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( Na Hyeon Kang ),( Su Yeon Choi ),( Young Kyoon Kim ),( Ie Ryung Yoo ),( Dae Hee Han ),( Dong Soo Lee ),( Yeon Sil Kim ),( Sook Hee Hong ),( Jin Hyoung Kang ),( Kyo Young Lee ),( Jae Gil Park ),( Soo 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Recent studies suggest that miR-137 functions as tumor suppressor in various tumors including colorectal cancer, glioblastoma multiforme, oral cancer, and squamous cell carcinoma of the head and neck. The silencing of miR-137 could be related with its abnormal promoter hypermethylation. The purpose of this study was toinvestigate the signifi cance of MIR137 promoter methylation in lung cancer. Methods: Lung cancer cell lines were treated with DNA methyltransferase inhibitor (5`-Aza) and/or HDAC inhibitor (Trichostatin A) whether miR-137 could be reactivated. From paired tumor and adjacent non-tumor lung tissues (n=50), real-time RT-PCR for miR-137 expression and cyclin dependent kinase 6 (CDK6), quantitative methylation specifi c PCR for methylation analysis, and bisulfi te modifi ed DNA sequencing for validation were used for the study. Results: miR-137 was reactivated by treatment with 5`-Aza and/or Trichostatin A in lung cancer cell lines. miR-137 was signifi cantly downregulated and CDK6 was significantlyupregulated in lung tumor tissues compared with adjacent non-tumor tissues. Quantitative methylation specifi c PCR showed increased MIR137 promoter methylation in lung tumor tissues compared with adjacent non-tumor tissues, which was further validated with bisulfi te sequencing. Conclusions: These results suggest that miR-137 has a role of tumor suppressor and its expression is regulated by promoter methylation. The decreased expression of miR- 137 combined with increased expression of CDK6 could be associated with lung cancer carcinogenesis.
Na, Sae Jung,Oh, Jin Kyoung,Hyun, Seung Hyup,Lee, Jeong Won,Hong, Il Ki,Song, Bong-Il,Kim, Tae-Sung,Eo, Jae Seon,Lee, Sung Won,Yoo, Ie Ryung,Chung, Yong An,Yun, Mijin Society of Nuclear Medicine 2017 The Journal of nuclear medicine Vol.58 No.5
<P>Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC) consists of a heterogeneous group of patients with a wide range of survival times, requiring further prognostic stratification to facilitate treatment allocation. We evaluated the prognostic value of F-18-FDG uptake on PET/CT at the time of presentation in patients with BCLC stage C HCC. Methods: A total of 291 patients with BCLC stage C HCC who underwent F-18-FDG PET/ CT between 2009 and 2010 for staging were retrospectively enrolled from 7 university hospitals. The patients were further divided into 2 groups according to the extent of disease, as intrahepatic or extrahepatic. Tumor-to-liver SUV ratio (TLR) of the primary tumor was measured on F-18-FDG PET/CT. Prognostic values of TLR and other clinical variables were analyzed to predict overall survival (OS) in univariate and multivariate analyses. Differences in the OS stratified by TLR were examined by the Kaplan Meier method. Results: Higher TLR was associated with extrahepatic disease (P = 0.018). On multivariate analysis, Child Pugh classification and TLR were independent prognostic factors in the intrahepatic disease group (all P < 0.05), whereas TLR was the only independent prognostic factor in the extrahepatic disease group (P < 0.05). Patients with high TLR showed a significantly worse OS than those with low TLR (P < 0.05) in both groups. Conclusion: In patients with BCLC stage C HCC, F-18-FDG uptake in the primary tumor was significantly higher in patients with extrahepatic disease than in those with intrahepatic disease. In addition, F-18-FDG uptake on pretreatment PET/CT had an incremental prognostic value for OS in both intrahepatic and extrahepatic disease groups.</P>
Successful treatment of central retinal artery occlusion using hyperbaric oxygen therapy
김수한,차용성,이윤석,김현,Ie-Na Yoon 대한응급의학회 2018 Clinical and Experimental Emergency Medicine Vol.5 No.4
Central retinal artery occlusion (CRAO) is considered an ophthalmologic emergency. The prognosis of this disease is very poor. Currently, there is no generally effective therapy available to treat CRAO. Hyperbaric oxygen therapy (HBOT) can increase the volume of oxygen delivered to the ischemic retinal tissue until spontaneous or assisted reperfusion occurs. We report the case of a patient who experienced sudden visual loss due to CRAO that was treated with HBOT. The patient was an 81-year-old woman who presented with CRAO in her right eye (OD). She exhibited “hand motion” visual acuity before treatment. She underwent three sessions of HBOT at a pressure of 2.8 atmospheres absolute, performed over 3 days. After 4 days in hospital, her visual acuity improved to 0.4 (OD) for far vision and 0.5 (OD) for near vision. Her vision was stable without the supply of oxygen; therefore, she was discharged.
Choi, Kyu-Ho,Yoo, Ie-Ryung,Han, Eun-Ji,Kim, Yeon-Sil,Kim, Gi-Won,Na, Sae-Jung,Sun, Dong-Il,Jung, So-Lyung,Jung, Chan-Kwon,Kim, Min-Sik,Lee, So-Yeon,Kim, Sung-Hoon The Korea Society of Nuclear Medicine 2011 핵의학 분자영상 Vol.45 No.1
Purpose We assessed the prognostic value of metabolic tumor volume (MTV) measured using$^{18}F$-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) inpatients with locally advanced head and neck squamous cell carcinoma (HNSCC). $Methods$ We retrospectively reviewed 56 patients (51 men, five women; mean age $56.0{\pm}8.8$years) who had locally advanced HNSCC and underwent FDG PET/CT for initial evaluation. All patients had surgical resection and radiotherapy with or without concurrent chemotherapy. The peak standardized uptake value ($SUV_{peak}$) and MTV of the target lesion, including primary HNSCC andmetastatic cervical lymph nodes, were measured from FDG PET/CT images. We compared $SUV_{peak}$, MTV, and clinicopathologic variables such as age, Eastern Cooperative Oncology Group (ECOG) performance status, pN stage, pT stage, TNM stage, histologic grade and treatment modality to disease-free survival (DFS) and overall survival (OS). Results On the initial FDG PET/CT scans, the median $SUV_{peak}$ was 7.8 (range, 1.8-19.0) and MTV was17.0 $cm^3$ (range, 0.1-131.0 $cm^3$). The estimated 2-year DFS and OS rates were 67.2% and 81.8%. The cutoff points of $SUV_{peak}$ 6.2 and MTV 20.7 $cm^3$ were the best discriminative values for predicting clinical outcome. MTV and ECOG performance status were significantly related to DFS and OS on univariate and multivariate analyses (p<0.05). Conclusion The MTV obtained from initial FDG PET/CT scan is a significant prognostic factor for disease recurrence and mortality in locally advanced HNSCC treated with surgery and radiotherapy with or without chemotherapy.
양측성 해리수직편위에서 일률적인 9 mm, 7 mm 양안 상직근 후전술 시행의 효과
윤이나,라상훈,이종혁,Ie-Na Yoon,Sang-Hoon Rah,Jong-Hyuck Lee 대한안과학회 2005 대한안과학회지 Vol.46 No.6
Purpose: To evaluate the effect of 9 mm and 7 mm bilateral recession of the superior rectus muscle in patients with bilateral dissociated vertical deviation (DVD) who had a deviation difference between the non-fixing and fixing eyes of less than 8PD. Methods: The subjects were chosen from the patients who visited our hospital for DVD between January 2001 and November 2003. We reviewed the surgical records of 19 patients who had undergone 9 mm recession of superior rectus muscle in the non-fixing eye and 7 mm in fixing eye, and who had been followed up for at least 6 months. Results: A residual DVD less than 8PD was regarded as successful. The overall success rate was 73.7%. The success rate of 10~14PD preoperative deviation of the non-fixing eye was 80.0%, and that of 15~19PD preoperative deviation of the non-fixing eye was 75.0%. However, the success rate was 66.7% in recession for the deviation over 20PD. Conclusions: Bilateral recession of 9 mm and 7 mm of the superior rectus muscle was effective for bilateral DVD in which the deviation difference of the non-fixing eye and fixing eyes was less than 8PD .
윤이나,이석준,이광호,Ie-Na Yoon,Seok-Joon Lee,Kwang-Ho Lee 대한안과학회 2005 대한안과학회지 Vol.46 No.6
Purpose: To examine the effect of stellate ganglion block (SGB) in various types of glaucoma and ocular hypertension. Methods: The subjects were chosen from patients who visited our hospital for glaucoma and postoperative ocular hypertension in the 6-month period from A to B (Ed-give the dates). SGB was performed one or four times with 15 eyes from four types of glaucoma and postoperative ocular hypertension patients. The intraocular pressure (IOP) of eyes that had undergone SGB was checked after 1 hour following SGB. We investigated the efficacy of SGB on the 15 patients. Results: In primary open-angle glaucoma (POAG), early secondary glaucoma and post- operative ocular hypertension, the mean IOP of eyes that had undergone SGB decreased after 1 hour following SGB. However, in primary angle-closure glaucoma (PACG) and advanced secondary glaucoma, there was a rise in mean IOP after 1 hour following SGB. Conclusions: In the present study, SGB may be effective in treating POAG, early secondary glaucoma and postoperative ocular hypertension. However, in PACG and advanced secondary glaucoma, SGB may be considered to be harmful treatment modality.
Original Articles : Clinical Progress in Impending Central Retinal Vein Occlusion
( Dong Hoon Lee ),( Seok Joon Lee ),( Ie Na Yoon ) 대한안과학회 2010 Korean Journal of Ophthalmology Vol.24 No.2
Purpose: Impending central retinal vein occlusion is associated with mild or no loss of vision; however, its progress and vision prognosis have not been clearly defined until now. Therefore, we studied the progress and prognoses in patients with impending central retinal vein occlusion. Methods: For this study, we selected ten subjects who had been diagnosed with impending central retinal vein occlusion, and we retrospectively reviewed their progress and prognoses. Results: The average age of the subjects was 31.0 years (18 to 48 years). Eight patients were male and two were female. The average observational period was 5.5 months. Six out of ten subjects were found to have no underlying systemic disease, four subjects had underlying disease. All ten patients were affected unilaterally. When initially tested, the affected eyes showed an average vision of LogMar 0.30. The final vision test revealed an average of LogMar 0.04, which indicates good progress and prognosis. In one patient, retinal hemorrhage and macular edema progressively worsened after the diagnosis, and the patient was treated with radial optic neurotomy. Conclusions: The cases of impending central retinal vein occlusion that we observed seemed to primarily affect young patients with generally good prognoses. However, in some cases, the degrees of obstruction and hemorrhage increased as time progressed. This suggests that impending central retinal vein occlusion could develop into the prodromal phase of an acute attack.
Case Report : Macular Infarction Associated with Reactive Arthritis
( Ju Young Kim ),( Jong Hyuck Lee ),( Ie Na Yoon ) 대한안과학회 2010 Korean Journal of Ophthalmology Vol.24 No.5
A 53-year-old woman visited the Department of Rheumatology with a chief complaint of a 3-day history of fever and chills and also presented with pain occuring in both knees at the time of outpatient visit. Based on rheumatologic and hematological lab studies, ultrasonography, and a needle aspiration biopsy of the articular cavity, the patient was diagnosed with reactive arthritis. On hospitalization day 3, consultation with the Department of Ophthalmology was requested regarding decreased visual acuity lasting for 3 days. Upon ophthalmologic examination, the corrected visual acuity was 0.1 in the right eye and 0.05 in the left eye. Upon slit lamp microscopy, there were no abnormal findings in the anterior segment. Upon fundus examination, however, there were yellow-white lesions in the macular area of both eyes. Fluorescein angiographywas performed to assess the macular lesions, and the findings were suggestive of macular infarction in both eyes. Due to a lack of other underlying disease, a past surgical history, and a past history of drug administration, the patient was diagnosed with macular infarction in both eyes associated with reactive arthritis. To date, there have been no other such cases reported. In a patient with reactive arthritis, we experienced a case of macular infarction in both eyes, which occurred without association with a past history of specific drug use or underlying disease. Herein, we report our case, with a review of the literature.