condition that inteleuldn-1beta was exposured to pancreatic beta cells. The concentration and exposure time of interleukin-1beta to set up prediabetic model in beta cell lines and isolated rat islets were 100-1000U/ml, 48hr. And 25-100U/ml, 48hr, respectively.
췌장 베타세포에서 스트렙토조토신으로 유도한 인슐린 의존형 당뇨병 실험 모델
이인순(Ihn Soon Lee),이인자(In Ja Rhee),김경태(Kyong Tai Kim) 대한약학회 1997 약학회지 Vol.41 No.2
To establish prediabetes in vitro model concerning the etiology of IDDM(Insulin Dependent Diabetes Mellitus) in cellular level we have designed prediabetes in vitro models in pancreatic beta cells. HIT-T15, RINm5F and isolated rat islets were chosen as pancreatic beta cells, and streptozotocin (STZ) used as diabetogenic agent. Degree of beta cell destruction to establish prediabetic in vitro model was determined by cell proliferation and insulin release using thymidine uptake and radio immuno assay. When HIT-T15 and RINm5F cells were treated with STZ, the degree of cell deterioration was dependent upon the origin and passage number of beta cells, and in the case of isolated islets STZ showed the more sensitivity than above two beta cell lines. The concentration and exposure time of STZ treatment to establish prediabetes in vitro model in beta cell lines and isolated rat islets were 2 ~ 10mM, 30 min. and 1 ~ 5mM, 30 min., respectively.