위장의 Helicobacter Pylori 감염에 따른 위 점막상피세포의 Nucleolar Organizer Regions : 장형의 위선암종과 비교

장태정,김동훈,배한익 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

1995년 3월부터 1995년 12월까지 동의의료원에서 위내시경 검사로 채취된 위 생검 조지절편에서 위염과 소화성 궤양 및 장형(intestinal type) 위선암종으로 진단된 증례 69예를 대상으로 Helicobacter Pylori(H. pylori)감염에 따른 세포증식능을 조사하고 장형 위선암종의 세포증식증과 비교하였다. 세포증식증은 은염색을 시행하여 AgNORs의수로 표시하였다. 이 중 위선암조은 16예, H. pylori감염 양성은 35예, 감염 음성은 18예 였다. H. pylori감염의 판정은 rapid urease 검사 ( CLO검사), hematoxylin-eosin염색 또는 Giemsa염색으로 하였고, H. pylori감염에 따른 염증반응은 H. pylori의 감염 양성군에서 중등도 이상의 중성구 침윤과 만성 염증세포의 침윤이 각각 82.9%(29/35),65.7%(23/35)였다.(P<0.05). 위 점막상피세포의 지저부 및 협부의 AgNORs갯수는 위선암종에서 4.01±0.50, H. pylori 감염 양성군에서 2.84±0.25, H. pylori의 감염 음성군에서 2.49±0.29 였다(P<0.05).H.pylori의 감염 양성군 및 음성군에서 중성구의 침윤에 따른 AgNORs갯수는 중성구의 침윤이 중등도이상인 경우가 2.80±0.24로써 중성구의 침윤이 없거나 미약한 경우(2.60±0.35) 보다 의의있게 높았지만(P<0.05) 만성염증세포의 침윤에 따른 AgNORs갯수는 유의한 차이가 없었다. 위염의 등급과 위염의 활동성 및 집락의 등급을 합친 위염점수가 높을수록 AgNORs갯수는 증가하는 경향을보였다(r=0.38, P<0.005). 그러므로 H. pylori의 감염이 있으면 위 점막에 염증반응이 생기고 이로 인하여 위 점막 상피세포의 세포증식능이 증가하는데 세포증식의 주 원인은 H. pylori자체일 수도 있고 H. pylori감염에 속발된 중성구 침윤일 수도 있다고 추측된다. The number of silver-staining nucleolar organizer regions(AgNORs) per nucleus has been correlated with proliferative rate and ploidy. The mean AgNOR counts of gastic mucosal epithelium in isthmus or base of nonmetaplastic area were examined in 18 Helicobacter pylori (H.pylori) negative cases, 35 H. pylori positive cases and 16 gastric adenocarcinoma of intestinal type. Acute and chronic inflammation of H. pylori positive cases were more serious than that of H.pylori negative cases(P<O.05). The mean number of AgNORs was 2.49±O.29 for H. pylori negative cases, 2.84±0.25 for H. pylori positive cases, and 4.01±0.50 for gastric adenocarcinoma. The difference among the groups was signiftcant(P<0.05). The mean number of AgNORs for those who showed moderate or severe infiltrate of neutrophil(2.80±0.24) was significantly different from that of patients with absent or mild infiltrate of neutrophi1(2.60±O.35)(P<O.O5). There was no difference of mean AgNORs counts according to chronic inflammatory cell infiltrate. A positive association between mean AgNORs counts and gastritis score was prescnt(r=0.38, P<O.OO5). The alteration of replication cycle of gastric mucosal epithelium may be caused by H. pylori infection or neutrophil.

주의력결핍 과잉운동장애 아동에서 지형학적 청각 사건 관련 전위의 임상적 의의

임태식,한상익,전양환,방승규 대한신경정신의학회 2001 신경정신의학 Vol.40 No.1

연구목적: 본 연구는 소아정신과 영역에서 가장 흔한 질환인 주의력결핍 과잉운동장애의 생활학적 표지자로서 지형학적 청각 사건관련전위의 임상적 의의를 알아보기 위하여 시도되었다. 방법: 치료 전 주의력결핍 과잉운동장애 아동 22명과 대조군인 정상 아동 20명을 대상으로 지형학적 청각 사건관련전위 N100과 P300의 잠복기와 전위값을 Global Field Power Measurement 방법을 이용하여 결정하였다. 그리고 주의력결핍 과잉운동장애 아동들을 치료제인 methylphenidate로 8주간 치료한 후 동일한 방법으로 N100과 P300의 잠복기와 전위값을 구한 후, 치료 전 후 그리고 정상대조군 세 군간의 N100과 P300의 잠복기와 전위값을 비교하였다. 결과: N100 잠복기는 치료 전 ADHD군과 정상 대조군, ADHD군 치료 전 후, 치료 후 ADHD군과 정상 대조군 등 세 간에 모두 유의한 차이가 있었다. 치료 전 ADHD군의 N100 전위값은 정상 대조군과 차이가 없었다. P300 잠복기와 전위값은 공히 치료 전 ADHD군과 정상 대조군. ADHD군 치료 전 후 간의 유의한 차이가 있었고, 치료 후 ADHD군과 정상 대조군 간의 차이는 없었다. 결론: 지형학적 청각 사건 관련 전위의 N100 잠복기은 주의력결핍 과잉운동 장애의 상태 표지자로서 의의가 있음을 알 수 있었고, P300 잠복기와 전위값은 상태 표지자일 가능성이 있음을 시사하였다. Objectives : This study was carried out to investigate the clinical availability of topographic auditory event related potential P300 as a biological marker in children with attention deficit hyperactivity disorder(ADHD) Methods : The subjects were composed of children with ADHD(n=22 ; 16 boys, 6 girls; mean age=89.8±17.1months) and normal controls(n=20 ; 12 boys, 8 girls ; mean age=90.6±16.8months). Topographic auditory event related potential was measured by "oddball paradigm",and the latencies and amplitudes of P300 of both groups were determined by Global Field Power Measurement. After 8 weeks treatment with methylphenidate, P300 of ADHD children were also measured. Results : Both P300 latency and amplitude were not different between ADHD children after treatment and normal controls, but significantly different between ADHD children before treatment and normal controls, and between before and after treatment of ADHD children. Conclusion : The results implicate that the latency and amplitude of P300 may be considered as state markers of ADHD.

'1998 한국인 우울증 선별의 날' 참가자들의 사회인구통계학적 특성과 우울증 선별검사 결과

한상익,이성필,고효진,박원명,장계호,유태열,전태연,채정호,방승규,김광수,최보문,이정태,백인호 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.5

연구목적 : 1998년 정신건강의 날 기념 한국인 우울증 선별의 날 행사에 자발적으로 참여한 참가자들의 사회인구 통계학적 특성을 분석하고 우울증 선별검사 결과를 평가하기 위하여 본 연구를 시행하였다. 방 법 : 8개 병원에서 얻어진 619명의 자료를 사용하여 선별검사로 밝혀진 우울증의 유병율과 사회인구통계학적 특성 및 응답자의 정신과적 치료를 포함한 과거력 등을 조사하였다. 결 과 : 우울증 척도 점수는 응답자 전체 평균 57.5±13.8로 경도의 우울 증상이 있는 것에 해당되었다. 전체 응답자의 69.5%(430명)가 최소한 경도 이상의 우울 증상을, 43.1%(267명)가 중등도 이상의 우울 증상을, 18.4%(114명)가 고도의 우울 증상을 보였다. 고도의 우울 증상이 있는 응답자의 56.8%와 중등도의 우울 증상이 있는 응답자의 63.9%가 정신과 치료를 받은 적이 전혀 없었다. 나이가 29세 이하인 것과 전임근무 중인 직업상태는 각각 나이가 60세 이상인 것과 직업이 없는 것에 비교하여 우울증으로부터 보호하는 인자임을 시사하였다. 결 론 : '1998 한국인 우울증 선별의 날' 행사를 통하여 많은 우울증 환자들을 선별해낼 수 있었고, 이들의 우울 증상은 몇몇 사회인구통계학적 특성과 유의한 관계가 있음을 확인하였다. 우울증 선별의 날 행사를 통한 우울증에 대한 교육과 우울증 선별검사는 치료받지 못하고 있는 우울증 환자 및 기존의 치료 중인 환자 모두에게 유용한 프로그램임을 알 수 있었다. Objectives : This study was performed to analyze the sociodemographic characteristics of participants in '1998 Korean Depression Screening Day' and to evaluate the results of the screening test. Methods : By using the survey results of 619 volunteers from 8 hospitals, the authors examined the prevalence of depression detected at the screening test and sociodemographic characteristics and the psychiatric treatment history of respondents. The assessment measure was the Zung Self-Rating Depression Scale. Results : The mean depression score of all participants was 57.5±13.8 and it came under mild depression. Of all participants, 69.5%(N=430) had at least mild depressive symptoms, 43.1%(N=267) had at least moderate symptoms, and 18.4%(N=114) had severe symptoms. Never have 56.8% of respondents in the severely depressed range and 63.9% of those in the moderately depressed range had psychiatric treatment. The results suggest that the age group of 29-year-old or younger(relative to 60-year-old or older group) and full-time employment status(relative to unemployment) are protective factors of depression. Conclusions : By '1998 Korean Depression Screening Day', many depressed patients were detected and their depressive symptoms had statistically significant relationships with some sociodemographic characteristics. The results suggest that the education and screening test programs for depressive illness facilitated by Depression Screening Day are useful to the patients regardless of being under current treatment or not.

腰痛症의 鍼灸療法에 關한 文獻的 考察

崔翊善,崔容泰 慶熙大學校韓醫科大學韓醫學硏究所 1978 慶熙韓醫大論文集 Vol.1 No.-

鑄鐵材料의 Melt Treatment 및 Carbon Contents에 關한 硏究

최익수,김성주,문형태,노무근 삼척대학교 산업과학기술연구소 2001 産業科學技術硏究論文集 Vol.6 No.1

It is the purpose of this study to investigate the melt treatment and properties of cast iron by varifying the holding time after inoculation treatment and carbon contents. The main results obtained by investigating the microstructure and carbon contents are as follows : The number of graphite in cast iron decreases by increasing the holding time of melts after inoculation treatment, and the coarsening of graphite is achieved by increasing the length and thickness of graphite. As the carbon contents increase in cast iron, the shape and size of graphite in cast iron structure increase continuously.

자동화된 공정계획을 위한 특징형상 기반 생산정보 생성에 관한 연구

명태식,오익수 大田産業大學校 1996 한밭대학교 논문집 Vol.13 No.0201

Separate implementation of the dasign and manufacturing blocks the flow of automated design and manufacturing and greatly increases the product life cycle time, and consequently makes the integration of design and maunfactuing activities highly desirable. Process planning, a linkage activity between design and manufacturing, translates the design information into manufacturing language. Feature-based automated process planning is considered as linkage between design and manufacturing. In this study, the generation of the manufacturing information is created by adopting the concept of feature. The feature-based modeling is implemented in the feature-based modeler developed in this study.

내과에 입원하여 정신과에 자문의뢰된 우울증 환자의 임상양상

한상익,이정표,유태열 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.3

In an attempt to establish some guidelines for psychiatric consultants who work in a general hospital setting who frequently are encountered with depressed medical inpatients, authors evaluated a few outstanding clinical characteristics of them. We discussed why these patients seek help at the internal medicine instend of seeking more than adequate help at the psychiatric service. We also tried to visualize who they are. Authors tried to suggest some specific future guidelines for those who work with this kind of patients. The subjects were consisted of 51 medical inpatients who were admitted at the Kang-Nam St. Mary’s Hospital from Apr. 1, 1983 to Jul. 31, 1984, who were seen on psychiatric consultation and were apparently suffering from clinical depression. Their clinical characteristics were compared with randomly selected 48 psychiatric inpatients with depression who were hospitalized at the same hospital for the same period. The conclusions were as follows: 1. For their age distribution, medical inpatients with depression group with age over 60(23.5%) were two times greater than psychiatric inpatients with depression group for the same age bracket (10.4%). This result shows current trend that senile depressed patients tend to seek medical help rather than to seek psychiatric help. 2. For their medical diagnostic distribution, medical inpatients with depression frequently received one of the gastrointestinal disorder diagnoses(26.6%) at the internal medicine. After psychiatric consultation, “medical diagnoses” decreased from 77.7% to 63.3% and diagnoses of “depression” increased from 6.4% to 27.6% for the medical inpatients. 3. For the depressed female medical inpatients who were seen on psychiatric consultation, marital problems were the most frequently observed psychiatric problems which needed psychiatric attention. This finding appears to reflect women’s trend to express their emotional conflicts in a more subtle and vague physical symptoms of depressive equivalents rather than outright depressed affect itself. 4. Most of the chronic dysthymic disorder patients with multiple physical complaints (62.7%) usually seek medical help rather than psychiatric help. Whe compared with this, patients who suffer from depressed affect itself rather than physical symptoms of depression came directly to psychiatric service. 5. Regarding their physical symptoms, both of the depressed medical inpatients and depressed psychiatric inpatients frequently complained of gastrointestinal symptoms, 39.9% and 41.9% respectively. For their frequency and number of physical symptoms, depressed medical inpatients complained more of them (3.76±1.70) than those of depressed psychiatric inpatients (1.73±1.94). 6. While they were admitted at the internal medicine, depressed medical inpatients frequently recieved antianxiety drugs (80.4%). However, very few of them (9.8%) recieved less than therapeutic dose of antidepressants before psychiatric consultation. After psychiatric consultation, 74.4% of the recieved antidepressant medication and 45.2% of them were followed-up by psychiatric consultants. Psychiatric diagnosis of “depression” was officially adopted on discharge summary for 44.0% of them. 7. Eventually, 80.0% of the depressed medical inpatients who were recommended transfer for psychiatric treatment were transferred to the psychiatric service for proper psychiatric treatment. However, their duration of hosptalization (23.8±14.41 days) was shorter than that of depressed psychiatric inpatients (31.21±21.91 days). These transferred depressed patients who originally seek medical help tends to discharge early as soon as their physical symptoms clear up and before gaining any insight. Those who were recommended out patient clinic followup only 14.3% of them were adequately followed up at outpatient clinic. 8. Findings of this study suggest that most of these patients could be more adequately managed by establishing a psychiatric liasion service at the gastroenterology section of internal medicine in the future.

합성재 개발

노태익,이병하 명지대학교 산업기술연구소 2006 産業技術硏究所論文集 Vol.25 No.-

The goal of this study is developing synthetic ash that has same qualities with natural ash in order to solve the problems of natural ash. In order to achieve the goal of this study, I analyzed the ingredients of natural ash (mixed ash) made from wood. Using seger's formula, I made four combinations of various materials, and put them under the test of albite-ash and UV analysis. As a result, I found that the synthetic ash that had closest qualities with natural ash's qualities had the composition as follows. PuYeo Albite 0.55%, Janggye Albite 23.63%, PuYeo Quartz 3.90%, ChungJu Limestone 54.47%, Ca₃(PO₄)₂ 2.20%, MgCO₃ 11.65%, Alumina 3.59%, Fe₂O₃ 2.00%, TiO₂ 0.60%, MnO₂ 0.61%. This synthetic ash also appears to have the same glaze effect with natural ash in the experiments of Kaolin-Silica addition using various clay bodies, when fired in reduction kiln atmosphere. The synthetic ash made from the mineral mixture following seger's formula shows excellent solubility and smoothness on ceramic as natural ash does. The synthetic ash does not show irregularity in the proportions of the ingredients in its composition and can be used as the material for the glaze such as Irabo glaze, Celadon glaze, Bunchung glaze, and Tenmok glaze. This synthetic ash is more convenient to acquire than natural ash : it also has merit and competitiveness in terms of economy.

거골의 박리성 골연골염

하권익,한성호,양보규,김치홍,김태성 대한스포츠의학회 1995 대한스포츠의학회지 Vol.13 No.1

거골의 박리성 골연골염은 연골과 연골하골이 균열되고 관절 면으로부터 부분적 혹은 전체적으로 분리되는 병변으로 흔치 않은 병변이다. 거골의 박리성 골연골염은 잘 알려져 있음에도 불구하고, 수술적 치료의 결과에 대한 지식은 적은 편이다. 저자들은 1998년 1월부터 1992년 12월까지 만 5년간 16명, 16례의 거골 박리성 골연 골염 환자를 평균 29개월 추시관찰 및 분석하여 다음과 같은 결과를 얻었다. 1) 연령 분포는 최소 15세에서 최장 58세 였으며 평균 30세 였다. 2) 16명의 환자중 남자가 14례 여자가 2례였고 우측 거골이 10례, 좌측 거골이 6례 였다. 3) 외상과 관계있는 환자는 16례중 15례였으며 거골의 내측에 병변이 있는 경우가 10례, 외측이 6례 였으며 양측인 경우는 없었다. 4) 증상 발현후 수술까지의 기간은 최단 3개월에서 최장 7년이 였으며 평균 25.9개월 이었다. 16명 전례에서 동통을 호소하였으며 6명에서 강직 및 불안정성을 각각 호소하였다. 5) Berndt와 Harty에 의한 병변 분류는 stage Ⅰ은 없었으며 stage Ⅱ는 4례, stage Ⅲ가 7례, stage Ⅳ는 5례로 stage Ⅲ이 가장 많았다. 6) 치료는 관절 개방술에 의한 절제술(1례), 절제술과 소파술 및 다발성 천공술(8례), 절제술 및 소파술 (3례), 소파술 및 bone peg(1례), 관절경적 소파술 및 다발성 천공술 (3례) 시행하였으며 치료결과는 O'Farrell 등이 사용한 평가 방법에 의하면 우수 13례 (81%), 양호 2례(12.5%), 불량 1례 (6.5%)였다. Osteochondritis dissecans of the talus is defined as a subchondral bony lesion of small fragment of bone, usually under two centimetres in diameter, with overlying intact articular cartilage. This fragment then becomes separated from its bed and undergoes necrosis. Although the lesion of osteochondritis dissecans of the talus is well known, there is little information in the literature concerning the results of surgical treatment. Sixteen cases of osteochondritis dissecans of the talus, operated on between January 1988 and December 1992, were studied. All were available for follow-up an average 29 months later and clinical analysis were as follows; 1. Age incidence was distributed from 15 years to 58 years (average 28) 2. 16 patients (14 male, 2 female) were examined and followed-up ; in ten the right ankle was involved and six the left ankle. 3. Of the 16 patients, 14 patients were associated with a history of trauma and 10 patients had medial lesions and 6 patients, lateral lesions. 4. The duration of symptom on these cases ranged from 3 months to 7 years, with an average of 25.9 months. All patients complain of pain when using the ankle and 6 patients complain of stiffness of the ankle and sensation of Berndt and Harty, four ankles had a stage Ⅱ lesion, nine had a stage Ⅲ lesion and five had a stage Ⅳ lesion. 6. The methods of treatment were excision (1 case), excision, curettage and drilling (8 cases), excision and curettage (3 cases), curettage with bone pegging (1 case) and arthroscopic curettage and drilling (3 cases). According to O'Farrell grading system which combined subjective with the objective assessment, 13 patients (81%) had good results, 2 patients (12.5%) had fair results, and 1 patient (6.5%) had a poor result.

혈액투석기간에 따른 불안의 변화

한상익,이성필,유태열 大韓神經精神醫學會 1989 신경정신의학 Vol.28 No.4

Hemodialysis has become one of the indispensible choice of treatment for the patients with chronic renal failure and also has become popular and practical in the clinical field. However, it has been know that during hemodialysis most patients develop various neuropsychiatric problems, of which depression and anxiety are the most fequent and serious responses to the situation of survival dependent on dialysis machine. Most of the reports about the change of depression according to the period of time of hemodialysis has been consistent but that of anxiety has been controversial. This study was designed to evaluate whither there are change of severity of anxiety following hemodialysis. Subjects were consisted of 17 short-term hemodialysis patients, 18 mid-term hemodialysis patients and 19 long-term hemodialysis patients who were undergoing maintenance hemodialysis at Kangnam St. Mary's hospital, St. Vincent hospital and Holy family hospital from March to July 1987. Two different self-rating scales, Spielberger's state-trait anxiety inventory and Zung's self-rating anxiety scale, were applied to the subjects for elucidating the change of severity of anxity according to the period of time on hemodialysis. The results were as following: 1) On Spielberger's state anxiety inventory, the scores of short-term hemodialysis patients was 41.8±2.1, mid-term hemodialysis patients was 41.1 ±2.0 and long-term hemodialysis patients was 44.9±2.1 There were no statistically significant differences among 3 groups. 2) The scores of Spielberger's trait anxiety inventory for short-term, mid-term and long-term hemodialysis patients were 41.9±2.4, 44.8±2.3 and 48.7±2.4 respectively. 3 patient groups did not showed statistically significant differences. 3) The scores of Zung self-rating anxiety scale were 40.0±2.1 in short-term hemodialysis patients, 43.6 ±2.0 in mid-term hemodialysis patients and 46.6±1.9 in long-term hemodialysis patients. They also had no significant differences in statitics. 4) But all the scores of 3 sets of psychological tests were similar to those of Korean high school students, chronic medical patients and cancer patients but lower than those of the anxiety disorder patients. In conclusion, it was implicated that most of hemodialysis patients have mild to moderate anxiety with superimposed transient episodic severe fear for death during maintenance hemodialysis, which appeared to be not significantly changed during the course of hemodialysis.