난수생성과 시뮬레이션 기법의 응용에 관한 연구

노형진 한국품질경영학회 2000 품질혁신 Vol.1 No.1

The purpose of this study is to suggest usefulness of random number generation and simulation to business administration and statistics. Some examples of their application are presented.

낙동강 하류의 식물플랑크톤 동태

노재순,박형숙 慶星大學校 1995 論文集 Vol.16 No.3

Dynamics of phytoplankton in the lower Nakdnng river was investigated from March to December, 1993. The results obtained on this study are as follows. The changing pattern of standing crop of phytoplankton in water temperature and precipitation. It was found that when water temperature was high and the weather was droughty the standing crop of upper region (Hanam, Samrangjin) were higher than lower region (Mulgum, Kupo), and when water temperature was low and the weather was droughty the results were opposite. The phytoplankton distribution patterns of the lower Nakdong River have a close relationship with the patterns of middle stream.

선박의장 배치 설계의 검도를 위한 컴퓨터 지원 시스템의 개발 사례

노재정,조형석,전진영,성낙운 경성대학교 공학기술연구소 1999 공학기술연구지 Vol.6 No.-

The purpose of this study is to develop a computer support system for the inspection of the outfitting arrangement of a ship design, which will increase the accuracy and the effectiveness of the inspection process. This system is integrated with a ORACLE database for transferring and storing 3D CAD data into the inspection system, and a dVISE virtual reality system for displaying the attributes of entities and the inspection results.

알록산 투여로 유발된 실험적 당뇨병에 대한 사인추출물의 치료 효과

노혜원,이지나,구본선,조정임,박진우,김형로 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.26 No.2

연구배경:사인추출물이 알록산에 의한 당뇨 유발을 억제하는 효과가 있음을 이미 확인하였던 바 사인 추출물이 췌장 베타세포가 손상되어 유발된 당뇨병의 치료에 사용할 수 있는지의 가능성을 알아보았다. 방법:실험적 당뇨는 알록산(60㎎/㎏)을 생쥐 꼬리 정맥을 통해 주사하여 유발시켰다. 당뇨에 미치는 사인추출물의 영향을 관찰하기 위하여 사인추출물의 영향을 관찰하기 위하여 사인추출물(2.5㎎/생쥐)을 하루에 두 번 생쥐 복강 내로 투여하였다. 당뇨에 미치는 사인추출물의 영향을 관찰하기 위하여 생쥐에 사인추출물을 처리한 다음 혈당 및 혈청 인슐린 농도 변화 및 조직학적인 소견으로 확인하였다. 결과:생쥐에 알록산을 투여하면 췌장 베타세포가 파괴되어 고혈당 및 hypoinsulinemia가 유발되었다. 사인추출물을 알록산 투여 전 2일 동안 전처리하면 알록산에 의한 고혈당이 완전히 억제되었다. 뿐만 아니라 알록산에 의해 유발된 췌장 베타세포의 손상은 사인추출물의 투여로 현저히 개선되어 혈당 및 혈청 인슐린 농도가 거의 정상 수준으로 회복되었다. 알록산을 투여한 생쥐의 췌장 소도는 정상군에 비해 수가 현저히 감소되었을 뿐 아니라 남아있는 소도의 크기도 현저히 줄어들어 있었으나, 사인추출물을 처리하면 모두 회복되어 정상군과 유사한 양상을 보였다. 결론:사인추출물은 알록산에 의해 유발되는 당뇨병을 억제하는 방어 작용 뿐만 아니라, 알록산 투여로 이미 손상된 췌장 베타세포를 개선시킬 수 있는 치료 효과작용도 가지고 있음을 확인하였다. 이를 토대로 사인의 당뇨 개선 기전을 규명하면 당뇨병 치료제로서 이용할 수 있으리라 사료된다. Background : During the screening of natural products for potential antidiabetogenic components, a strong protective effect of Amomum xanthoides extract on alloxan-induced β-cell damage and in a mice diabetic model. In this study, the therapeutic effect of Amomum xanthoides extract was investigated after induction of diabetes by alloxan. Methods : Experimental diabetes was induced by the injection of alloxan(60mg/kg) to the mouse via the tail vein. To examine the effect the of Amomum xanthoides extract on diabetes, Amomum xanthoides extract (2.5mg/mouse) was admini-strated intraperitoneally. The effect of the Amomum xanthoides extract on alloxan-induced diabetes was observed by measuring the blood glucose and serum insulin level, and a histological examination. Results : Alloxan caused hyperglycemia and hypoinsulinemia by a selectively destroying pancreatic β-cell. Pretreating the with an Amoumum xanthoides extract completely protected them from the hyperglycemia induced by alloxan. In addition, the Amomum xanthoides extract administe 3 days after the of alloxan injection significantly abolished the hyperglycemia and hypoinsulinemia induced by alloxan. The alloxan-treated mice showed a marked change of in the pancreatic islets: the number of islets was reduced and the size of the remaining islets also decreased. However these effects of alloxan were significantly recovered by a later administration of the Amomum xanthoides extract. Conclusion : The amomum xanthoides extract contains potentially effective components, which both protect and treat alloxan-induced diabetes. The identification and action mechanism of the effective components of the Amomum xanthoides extract requires further investigation and it is suggested that the Amomum xanthoides extract be used as a therapeutic drug for diabetes(J Kor Diabetes 26:126~133, 2002).

범주형 다변량 데이터의 상관관계분석에 관한 기초적 연구(I)

노형진 경기대학교 한국산업경제연구소 2000 産業硏究 Vol.12 No.-

The purpose of this study is to suggest usefulness of correlation analyisi about categorical muitivariate datato business administration and other social sciences. Some clitiques of the theory are presented.

닭赤血球膜 Ca^(2+)-Adenosine Triphosphatase에 關한 硏究

金炯魯,池垠政 全南大醫大 1975 전남의대학술지 Vol.12 No.2

기계부하를 고려한 GT 셀 형성방법

신동목,노형민,이종원 한국경영과학회 1989 한국경영과학회 학술대회논문집 Vol.- No.1

The purpose of this study is to develop Balanced Clustering (BC) algorithm for forming GT cells in manufacturing system. The BC algorithm considers the number of products per machine and production time as well as the kinds of machines. This consideration can relieve in some degree the bottleneck machine problem and the unbalance of machine load after clustering, which exist in current clustering algorithms. The BC algorithm is written in PASCAL and compared with another algorithm through an example.

급성 척수허혈 및 재관류손상에 대한 Na^+/H^+ 교환억제제(DMA)의 보호효과 : 가토 척수의 허혈 및 재관류손상 모형에 의한 실험적 연구 An Experimental Study in Spinal Cord Ischemia and Reperfusion Injury Model

고정관,박형주,이길노 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Spinal cord injury after operations on the descending thoracic and thoracoabdominal aorta remains a persistant clinical problem. Previous attemps to decrease the risk of this devastating complication by lowering the rate of metabloism of the spinal cord have met with varying success. We hypothesized that the tolerance of the spinal cord to an ischemic insult could be improved by means of Na^+/H^+ exchange inhibitor(DMA). DMA prevent intracellular Na^+ influx and maintain intracellular acid pH during ischemia by blocking the Na^+/H^+ exchange system. Additionally, subsequent Ca^++ influx during reperfusion is prevented by blocking the Na^+/Ca^++ exchange as well. It is well established that not only the intracellular acidosis during ischemia prolongs cellular survival but almost all of the reperfusion injury is associated with intracellular Ca^++ overload. Twenty four New zealnad white rabbits underwent 30 minutes of isolated infrarenal aortic occlusion after heparin anticoagulation. Clamps were placed both below the left renal vein and above the aortic bifurcation. In 12 rabbit(Amiloride Group), a bolus of amiloride(3㎎/㎏) intravenous injection and a bolus of diluted amiloride(100uM) was infused the isolated aortic segment immediately after crossclamping and immediately before release of clamping. In another control group(12 rabbits), the aortic segment was flushed with normothermic saline in a fashion identical to that of the study group. The aortic clamps were removed after 30 minutes, the abdomen was closed, and the animals were allowed to recover from anesthesia. Spinal cord function was assessed 72 hours after operation by the Talov's scale. All animals were put to death at 72 hours after operation and spinal cords were harvested for MDA and histologic analysis. The spinal cord function of all Amiloride group animals were fully intact with Talov's scores of 3-5; control group animals were all paraplegic with Talov's score of 0-2(p<0.001, student t-test). MDA level in Amiloride group was 0.046±0.06 and control group was 0.065±0.01(p<0.0001, student t-test). Histologic examination of spinal cords from Amiloride gropup rabbits revealed a little evidence of cord injury, whereas spinal cords from control group had evidence of extensive cord injuty with central gray necrosis, axonal swelling, dissolution of Nissl substance, and astrocyte and macrophage infiltration. Systemic and regional infusion of the crossclamped infrarenal rabbit aorta with Na^+/H^+ exchange inhibitor(DMA) nearly complete prevented paraplegia in our model despite a 30-minute ischemic insult.

골반 골절 환자에 있어서 골절 위치에 따른 하부 요로 손상의 연관성

신대은,문형윤,박성운,노준 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.3

Background and Objectives: Lower urinary tract injuries in pelvic bone fracture can lead to significant complication. We tried to find out the relationship between the fracture location and the bladder, urethra injury in patients who sustaining pelvic bone fracture. We thought that the fracture locations could serves as markers for injury. Materials and Methods: A clinical study was made on 43 patients who sustaining pelvic bone fracture with bladder or urethra injury in the Chosun University hospital during the period of 5 years from January, 2002 to December 2006. Diagnosis was done by retrograde cystography, retrograde urethragraphy, abdomenpelvic computed tomography. Results: Of the 43 patients reviewed, 27 patients had intraperitoneal type bladder rupture, and 12 patients had extra-peritoneal type bladder rupture. 9 patients had urethral rupture. Intraperitoneal type bladder rupture cases are most commonly associated with infrapubic ramus, suprapubic ramus and acetabulum. but the statistically significance is abscent (p= 0.642). Also extraperitoneal type bladder rupture cases are most commonly associated with infrapubic ramus, suprapubic ramus and acetabulum. but the statistically significance is abscent (p= 0.548). And all type bladder rupture cases are most commonly associated with infrapubic ramus, suprapubic ramus and acetabulum. but the statistically significance is abscent (p= 0.775). And urethral rupture cases are most commonly associated with infrapubic ramus, suprapubic ramus and acetabulum but the statistically significance is abscent (p= 0.528). Lastly, Combineded bladder rupture and urethral rupture cases are most commonly associated with infrapubic ramus, llium, Symphysis pubis. But the statistically significance is abscent (p= 0.462). Conclusions: In our study when there is a pelvic bone fracture, the fractured site of pelvic bone have no statistically association with lower urinary tract injury. But most common pelvic bone fracture site of all lower urinary tract injury cases is infrapubic ramus. Therefore, if infrapubic ramus fracture is found in the condition of pelvic bone fracture, it is highly likely to have lower urinary tract injury. More careful observation and diagnosis is necessary for this case.

방광에 발생한 염증성 근섬유아세포종

강윤일,문형윤,노준,김철성 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1

Inflammatory myofibroblastic tumor of urinary bladder is a rare benign entity that clinically and radiologically simulates a malignant tumor. This benign lesion must be differentiated histoloeically from several malignant lesion of the bladder. Complete surgical excision, either by transurethral resection or partial cystectomy, appears to be curative. We report a case of inflammatory myofibroblastic tumor of the urinary bladder in a 25-year-old female.