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      • KCI등재

        장 주네 혹은 존재를 위한 변명

        박형섭 ( Park¸ Hyung-sub ) 부산외국어대학교 지중해지역원 2020 지중해지역연구 Vol.22 No.4

        From the time he was born, Jean Genet was abandoned from the world. Therefore, he also has the right to reject the world. Since then, his rebellion and rejection have become ontological characteristics. His betrayal, theft and homosexuality can be understood in that context. Genet’s actions are self-selected and homosexuality is also in accordance with the inevitable circumstances of existence. It may be an unconscious desire. Moreover, Genet’s sexual desire appears to be a blind devotion to nature, life, and race. All of Jean Genet’s text is a record of living his own way. There, the artist’s attitude and position toward life are melted. His ideas or thoughts are based on existence. In addition, Genet’s text, in any form, appears to be a testimony or excuse for his existence. From this point of view, I would like to explore Genet’s work, political and social discourse, and the engagement movement. It will be a research to find out the identity of the problematic writer Genet and his truth. The identity of Genet is evident avove all in his writings. This is because writing is the crystal of thought. His words, writings and actions form one body. The characters in the work and the people he met in life almost coincide. Although the background or situation of the work lies between reality and unreality, they all project Genet’s personality. There are excuses, protests and confessions about existence. Sometimes he lived as an injured protagonist in novels, but at the same time he lived as a free man and a rebellious intellectual who led social change dynamically.

      • KCI등재후보
      • KCI등재

        Development of R packages: ‘NonCompart’ and ‘ncar’ for noncompartmental analysis (NCA)

        Hyungsub Kim,Sungpil Han,조용순,Seok-Kyu Yoon,Kyun-Seop Bae 대한임상약리학회 2018 Translational and Clinical Pharmacology Vol.26 No.1

        Noncompartmental analysis (NCA) is a primary analytical approach for pharmacokinetic studies,and its parameters act as decision criteria in bioequivalent studies. Currently, NCA is usuallycarried out by commercial softwares such as WinNonlin®. In this article, we introduce our newlydevelopedtwo R packages, NonCompart (NonCompartmental analysis for pharmacokinetic data)and ncar (NonCompartmental Analysis for pharmacokinetic Report), which can perform NCAand produce complete NCA reports in both pdf and rtf formats. These packages are compatiblewith CDISC (Clinical Data Interchange Standards Consortium) standard as well. We demonstratehow the results of WinNonlin® are reproduced and how NCA reports can be obtained. With these Rpackages, we aimed to help researchers carry out NCA and utilize the output for early stages of drugdevelopment process. These R packages are freely available for download from the CRAN repository.

      • KCI등재

        Mechanistic ligand-receptor interaction model: operational model of agonism

        Hyungsub Kim,Hyeong-Seok Lim 대한임상약리학회 2018 Translational and Clinical Pharmacology Vol.26 No.3

        This tutorial explains the basic principles of mechanistic ligand-receptor interaction model, whichis an operational model of agonism. A growing number of agonist drugs, especially immune oncologydrugs, is currently being developed. In this tutorial, time-dependent ordinary differentialequation for simple Emax operational model of agonism was derived step by step. The differentialequation could be applied in a pharmacodynamic modeling software, such as NONMEM, for usein non-steady state experiments, in which experimental data are generated while the interaction betweenligand and receptor changes over time. Making the most of the non-steady state experimentaldata would simplify the experimental processes, and furthermore allow us to identify more detailedkinetics of a potential drug. The operational model of agonism could be useful to predict the optimaldose for agonistic drugs from in vitro and in vivo animal pharmacology experiments at the veryearly phase of drug development.

      • KCI등재

        Connectivity and network burst properties of in‑vitro neuronal networks induced by a clustered structure with alginate hydrogel patterning

        Hyungsub Lee,Gwan-Su Yi,Yoonkey Nam 대한의용생체공학회 2023 Biomedical Engineering Letters (BMEL) Vol.13 No.4

        Modularity is one of the important structural properties that affect information processing and other functionalities of neuronalnetworks. Researchers have developed in-vitro clustered network models for reproducing the modularity, but it is stillchallenging to control the segregation and integration of several sub-populations of them. We cultured clustered networkswith alginate patterning and collected the electrophysiological signals to investigate the changes in functional propertiesduring the development. We built inter-connected neuronal clusters using alginate micro-patterning with a circular shape onthe surface of the micro-electrode array. The neuronal clusters were enabled to be connected at 3 or 10 days-in-vitro (DIV)by removing the barrier. The neuronal signals from different types of networks were collected from 16 to 34 DIV, and functionalcharacteristics were examined. Connectivity and burst motif analysis were carried out to find out the relation betweenthe structure and function of the networks. Neuronal networks with clustered structure showed different activity propertiesfrom the random networks along the development. The clustered networks had more short-range connections compared tothe random networks. In the network burst motif analysis, the clustered networks showed more various patterns and a slowerpropagation of the activation patterns. In this study, we successfully cultured neuronal networks with clustered structure,and the structure affected the functional properties. The network model suggested in this study will be a good solution forobserving the effect of structure on function during their development.

      • Anomalous Jahn–Teller behavior in a manganese-based mixed-phosphate cathode for sodium ion batteries

        Kim, Hyungsub,Yoon, Gabin,Park, Inchul,Park, Kyu-Young,Lee, Byungju,Kim, Jongsoon,Park, Young-Uk,Jung, Sung-Kyun,Lim, Hee-Dae,Ahn, Docheon,Lee, Seongsu,Kang, Kisuk The Royal Society of Chemistry 2015 ENERGY AND ENVIRONMENTAL SCIENCE Vol.8 No.11

        <P>We report a 3.8 V manganese-based mixed-phosphate cathode material for applications in sodium rechargeable batteries; i.e., Na4Mn3(PO4)(2)(P2O7). This material exhibits a largest Mn2+/Mn3+ redox potential of 3.84 V vs. Na+/Na yet reported for a manganese-based cathode, together with the largest energy density of 416 W h kg (1). We describe first-principles calculations and experimental results which show that three-dimensional Na diffusion pathways with low-activation-energy barriers enable the rapid sodium insertion and extraction at various states of charge of the Na4-xMn3(PO4)(2)(P2O7) electrode (where x = 0, 1, 3). Furthermore, we show that the sodium ion mobility in this crystal structure is not decreased by the structural changes induced by Jahn-Teller distortion (Mn3+), in contrast to most manganese-based electrodes, rather it is increased due to distortion, which opens up sodium diffusion channels. This feature stabilizes the material, providing high cycle stability and high power performance for sodium rechargeable batteries. The high voltage, large energy density, cycle stability and the use of low-cost Mn give Na4Mn3(PO4)(2)(P2O7) significant potential for applications as a cathode material for large-scale Na-ion batteries.</P>

      • Neutron and X-ray Diffraction Study of Pyrophosphate-Based Li<sub>2–<i>x</i></sub>MP<sub>2</sub>O<sub>7</sub> (M = Fe, Co) for Lithium Rechargeable Battery Electrodes

        Kim, Hyungsub,Lee, Seongsu,Park, Young-Uk,Kim, Haegyeom,Kim, Jongsoon,Jeon, Seokwoo,Kang, Kisuk American Chemical Society 2011 Chemistry of materials Vol.23 No.17

        <P>Structural characterization of Li<SUB>2–<I>x</I></SUB>MP<SUB>2</SUB>O<SUB>7</SUB> (M = Fe, Co) was carried out using neutron diffraction (ND) and X-ray diffraction (XRD) analyses to elucidate structural information and structural changes during an electrochemical reaction. The crystal system and space group were determined to be monoclinic <I>P</I>2<SUB>1</SUB>/<I>c</I> for both materials with <I>a</I> = 11.0192 (4) Å, <I>b</I> = 9.7488 (3) Å, <I>c</I> = 9.8057 (4) Å, and β = 101.569 (3)° for Li<SUB>2–<I>x</I></SUB>FeP<SUB>2</SUB>O<SUB>7</SUB> and <I>a</I> = 10.9574 (3), <I>b</I> = 9.6921 (3), <I>c</I> = 9.7611 (3), and β = 101.776 (2)° for Li<SUB>2–<I>x</I></SUB>CoP<SUB>2</SUB>O<SUB>7</SUB>. XRD analysis revealed partial occupancy of iron and cobalt in the structures of Li<SUB>2–<I>x</I></SUB>FeP<SUB>2</SUB>O<SUB>7</SUB> and Li<SUB>2–<I>x</I></SUB>CoP<SUB>2</SUB>O<SUB>7</SUB>, respectively. Also, ND identified lithium positions and partial occupancies in five different Li sites of Li<SUB>2–<I>x</I></SUB>MP<SUB>2</SUB>O<SUB>7</SUB> (M = Fe, Co). Further ex situ XRD showed that the charging/discharging of Li<SUB>2–<I>x</I></SUB>FeP<SUB>2</SUB>O<SUB>7</SUB> occurred primarily via a two-phase reaction with a slight solid solution behavior. We also demonstrated for the first time that Li<SUB>2–<I>x</I></SUB>CoP<SUB>2</SUB>O<SUB>7</SUB> electrodes are electrochemically active, with a redox potential of ∼5 V (versus Li).</P><P>We report the detailed structural analysis of Li<SUB>2−<I>x</I></SUB>MP<SUB>2</SUB>O<SUB>7</SUB> (M = Fe, Co) by combined neutron diffraction and X-ray diffraction analyses. XRD analysis revealed the partial occupancies of iron and cobalt in Li<SUB>2−<I>x</I></SUB>MP<SUB>2</SUB>O<SUB>7</SUB>, and ND identified lithium positions and partial occupancies of four different Li sites in the complex crystal structure of Li<SUB>2−<I>x</I></SUB>MP<SUB>2</SUB>O<SUB>7</SUB>. Atomic sites and occupancies were determined by simultaneous Rietveld refinement against XRD and ND patterns, and ex situ XRD analysis revealed that charging/discharging of Li<SUB>2−<I>x</I></SUB>FeP<SUB>2</SUB>O<SUB>7</SUB> occurs primarily via a two-phase reaction. Also, the Li<SUB>2−<I>x</I></SUB>CoP<SUB>2</SUB>O<SUB>7</SUB> electrode is electrochemically active with a redox potential of ∼4.9 V and a high capacity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cmatex/2011/cmatex.2011.23.issue-17/cm201305z/production/images/medium/cm-2011-01305z_0003.gif'></P>

      • 능동소음제어 성능향상을 위한 탑승자 위치 기반 2차 경로 모델링 컨셉 연구

        임형섭(HyungSub Lim),정종인(JongIn Jung),장세영(SeYeong Jang) 한국자동차공학회 2018 한국자동차공학회 학술대회 및 전시회 Vol.2018 No.11

        In this paper we present secondary path modeling based on occupants position for active noise control system. In most ANC systems, the secondary path filters are constructed by designing the system without considering the position of the occupants in the modeling of the secondary path. The disadvantage of such a system is that the convergence of noise control is impaired when the occupant"s position changes from the optimal position designed for secondary path modeling. To avoid this issue, this thesis allows optimal feedback to be provided to occupants by considering the location of the occupants in the secondary route modeling and configuring the active noise control system by referring to the various secondary routes designed for this purpose. Experimentation with modeling and simulation using the proposed method has shown that the convergence performance of active noise control systems is improved.

      • New Iron-Based Mixed-Polyanion Cathodes for Lithium and Sodium Rechargeable Batteries: Combined First Principles Calculations and Experimental Study

        Kim, Hyungsub,Park, Inchul,Seo, Dong-Hwa,Lee, Seongsu,Kim, Sung-Wook,Kwon, Woo Jun,Park, Young-Uk,Kim, Chul Sung,Jeon, Seokwoo,Kang, Kisuk American Chemical Society 2012 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.134 No.25

        <P>New iron-based mixed-polyanion compounds Li<SUB><I>x</I></SUB>Na<SUB>4–<I>x</I></SUB>Fe<SUB>3</SUB>(PO<SUB>4</SUB>)<SUB>2</SUB>(P<SUB>2</SUB>O<SUB>7</SUB>) (<I>x</I> = 0–3) were synthesized, and their crystal structures were determined. The new compounds contained three-dimensional (3D)sodium/lithium paths supported by P<SUB>2</SUB>O<SUB>7</SUB> pillars in the crystal. First principles calculations identified the complex 3D paths with their activation barriers and revealed them as fast ionic conductors. The reversible electrode operation was found in both Li and Na cells with capacities of one-electron reaction per Fe atom, 140 and 129 mAh g<SUP>–1</SUP>, respectively. The redox potential of each phase was ∼3.4 V (vs Li) for the Li-ion cell and ∼3.2 V (vs Na) for the Na-ion cell. The properties of high power, small volume change, and high thermal stability were also recognized, presenting this new compound as a potential competitor to other iron-based electrodes such as Li<SUB>2</SUB>FeP<SUB>2</SUB>O<SUB>7</SUB>, Li<SUB>2</SUB>FePO<SUB>4</SUB>F, and LiFePO<SUB>4</SUB>.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2012/jacsat.2012.134.issue-25/ja3038646/production/images/medium/ja-2012-038646_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja3038646'>ACS Electronic Supporting Info</A></P>

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